JP2016523938A - Uvフィルター、紫外線吸収剤で官能基付与されたオルガノポリシロキサン、および多孔質シリカおよび/またはポリメチルメタクリレート粒子を含む紫外線遮断組成物 - Google Patents
Uvフィルター、紫外線吸収剤で官能基付与されたオルガノポリシロキサン、および多孔質シリカおよび/またはポリメチルメタクリレート粒子を含む紫外線遮断組成物 Download PDFInfo
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- IAJNXBNRYMEYAZ-UHFFFAOYSA-N ethyl 2-cyano-3,3-diphenylprop-2-enoate Chemical compound C=1C=CC=CC=1C(=C(C#N)C(=O)OCC)C1=CC=CC=C1 IAJNXBNRYMEYAZ-UHFFFAOYSA-N 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
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- 238000010528 free radical solution polymerization reaction Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
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- 235000011852 gelatine desserts Nutrition 0.000 description 1
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- GKKMCECQQIKAHA-UHFFFAOYSA-N hexadecyl dihydrogen phosphate;2-(2-hydroxyethylamino)ethanol Chemical compound OCCNCCO.CCCCCCCCCCCCCCCCOP(O)(O)=O GKKMCECQQIKAHA-UHFFFAOYSA-N 0.000 description 1
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- 239000003755 preservative agent Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- DCBSHORRWZKAKO-UHFFFAOYSA-N rac-1-monomyristoylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(O)CO DCBSHORRWZKAKO-UHFFFAOYSA-N 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
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- CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
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- 229940083037 simethicone Drugs 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 229940045898 sodium stearoyl glutamate Drugs 0.000 description 1
- KDHFCTLPQJQDQI-BDQAORGHSA-M sodium;(4s)-4-amino-5-octadecanoyloxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O KDHFCTLPQJQDQI-BDQAORGHSA-M 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
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- DHCDFWKWKRSZHF-UHFFFAOYSA-N sulfurothioic S-acid Chemical compound OS(O)(=O)=S DHCDFWKWKRSZHF-UHFFFAOYSA-N 0.000 description 1
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 1
- 229960000368 sulisobenzone Drugs 0.000 description 1
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- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 description 1
- ZQTYRTSKQFQYPQ-UHFFFAOYSA-N trisiloxane Chemical compound [SiH3]O[SiH2]O[SiH3] ZQTYRTSKQFQYPQ-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
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- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
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- 238000005303 weighing Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Classifications
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- Cosmetics (AREA)
Abstract
Description
から選択される少なくとも1つの単位と、
任意選択的に式(II)
の1つまたはいくつかの単位と、を含み、
上記式中、aは、0、1または2であり、
bは、0、1、2、3であり;
R1は、C1〜C30炭化水素基またはトリメチルシリルオキシ基であり、
R2は、水素、C1〜C10炭化水素基またはトリメチルシリルオキシ基であり、
Yは、二価C1〜C10アルキレンまたはC2〜C10アルケニレン鎖、好ましくはC1〜C4アルキレン鎖、最も好ましくはメチレン基であり、
Xは、O、NHまたはNR3であり、R3は、C1〜C30、特にC1〜C3炭化水素基であり、
Aは、UV−B線吸収基、UV−A線吸収基、UV−C線吸収基または広帯域光吸収基である。
と、
a=1である場合に、上記の(Ia)、(Ib)、(Ic)および/または(Id)の群から選択されるs個の単位と、
式(IV)のr個の単位[b=2である場合に、式(II)の単位に相当する]
(式中、sが0である場合に、少なくともBまたはB’がI、II、IIIまたはIV基であるという条件で、
sは、0〜50の整数であり、
rは、0〜200の整数であり;
R1、R4、R5、R6、R7は独立して、R1について上記で定義されるとおりであり;
R8およびR9は独立して、R2について上記で定義されるとおりであり
BおよびB’は独立して、R1基であるか、または
から選択される紫外線吸収基である)と、
を含む直鎖状オルガノポリシロキサンである。
(式中、R5、R6およびR7は、水素、炭素1〜22個、好ましくは炭素12〜18個のアルキル;または炭素1〜22個、好ましくは炭素12〜18個を有し、かつ1モル以上、好ましくは2〜25モル、最も好ましくは2〜12モルのエチレンオキシドを有する、アルコキシル化アルキルであり、但し、R5、R6およびR7のうちの少なくとも1つが、前記アルキルまたはアルコキシル化アルキル基において上記で定義される通りであるが、少なくとも6個のアルキル炭素を有するアルキルまたはアルコキシル化アルキルであることを条件とする)
のリン酸エステル乳化剤を包含する。
[1.生体外(In vitro)でのSPF測定]
生体外SPF法:3つのSchoenbergプレート上にそれぞれの試料を1.3mg/cm2で塗布する:粗さ5μm;9箇所/プレートの測定;Labsphere UV Transmittance Analyzer2000。
COLIPA International Sun Protection Factor Test Methodに準拠して、外部試験機関(Dermaconsult Concept GmbH,Bonn,Germany)にて、本発明による数種のO/Wエマルジョンの生体外SPFを試験した。その結果を表2および3に示す。
COLIPA International Sun Protection Factor Test Methodに準拠して、外部試験機関(Dermaconsult Concept GmbH,Bonn,Germany)にて、本発明によるUVフィルターの組み合わせ(すなわち、親水性ベンズイミダゾール型UVBフィルターと少なくとも1つの紫外線吸収基で官能基付与されたオルガノポリシロキサン)を含まない数種のO/Wエマルジョンの生体内SPFを試験した。その結果を表4および5に示す。
以下の条件下にて、8名からなる、訓練された感覚パネル(trained sensorial panel)を用いて、上記のように製造された試料を盲検試験で試験した。
Claims (15)
- 親水性ベンズイミダゾール型UVBフィルターと、少なくとも1つの紫外線吸収基で官能基付与されたオルガノポリシロキサンと、0.3μmを超える粒径Dv0、35μm未満のDv100、9〜15μmの範囲で選択されるDv50、および1.2〜2.5cc/gの範囲で選択されるオイル吸収能力を有する高多孔質シリカビーズおよび/または高多孔質架橋ポリメチルメタクリレートビーズと、を含む局所組成物。
- 前記ビーズの量が、互いに独立して、化粧品組成物の全重量に対して0.1〜5重量%の範囲で選択されることを特徴とする、請求項1に記載の局所組成物。
- シリカビーズのみを含むことを特徴とする、請求項1または2に記載の局所組成物。
- 前記シリカビーズの前記オイル吸収能力が、1.3〜1.8cc/gの範囲で選択されることを特徴とする、請求項3に記載の局所組成物。
- 前記シリカビーズがさらに、ジメチコンでコーティングされることを特徴とする、請求項1〜4のいずれか一項に記載の局所組成物。
- 架橋ポリメチルメタクリレートビーズのみを含むことを特徴とする、請求項1または2に記載の局所組成物。
- 前記架橋ポリメチルメタクリレートビーズの前記オイル吸収能力が、1.5〜2.0cc/gの範囲で選択されることを特徴とする、請求項6に記載の局所組成物。
- 前記ベンズイミダゾール型UVBフィルターが2−フェニルベンズイミダゾール−スルホン酸であり、かつ少なくとも1つの紫外線吸収基で官能基付与された前記オルガノポリシロキサンがポリシリコーン−15であることを特徴とする、請求項1〜7のいずれか一項に記載の局所組成物。
- 前記親水性ベンズイミダゾール型UVBフィルターの量が、前記組成物の全重量に対して0.1〜5重量%の範囲で選択される、請求項1〜8のいずれか一項に記載の局所組成物。
- 少なくとも1つの紫外線吸収基で官能基付与された前記オルガノポリシロキサンの量が、前記組成物の全重量に対して0.1〜15重量%の範囲で選択されることを特徴とする、請求項1〜9のいずれか一項に記載の局所組成物。
- ブチルメトキシジベンゾイルメタン、オクトクリレン、ホモサレートまたは二酸化チタンの群から選択される少なくとも1つの更なるUVフィルターならびにその混合物をさらに含むことを特徴とする、請求項1〜10のいずれか一項に記載の局所組成物。
- O/W乳化剤の存在下にて水相中に分散された油相を含む水中油型(O/W)エマルジョンの形態であることを特徴とする、請求項1〜11のいずれか一項に記載の局所組成物。
- 前記O/W乳化剤がカリウムセチルホスフェートであることを特徴とする、請求項12に記載の局所組成物。
- 親水性ベンズイミダゾール型UVBフィルターと少なくとも1つの紫外線吸収基で官能基付与されたオルガノポリシロキサンとを含む局所組成物の生体内SPFを向上させるための、0.3μmを超える粒径Dv0、35μm未満のDv100、9〜15μmの範囲で選択されるDv50、および1.2〜2.5cc/gの範囲で選択されるオイル吸収能力を有する高多孔質シリカおよび/または高多孔質架橋ポリメチルメタクリレートビーズの使用。
- 親水性ベンズイミダゾール型UVBフィルターと少なくとも1つの紫外線吸収基で官能基付与されたオルガノポリシロキサンとを含む局所組成物の生体内SPFを向上させる方法であって、0.3μmを超える粒径Dv0、35μm未満のDv100、9〜15μmの範囲で選択されるDv50、および1.2〜2.5cc/gの範囲で選択されるオイル吸収能力を有する高多孔質シリカおよび/または高多孔質架橋ポリメチルメタクリレートビーズを前記局所組成物に添加する工程と、効果を評価する工程と、を含む方法。
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