JP2016520310A - Ｂ細胞ｃｌｌ／リンパ腫１１ａ（ｂｃｌ１１ａ）のオリゴヌクレオチドモデュレーター及びその使用 - Google Patents

Ｂ細胞ｃｌｌ／リンパ腫１１ａ（ｂｃｌ１１ａ）のオリゴヌクレオチドモデュレーター及びその使用 Download PDF

Info

Publication number
JP2016520310A
JP2016520310A JP2016514446A JP2016514446A JP2016520310A JP 2016520310 A JP2016520310 A JP 2016520310A JP 2016514446 A JP2016514446 A JP 2016514446A JP 2016514446 A JP2016514446 A JP 2016514446A JP 2016520310 A JP2016520310 A JP 2016520310A
Authority
JP
Japan
Prior art keywords
seq
bcl11a
lna
antisense oligonucleotide
nucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016514446A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016520310A5 (https=
Inventor
ヒズチャーン，マイ
ニルスン，ニルス・フィスカー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Innovation Center Copenhagen AS
Original Assignee
Roche Innovation Center Copenhagen AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Innovation Center Copenhagen AS filed Critical Roche Innovation Center Copenhagen AS
Publication of JP2016520310A publication Critical patent/JP2016520310A/ja
Publication of JP2016520310A5 publication Critical patent/JP2016520310A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016514446A 2013-05-24 2014-05-26 Ｂ細胞ｃｌｌ／リンパ腫１１ａ（ｂｃｌ１１ａ）のオリゴヌクレオチドモデュレーター及びその使用 Pending JP2016520310A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361827484P 2013-05-24 2013-05-24
US61/827,484 2013-05-24
PCT/EP2014/060813 WO2014188001A1 (en) 2013-05-24 2014-05-26 Oligonucleotide modulators of b-cell cll/lymphoma 11a (bcl11a) and uses thereof

Publications (2)

Publication Number Publication Date
JP2016520310A true JP2016520310A (ja) 2016-07-14
JP2016520310A5 JP2016520310A5 (https=) 2017-06-01

Family

ID=50780484

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016514446A Pending JP2016520310A (ja) 2013-05-24 2014-05-26 Ｂ細胞ｃｌｌ／リンパ腫１１ａ（ｂｃｌ１１ａ）のオリゴヌクレオチドモデュレーター及びその使用

Country Status (12)

Country Link
US (1) US20160130582A1 (https=)
EP (1) EP3004352B1 (https=)
JP (1) JP2016520310A (https=)
KR (1) KR20160013110A (https=)
CN (1) CN105247052A (https=)
BR (1) BR112015029327A2 (https=)
CA (1) CA2907694A1 (https=)
DK (1) DK3004352T3 (https=)
HK (1) HK1213595A1 (https=)
MX (1) MX363846B (https=)
RU (1) RU2015155332A (https=)
WO (1) WO2014188001A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022507464A (ja) * 2018-11-13 2022-01-18 リピゴン ファーマスーティカルス アー・ベー 脂肪酸代謝の調節に影響を与えるａｎｇｐｔｌ４オリゴヌクレオチド

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
RU2612521C2 (ru) 2009-07-06 2017-03-09 Онтории, Инк. Новые пролекарства нуклеиновых кислот и способы их применения
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
CN103796657B (zh) 2011-07-19 2017-07-11 波涛生命科学有限公司 合成官能化核酸的方法
PL2872485T3 (pl) 2012-07-13 2021-05-31 Wave Life Sciences Ltd. Asymetryczna grupa pomocnicza
KR102213609B1 (ko) 2012-07-13 2021-02-08 웨이브 라이프 사이언시스 리미티드 키랄 제어
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
BR112016016400A2 (pt) 2014-01-16 2017-10-03 Wave Life Sciences Ltd Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos
WO2017184082A1 (en) * 2016-04-22 2017-10-26 Nanyang Technological University A lymphocyte permeating chimeric oligonucleotide, methods and uses thereof
US11957718B2 (en) 2016-12-22 2024-04-16 University Of Maryland, Baltimore Methods for generating multipotent stem cells from tonsillar biopsies
TW201839136A (zh) 2017-02-06 2018-11-01 瑞士商諾華公司 治療血色素異常症之組合物及方法
CN114903992B (zh) * 2022-04-18 2024-01-16 南通大学 转录因子bcl11a在制备施万细胞调控药物中的应用
AU2024299328A1 (en) 2023-07-21 2026-01-22 Marrow Therapeutics, Inc. Hematopoietic cell targeting conjugates and related methods

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010030963A2 (en) * 2008-09-15 2010-03-18 Children's Medical Center Corporation Modulation of bcl11a for treatment of hemoglobinopathies
CN102352356A (zh) * 2011-09-28 2012-02-15 暨南大学 抑制BCL11A表达和肿瘤性B细胞增殖的Bcl11a siRNA-2292及其应用
WO2012073047A2 (en) * 2010-12-03 2012-06-07 Genome Research Limited Compositions and methods
WO2012079046A2 (en) * 2010-12-10 2012-06-14 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
WO2013055985A1 (en) * 2011-10-12 2013-04-18 Children's Medical Center Corporation Combinatorial compositions and methods of treating hemoglobinopathies

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6617442B1 (en) 1999-09-30 2003-09-09 Isis Pharmaceuticals, Inc. Human Rnase H1 and oligonucleotide compositions thereof
WO2004046160A2 (en) 2002-11-18 2004-06-03 Santaris Pharma A/S Amino-lna, thio-lna and alpha-l-oxy-ln
WO2007031091A2 (en) 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
WO2007090071A2 (en) 2006-01-27 2007-08-09 Isis Pharmaceuticals, Inc. 6-modified bicyclic nucleic acid analogs
JP2009536222A (ja) 2006-05-05 2009-10-08 アイシス ファーマシューティカルズ， インコーポレーテッド Ｐｃｓｋ９の発現を調節するための化合物および方法
AU2007249349B2 (en) 2006-05-11 2012-03-08 Isis Pharmaceuticals, Inc. 5'-Modified bicyclic nucleic acid analogs
CN101554074B (zh) 2006-10-30 2012-08-22 诺基亚公司 为用户设备提供运营商控制的移动性的方法、设备和系统
DK2149605T3 (da) * 2007-03-22 2013-09-30 Santaris Pharma As Korte RNA antagonist forbindelser til modulering af det ønskede mRNA
CA2688321A1 (en) 2007-05-30 2008-12-11 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
DK2173760T4 (en) 2007-06-08 2016-02-08 Isis Pharmaceuticals Inc Carbocyclic bicyclic nukleinsyreanaloge
AU2008272918B2 (en) 2007-07-05 2012-09-13 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs
WO2009067647A1 (en) 2007-11-21 2009-05-28 Isis Pharmaceuticals, Inc. Carbocyclic alpha-l-bicyclic nucleic acid analogs
EP2238249A2 (en) * 2007-12-07 2010-10-13 Santaris Pharma A/S Rna antagonist compounds for the modulation of mcl-1
WO2009090182A1 (en) 2008-01-14 2009-07-23 Santaris Pharma A/S C4'-substituted - dna nucleotide gapmer oligonucleotides
WO2009100320A2 (en) 2008-02-07 2009-08-13 Isis Pharmaceuticals, Inc. Bicyclic cyclohexitol nucleic acid analogs
EP2274423A2 (en) 2008-04-04 2011-01-19 Isis Pharmaceuticals, Inc. Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
DK2356129T3 (da) 2008-09-24 2013-05-13 Isis Pharmaceuticals Inc Substituerede alpha-L-bicykliske nukleosider
US9012421B2 (en) 2009-08-06 2015-04-21 Isis Pharmaceuticals, Inc. Bicyclic cyclohexose nucleic acid analogs
WO2011085102A1 (en) 2010-01-11 2011-07-14 Isis Pharmaceuticals, Inc. Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
US9193752B2 (en) 2010-03-17 2015-11-24 Isis Pharmaceuticals, Inc. 5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
CN102329794B (zh) * 2011-09-28 2012-11-14 暨南大学 抑制BCL11A表达和肿瘤性B细胞增殖的Bcl11a siRNA-585及其应用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010030963A2 (en) * 2008-09-15 2010-03-18 Children's Medical Center Corporation Modulation of bcl11a for treatment of hemoglobinopathies
WO2012073047A2 (en) * 2010-12-03 2012-06-07 Genome Research Limited Compositions and methods
WO2012079046A2 (en) * 2010-12-10 2012-06-14 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
CN102352356A (zh) * 2011-09-28 2012-02-15 暨南大学 抑制BCL11A表达和肿瘤性B细胞增殖的Bcl11a siRNA-2292及其应用
WO2013055985A1 (en) * 2011-10-12 2013-04-18 Children's Medical Center Corporation Combinatorial compositions and methods of treating hemoglobinopathies

Non-Patent Citations (20)

* Cited by examiner, † Cited by third party
Title
BENNETT, C.F. AND SWAYZE, E.E., ANNU. REV. PHARMACOL. TOXICOL., vol. 50, JPN6018007896, 2010, pages 259 - 293, ISSN: 0003754563 *
BO, X. ET AL., BMC BIOINFORMATICS, vol. 7, JPN6018046554, 2006, pages 122 - 1, ISSN: 0003928030 *
BO, X. ET AL., NUCL. ACIDS RES., vol. 34, JPN6018046555, 2006, pages 664 - 667, ISSN: 0003928031 *
GAO, Y. ET AL., BIOMED. REP., vol. 1, JPN6018007914, 5 September 2012 (2012-09-05), pages 47 - 52, ISSN: 0003754570 *
GRUNWELLER, A. ET AL., NUCL. ACIDS RES., vol. 31, no. 12, JPN6018007922, 2003, pages 3185 - 3193, ISSN: 0003928032 *
JEPSEN, J.S. AND WENGEL, J., CURR. OPIN. DRUG DISCOV. DEVEL., vol. 7, no. 2, JPN6018007901, 2004, pages 188 - 194, ISSN: 0003754565 *
KOIZUMI, M., CURR. OPIN. MOL. THER., vol. 8, no. 2, JPN6018007912, 2006, pages 144 - 149, ISSN: 0003754569 *
KOLE, R. ET AL., NAT. REV. DRUG DISCOV., vol. 11, no. 2, JPN6018007916, 2012, pages 125 - 140, ISSN: 0003928033 *
KRETSCHMER-KAZEMI FAR, R. AND SCZAKIEL, G., NUCL. ACIDS RES., vol. 31, no. 15, JPN6018007904, 2003, pages 4417 - 4424, ISSN: 0003754566 *
KURRECK, J. ET AL. , NUCL. ACIDS RES., vol. 30, no. 9, JPN6018007924, 2002, pages 1911 - 1918, ISSN: 0003754574 *
LU, Z.J. AND MATHEWS, D.H., NUCL. ACIDS RES., vol. 36, no. 11, JPN6018046552, 2008, pages 3738 - 3745, ISSN: 0003928029 *
MCKAY, R.A. ET AL., J. BIOL. CHEM., vol. 274, no. 3, JPN6018046553, 1999, pages 1715 - 1722, ISSN: 0003928026 *
PERALTA, R. ET AL., BLOOD, vol. 122, no. 21, JPN6018007909, 15 November 2013 (2013-11-15), pages 1022, ISSN: 0003754568 *
SANKARAN, V.G. ET AL., SCIENCE, vol. 322, JPN6018007906, 2008, pages 1839 - 1842, ISSN: 0003754567 *
SETH, P.P. ET AL., J. MED. CHEM., vol. 52, JPN6018007899, 2009, pages 10 - 13, ISSN: 0003754564 *
SWAYZE, E.E. ET AL., NUCL. ACIDS RES., vol. 35, no. 2, JPN6018007927, 2007, pages 687 - 700, ISSN: 0003754575 *
VICKERS, T.A. ET AL., J. BIOL. CHEM., vol. 278, no. 9, JPN6018007893, 2003, pages 7108 - 7118, ISSN: 0003754562 *
WATTS, J.K. AND COREY, D.R., J. PATHOL., vol. 226, no. 2, JPN6018007919, 2012, pages 365 - 379, ISSN: 0003928028 *
WENGEL, J., ACC. CHEM. RES., vol. 32, JPN6018046556, 1999, pages 301 - 310, ISSN: 0003928034 *
XU, Y. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 306, JPN6018046551, 2003, pages 712 - 717, ISSN: 0003928027 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022507464A (ja) * 2018-11-13 2022-01-18 リピゴン ファーマスーティカルス アー・ベー 脂肪酸代謝の調節に影響を与えるａｎｇｐｔｌ４オリゴヌクレオチド
US12024708B2 (en) 2018-11-13 2024-07-02 Lipigon Pharmaceuticals Ab ANGPTL4 oligonucleotides influencing the regulation of the fatty acid metabolism
JP2024147796A (ja) * 2018-11-13 2024-10-16 リピゴン ファーマスーティカルス アー・ベー 脂肪酸代謝の調節に影響を与えるａｎｇｐｔｌ４オリゴヌクレオチド
JP7577654B2 (ja) 2018-11-13 2024-11-05 リピゴン ファーマスーティカルス アー・ベー 脂肪酸代謝の調節に影響を与えるａｎｇｐｔｌ４オリゴヌクレオチド
JP7781220B2 (ja) 2018-11-13 2025-12-05 リピゴン ファーマスーティカルス アー・ベー 脂肪酸代謝の調節に影響を与えるａｎｇｐｔｌ４オリゴヌクレオチド

Also Published As

Publication number Publication date
DK3004352T3 (da) 2017-11-27
CN105247052A (zh) 2016-01-13
MX363846B (es) 2019-04-05
US20160130582A1 (en) 2016-05-12
BR112015029327A2 (pt) 2017-09-19
RU2015155332A (ru) 2017-06-27
MX2015015564A (es) 2016-02-05
WO2014188001A1 (en) 2014-11-27
EP3004352B1 (en) 2017-09-27
CA2907694A1 (en) 2014-11-27
HK1213595A1 (zh) 2016-07-08
EP3004352A1 (en) 2016-04-13
KR20160013110A (ko) 2016-02-03

Similar Documents

Publication Publication Date Title
EP3004352B1 (en) Oligonucleotide modulators of b-cell cll/lymphoma 11a (bcl11a) and uses thereof
JP5872162B2 (ja) アンドロゲン受容体を標的化するｌｎａアンタゴニスト
KR20100024399A (ko) 베타-카테닌의 조절용 ｒｎａ 길항제 화합물
WO2022270585A1 (ja) アンチセンスオリゴマーの組み合わせ
WO2016024205A1 (en) Oligomers targeting hexanucleotide repeat expansion in human c9orf72 gene
US20110224280A1 (en) Pharmaceutical Composition Comprising Anti PCSK9 Oligomers
JP2014533944A (ja) Ｓｍｎ２スプライシングの調節のための化合物
JP7446443B2 (ja) Ｓｍｎ２を調節するための化合物及び方法
JP2011526482A (ja) ミトコンドリアグリセロール−３−リン酸アシルトランスフェラーゼ１（ｍｔｇｐａｔ１）の発現を阻害するためのｒｎａアンタゴニスト化合物
KR20100105648A (ko) Ｐｉｋ３ｃａ 발현 조절용 ｒｎａ 길항제 화합물
AU2019206731A1 (en) Modulators of DNM2 expression
US20110124709A1 (en) Rna antagonists targeting gli2
EP2440215B1 (en) New potent anti apob antisense compounds
US20100249219A1 (en) Short rna antagonist compounds for the modulation of hif-1alpha
KR20190093207A (ko) 다낭성 신장 질환의 치료 방법
JP2011505798A (ja) Ｍｃｌ−１を調節するためのＲＮＡアンタゴニスト化合物
US8440809B2 (en) RNA antagonists targeting Hsp27
US20110224281A1 (en) Rna antagonists targeting hsp70-2
EP2205738A2 (en) Short rna antagonist compounds for the modulation of hif1alpha
WO2012066092A1 (en) Compounds for the modulation of aurora kinase a expression

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170411

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170411

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180313

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180613

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180620

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20181204