JP2016521971A5 - - Google Patents

Download PDF

Info

Publication number
JP2016521971A5
JP2016521971A5 JP2016509588A JP2016509588A JP2016521971A5 JP 2016521971 A5 JP2016521971 A5 JP 2016521971A5 JP 2016509588 A JP2016509588 A JP 2016509588A JP 2016509588 A JP2016509588 A JP 2016509588A JP 2016521971 A5 JP2016521971 A5 JP 2016521971A5
Authority
JP
Japan
Prior art keywords
psc
inhibitor
naive
culture medium
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016509588A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016521971A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2014/060954 external-priority patent/WO2014174470A1/en
Publication of JP2016521971A publication Critical patent/JP2016521971A/ja
Publication of JP2016521971A5 publication Critical patent/JP2016521971A5/ja
Pending legal-status Critical Current

Links

JP2016509588A 2013-04-23 2014-04-23 単離ナイーブ型多能性幹細胞およびそれを発生させる方法関連出願本出願は、米国特許法１１９条第（ｅ）項に基づき、２０１４年１月２９日出願の米国特許仮出願第６１／９３２，９３５号、２０１３年９月１７日出願の米国特許仮出願第６１／８７８，７６９号、および２０１３年４月２３日出願の米国特許仮出願第６１／８１４，９２０号の優先権を主張する。また、本出願は、同時に提出された同出願人による同時係属出願である、ＹａｑｕｂＨＡＮＮＡ、ＮｏａＮＯＶＥＲＳＨＴＥＲＮ、およびＹｏａｃｈＲＡＩＳによる米国特許出願（発明の名称「単離ナイーブ型多能性幹細胞およびそれを発生させる方法（ＩＳＯＬＡＴＥＤＮＡＩＶＥＰＬＵＲＩＰＯＴＥＮＴＳＴＥＭＣＥＬＬＳＡＮＤＭＥＴＨＯＤＳＯＦＧＥＮＥＲＡＴＩＮＧＳＡＭＥ）」）（代理人事件記録簿第５８８７０号）にも関する。上記出願の内容はその全体を参考として本明細書に組み込む。 Pending JP2016521971A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361814920P 2013-04-23 2013-04-23
US61/814,920 2013-04-23
US201361878769P 2013-09-17 2013-09-17
US61/878,769 2013-09-17
US201461932935P 2014-01-29 2014-01-29
US61/932,935 2014-01-29
PCT/IB2014/060954 WO2014174470A1 (en) 2013-04-23 2014-04-23 Isolated naive pluripotent stem cells and methods of generating same

Publications (2)

Publication Number Publication Date
JP2016521971A JP2016521971A (ja) 2016-07-28
JP2016521971A5 true JP2016521971A5 (https=) 2017-06-01

Family

ID=50842281

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016509588A Pending JP2016521971A (ja) 2013-04-23 2014-04-23 単離ナイーブ型多能性幹細胞およびそれを発生させる方法関連出願本出願は、米国特許法１１９条第（ｅ）項に基づき、２０１４年１月２９日出願の米国特許仮出願第６１／９３２，９３５号、２０１３年９月１７日出願の米国特許仮出願第６１／８７８，７６９号、および２０１３年４月２３日出願の米国特許仮出願第６１／８１４，９２０号の優先権を主張する。また、本出願は、同時に提出された同出願人による同時係属出願である、ＹａｑｕｂＨＡＮＮＡ、ＮｏａＮＯＶＥＲＳＨＴＥＲＮ、およびＹｏａｃｈＲＡＩＳによる米国特許出願（発明の名称「単離ナイーブ型多能性幹細胞およびそれを発生させる方法（ＩＳＯＬＡＴＥＤＮＡＩＶＥＰＬＵＲＩＰＯＴＥＮＴＳＴＥＭＣＥＬＬＳＡＮＤＭＥＴＨＯＤＳＯＦＧＥＮＥＲＡＴＩＮＧＳＡＭＥ）」）（代理人事件記録簿第５８８７０号）にも関する。上記出願の内容はその全体を参考として本明細書に組み込む。

Country Status (7)

Country Link
US (3) US10920192B2 (https=)
EP (1) EP2989199B1 (https=)
JP (1) JP2016521971A (https=)
CN (1) CN105531365A (https=)
ES (1) ES2831424T3 (https=)
IL (1) IL241930B (https=)
WO (1) WO2014174470A1 (https=)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011503232A (ja) 2007-11-20 2011-01-27 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド 免疫応答の調節
CN105531365A (zh) 2013-04-23 2016-04-27 耶达研究及发展有限公司 分离的幼稚多能干细胞和产生所述细胞的方法
KR102170502B1 (ko) 2013-12-11 2020-10-28 리제너론 파마슈티칼스 인코포레이티드 게놈의 표적화된 변형을 위한 방법 및 조성물
US20170114323A1 (en) 2014-06-19 2017-04-27 Whitehead Institute For Biomedical Research Uses of kinase inhibitors for inducing and maintaining pluripotency
CN108064274A (zh) 2014-07-30 2018-05-22 耶达研究及发展有限公司 用于培养多能干细胞的培养基
SG11201701398SA (en) * 2014-08-22 2017-03-30 Cambridge Entpr Ltd Resetting pluripotent stem cells
CN105441384B (zh) * 2014-09-26 2021-01-05 北京大学 一种制备动物和人类原始多潜能干细胞的方法，试剂盒及用途
BR112017007770A2 (pt) 2014-10-15 2018-01-16 Regeneron Pharma cultura in vitro, população de hipscs, método para modificar um locus-alvo genômico, e, hipsc.
US10745670B2 (en) 2014-11-17 2020-08-18 Genome Research Limited In vitro production of expanded potential stem cells
US20180071376A1 (en) 2015-03-23 2018-03-15 The Brigham And Women`S Hospital, Inc. Tolerogenic nanoparticles for treating diabetes mellitus
WO2016169903A1 (en) * 2015-04-23 2016-10-27 Koninklijke Philips N.V. Model-based segmentation of an anatomical structure
US20180142206A1 (en) * 2015-05-05 2018-05-24 The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads Reversion of primed pluripotent stem cells to naive pluripotent stem cells
US10563171B2 (en) * 2015-06-29 2020-02-18 Kyoto University Method for inducing differentiation of pluripotent stem cells into germ cells
WO2017025061A1 (en) * 2015-08-13 2017-02-16 Peking University Induced extended pluripotent stem cells, methods of making and using
CN108699515A (zh) 2016-02-24 2018-10-23 诺和诺德股份有限公司 由人多能干细胞衍生的内分泌祖细胞生成功能性β细胞
EP3438248A4 (en) * 2016-03-30 2019-11-06 Kyowa Hakko Bio Co., Ltd. NAIVES PLURIPOTENT STEM CELL CULTIVATION MEDIUM AND PLURIPOTENT STEM CELL CULTIVATION PROCEDURE
CN106244522A (zh) * 2016-08-12 2016-12-21 浙江译美生物科技有限公司 一种干细胞培养体系及其培养方法
CA3032972A1 (en) * 2016-08-19 2018-02-22 Memorial Sloan-Kettering Cancer Center Methods of differentiating stem cells into endoderm
GB201615343D0 (en) * 2016-09-09 2016-10-26 Zernicka-Goetz Magdalena And Harrison Sarah E M Methods
JP7248571B2 (ja) * 2016-10-05 2023-03-29 フジフィルム セルラー ダイナミクス，インコーポレイテッド ＭｅＣＰ２が破壊された誘導多能性幹細胞からの成熟系列の生成
WO2018119213A1 (en) * 2016-12-23 2018-06-28 StemBios Technologies, Inc. Use of somatic stem cells for decreasing il-6 level
US11697796B2 (en) * 2017-01-23 2023-07-11 Stemcell Technologies Canada Inc. Media and methods for enhancing the survival and proliferation of stem cells
US10783627B2 (en) * 2017-03-03 2020-09-22 Case Western Reserve University Predicting cancer recurrence using local co-occurrence of cell morphology (LoCoM)
WO2018209232A1 (en) * 2017-05-12 2018-11-15 Regents Of The University Of Minnesota Methods of preparing naive human pluripotent stem cells
ES2903187T3 (es) * 2017-06-13 2022-03-31 Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin Procedimientos de producción de organoides neuronales de bioingeniería (BENO) y sus usos
CN107523540B (zh) * 2017-06-27 2021-02-12 香港大学深圳医院 一种建立家族遗传性卵巢早衰来源的诱导全能干细胞向原始生殖嵴细胞诱导分化的方法
MX2020005668A (es) 2017-11-30 2020-11-24 Univ Kyoto Metodo de cultivo de celulas.
CN108707629A (zh) * 2018-05-28 2018-10-26 上海海洋大学 斑马鱼notch1b基因突变体的制备方法
KR102131921B1 (ko) * 2018-10-30 2020-07-08 차의과학대학교 산학협력단 줄기 세포의 신경전구세포로의 분화용 조성물, 키트, 및 이를 이용한 방법
CN109355300B (zh) * 2018-11-26 2022-01-28 成都中医药大学 黄连sdir转录因子在提高植物抗旱中的应用
EP3914698B1 (en) 2019-01-23 2024-12-11 Yeda Research and Development Co. Ltd Culture media for pluripotent stem cells
WO2021015228A1 (ja) * 2019-07-25 2021-01-28 富士フイルム株式会社 特定の分化細胞の製造方法
WO2021020267A1 (ja) * 2019-07-26 2021-02-04 富士フイルム株式会社 ナイーブ型多能性幹細胞の増殖能亢進用培地および多能性幹細胞の製造方法
CN110592014A (zh) * 2019-08-14 2019-12-20 广东美赛尔细胞生物科技有限公司 一种在nk细胞治疗中免辐照体外体内持续去除饲养细胞的方法
CN110564674B (zh) * 2019-09-29 2021-05-11 广东工业大学 一种干细胞铺底工作液及其应用
CN110646335A (zh) * 2019-09-29 2020-01-03 广东工业大学 一种封闭液及其应用
EP4059572A4 (en) * 2019-11-14 2024-01-17 Shimasaki, Takeo CELLULAR REPROGRAMMING METHOD
US20230220331A1 (en) * 2020-03-24 2023-07-13 Jichi Medical University Temporary treatment medium, treatment kit, embryogenesis arrest inhibitor, embryogenesis arrest inhibitory method, developmental engineering product preparation method, transplantation method, therapeutic method, and developmental engineering product
CN111487399B (zh) * 2020-03-26 2021-09-17 湖南师范大学 一种蛋白分子标记在鱼类生殖细胞发育研究中的应用
TWI761837B (zh) * 2020-05-20 2022-04-21 國立中央大學 通用人類誘導多能性幹細胞及其生成方法
WO2021243252A1 (en) * 2020-05-29 2021-12-02 The Board Of Trustees Of The Leland Stanford Junior University Generation of primordial germ cells and methods of using the same
JP2023531963A (ja) * 2020-06-22 2023-07-26 ライフ テクノロジーズ コーポレーション 多能性細胞懸濁物を培養するための方法及び組成物
US20230250394A1 (en) * 2020-06-24 2023-08-10 Syracuse University Generation of perinatal-like mesenchymal stem cells from human induced pluripotent stem cells
CN111650327B (zh) * 2020-07-16 2023-06-02 扬州大学 一种基于非标定量蛋白质组学技术寻找如皋黄鸡不同细胞或组织间差异表达蛋白的方法
CN112048467A (zh) * 2020-09-11 2020-12-08 江苏集萃药康生物科技有限公司 Ksom-aa培养液在体外培养nod背景鼠胚胎中的应用
US20230407245A1 (en) * 2020-11-11 2023-12-21 Bgi Shenzhen Group Holdings Co., Limited Media and methods for establishing and maintaining early embryo-like cells
WO2022114188A1 (ja) * 2020-11-30 2022-06-02 国立大学法人京都大学 二層性胚盤モデルおよびその製造方法
CN112831461B (zh) * 2021-02-26 2023-08-08 澳门大学 一种诱导干细胞分化成中胚层谱系或滋养细胞谱系的方法及药物
US12467917B2 (en) 2021-03-16 2025-11-11 California Institute Of Technology Reconstructing human early embryogenesis in vitro with pluripotent stem cells
WO2023082007A1 (en) * 2021-11-12 2023-05-19 L'alliance Boviteq Inc. Derivation of naïve bovine embryonic stem cells
CN114164258B (zh) * 2021-12-22 2022-08-19 北京泽辉辰星生物科技有限公司 一种多能性基因表达水平检验方法
WO2023173370A1 (en) * 2022-03-17 2023-09-21 Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences Media and methods for producing human cells and tissues from teratoma, organoids and embryoid bodies
CN114651787A (zh) * 2022-04-21 2022-06-24 贵州医科大学附属医院 用于构建小鼠视神经特异性脱髓鞘模型的小鼠的构建方法及其应用
CN117431258B (zh) * 2023-12-20 2024-06-28 上海元戊医学技术有限公司 使用含有Tet1基因的重编程因子诱导人体细胞重编程的方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
IL68218A (en) 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US5489304A (en) 1994-04-19 1996-02-06 Brigham & Women's Hospital Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft
US5541110A (en) 1994-05-17 1996-07-30 Bristol-Myers Squibb Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
WO2003006950A2 (en) 2001-07-12 2003-01-23 Geron Corporation Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
US20060194315A1 (en) 2003-03-31 2006-08-31 Condie Brian G Compositions and methods for the control, differentiaton and/or manipulation of pluripotent cells through a gamma-secretase signaling pathway
WO2006040763A2 (en) 2004-10-12 2006-04-20 Technion Research & Development Foundation Ltd. Isolated primate embryonic cells and methods of generating and using same
JP5680850B2 (ja) 2006-03-30 2015-03-04 ザ・ユニバーシティ・コート・オブ・ザ・ユニバーシティ・オブ・エディンバラＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｃｏｕｒｔ ｏｆ ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｅｄｉｎｂｕｒｇｈ キナーゼインヒビターを含む培養培地およびその使用
CN105861443A (zh) 2007-04-07 2016-08-17 怀特黑德生物医学研究所 体细胞重编程
EP2090649A1 (en) 2008-02-13 2009-08-19 Fondazione Telethon Method for reprogramming differentiated cells
WO2010077955A1 (en) 2008-12-17 2010-07-08 The Scripps Research Institute Generation and maintenance of stem cells
WO2010124290A2 (en) * 2009-04-24 2010-10-28 Whitehead Institute For Biomedical Research Compositions and methods for deriving or culturing pluripotent cells
US20130273649A1 (en) 2012-04-13 2013-10-17 University Of Southern California Culture medium for pluripotent stem cells
CN105531365A (zh) 2013-04-23 2016-04-27 耶达研究及发展有限公司 分离的幼稚多能干细胞和产生所述细胞的方法
CN108064274A (zh) 2014-07-30 2018-05-22 耶达研究及发展有限公司 用于培养多能干细胞的培养基
US10745670B2 (en) 2014-11-17 2020-08-18 Genome Research Limited In vitro production of expanded potential stem cells
US10246679B2 (en) 2015-03-02 2019-04-02 The University Of Tokyo Method for producing pluripotent stem cell having improved chimera forming ability from primed pluripotent stem cell, and composition and combination therefor

Similar Documents

Publication Publication Date Title
JP2016521971A5 (https=)
US20240299462A1 (en) Endocrine cells that express chromogranin a
Weinberger et al. Dynamic stem cell states: naive to primed pluripotency in rodents and humans
US12264322B2 (en) Minimal volume reprogramming of mononuclear cells
KR101909847B1 (ko) 줄기 세포의 생성 및 유지
US20250075175A1 (en) Efficient derivation of stable pluripotent bovine embryonic stem cells
US20100272695A1 (en) Cell compositions derived from dedifferentiated reprogrammed cells
CN105849252A (zh) 培养多能干细胞
Guo et al. A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells
EP3914698B1 (en) Culture media for pluripotent stem cells
Surani et al. Germ line, stem cells, and epigenetic reprogramming
JP2015516161A5 (https=)
Avery et al. The role of SMAD4 in human embryonic stem cell self-renewal and stem cell fate
Tomaz et al. Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation
Chang et al. Clonal isolation of an intermediate pluripotent stem cell state
CN111511902A (zh) 通过crispr激活生成诱导性多能细胞
Zhang et al. MiR‐134‐Mbd3 axis regulates the induction of pluripotency
JPWO2017131238A1 (ja) 未分化性低減による多能性幹細胞の分化促進法
Kim et al. X-chromosome epigenetic reprogramming in pluripotent stem cells via noncoding genes
Bieberich et al. Molecular mechanisms underlying pluripotency
WO2022039279A1 (ja) ヒト始原生殖細胞／ヒト始原生殖細胞様細胞の維持増幅方法
Renard et al. Nuclear reprogramming and pluripotency of embryonic cells: Application to the isolation of embryonic stem cells in farm animals
Li et al. Muse cells as a robust source of induced pluripotent stem cells
De Los Angeles et al. ERK-independent African Green monkey pluripotent stem cells in a putative chimera-competent state
Panova et al. Epigenetic reprogramming by naïve conditions establishes an irreversible state of partial X chromosome reactivation in female stem cells