JP2016525563A5 - - Google Patents

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Publication number

JP2016525563A5

JP2016525563A5 JP2016530548A JP2016530548A JP2016525563A5 JP 2016525563 A5 JP2016525563 A5 JP 2016525563A5 JP 2016530548 A JP2016530548 A JP 2016530548A JP 2016530548 A JP2016530548 A JP 2016530548A JP 2016525563 A5 JP2016525563 A5 JP 2016525563A5

Authority

JP

Japan

Prior art keywords

carbon atoms

alkyl

therapeutic agent

halogen atom

diazepin

Prior art date

2014-08-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000004432 carbon atom Chemical group C* 0.000 claims 44
• 150000001875 compounds Chemical class 0.000 claims 33
• 125000000217 alkyl group Chemical group 0.000 claims 28
• 239000003814 drug Substances 0.000 claims 28
• 229940124597 therapeutic agent Drugs 0.000 claims 28
• 125000005843 halogen group Chemical group 0.000 claims 24
• -1 Methyl (S)-{4- (3′-cyanobiphenyl-4-yl) -2,3,9-trimethyl-6H-thieno [3,2-f] [1,2,4] tri- Azolo [4,3-a] [1,4] diazepin-6-yl} acetate Chemical compound 0.000 claims 16
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 16
• 125000003545 alkoxy group Chemical group 0.000 claims 12
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 12
• 239000007962 solid dispersion Substances 0.000 claims 12
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
• 229920000642 polymer Polymers 0.000 claims 8
• 125000004076 pyridyl group Chemical group 0.000 claims 8
• 150000003839 salts Chemical class 0.000 claims 6
• GNMUEVRJHCWKTO-FQEVSTJZSA-N 6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-n-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6s)- Chemical compound C([C@@H]1N=C(C2=C(N3C(C)=NN=C31)SC(=C2C)C)C=1C=CC(Cl)=CC=1)C(=O)NC1=CC=C(O)C=C1 GNMUEVRJHCWKTO-FQEVSTJZSA-N 0.000 claims 4
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
• IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 claims 4
• 229910052799 carbon Inorganic materials 0.000 claims 4
• 125000004093 cyano group Chemical group *C#N 0.000 claims 4
• 150000004683 dihydrates Chemical class 0.000 claims 4
• 230000009477 glass transition Effects 0.000 claims 4
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
• 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 4
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 4
• 238000000634 powder X-ray diffraction Methods 0.000 claims 4
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
• 239000012453 solvate Substances 0.000 claims 4
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
• WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
• 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
• 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1