KR20160036591A - 티에노트리아졸로디아제핀 화합물을 함유하는 약학적 제제 - Google Patents
티에노트리아졸로디아제핀 화합물을 함유하는 약학적 제제 Download PDFInfo
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- KR20160036591A KR20160036591A KR1020167004843A KR20167004843A KR20160036591A KR 20160036591 A KR20160036591 A KR 20160036591A KR 1020167004843 A KR1020167004843 A KR 1020167004843A KR 20167004843 A KR20167004843 A KR 20167004843A KR 20160036591 A KR20160036591 A KR 20160036591A
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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| US201361861291P | 2013-08-01 | 2013-08-01 | |
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| US61/863,118 | 2013-08-07 | ||
| PCT/EP2014/066629 WO2015014998A1 (en) | 2013-08-01 | 2014-08-01 | Pharmaceutical formulation containing thienotriazolodiazepine compounds |
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| US9757385B2 (en) * | 2013-11-27 | 2017-09-12 | Merck Sharp & Dohme Corp. | Method of treating leukemia using pharmaceutical formulation containing thienotriazolodiazepine compounds |
| KR20160145833A (ko) * | 2014-05-02 | 2016-12-20 | 온코에틱스 게엠베하 | 티에노트리아졸로디아제핀 화합물을 사용한 급성 골수성 백혈병 및/또는 급성 림프아구성 백혈병의 치료 방법 |
| CN107427524A (zh) * | 2014-08-28 | 2017-12-01 | 翁科埃斯克斯有限公司 | 利用包含噻吩并三唑并二氮杂*化合物的药物组合物治疗急性髓细胞白血病或急性淋巴性白血病的方法 |
| US20180098997A1 (en) * | 2015-04-03 | 2018-04-12 | Oncoethix Gmbh | Pharmaceutical doses for a bromodomain and extraterminal protein (bet) inhibitor |
| US10683305B2 (en) | 2015-04-27 | 2020-06-16 | Concert Pharmaceuticals, Inc. | Deuterated OTX-015 |
| US10792249B2 (en) | 2017-07-24 | 2020-10-06 | Acryspharm Llc | High drug loading pharmaceutical compositions |
| BR112023025562A2 (pt) | 2021-06-08 | 2024-02-20 | Poseidon Innovation Llc | Compostos anticâncer |
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| AU2001264303A1 (en) * | 2000-06-16 | 2001-12-24 | Mitsubishi Pharma Corporation | Compositions controlling release ph range and/or speed |
| EP1904654A2 (en) * | 2005-07-15 | 2008-04-02 | Brystol-Myers Squibb Company | Methods of identifying and treating individuals exhibiting mutant src kinase polypeptides |
| EP2102356A2 (en) * | 2007-01-09 | 2009-09-23 | Brystol-Myers Squibb Company | Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in prostate cells |
| CN101910182B (zh) * | 2007-12-28 | 2013-07-17 | 田边三菱制药株式会社 | 抗癌剂 |
| NZ593937A (en) * | 2008-12-08 | 2014-05-30 | Vm Pharma Llc | Compositions of protein receptor tyrosine kinase inhibitors |
| CA2799403C (en) | 2010-05-14 | 2020-01-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
| CN103119160B (zh) * | 2010-05-14 | 2016-06-01 | 达那-法伯癌症研究所 | 用于调节代谢的组合物和方法 |
| AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| EP2863923B1 (en) * | 2012-06-25 | 2019-05-08 | Oncoethix GmbH | Thienotriazolodiazepine compounds for the treatment of lymphomas |
| MX2015003771A (es) * | 2012-09-28 | 2016-03-04 | Oncoethix Gmbh | Formulacion farmaceutica que contiene compuestos de tienotriazolodiazepina. |
| US9757385B2 (en) * | 2013-11-27 | 2017-09-12 | Merck Sharp & Dohme Corp. | Method of treating leukemia using pharmaceutical formulation containing thienotriazolodiazepine compounds |
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| JP2016525563A (ja) | 2016-08-25 |
| CN106029077A (zh) | 2016-10-12 |
| EP3027194A1 (en) | 2016-06-08 |
| WO2015014998A1 (en) | 2015-02-05 |
| US9795612B2 (en) | 2017-10-24 |
| JP6453877B2 (ja) | 2019-01-16 |
| US20160158245A1 (en) | 2016-06-09 |
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