JP2016523919A5 - - Google Patents
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- JP2016523919A5 JP2016523919A5 JP2016524268A JP2016524268A JP2016523919A5 JP 2016523919 A5 JP2016523919 A5 JP 2016523919A5 JP 2016524268 A JP2016524268 A JP 2016524268A JP 2016524268 A JP2016524268 A JP 2016524268A JP 2016523919 A5 JP2016523919 A5 JP 2016523919A5
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- Prior art keywords
- amino acids
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- chimeric molecule
- vwf
- item
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- 150000001413 amino acids Chemical class 0.000 claims description 200
- 108010047303 von Willebrand Factor Proteins 0.000 claims description 93
- 102100036537 von Willebrand factor Human genes 0.000 claims description 93
- 108010054218 Factor VIII Proteins 0.000 claims description 69
- 102000001690 Factor VIII Human genes 0.000 claims description 69
- 229960001134 von willebrand factor Drugs 0.000 claims description 59
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 43
- 239000002157 polynucleotide Substances 0.000 claims description 42
- 102000040430 polynucleotide Human genes 0.000 claims description 42
- 108091033319 polynucleotide Proteins 0.000 claims description 42
- 229960000301 factor viii Drugs 0.000 claims description 41
- 229920001184 polypeptide Polymers 0.000 claims description 39
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 39
- 239000013598 vector Substances 0.000 claims description 26
- 230000000740 bleeding effect Effects 0.000 claims description 24
- 108090000190 Thrombin Proteins 0.000 claims description 19
- 229960004072 thrombin Drugs 0.000 claims description 19
- 239000012634 fragment Substances 0.000 claims description 14
- 101001098529 Homo sapiens Proteinase-activated receptor 1 Proteins 0.000 claims description 11
- 101000713169 Homo sapiens Solute carrier family 52, riboflavin transporter, member 2 Proteins 0.000 claims description 11
- 102100036862 Solute carrier family 52, riboflavin transporter, member 2 Human genes 0.000 claims description 11
- 230000003993 interaction Effects 0.000 claims description 11
- 238000003776 cleavage reaction Methods 0.000 claims description 9
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims description 8
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- -1 aliphatic amino acid Chemical group 0.000 claims description 6
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims description 3
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- 102000002110 C2 domains Human genes 0.000 claims description 2
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- 241001024304 Mino Species 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
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- 239000003937 drug carrier Substances 0.000 claims description 2
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
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- 208000032843 Hemorrhage Diseases 0.000 description 20
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- 238000000034 method Methods 0.000 description 14
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 8
- 102000009027 Albumins Human genes 0.000 description 5
- 108010088751 Albumins Proteins 0.000 description 5
- 101800001415 Bri23 peptide Proteins 0.000 description 5
- 101800000655 C-terminal peptide Proteins 0.000 description 5
- 102400000107 C-terminal peptide Human genes 0.000 description 5
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 4
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 description 4
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 229940050526 hydroxyethylstarch Drugs 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
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- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 101100380342 Catharanthus roseus ASO gene Proteins 0.000 description 2
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 2
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 2
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 238000013169 thromboelastometry Methods 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 206010019196 Head injury Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 108010015340 Low Density Lipoprotein Receptor-Related Protein-1 Proteins 0.000 description 1
- 206010028309 Muscle haemorrhage Diseases 0.000 description 1
- 102100021923 Prolow-density lipoprotein receptor-related protein 1 Human genes 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 208000015294 blood coagulation disease Diseases 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 208000030304 gastrointestinal bleeding Diseases 0.000 description 1
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- 238000007917 intracranial administration Methods 0.000 description 1
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- 238000007913 intrathecal administration Methods 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 210000000574 retroperitoneal space Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361840872P | 2013-06-28 | 2013-06-28 | |
| US61/840,872 | 2013-06-28 | ||
| PCT/US2014/044731 WO2014210558A1 (en) | 2013-06-28 | 2014-06-27 | Thrombin cleavable linker with xten and its uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018195860A Division JP2019010124A (ja) | 2013-06-28 | 2018-10-17 | Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016523919A JP2016523919A (ja) | 2016-08-12 |
| JP2016523919A5 true JP2016523919A5 (cg-RX-API-DMAC7.html) | 2017-08-10 |
Family
ID=52142742
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016524268A Pending JP2016523919A (ja) | 2013-06-28 | 2014-06-27 | Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用 |
| JP2018195860A Pending JP2019010124A (ja) | 2013-06-28 | 2018-10-17 | Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用 |
| JP2021018123A Active JP7005800B2 (ja) | 2013-06-28 | 2021-02-08 | Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用 |
| JP2021163956A Active JP7297837B2 (ja) | 2013-06-28 | 2021-10-05 | Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用 |
| JP2023097660A Active JP7623426B2 (ja) | 2013-06-28 | 2023-06-14 | Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用 |
| JP2025005420A Pending JP2025061316A (ja) | 2013-06-28 | 2025-01-15 | Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018195860A Pending JP2019010124A (ja) | 2013-06-28 | 2018-10-17 | Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用 |
| JP2021018123A Active JP7005800B2 (ja) | 2013-06-28 | 2021-02-08 | Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用 |
| JP2021163956A Active JP7297837B2 (ja) | 2013-06-28 | 2021-10-05 | Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用 |
| JP2023097660A Active JP7623426B2 (ja) | 2013-06-28 | 2023-06-14 | Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用 |
| JP2025005420A Pending JP2025061316A (ja) | 2013-06-28 | 2025-01-15 | Ｘｔｅｎを有するトロンビン切断可能リンカー及びその使用 |
Country Status (17)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102741422B (zh) | 2009-08-24 | 2016-06-08 | 阿穆尼克斯运营公司 | 凝血因子ⅶ组合物及其制备和使用方法 |
| EP2804623B1 (en) | 2012-01-12 | 2019-08-07 | Bioverativ Therapeutics Inc. | Chimeric factor viii polypeptides and uses thereof |
| JP6383666B2 (ja) | 2012-02-15 | 2018-08-29 | バイオベラティブ セラピューティクス インコーポレイテッド | 組換え第ｖｉｉｉ因子タンパク質 |
| EP2814840B1 (en) | 2012-02-15 | 2019-11-13 | Bioverativ Therapeutics Inc. | Factor viii compositions and methods of making and using same |
| EP2870250B2 (en) | 2012-07-06 | 2022-06-29 | Bioverativ Therapeutics Inc. | Cell line expressing single chain factor viii polypeptides and uses thereof |
| SG10201701037WA (en) * | 2012-07-11 | 2017-03-30 | Amunix Operating Inc | Factor viii complex with xten and von willebrand factor protein, and uses thereof |
| EP3033097B1 (en) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
| HRP20220960T1 (hr) * | 2014-01-10 | 2022-10-28 | Bioverativ Therapeutics Inc. | Kimerni proteini faktora viii i njihova upotreba |
| AU2016231328B2 (en) * | 2015-03-06 | 2018-07-05 | CSL Behring Lengnau AG | Compounds for improving the half-life of von Willebrand factor |
| WO2017024060A1 (en) | 2015-08-03 | 2017-02-09 | Biogen Ma Inc. | Factor ix fusion proteins and methods of making and using same |
| EP3476937A4 (en) * | 2016-06-24 | 2019-12-04 | Mogam Institute for Biomedical Research | CHIMERIC PROTEIN WITH FVIII AND VWF FACTORS AND USE THEREOF |
| SG10201912360SA (en) * | 2016-11-11 | 2020-02-27 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for treating hemophilia |
| IL266972B2 (en) | 2016-12-02 | 2024-04-01 | Bioverativ Therapeutics Inc | Methods of treating hemophilic arthropathy using chimeric clotting factors |
| CA3099049A1 (en) | 2018-05-18 | 2019-11-21 | Bioverativ Therapeutics Inc. | Methods of treating hemophilia a |
| JP2021535739A (ja) | 2018-08-27 | 2021-12-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 下流精製でのラマン分光法の使用 |
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