JP2016520114A5 - - Google Patents
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- Publication number
- JP2016520114A5 JP2016520114A5 JP2016516232A JP2016516232A JP2016520114A5 JP 2016520114 A5 JP2016520114 A5 JP 2016520114A5 JP 2016516232 A JP2016516232 A JP 2016516232A JP 2016516232 A JP2016516232 A JP 2016516232A JP 2016520114 A5 JP2016520114 A5 JP 2016520114A5
- Authority
- JP
- Japan
- Prior art keywords
- treatment
- subject
- pain
- manufacture
- dihydroetorphine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004519 manufacturing process Methods 0.000 claims 48
- 239000003814 drug Substances 0.000 claims 47
- 208000002193 Pain Diseases 0.000 claims 39
- 230000036407 pain Effects 0.000 claims 39
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims 28
- 206010038678 Respiratory depression Diseases 0.000 claims 28
- 206010002091 Anaesthesia Diseases 0.000 claims 23
- 230000037005 anaesthesia Effects 0.000 claims 23
- 229940079593 drug Drugs 0.000 claims 17
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 12
- 208000008784 apnea Diseases 0.000 claims 12
- 208000000114 Pain Threshold Diseases 0.000 claims 11
- 230000037040 pain threshold Effects 0.000 claims 11
- 238000009423 ventilation Methods 0.000 claims 10
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 6
- 239000001569 carbon dioxide Substances 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 4
- 206010028813 Nausea Diseases 0.000 claims 3
- 206010039897 Sedation Diseases 0.000 claims 3
- 208000002173 dizziness Diseases 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 3
- 230000008693 nausea Effects 0.000 claims 3
- 230000036280 sedation Effects 0.000 claims 3
- 230000036592 analgesia Effects 0.000 claims 2
- 231100000673 dose–response relationship Toxicity 0.000 claims 2
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 2
- 229960002428 fentanyl Drugs 0.000 claims 2
- 230000000241 respiratory effect Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 241001539473 Euphoria Species 0.000 claims 1
- 206010015535 Euphoric mood Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- BRTSNYPDACNMIP-FAWZKKEFSA-N dihydroetorphine Chemical compound O([C@H]1[C@@]2(OC)CC[C@@]34C[C@@H]2[C@](C)(O)CCC)C2=C5[C@]41CCN(C)[C@@H]3CC5=CC=C2O BRTSNYPDACNMIP-FAWZKKEFSA-N 0.000 claims 1
- CAHCBJPUTCKATP-FAWZKKEFSA-N etorphine Chemical compound O([C@H]1[C@@]2(OC)C=C[C@@]34C[C@@H]2[C@](C)(O)CCC)C2=C5[C@]41CCN(C)[C@@H]3CC5=CC=C2O CAHCBJPUTCKATP-FAWZKKEFSA-N 0.000 claims 1
- 229950004155 etorphine Drugs 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1309654.0A GB201309654D0 (en) | 2013-05-30 | 2013-05-30 | Method |
| GB1309654.0 | 2013-05-30 | ||
| PCT/GB2014/000206 WO2014191710A1 (en) | 2013-05-30 | 2014-05-30 | Dihydroetorphine for the provision of pain relief and anaesthesia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019051613A Division JP2019123730A (ja) | 2013-05-30 | 2019-03-19 | 除痛および麻酔の提供のためのジヒドロエトルフィン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016520114A JP2016520114A (ja) | 2016-07-11 |
| JP2016520114A5 true JP2016520114A5 (cg-RX-API-DMAC7.html) | 2017-07-13 |
Family
ID=48805475
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016516232A Pending JP2016520114A (ja) | 2013-05-30 | 2014-05-30 | 除痛および麻酔の提供のためのジヒドロエトルフィン |
| JP2019051613A Pending JP2019123730A (ja) | 2013-05-30 | 2019-03-19 | 除痛および麻酔の提供のためのジヒドロエトルフィン |
| JP2020156242A Pending JP2020200345A (ja) | 2013-05-30 | 2020-09-17 | 除痛および麻酔の提供のためのジヒドロエトルフィン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019051613A Pending JP2019123730A (ja) | 2013-05-30 | 2019-03-19 | 除痛および麻酔の提供のためのジヒドロエトルフィン |
| JP2020156242A Pending JP2020200345A (ja) | 2013-05-30 | 2020-09-17 | 除痛および麻酔の提供のためのジヒドロエトルフィン |
Country Status (13)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3287123T (lt) | 2011-03-04 | 2020-06-10 | Grünenthal GmbH | Vandeninė farmacinė tapentadolio kompozicija, skirta gerti |
| EA036258B1 (ru) | 2015-03-27 | 2020-10-20 | Грюненталь Гмбх | Стабильный препарат для парентерального введения тапентадола |
| GB201513442D0 (en) * | 2015-07-30 | 2015-09-16 | Euro Celtique Sa | Transdermal patch |
| WO2018055070A1 (en) | 2016-09-23 | 2018-03-29 | Grünenthal GmbH | Stable formulation for parenteral administration of tapentadol |
| WO2018153947A1 (en) | 2017-02-23 | 2018-08-30 | Grünenthal GmbH | Tapentadol as local anesthetic |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB925723A (en) | 1960-09-05 | 1963-05-08 | J F Macfarlan & Company Ltd | Novel thebaine derivatives |
| GB937214A (en) | 1961-06-02 | 1963-09-18 | J F Macfarlan & Company Ltd | Oripavine derivatives |
| JPS59184182A (ja) | 1983-04-02 | 1984-10-19 | Res Inst For Prod Dev | ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルベンチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エタノモルヒナン |
| JPS62153214A (ja) | 1985-12-26 | 1987-07-08 | Nitto Electric Ind Co Ltd | 医薬製剤 |
| JPS62281815A (ja) | 1986-05-27 | 1987-12-07 | Teisan Seiyaku Kk | 貼付剤及びその製造法 |
| JPS63201119A (ja) | 1987-02-17 | 1988-08-19 | Kao Corp | 貼付剤組成物 |
| US4891377A (en) | 1988-12-02 | 1990-01-02 | Board Of Regents Acting For And On Behalf Of University Of Michigan | Transdermal delivery of the narcotic analgesics etorphine and analogs |
| PT95069B (pt) | 1989-08-24 | 1997-10-31 | Searle & Co | Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos |
| US5271940A (en) | 1989-09-14 | 1993-12-21 | Cygnus Therapeutic Systems | Transdermal delivery device having delayed onset |
| US5633259A (en) | 1992-09-21 | 1997-05-27 | United Biomedical, Inc. | Method for identification of low/non-addictive opioid analgesics and the use of said analgesics for treatment of opioid addiction |
| JPH08504189A (ja) | 1992-09-21 | 1996-05-07 | キン、ボーイ | 低／非たんでき性オピオイド鎮痛剤の確認及び使用方法 |
| JP2819236B2 (ja) | 1994-05-06 | 1998-10-30 | 日東電工株式会社 | 経皮吸収製剤 |
| IL122432A (en) | 1995-06-07 | 2000-07-16 | Cygnus Therapeutic Systems | Transdermal patch for preventing ovulation |
| AUPN603895A0 (en) | 1995-10-19 | 1995-11-09 | University Of Queensland, The | Production of analgesic synergy by co-administration of sub-analgesic doses of two strong opioids |
| US6103258A (en) | 1996-04-12 | 2000-08-15 | Simon; David Lew | Salts and bases of the 17-(Cyclopropylmethyl)-4,5 alpha-epoxy-6-Methylenemorphinan-3,14 diol molecule for optimizing dopamine homeostasis during administration of opioid analgesics |
| KR100204659B1 (ko) | 1996-05-28 | 1999-06-15 | 강재헌 | 신규한 부프레노핀계 진통제용 화합물 |
| JPH10231248A (ja) | 1997-02-19 | 1998-09-02 | T T S Gijutsu Kenkyusho:Kk | ジヒドロエトルフィン含有経皮吸収型製剤 |
| US6770295B1 (en) | 1998-08-27 | 2004-08-03 | Pharmacia Ab | Therapeutic formulation for administering tolterodine with controlled release |
| US6194382B1 (en) | 1999-03-03 | 2001-02-27 | Albert Einstein College Of Medicine Of Yeshiva University | Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists |
| US6765010B2 (en) | 1999-05-06 | 2004-07-20 | Pain Therapeutics, Inc. | Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects |
| US6312716B1 (en) | 1999-05-10 | 2001-11-06 | Peierce Management Llc | Patch and method for transdermal delivery of bupropion base |
| US6716449B2 (en) | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
| JP4659943B2 (ja) | 2000-02-25 | 2011-03-30 | 帝三製薬株式会社 | 塩酸ブプレノルフィン含有貼付剤 |
| DE60143477D1 (de) | 2000-04-26 | 2010-12-30 | Watson Pharmaceuticals Inc | Verminderung der nebenwirkungen bei der oxybutynin-therapie |
| US6372252B1 (en) | 2000-04-28 | 2002-04-16 | Adams Laboratories, Inc. | Guaifenesin sustained release formulation and tablets |
| CA2386794A1 (en) | 2000-07-13 | 2002-01-24 | Euro-Celtique, S.A. | Salts and bases of 17-(cyclopropylmethyl)-4,5 alpha-epoxy-6-methylenemorphinan-3,14 diol for optimizing dopamine homeostasis during administration of opioid analgesics |
| US7332182B2 (en) | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
| US7141250B2 (en) | 2001-08-06 | 2006-11-28 | Euro-Celtique S.A. | Pharmaceutical formulation containing bittering agent |
| AU2002322169B2 (en) | 2001-08-10 | 2008-10-30 | Monash University | Derivatives of morphine-like opioid compounds |
| CN1233645C (zh) | 2001-09-14 | 2005-12-28 | 中国人民解放军军事医学科学院毒物药物研究所 | 新的东罂粟碱衍生物及其医药用途 |
| WO2003061594A2 (en) | 2002-01-23 | 2003-07-31 | The Regents Of The University Of California | Methods and compositions for reducing the development of drug tolerance and/or physical dependence |
| US20060177381A1 (en) | 2002-02-15 | 2006-08-10 | Howard Brooks-Korn | Opiopathies |
| US20040033253A1 (en) | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
| US20030191147A1 (en) | 2002-04-09 | 2003-10-09 | Barry Sherman | Opioid antagonist compositions and dosage forms |
| CN1655772B (zh) | 2002-05-28 | 2010-05-26 | 拉伯泰克技术研发有限公司 | 含有芬太尼的贴剂 |
| US20040033255A1 (en) | 2002-06-10 | 2004-02-19 | Baker Carl J. | Transdermal delivery device disposal system |
| US20040126323A1 (en) | 2002-08-20 | 2004-07-01 | Ihor Shevchuk | Transdermal dosage form comprising an active agent and a salt and free-base form of an adverse agent |
| AU2002951965A0 (en) | 2002-10-09 | 2002-10-24 | Monash University | Amidine compounds |
| TWI296531B (en) | 2002-10-18 | 2008-05-11 | Hisamitsu Pharmaceutical Co | Transdermal adhesive preparations for topical administration of fentanyl |
| TW200500067A (en) | 2003-01-21 | 2005-01-01 | Control Delivery Sys Inc | Salts of codrugs and uses related thereto |
| US20040208917A1 (en) | 2003-04-16 | 2004-10-21 | Wilfried Fischer | Transdermal systems for the release of clonidine |
| KR101159828B1 (ko) | 2003-04-30 | 2012-07-04 | 퍼듀 퍼머 엘피 | 활성제 구성요소 및 활성제 층의 원위부에 억제제 구성요소를 포함하는 내변조성 경피제형 |
| US20050113365A1 (en) | 2003-11-10 | 2005-05-26 | Sir Isaac Newton Enterprises Llc | Method and medicine for treating gastrointestinal disorder including irritable bowel syndrome |
| CN100500151C (zh) | 2004-04-02 | 2009-06-17 | 北京万全阳光医药科技有限公司 | 一种水溶性药物舌下给药制剂 |
| WO2005112926A1 (en) | 2004-05-17 | 2005-12-01 | Pharmacofore, Inc. | Compositions and methods for treating or preventing pain |
| EP1868593A2 (en) | 2005-04-07 | 2007-12-26 | Hythiam, Inc. | Improved methods of and compositions for the prevention of anxiety, substance abuse, and dependence |
| US8574604B2 (en) | 2005-04-15 | 2013-11-05 | Interface Biologics, Inc. | Methods and compositions for the delivery of biologically active agents |
| KR100764679B1 (ko) | 2005-07-22 | 2007-10-09 | 익수제약 주식회사 | 파록세틴을 함유하는 경피투여용 패취제 |
| EP1928881A2 (en) | 2005-08-19 | 2008-06-11 | Pharmacofore, Inc. | Prodrugs of active agents |
| WO2007052308A2 (en) | 2005-11-03 | 2007-05-10 | Brain N' Beyond Biotech Pvt. Ltd. | Glyco-phosphorylated biologically active agents |
| GB0523031D0 (en) | 2005-11-11 | 2005-12-21 | Yaupon Therapeutics | Enhancement of morphine analgesia by s(-)-norketamine |
| TWI389709B (zh) | 2005-12-01 | 2013-03-21 | Novartis Ag | 經皮治療系統 |
| CN101370486B (zh) | 2005-12-09 | 2012-12-05 | 北京康倍得医药技术开发有限公司 | 含有硝酸异山梨酯和比索洛尔的透皮贴剂 |
| WO2007106597A2 (en) | 2006-03-15 | 2007-09-20 | Alza Corporation | Method for the transdermal delivery of parathyroid hormone agents for treating osteopenia |
| USD576282S1 (en) | 2006-06-16 | 2008-09-02 | Activatek, Inc. | Adhesive transdermal medicament patch |
| USD625017S1 (en) | 2006-08-11 | 2010-10-05 | Hisamitsu Pharmaceutical Co., Inc. | Medical transdermal patch |
| DE102006050558B4 (de) | 2006-10-26 | 2009-03-26 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System enthaltend Norelgestromin zur Kontrazeption und Hormonsubstitution |
| CN100512817C (zh) | 2006-11-15 | 2009-07-15 | 闫章年 | 复方噻拉嗪注射液及制备工艺 |
| DE102006054731B4 (de) | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie |
| JP2010514789A (ja) | 2006-12-27 | 2010-05-06 | アベール ファーマシューティカルズ インコーポレイテッド | 副腎皮質ステロイド投与のための経皮的方法及びパッチ |
| CA2707757C (en) | 2007-03-06 | 2017-01-03 | Peter X. Wang | Process for the preparation of quaternary n-alkyl morphinan alkaloid salts |
| CN101147739B (zh) | 2007-07-06 | 2010-12-08 | 北京康倍得医药技术开发有限公司 | 含罗替戈汀的组合物及其制药用途以及含该组合物的透皮贴剂 |
| KR100929560B1 (ko) | 2008-01-09 | 2009-12-03 | 에코 퍼시픽 엘티디 | 그라니세트론을 함유한 매트릭스 형태의 경피 흡수제 |
| EP2286814B1 (en) | 2008-05-15 | 2013-10-16 | Hisamitsu Pharmaceutical Co., Inc. | Transdermal preparation containing palonosetron |
| TWI630208B (zh) | 2008-12-08 | 2018-07-21 | 歐陸斯迪公司 | 二氫羥戊甲嗎啡 |
| EP2298277A1 (en) | 2009-09-09 | 2011-03-23 | Labtec GmbH | Transdermal patch formulation |
| DE102010040299A1 (de) | 2010-09-06 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Transdermale therapeutische Systeme mit kristallisationsinhibierender Schutzfolie (Release Liner) |
-
2013
- 2013-05-30 GB GBGB1309654.0A patent/GB201309654D0/en not_active Ceased
-
2014
- 2014-05-30 HK HK16110921.5A patent/HK1222585A1/zh unknown
- 2014-05-30 KR KR1020157036442A patent/KR20160013977A/ko not_active Ceased
- 2014-05-30 JP JP2016516232A patent/JP2016520114A/ja active Pending
- 2014-05-30 CA CA2913849A patent/CA2913849A1/en not_active Abandoned
- 2014-05-30 EP EP14731983.4A patent/EP3003310A1/en not_active Ceased
- 2014-05-30 CN CN201480042250.XA patent/CN105555274A/zh active Pending
- 2014-05-30 MX MX2015016418A patent/MX2015016418A/es unknown
- 2014-05-30 AU AU2014272924A patent/AU2014272924B2/en not_active Ceased
- 2014-05-30 WO PCT/GB2014/000206 patent/WO2014191710A1/en not_active Ceased
- 2014-05-30 BR BR112015029709A patent/BR112015029709A2/pt not_active IP Right Cessation
- 2014-05-30 US US14/894,775 patent/US10898479B2/en not_active Expired - Fee Related
-
2015
- 2015-11-27 PH PH12015502655A patent/PH12015502655A1/en unknown
-
2019
- 2019-03-19 JP JP2019051613A patent/JP2019123730A/ja active Pending
-
2020
- 2020-09-17 JP JP2020156242A patent/JP2020200345A/ja active Pending
- 2020-09-30 US US17/038,651 patent/US20210085673A1/en not_active Abandoned
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