JP2016520637A5 - - Google Patents

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Publication number
JP2016520637A5
JP2016520637A5 JP2016517275A JP2016517275A JP2016520637A5 JP 2016520637 A5 JP2016520637 A5 JP 2016520637A5 JP 2016517275 A JP2016517275 A JP 2016517275A JP 2016517275 A JP2016517275 A JP 2016517275A JP 2016520637 A5 JP2016520637 A5 JP 2016520637A5
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JP
Japan
Prior art keywords
methyl
methoxy
imidazol
trifluoroethoxy
phenyl
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JP2016517275A
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English (en)
Japanese (ja)
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JP2016520637A (ja
JP6368777B2 (ja
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Priority claimed from PCT/EP2014/061503 external-priority patent/WO2014195323A1/en
Publication of JP2016520637A publication Critical patent/JP2016520637A/ja
Publication of JP2016520637A5 publication Critical patent/JP2016520637A5/ja
Application granted granted Critical
Publication of JP6368777B2 publication Critical patent/JP6368777B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2016517275A 2013-06-04 2014-06-03 ピリミジン化合物およびガンマセクレターゼモジュレーターとしてのその使用 Expired - Fee Related JP6368777B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1350685 2013-06-04
SE1350685-2 2013-06-04
PCT/EP2014/061503 WO2014195323A1 (en) 2013-06-04 2014-06-03 Pyrimidine compounds and their use as gamma secretase modulators

Publications (3)

Publication Number Publication Date
JP2016520637A JP2016520637A (ja) 2016-07-14
JP2016520637A5 true JP2016520637A5 (enExample) 2017-06-01
JP6368777B2 JP6368777B2 (ja) 2018-08-01

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ID=50877325

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016517275A Expired - Fee Related JP6368777B2 (ja) 2013-06-04 2014-06-03 ピリミジン化合物およびガンマセクレターゼモジュレーターとしてのその使用

Country Status (9)

Country Link
US (1) US9439904B2 (enExample)
EP (1) EP3004079B1 (enExample)
JP (1) JP6368777B2 (enExample)
CN (1) CN105263923B (enExample)
DK (1) DK3004079T3 (enExample)
ES (1) ES2665421T3 (enExample)
NO (1) NO3004079T3 (enExample)
PL (1) PL3004079T3 (enExample)
WO (1) WO2014195323A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109415369B (zh) * 2016-07-08 2021-12-07 豪夫迈·罗氏有限公司 稠合嘧啶衍生物
CN108191776A (zh) * 2018-01-22 2018-06-22 无锡富泽药业有限公司 一种尿嘧啶的绿色生产工艺
US12297244B2 (en) 2019-06-05 2025-05-13 Rensselaer Polytechnic Institute Systems and methods for inhibiting γ-secretase production of amyloid-β peptides
WO2020247707A1 (en) * 2019-06-05 2020-12-10 Chunyu Wang SYSTEMS AND METHOD FOR INHIBITING γ-SECRETASE PRODUCTION OF AMYLOID-β PEPTIDES
CN110372603A (zh) * 2019-06-24 2019-10-25 南京普锐达医药科技有限公司 一种2-氯-5-氟-6-乙基嘧啶的合成方法
CN113149977A (zh) 2020-01-22 2021-07-23 苏州爱科百发生物医药技术有限公司 一类呼吸道合胞病毒抑制剂的合成与用途
AU2022246081A1 (en) 2021-03-23 2023-10-12 Halia Therapeutics, Inc. Pyrimidine derivatives useful as lrrk2 kinase inhibitors

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CA2348234A1 (en) * 1998-10-29 2000-05-11 Chunjian Liu Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
ITMI20030312A1 (it) 2003-02-21 2004-08-22 Chiesi Farma Spa Derivati di acidi 2-fenil-2-alchil-acetici per il trattamento della malattia di alzheimer.
DE602004026597D1 (de) 2003-08-07 2010-05-27 Merck Sharp & Dohme Behandlung von alzheimer-krankheit und verwandten zuständen
CA2549119A1 (en) 2003-12-03 2005-06-16 Merck & Co., Inc. 1-alkyl-3-thio-substituted indole-2-alkynoic acids useful for the treatment for alzheimer's disease and related conditions
BRPI0511504A (pt) * 2004-05-26 2008-01-22 Eisai R&D Man Co Ltd composto ou um sal farmaceuticamente aceitável do mesmo, e, agente preventivo ou terapêutico para uma doença resultante de beta-amilóides
MX362412B (es) * 2005-11-01 2019-01-15 Targegen Inc Inhibidores de biaril meta-pirimidina de cinasas.
WO2007125364A1 (en) 2006-04-26 2007-11-08 Merck Sharp & Dohme Limited Piperidines and related compounds for treatment of alzheimer’s disease
KR20090018963A (ko) 2006-05-19 2009-02-24 에자이 알앤드디 매니지먼트 가부시키가이샤 우레아계 신나미드 유도체
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
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JP2010518083A (ja) 2007-02-12 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション ピペリジン誘導体
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AU2009203773B2 (en) 2008-01-11 2013-04-18 F. Hoffmann-La Roche Ag Modulators for amyloid beta
EP2257541B1 (en) 2008-02-22 2013-08-14 F. Hoffmann-La Roche AG Modulators for amyloid beta
CA2736924C (en) * 2008-10-09 2016-06-28 F. Hoffmann-La Roche Ag Modulators for amyloid beta
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TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
UY32622A (es) * 2009-05-12 2010-12-31 Astrazeneca Ab Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)
ES2519565T3 (es) 2009-07-15 2014-11-07 Janssen Pharmaceuticals Inc. Derivados de triazol e imidazol sustituidos como moduladores de gamma secretasa
TWI468402B (zh) 2009-07-31 2015-01-11 必治妥美雅史谷比公司 降低β－類澱粉生成之化合物
WO2011086098A1 (en) 2010-01-15 2011-07-21 Ortho-Mcneil-Janssen Pharmaceuticals, Inc Novel substituted bicyclic triazole derivatives as gamma secretase modulators
US20110190269A1 (en) 2010-02-01 2011-08-04 Karlheinz Baumann Gamma secretase modulators
TW201206946A (en) 2010-07-15 2012-02-16 Bristol Myers Squibb Co Compounds for the reduction of beta-amyloid production

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