JP2016523671A - 自動注射器 - Google Patents
自動注射器 Download PDFInfo
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- JP2016523671A JP2016523671A JP2016524775A JP2016524775A JP2016523671A JP 2016523671 A JP2016523671 A JP 2016523671A JP 2016524775 A JP2016524775 A JP 2016524775A JP 2016524775 A JP2016524775 A JP 2016524775A JP 2016523671 A JP2016523671 A JP 2016523671A
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- case
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- plunger
- needle shroud
- needle
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- XVVOERDUTLJJHN-IAEQDCLQSA-N lixisenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 XVVOERDUTLJJHN-IAEQDCLQSA-N 0.000 description 1
- 108010004367 lixisenatide Proteins 0.000 description 1
- 229960001093 lixisenatide Drugs 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- RWHUEXWOYVBUCI-ITQXDASVSA-N nafarelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 RWHUEXWOYVBUCI-ITQXDASVSA-N 0.000 description 1
- 229960002333 nafarelin Drugs 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000013777 protein digestion Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
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Images
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Abstract
Description
ここで、一実施形態において、薬学的に活性な化合物は、最大1500Daまでの分子量を有し、および/または、ペプチド、タンパク質、多糖類、ワクチン、DNA、RNA、酵素、抗体もしくはそのフラグメント、ホルモンもしくはオリゴヌクレオチド、または上述の薬学的に活性な化合物の混合物であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病、または糖尿病性網膜症などの糖尿病関連の合併症、深部静脈血栓塞栓症または肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、がん、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症および/または関節リウマチの処置および/または予防に有用であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病または糖尿病性網膜症などの糖尿病に関連する合併症の処置および/または予防のための少なくとも1つのペプチドを含み、
ここで、さらなる実施形態において、薬学的に活性な化合物は、少なくとも1つのヒトインスリンもしくはヒトインスリン類似体もしくは誘導体、グルカゴン様ペプチド(GLP−1)もしくはその類似体もしくは誘導体、またはエキセンジン−3もしくはエキセンジン−4もしくはエキセンジン−3もしくはエキセンジン−4の類似体もしくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36エキセンジン−4(1−39)、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);または
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
(ここで、基−Lys6−NH2が、エキセンジン−4誘導体のC−末端に結合していてもよい);
desPro36エキセンジン−4(1−39)−Lys6−NH2(AVE0010)、
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
または前述のいずれか1つのエキセンジン−4誘導体の薬学的に許容される塩もしくは溶媒和化合物
から選択される。
Claims (15)
- 自動注射器(1)であって:
針(4)を有する薬剤容器を保持するように適用されたケース(2)と;
該ケース(2)に嵌め込み式に連結されると共に、針(4)が覆われるケース(2)に対する第1の伸張位置(FEP)と、針(4)が露出するケース(2)に対する後退位置(RP)と、針(4)が覆われニードルシュラウド(7)がケース(2)に対して並進運動できない、ケース(2)に対する第2の伸張位置(SEP)との間で可動のニードルシュラウド(7)と;
ケース(2)内に摺動可能に配置されると共に、ケース(2)に対する近位位置と、中間位置と、遠位位置との間で可動のプランジャ(10)と
を含み、
ここで、プランジャ(10)が中間位置にあり、かつニードルシュラウド(7)が後退位置(RP)にあるとき、プランジャ(10)はケース(2)に当接して、ニードルシュラウド(7)が第1の伸張位置(FEP)に戻ることを防止し、
プランジャ(10)が遠位位置にあり、かつニードルシュラウド(7)が第2の伸張位置(SEP)にあるとき、プランジャ(10)はケース(2)に当接して、ニードルシュラウド(7)が後退位置(RP)に戻ることを防止する、前記自動注射器。 - ケース(2)は、プランジャ(10)が近位位置にあるときにプランジャ(10)の半径方向プランジャ開口部(10.1)と係合するように適用された第1のボス(2.4)を有する第1のコンプライアントケースビーム(2.3)を含む、請求項1に記載の自動注射器(1)。
- ニードルシュラウド(7)は、該ニードルシュラウド(7)が第1の伸張位置(FEP)にあるときに第1のボス(2.4)に半径方向に当接する、請求項2に記載の自動注射器(1)。
- ニードルシュラウド(7)は、該ニードルシュラウド(7)が後退位置(RP)にあり、かつ第1のコンプライアントケースビーム(2.3)が半径方向に偏向したときに第1のボス(2.4)を収容するように適用された半径方向シュラウド開口部(7.2)を含む、請求項2に記載の自動注射器(1)。
- ケース(2)は、ニードルシュラウド(7)の制御構造体(7.3)と係合するように適用された第2のボス(2.6)を有する第2のコンプライアントケースビーム(2.5)を含み、該第2のコンプライアントケースビーム(2.5)は、ケース(2)に対して半径方向および接線方向に可動である、請求項1〜4のいずれか1項に記載の自動注射器(1)。
- 制御構造体(7.3)は、ニードルシュラウド(7)が第1の伸張位置(EP)にあるときに第2のボス(2.6)に半径方向に当接するように適用された第1の面(7.4)を含む、請求項5に記載の自動注射器(1)。
- 制御構造体(7.3)は、ニードルシュラウド(7)が第1の伸張位置(EP)にあるときに第2のボス(2.6)に接線方向に当接するように適用された第2の面(7.6)を含む、請求項5に記載の自動注射器(1)。
- 制御構造体(7.3)は、第1の面(7.4)または第2の面(7.6)の近位に凹部(7.5)を含み、該凹部(7.5)は、ニードルシュラウド(7)が後退位置(RP)にあり、かつ第2のコンプライアントケースビーム(2.5)が半径方向または接線方向に偏向したときに第2のボス(2.6)を受けるように適用される、請求項5または6に記載の自動注射器(1)。
- プランジャ(10)は、第2のボス(2.6)が凹部(7.5)に受け入れられ、かつプランジャ(10)が中間位置にあるときに第2のボス(2.6)に当接する、請求項8に記載の自動注射器(1)。
- 制御構造体(7.3)は、ニードルシュラウド(7)が後退位置(RP)から第2の伸張位置(SEP)へと並進運動すると、第2のボス(2.6)に半径方向に当接するように適用された第1の面(7.4)から半径方向および接線方向にオフセットされている第3の面(7.7)を含む、請求項5に記載の自動注射器(1)。
- 制御構造体(7.3)は、ニードルシュラウド(7)が後退位置(RP)から第2の伸張位置(SEP)へと並進運動すると、第2のボス(2.6)を接線方向に変位させるように適用された第3の面(7.7)の近位に傾斜ボス(7.10)を含む、請求項5に記載の自動注射器(1)。
- 制御構造体(7.3)は、ニードルシュラウド(7)が第2の伸張位置(SEP)にあり、かつプランジャ(10)が中間位置または遠位位置にあるときに第2のボス(2.6)を受けるように適用された傾斜ボス(7.10)の近位に切欠きを含む、請求項11に記載の自動注射器(1)。
- 制御構造体(7.3)は、ニードルシュラウド(7)が第1の伸張位置(FEP)から後退位置(RP)へと並進運動すると第2のボス(2.6)を半径方向または接線方向に変位させるように適用された凹部(7.5)の近位の、第1の面(7.4)または第2の面(7.6)に形成された当接部(7.8)を含む、請求項5に記載の自動注射器(1)。
- ニードルシュラウド(7)をケース(2)に対して付勢するシュラウドばね(8)
をさらに含む、請求項1〜13のいずれか1項に記載の自動注射器(1)。 - プランジャ(10)をケース(2)に対して付勢する駆動ばね(9)
をさらに含む、請求項1〜14のいずれか1項に記載の自動注射器(1)。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13175663.7A EP2823840A1 (en) | 2013-07-09 | 2013-07-09 | Autoinjector |
EP13175663.7 | 2013-07-09 | ||
PCT/EP2014/064426 WO2015004051A1 (en) | 2013-07-09 | 2014-07-07 | Autoinjector |
Publications (2)
Publication Number | Publication Date |
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JP2016523671A true JP2016523671A (ja) | 2016-08-12 |
JP6637416B2 JP6637416B2 (ja) | 2020-01-29 |
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Application Number | Title | Priority Date | Filing Date |
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JP2016524775A Active JP6637416B2 (ja) | 2013-07-09 | 2014-07-07 | 自動注射器 |
Country Status (9)
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US (4) | US10137256B2 (ja) |
EP (2) | EP2823840A1 (ja) |
JP (1) | JP6637416B2 (ja) |
CN (1) | CN105530969B (ja) |
AR (1) | AR096830A1 (ja) |
DK (1) | DK3019219T3 (ja) |
HK (1) | HK1218400A1 (ja) |
TW (1) | TW201521815A (ja) |
WO (1) | WO2015004051A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2823840A1 (en) * | 2013-07-09 | 2015-01-14 | Sanofi-Aventis Deutschland GmbH | Autoinjector |
KR102384133B1 (ko) | 2016-06-03 | 2022-04-08 | 에스에이치엘 메디컬 아게 | 약물 전달 장치 |
EP3781235A1 (en) * | 2018-04-19 | 2021-02-24 | Sanofi | Force reduction in injection devices |
GB2577549B (en) | 2018-09-28 | 2021-08-04 | Owen Mumford Ltd | Injection device with commit feature |
US20210093792A1 (en) * | 2019-09-30 | 2021-04-01 | Amgen Inc. | Drug delivery device and methods of delivering a drug |
JP2022549883A (ja) | 2019-09-30 | 2022-11-29 | アムジエン・インコーポレーテツド | 薬物送達デバイス |
EP4173656A1 (en) | 2021-10-27 | 2023-05-03 | medmix Switzerland AG | Needle guard, drug delivery device and method for manufacturing |
Citations (3)
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US20110196339A1 (en) * | 2008-08-11 | 2011-08-11 | Hirschel Juerg | Automatic injection device for administering a fixed dose |
US20120203186A1 (en) * | 2009-05-29 | 2012-08-09 | Patrick Vogt | Injection device with pricking protection and/or overload protection for a product container |
WO2013034984A2 (en) * | 2011-09-09 | 2013-03-14 | Merck Patent Gmbh | An auto injector with separate needle injection |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2899482A1 (fr) | 2006-04-11 | 2007-10-12 | Becton Dickinson France Soc Pa | Dispositif d'injection automatique |
EP2438942A1 (en) * | 2010-10-08 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
EP2823840A1 (en) * | 2013-07-09 | 2015-01-14 | Sanofi-Aventis Deutschland GmbH | Autoinjector |
-
2013
- 2013-07-09 EP EP13175663.7A patent/EP2823840A1/en not_active Withdrawn
-
2014
- 2014-07-07 AR ARP140102514A patent/AR096830A1/es unknown
- 2014-07-07 EP EP14737212.2A patent/EP3019219B1/en active Active
- 2014-07-07 TW TW103123255A patent/TW201521815A/zh unknown
- 2014-07-07 WO PCT/EP2014/064426 patent/WO2015004051A1/en active Application Filing
- 2014-07-07 JP JP2016524775A patent/JP6637416B2/ja active Active
- 2014-07-07 US US14/903,363 patent/US10137256B2/en active Active
- 2014-07-07 DK DK14737212.2T patent/DK3019219T3/en active
- 2014-07-07 CN CN201480048991.9A patent/CN105530969B/zh active Active
-
2016
- 2016-06-06 HK HK16106417.4A patent/HK1218400A1/zh unknown
-
2018
- 2018-10-11 US US16/157,163 patent/US10814074B2/en active Active
-
2020
- 2020-09-23 US US17/029,514 patent/US11369750B2/en active Active
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2022
- 2022-06-24 US US17/849,222 patent/US20220313926A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110196339A1 (en) * | 2008-08-11 | 2011-08-11 | Hirschel Juerg | Automatic injection device for administering a fixed dose |
US20120203186A1 (en) * | 2009-05-29 | 2012-08-09 | Patrick Vogt | Injection device with pricking protection and/or overload protection for a product container |
WO2013034984A2 (en) * | 2011-09-09 | 2013-03-14 | Merck Patent Gmbh | An auto injector with separate needle injection |
Also Published As
Publication number | Publication date |
---|---|
HK1218400A1 (zh) | 2017-02-17 |
WO2015004051A1 (en) | 2015-01-15 |
US20190038848A1 (en) | 2019-02-07 |
US20220313926A1 (en) | 2022-10-06 |
DK3019219T3 (en) | 2018-12-17 |
EP3019219A1 (en) | 2016-05-18 |
TW201521815A (zh) | 2015-06-16 |
JP6637416B2 (ja) | 2020-01-29 |
EP3019219B1 (en) | 2018-08-22 |
AR096830A1 (es) | 2016-02-03 |
CN105530969B (zh) | 2019-01-25 |
CN105530969A (zh) | 2016-04-27 |
US20210030973A1 (en) | 2021-02-04 |
US11369750B2 (en) | 2022-06-28 |
EP2823840A1 (en) | 2015-01-14 |
US10137256B2 (en) | 2018-11-27 |
US10814074B2 (en) | 2020-10-27 |
US20160144135A1 (en) | 2016-05-26 |
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