JP2016525548A5 - - Google Patents
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- JP2016525548A5 JP2016525548A5 JP2016529872A JP2016529872A JP2016525548A5 JP 2016525548 A5 JP2016525548 A5 JP 2016525548A5 JP 2016529872 A JP2016529872 A JP 2016529872A JP 2016529872 A JP2016529872 A JP 2016529872A JP 2016525548 A5 JP2016525548 A5 JP 2016525548A5
- Authority
- JP
- Japan
- Prior art keywords
- combination
- desmopressin
- combination medicament
- hours
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 20
- 108010000437 Deamino Arginine Vasopressin Proteins 0.000 claims 11
- NFLWUMRGJYTJIN-PNIOQBSNSA-N desmopressin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSCCC(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O)=O)CCC(=O)N)C1=CC=CC=C1 NFLWUMRGJYTJIN-PNIOQBSNSA-N 0.000 claims 11
- 229960004281 desmopressin Drugs 0.000 claims 11
- 102100014184 ADRB3 Human genes 0.000 claims 4
- 101700073744 ADRB3 Proteins 0.000 claims 4
- 230000036470 plasma concentration Effects 0.000 claims 3
- PBAPPPCECJKMCM-IBGZPJMESA-N Mirabegron Chemical compound S1C(N)=NC(CC(=O)NC=2C=CC(CCNC[C@H](O)C=3C=CC=CC=3)=CC=2)=C1 PBAPPPCECJKMCM-IBGZPJMESA-N 0.000 claims 2
- 210000002200 Mouth Mucosa Anatomy 0.000 claims 2
- 239000000048 adrenergic agonist Substances 0.000 claims 2
- 230000002686 anti-diuretic Effects 0.000 claims 2
- 229960001551 mirabegron Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- XSOXUIXLUNBLJA-RNRVQEDPSA-N (2R)-6-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid Chemical compound C1([C@@H](O)CN[C@@H](CC=2C=C3OC[C@@H](OC3=CC=2)C(O)=O)C)=CC=CC(Cl)=C1 XSOXUIXLUNBLJA-RNRVQEDPSA-N 0.000 claims 1
- VMMYRRFPMAGXNP-BTYIYWSLSA-N 2-[4-[2-[[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]-2,5-dimethylphenoxy]acetic acid Chemical compound N([C@@H](C)[C@H](O)C=1C=CC(O)=CC=1)CCC1=CC(C)=C(OCC(O)=O)C=C1C VMMYRRFPMAGXNP-BTYIYWSLSA-N 0.000 claims 1
- ZGGNJJJYUVRADP-UHFFFAOYSA-N 2-[4-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetic acid Chemical compound C=1C=CC(Cl)=CC=1C(O)CNC(C)CC1=CC=C(OCC(O)=O)C=C1 ZGGNJJJYUVRADP-UHFFFAOYSA-N 0.000 claims 1
- IBPCNRNTIRZRJZ-QFIPXVFZSA-N 4-[4-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]phenyl]-2-methoxybenzoic acid Chemical compound C1=C(C(O)=O)C(OC)=CC(C=2C=CC(CCNC[C@H](O)C=3C=C(Cl)C=CC=3)=CC=2)=C1 IBPCNRNTIRZRJZ-QFIPXVFZSA-N 0.000 claims 1
- 229950003058 Fasobegron Drugs 0.000 claims 1
- 210000002850 Nasal Mucosa Anatomy 0.000 claims 1
- 229950008844 Ritobegron Drugs 0.000 claims 1
- 230000001058 adult Effects 0.000 claims 1
- 229950008231 amibegron Drugs 0.000 claims 1
- RDJQCOBTKKAQAH-FPOVZHCZSA-N ethyl 2-[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydronaphthalen-2-yl]oxy]acetate Chemical group C1([C@@H](O)CN[C@H]2CCC3=CC=C(C=C3C2)OCC(=O)OCC)=CC=CC(Cl)=C1 RDJQCOBTKKAQAH-FPOVZHCZSA-N 0.000 claims 1
- 230000001766 physiological effect Effects 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Claims (15)
- 成人ヒト対象における排尿の衝動を約2時間〜約8時間以下の間隔にわたって抑制するための組合せ医薬であって、前記組合せ医薬は、有効な低用量のデスモプレシン及びβ−3アドレナリン受容体刺激薬を含み、重複期間中に前記デスモプレシン及び前記β−3アドレナリン受容体刺激薬が生理学的活性を発揮する、組合せ医薬。
- 前記組合せ医薬は、ヒト対象における排尿の前記衝動を約4時間〜約7時間の間隔にわたって抑制する、請求項1に記載の組合せ医薬。
- 抗利尿効果は、約2時間〜約6時間以下の間隔にわたって達成される、請求項1に記載の組合せ医薬。
- 抗利尿効果は、約4時間〜約7時間以下の間隔にわたって達成される、請求項1に記載の組合せ医薬。
- 前記組合せ医薬は、前記対象において10または15pg/mLを超えないデスモプレシンの血漿濃度を達成する、請求項1に記載の組合せ医薬。
- 前記組合せ医薬は、前記対象において約0.5pg/mL〜約5pg/mLの範囲のデスモプレシンの血漿濃度を達成する、請求項1に記載の組合せ医薬。
- 前記組合せ医薬は、前記ヒト対象において約0.5pg/mL〜約2.5pg/mLの範囲のデスモプレシンの血漿濃度を達成する、請求項1に記載の組合せ医薬。
- デスモプレシンは、経皮的に、皮内に、または口腔もしくは鼻粘膜を介して経粘膜的に投与される、請求項1に記載の組合せ医薬。
- デスモプレシンは、経皮的にまたは皮内に投与される、請求項1に記載の組合せ医薬。
- デスモプレシンは、鼻腔内に投与される、請求項1に記載の組合せ医薬。
- デスモプレシンは、口腔粘膜を介して舌下に投与される、請求項1に記載の組合せ医薬。
- デスモプレシンは、約5ng/時間〜約35ng/時間の範囲の流動速度で投与される、請求項9に記載の組合せ医薬。
- デスモプレシンは、約5ng/時間〜約15ng/時間の範囲の流動速度で投与される、請求項9に記載の組合せ医薬。
- 前記β−3アドレナリン受容体刺激薬は、アミベグロン、ファソベグロン、ミラベグロン、リトベグロン、ソラベグロン、BRL−37344、CL−316,243、GS−332、KRP−204、L−796568、またはそれらの薬学的に許容される塩である、請求項1に記載の組合せ医薬。
- 前記β−3アドレナリン受容体刺激薬は、ミラベグロンである、請求項1に記載の組合せ医薬。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361857431P | 2013-07-23 | 2013-07-23 | |
US61/857,431 | 2013-07-23 | ||
PCT/US2014/047899 WO2015013454A1 (en) | 2013-07-23 | 2014-07-23 | Methods and compositions comprising desmopressin in combination with a beta-3 adrenergic receptor agonist |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020065913A Division JP7219736B2 (ja) | 2013-07-23 | 2020-04-01 | Β-3アドレナリン受容体刺激薬と組み合わせたデスモプレシンを含む方法及び組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016525548A JP2016525548A (ja) | 2016-08-25 |
JP2016525548A5 true JP2016525548A5 (ja) | 2017-08-31 |
Family
ID=51299056
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016529872A Pending JP2016525548A (ja) | 2013-07-23 | 2014-07-23 | Β−3アドレナリン受容体刺激薬と組み合わせたデスモプレシンを含む方法及び組成物 |
JP2020065913A Active JP7219736B2 (ja) | 2013-07-23 | 2020-04-01 | Β-3アドレナリン受容体刺激薬と組み合わせたデスモプレシンを含む方法及び組成物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020065913A Active JP7219736B2 (ja) | 2013-07-23 | 2020-04-01 | Β-3アドレナリン受容体刺激薬と組み合わせたデスモプレシンを含む方法及び組成物 |
Country Status (11)
Country | Link |
---|---|
US (2) | US9814753B2 (ja) |
EP (1) | EP3024474B1 (ja) |
JP (2) | JP2016525548A (ja) |
KR (3) | KR20210103589A (ja) |
CN (1) | CN105579057A (ja) |
AU (1) | AU2014293141A1 (ja) |
CA (1) | CA2919198A1 (ja) |
DK (1) | DK3024474T3 (ja) |
ES (1) | ES2910361T3 (ja) |
MX (1) | MX2016001030A (ja) |
WO (1) | WO2015013454A1 (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0623838D0 (en) * | 2006-11-29 | 2007-01-10 | Malvern Cosmeceutics Ltd | Novel compositions |
PT2442821T (pt) * | 2009-06-18 | 2017-09-29 | Allergan Inc | Administração segura de desmopressina |
US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
EP3024474B1 (en) * | 2013-07-23 | 2022-01-05 | Serenity Pharmaceuticals LLC | Compositions comprising desmopressin in combination with a beta-3 adrenergic receptor agonist |
KR20210103590A (ko) | 2013-07-23 | 2021-08-23 | 세레니티 파마슈티컬즈 엘엘씨 | 5-알파 환원효소 억제제와 함께 데스모프레신을 포함하는 방법 및 조성물 |
DK3220942T3 (da) | 2014-11-20 | 2022-07-18 | Serenity Pharmaceuticals Llc | Sammensætninger omfattende lav dosis af desmopressin i kombination med en alpha-adrenerg receptorantagonist |
US9956194B2 (en) | 2014-12-03 | 2018-05-01 | Velicept Therapeutics, Inc. | Compositions and methods of using modified release solabegron for lower urinary tract symptoms |
WO2017210700A1 (en) * | 2016-06-03 | 2017-12-07 | Velicept Therapeutics, Inc. | Compositions and methods of using modified release solabegron for lower urinary tract symptoms |
KR101877834B1 (ko) * | 2017-04-27 | 2018-07-12 | 주식회사 다산제약 | 미라베그론의 신규한 염 및 이의 제조방법 |
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US4316893A (en) | 1975-06-19 | 1982-02-23 | Nelson Research & Development Co. | Vehicle composition containing 1-substituted azacycloalkan-2-ones |
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US3989816A (en) | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
US4557934A (en) | 1983-06-21 | 1985-12-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
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IL101243A (en) | 1991-03-20 | 1999-12-22 | Merck & Co Inc | Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history |
US5534496A (en) | 1992-07-07 | 1996-07-09 | University Of Southern California | Methods and compositions to enhance epithelial drug transport |
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JP5596252B2 (ja) * | 2003-11-10 | 2014-09-24 | アラーガン、インコーポレイテッド | 低用量デスモプレシンを含有する医薬組成物 |
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EP3024474B1 (en) | 2013-07-23 | 2022-01-05 | Serenity Pharmaceuticals LLC | Compositions comprising desmopressin in combination with a beta-3 adrenergic receptor agonist |
KR20210103590A (ko) | 2013-07-23 | 2021-08-23 | 세레니티 파마슈티컬즈 엘엘씨 | 5-알파 환원효소 억제제와 함께 데스모프레신을 포함하는 방법 및 조성물 |
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DK3220942T3 (da) | 2014-11-20 | 2022-07-18 | Serenity Pharmaceuticals Llc | Sammensætninger omfattende lav dosis af desmopressin i kombination med en alpha-adrenerg receptorantagonist |
-
2014
- 2014-07-23 EP EP14748451.3A patent/EP3024474B1/en active Active
- 2014-07-23 KR KR1020217025792A patent/KR20210103589A/ko active Application Filing
- 2014-07-23 DK DK14748451.3T patent/DK3024474T3/da active
- 2014-07-23 KR KR1020167004515A patent/KR20160033220A/ko not_active Application Discontinuation
- 2014-07-23 KR KR1020247002750A patent/KR20240015735A/ko active Application Filing
- 2014-07-23 CN CN201480052301.7A patent/CN105579057A/zh active Pending
- 2014-07-23 MX MX2016001030A patent/MX2016001030A/es unknown
- 2014-07-23 WO PCT/US2014/047899 patent/WO2015013454A1/en active Application Filing
- 2014-07-23 US US14/338,554 patent/US9814753B2/en not_active Expired - Fee Related
- 2014-07-23 JP JP2016529872A patent/JP2016525548A/ja active Pending
- 2014-07-23 CA CA2919198A patent/CA2919198A1/en active Pending
- 2014-07-23 ES ES14748451T patent/ES2910361T3/es active Active
- 2014-07-23 AU AU2014293141A patent/AU2014293141A1/en not_active Abandoned
-
2017
- 2017-11-13 US US15/811,384 patent/US10568927B2/en active Active
-
2020
- 2020-04-01 JP JP2020065913A patent/JP7219736B2/ja active Active
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