KR102151299B1 - N-(4-하이드록시-4-메틸-사이클로헥실)-4-페닐-벤젠설폰아미드 및 n-(4-하이드록시-4-메틸-사이클로헥실)-4-(2-피리딜)벤젠설폰아미드 및 이들의 치료 용도 - Google Patents

N-(4-하이드록시-4-메틸-사이클로헥실)-4-페닐-벤젠설폰아미드 및 n-(4-하이드록시-4-메틸-사이클로헥실)-4-(2-피리딜)벤젠설폰아미드 및 이들의 치료 용도 Download PDF

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KR102151299B1
KR102151299B1 KR1020167002015A KR20167002015A KR102151299B1 KR 102151299 B1 KR102151299 B1 KR 102151299B1 KR 1020167002015 A KR1020167002015 A KR 1020167002015A KR 20167002015 A KR20167002015 A KR 20167002015A KR 102151299 B1 KR102151299 B1 KR 102151299B1
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compound
cancer
disease
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solvate
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리사 파텔
스티븐 알란 스미스
이안 로버트 그레이그
사무엘 카메론 윌리엄스
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핌코 2664 리미티드
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    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
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    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Health & Medical Sciences (AREA)
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  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020167002015A 2013-06-26 2014-06-24 N-(4-하이드록시-4-메틸-사이클로헥실)-4-페닐-벤젠설폰아미드 및 n-(4-하이드록시-4-메틸-사이클로헥실)-4-(2-피리딜)벤젠설폰아미드 및 이들의 치료 용도 Active KR102151299B1 (ko)

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GBGB1311361.8A GB201311361D0 (en) 2013-06-26 2013-06-26 Compounds and their therapeutic use
GB1311361.8 2013-06-26
PCT/GB2014/051921 WO2014207445A1 (en) 2013-06-26 2014-06-24 N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and their therapeutic use

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KR20160024392A KR20160024392A (ko) 2016-03-04
KR102151299B1 true KR102151299B1 (ko) 2020-09-02

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US (4) US9624167B2 (https=)
EP (1) EP3013799B1 (https=)
JP (1) JP6360555B2 (https=)
KR (1) KR102151299B1 (https=)
CN (1) CN105492426B (https=)
AU (1) AU2014300745B2 (https=)
BR (1) BR112015031527B1 (https=)
CA (1) CA2915075C (https=)
CY (1) CY1119438T1 (https=)
DK (1) DK3013799T3 (https=)
EA (1) EA028077B1 (https=)
ES (1) ES2641758T3 (https=)
GB (1) GB201311361D0 (https=)
HR (1) HRP20171611T1 (https=)
HU (1) HUE034983T2 (https=)
IL (1) IL243103B (https=)
LT (1) LT3013799T (https=)
ME (1) ME02834B (https=)
MX (1) MX374328B (https=)
NZ (1) NZ715192A (https=)
PL (1) PL3013799T3 (https=)
PT (1) PT3013799T (https=)
RS (1) RS56256B1 (https=)
SG (1) SG11201510646SA (https=)
SI (1) SI3013799T1 (https=)
SM (1) SMT201700503T1 (https=)
WO (1) WO2014207445A1 (https=)
ZA (1) ZA201600202B (https=)

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AU2015367528B2 (en) * 2014-12-17 2020-05-14 Pimco 2664 Limited N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and their therapeutic use
GB201813312D0 (en) * 2018-08-15 2018-09-26 Modern Biosciences Ltd Compounds and their therapeutic use
GB201905520D0 (en) * 2019-04-18 2019-06-05 Modern Biosciences Ltd Compounds and their therapeutic use
EP4431090A1 (en) 2023-03-15 2024-09-18 Istesso 1 Limited Solfonamides acting as mitochondrial complex i modulator compounds
GB202308547D0 (en) 2023-06-08 2023-07-26 Istesso 2 Ltd Tnf inhibitor combination therapies
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GB202315822D0 (en) 2023-10-16 2023-11-29 Istesso 3 Ltd Anti-fibrotic combination therapeutics
GB202317050D0 (en) 2023-11-07 2023-12-20 Istesso 2 Ltd Disease modifying anti-rheumatic drug combination therapies
EP4647071A1 (en) 2024-05-10 2025-11-12 Istesso Therapeutics Limited Mitochondrial complex i modulator for use in the treatment of arthritis
GB202411554D0 (en) 2024-08-06 2024-09-18 Istesso 2 Ltd NF-kB inhibitor combination therapies

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