JP2016525130A - 治療活性化合物及びその使用 - Google Patents

治療活性化合物及びその使用 Download PDF

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JP2016525130A
JP2016525130A JP2016528335A JP2016528335A JP2016525130A JP 2016525130 A JP2016525130 A JP 2016525130A JP 2016528335 A JP2016528335 A JP 2016528335A JP 2016528335 A JP2016528335 A JP 2016528335A JP 2016525130 A JP2016525130 A JP 2016525130A
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compound
mmol
optionally substituted
oxoethyl
carboxamide
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JP2016525130A5 (https=
Inventor
エム．レミエウク レネ
エム．レミエウク レネ
ポポビシ‐ムレル ジャネタ
ポポビシ‐ムレル ジャネタ
エム．トラビンス ジェレミ
エム．トラビンス ジェレミ
カイ ズヘンウエイ
カイ ズヘンウエイ
クイ ダウエイ
クイ ダウエイ
ズホウ ディング
ズホウ ディング
Original Assignee
アギオス ファーマシューティカルス，インコーポレーテッド
アギオス ファーマシューティカルス，インコーポレーテッド
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Publication of JP2016525130A publication Critical patent/JP2016525130A/ja
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
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JP2016528335A 2013-07-25 2014-07-24 治療活性化合物及びその使用 Withdrawn JP2016525130A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2013/080105 2013-07-25
PCT/CN2013/080105 WO2015010297A1 (en) 2013-07-25 2013-07-25 Therapeutically active compounds and their methods of use
PCT/CN2014/082869 WO2015010626A1 (en) 2013-07-25 2014-07-24 Therapeutically active compounds and use thereof

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JP2016525130A true JP2016525130A (ja) 2016-08-22
JP2016525130A5 JP2016525130A5 (https=) 2017-08-31

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US (4) US20150031627A1 (https=)
EP (1) EP3024824A4 (https=)
JP (2) JP2016525130A (https=)
AR (1) AR097082A1 (https=)
CA (1) CA2918500C (https=)
MX (2) MX2016000696A (https=)
TW (1) TWI662023B (https=)
WO (2) WO2015010297A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
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JP2020523344A (ja) * 2017-06-12 2020-08-06 アジオス ファーマシューティカルズ， インコーポレイテッド 併用療法を用いて脳腫瘍を処置する方法
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