JP2016519068A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016519068A5 JP2016519068A5 JP2016502228A JP2016502228A JP2016519068A5 JP 2016519068 A5 JP2016519068 A5 JP 2016519068A5 JP 2016502228 A JP2016502228 A JP 2016502228A JP 2016502228 A JP2016502228 A JP 2016502228A JP 2016519068 A5 JP2016519068 A5 JP 2016519068A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cell
- region
- subject
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 105
- 210000004027 cell Anatomy 0.000 claims description 73
- 239000003446 ligand Substances 0.000 claims description 62
- 238000000034 method Methods 0.000 claims description 47
- 229920001184 polypeptide Polymers 0.000 claims description 34
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 34
- 239000012634 fragment Substances 0.000 claims description 33
- 230000011664 signaling Effects 0.000 claims description 30
- 206010028980 Neoplasm Diseases 0.000 claims description 24
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 230000008685 targeting Effects 0.000 claims description 18
- 239000013598 vector Substances 0.000 claims description 18
- 230000001086 cytosolic effect Effects 0.000 claims description 17
- 230000001939 inductive effect Effects 0.000 claims description 17
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 14
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 14
- 201000010099 disease Diseases 0.000 claims description 14
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 13
- 210000004881 tumor cell Anatomy 0.000 claims description 12
- 108020004707 nucleic acids Proteins 0.000 claims description 11
- 102000039446 nucleic acids Human genes 0.000 claims description 11
- 150000007523 nucleic acids Chemical class 0.000 claims description 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 10
- 230000007812 deficiency Effects 0.000 claims description 10
- 239000002773 nucleotide Substances 0.000 claims description 10
- 125000003729 nucleotide group Chemical group 0.000 claims description 10
- 230000000139 costimulatory effect Effects 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 9
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 8
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 8
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 8
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 8
- 108091033319 polynucleotide Proteins 0.000 claims description 7
- 102000040430 polynucleotide Human genes 0.000 claims description 7
- 239000002157 polynucleotide Substances 0.000 claims description 7
- 206010010099 Combined immunodeficiency Diseases 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 208000035475 disorder Diseases 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 230000001177 retroviral effect Effects 0.000 claims description 6
- 239000013603 viral vector Substances 0.000 claims description 6
- 102100027207 CD27 antigen Human genes 0.000 claims description 5
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 5
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims description 5
- 101150013553 CD40 gene Proteins 0.000 claims description 4
- 206010010356 Congenital anomaly Diseases 0.000 claims description 4
- 241000701022 Cytomegalovirus Species 0.000 claims description 4
- 208000036066 Hemophagocytic Lymphohistiocytosis Diseases 0.000 claims description 4
- 208000032672 Histiocytosis haematophagic Diseases 0.000 claims description 4
- 241000701027 Human herpesvirus 6 Species 0.000 claims description 4
- -1 ICOS Proteins 0.000 claims description 4
- 208000030289 Lymphoproliferative disease Diseases 0.000 claims description 4
- 241000714177 Murine leukemia virus Species 0.000 claims description 4
- 108010038036 Receptor Activator of Nuclear Factor-kappa B Proteins 0.000 claims description 4
- 102000010498 Receptor Activator of Nuclear Factor-kappa B Human genes 0.000 claims description 4
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 210000001185 bone marrow Anatomy 0.000 claims description 4
- 208000015322 bone marrow disease Diseases 0.000 claims description 4
- 208000014752 hemophagocytic syndrome Diseases 0.000 claims description 4
- 230000003463 hyperproliferative effect Effects 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- 208000032839 leukemia Diseases 0.000 claims description 4
- 102000005962 receptors Human genes 0.000 claims description 4
- 108020003175 receptors Proteins 0.000 claims description 4
- 208000007056 sickle cell anemia Diseases 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- 241000701161 unidentified adenovirus Species 0.000 claims description 4
- 102100027913 Peptidyl-prolyl cis-trans isomerase FKBP1A Human genes 0.000 claims description 3
- 108010006877 Tacrolimus Binding Protein 1A Proteins 0.000 claims description 3
- 239000000539 dimer Substances 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- 210000000822 natural killer cell Anatomy 0.000 claims description 3
- 230000004850 protein–protein interaction Effects 0.000 claims description 3
- 102100033051 40S ribosomal protein S19 Human genes 0.000 claims description 2
- 208000004881 Amebiasis Diseases 0.000 claims description 2
- 206010001980 Amoebiasis Diseases 0.000 claims description 2
- 208000033932 Blackfan-Diamond anemia Diseases 0.000 claims description 2
- 208000019838 Blood disease Diseases 0.000 claims description 2
- 201000007155 CD40 ligand deficiency Diseases 0.000 claims description 2
- 201000006082 Chickenpox Diseases 0.000 claims description 2
- 201000003874 Common Variable Immunodeficiency Diseases 0.000 claims description 2
- 206010053138 Congenital aplastic anaemia Diseases 0.000 claims description 2
- 208000025212 Constitutional neutropenia Diseases 0.000 claims description 2
- 102100024350 Dedicator of cytokinesis protein 8 Human genes 0.000 claims description 2
- 201000004449 Diamond-Blackfan anemia Diseases 0.000 claims description 2
- 206010058314 Dysplasia Diseases 0.000 claims description 2
- 206010014612 Encephalitis viral Diseases 0.000 claims description 2
- 208000017701 Endocrine disease Diseases 0.000 claims description 2
- 208000000259 GATA2 Deficiency Diseases 0.000 claims description 2
- 208000022140 GATA2 deficiency with susceptibility to MDS/AML Diseases 0.000 claims description 2
- 206010019799 Hepatitis viral Diseases 0.000 claims description 2
- 101001052946 Homo sapiens Dedicator of cytokinesis protein 8 Proteins 0.000 claims description 2
- 206010020649 Hyperkeratosis Diseases 0.000 claims description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 2
- 206010061598 Immunodeficiency Diseases 0.000 claims description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 claims description 2
- 206010052210 Infantile genetic agranulocytosis Diseases 0.000 claims description 2
- 102000004551 Interleukin-10 Receptors Human genes 0.000 claims description 2
- 108010017550 Interleukin-10 Receptors Proteins 0.000 claims description 2
- 208000001126 Keratosis Diseases 0.000 claims description 2
- 208000004554 Leishmaniasis Diseases 0.000 claims description 2
- 201000001779 Leukocyte adhesion deficiency Diseases 0.000 claims description 2
- 201000005505 Measles Diseases 0.000 claims description 2
- 201000011442 Metachromatic leukodystrophy Diseases 0.000 claims description 2
- 241000713869 Moloney murine leukemia virus Species 0.000 claims description 2
- 208000002678 Mucopolysaccharidoses Diseases 0.000 claims description 2
- 241001631646 Papillomaviridae Species 0.000 claims description 2
- 206010035664 Pneumonia Diseases 0.000 claims description 2
- 208000000474 Poliomyelitis Diseases 0.000 claims description 2
- 201000004283 Shwachman-Diamond syndrome Diseases 0.000 claims description 2
- 208000010346 Sphingolipidoses Diseases 0.000 claims description 2
- 201000001307 Sphingolipidosis Diseases 0.000 claims description 2
- 201000001322 T cell deficiency Diseases 0.000 claims description 2
- 208000002903 Thalassemia Diseases 0.000 claims description 2
- 208000005448 Trichomonas Infections Diseases 0.000 claims description 2
- 206010044620 Trichomoniasis Diseases 0.000 claims description 2
- 206010046980 Varicella Diseases 0.000 claims description 2
- 230000002159 abnormal effect Effects 0.000 claims description 2
- 208000007502 anemia Diseases 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 210000000845 cartilage Anatomy 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 230000007423 decrease Effects 0.000 claims description 2
- 208000030172 endocrine system disease Diseases 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 210000004700 fetal blood Anatomy 0.000 claims description 2
- 208000014951 hematologic disease Diseases 0.000 claims description 2
- 208000018706 hematopoietic system disease Diseases 0.000 claims description 2
- 208000034737 hemoglobinopathy Diseases 0.000 claims description 2
- 230000003258 hemophagocytic effect Effects 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 230000007813 immunodeficiency Effects 0.000 claims description 2
- 208000014165 immunodeficiency 21 Diseases 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 206010022000 influenza Diseases 0.000 claims description 2
- 208000028774 intestinal disease Diseases 0.000 claims description 2
- 201000004792 malaria Diseases 0.000 claims description 2
- 208000030159 metabolic disease Diseases 0.000 claims description 2
- 206010028093 mucopolysaccharidosis Diseases 0.000 claims description 2
- 210000002997 osteoclast Anatomy 0.000 claims description 2
- 208000002865 osteopetrosis Diseases 0.000 claims description 2
- 239000011886 peripheral blood Substances 0.000 claims description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims description 2
- 208000028529 primary immunodeficiency disease Diseases 0.000 claims description 2
- 238000011476 stem cell transplantation Methods 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 208000006379 syphilis Diseases 0.000 claims description 2
- 230000002463 transducing effect Effects 0.000 claims description 2
- 201000002311 trypanosomiasis Diseases 0.000 claims description 2
- 201000008827 tuberculosis Diseases 0.000 claims description 2
- 201000002498 viral encephalitis Diseases 0.000 claims description 2
- 201000001862 viral hepatitis Diseases 0.000 claims description 2
- 230000003612 virological effect Effects 0.000 claims description 2
- 102000003735 Mesothelin Human genes 0.000 claims 1
- 108090000015 Mesothelin Proteins 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 210000004976 peripheral blood cell Anatomy 0.000 claims 1
- 230000008569 process Effects 0.000 claims 1
- 230000009467 reduction Effects 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
- 102000001493 Cyclophilins Human genes 0.000 description 1
- 108010068682 Cyclophilins Proteins 0.000 description 1
- 108010027179 Tacrolimus Binding Proteins Proteins 0.000 description 1
- 102000018679 Tacrolimus Binding Proteins Human genes 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361783445P | 2013-03-14 | 2013-03-14 | |
| US61/783,445 | 2013-03-14 | ||
| PCT/US2014/026734 WO2014151960A2 (en) | 2013-03-14 | 2014-03-13 | Methods for controlling t cell proliferation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018105044A Division JP2018145194A (ja) | 2013-03-14 | 2018-05-31 | Ｔ細胞増殖をコントロールするための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519068A JP2016519068A (ja) | 2016-06-30 |
| JP2016519068A5 true JP2016519068A5 (enExample) | 2017-04-06 |
| JP6541639B2 JP6541639B2 (ja) | 2019-07-10 |
Family
ID=51569299
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502228A Active JP6541639B2 (ja) | 2013-03-14 | 2014-03-13 | Ｔ細胞増殖をコントロールするための方法 |
| JP2018105044A Withdrawn JP2018145194A (ja) | 2013-03-14 | 2018-05-31 | Ｔ細胞増殖をコントロールするための方法 |
| JP2019225565A Withdrawn JP2020055863A (ja) | 2013-03-14 | 2019-12-13 | Ｔ細胞増殖をコントロールするための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018105044A Withdrawn JP2018145194A (ja) | 2013-03-14 | 2018-05-31 | Ｔ細胞増殖をコントロールするための方法 |
| JP2019225565A Withdrawn JP2020055863A (ja) | 2013-03-14 | 2019-12-13 | Ｔ細胞増殖をコントロールするための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9944690B2 (enExample) |
| EP (1) | EP2968502B1 (enExample) |
| JP (3) | JP6541639B2 (enExample) |
| KR (1) | KR20150131218A (enExample) |
| CN (1) | CN105209065B (enExample) |
| AU (2) | AU2014236726A1 (enExample) |
| CA (1) | CA2905352A1 (enExample) |
| HK (1) | HK1217000A1 (enExample) |
| SG (1) | SG11201506974XA (enExample) |
| WO (1) | WO2014151960A2 (enExample) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2557164A1 (en) * | 2003-02-18 | 2013-02-13 | Kevin M. Slawin | Induced activation in dendritic cells |
| DK2331680T3 (en) | 2008-09-22 | 2017-08-21 | Baylor College Medicine | Methods and Compositions for Generating an Immune Response by Induction of CD-40 as well as Pattern Recognition Receptor Adapters |
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| LT2956175T (lt) | 2013-02-15 | 2017-12-11 | The Regents Of The University Of California | Chimerinis antigeno receptorius ir jo panaudojimo būdai |
| KR20150131218A (ko) | 2013-03-14 | 2015-11-24 | 벨리쿰 파마슈티컬스, 인크. | T 세포 증식의 제어 방법 |
| CN105518018B (zh) | 2013-03-15 | 2020-04-03 | 细胞基因公司 | 修饰的t淋巴细胞 |
| CN106132423B (zh) | 2014-02-14 | 2020-07-31 | 贝里坤制药股份有限公司 | 用诱导型嵌合多肽活化t细胞的方法 |
| FI3888674T3 (fi) | 2014-04-07 | 2024-07-02 | Novartis Ag | Syövän hoito käyttäen kimeeristä anti-cd19-antigeenireseptoria |
| JP6868554B2 (ja) * | 2014-09-02 | 2021-05-12 | ベリカム ファーマシューティカルズ， インコーポレイテッド | ＭｙＤ８８およびＣＤ４０ポリペプチドによるキメラ抗原受容体の共刺激 |
| CN106973568B (zh) | 2014-10-08 | 2021-07-23 | 诺华股份有限公司 | 预测针对嵌合抗原受体疗法的治疗应答性的生物标志及其用途 |
| AU2015341481C1 (en) | 2014-11-03 | 2021-09-16 | ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) | T cell receptors directed against Bob1 and uses thereof |
| CA2966234A1 (en) * | 2014-12-15 | 2016-06-23 | Bellicum Pharmaceuticals, Inc. | Methods for controlled elimination of therapeutic cells |
| EP3608408A1 (en) * | 2014-12-15 | 2020-02-12 | Bellicum Pharmaceuticals, Inc. | Methods for controlled activation or elimination of therapeutic cells |
| IL303247A (en) | 2014-12-29 | 2023-07-01 | Novartis Ag | Methods for preparing cells expressing a chimeric receptor antigen |
| US10377988B2 (en) | 2015-01-23 | 2019-08-13 | Musc Foundation For Research Development | Cytokine receptor genes and the use thereof to enhance therapy |
| CN107683289B (zh) | 2015-01-26 | 2021-08-06 | 芝加哥大学 | IL13Rα2结合剂和其在癌症治疗中的用途 |
| CA2973529A1 (en) | 2015-01-26 | 2016-08-04 | Cellectis | Cll1-specific multi-chain chimeric antigen receptor |
| JP6912386B2 (ja) | 2015-01-26 | 2021-08-04 | ザ ユニバーシティー オブ シカゴ | 癌特異的なＩＬ１３Ｒα２を認識するＣＡＲ Ｔ細胞 |
| KR102624023B1 (ko) | 2015-02-24 | 2024-01-11 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 결합-촉발된 전사 스위치 및 이들의 이용 방법 |
| EP3270936A4 (en) | 2015-03-17 | 2018-08-08 | Chimera Bioengineering Inc. | Smart car devices, de car polypeptides, side cars and uses thereof |
| IL254817B2 (en) | 2015-04-08 | 2023-12-01 | Novartis Ag | Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell |
| CN108473957B (zh) | 2015-04-17 | 2024-07-16 | 诺华股份有限公司 | 改善嵌合抗原受体表达细胞的功效和扩增的方法 |
| JP7146632B2 (ja) | 2015-07-21 | 2022-10-04 | ノバルティス アーゲー | 免疫細胞の有効性および増大を改善する方法 |
| GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
| EP3340995A4 (en) | 2015-08-28 | 2019-04-03 | The Trustees Of The University Of Pennsylvania | METHOD AND COMPOSITIONS FOR CELLS FOR EXPRESSING A CHIMERIC INTRA-CELLULAR SIGNAL MOLECULE |
| EP3340998B1 (en) * | 2015-08-28 | 2023-01-11 | The Trustees of the University of Pennsylvania | Methods and compositions for cells expressing a chimeric intracellular signaling molecule |
| US11747346B2 (en) | 2015-09-03 | 2023-09-05 | Novartis Ag | Biomarkers predictive of cytokine release syndrome |
| DK3356524T3 (da) * | 2015-09-30 | 2021-11-15 | Vycellix Inc | Forøget genlevering til naturlige dræberceller, hæmatopoietiske stamceller og makrofager |
| EP3365442B8 (en) | 2015-10-23 | 2022-06-08 | Fred Hutchinson Cancer Center | Methods to create chemically-induced dimerizing protein systems for regulation of cellular events |
| MA44314A (fr) * | 2015-11-05 | 2018-09-12 | Juno Therapeutics Inc | Récepteurs chimériques contenant des domaines induisant traf, et compositions et méthodes associées |
| US11052111B2 (en) | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
| EP3390434A2 (en) * | 2015-12-14 | 2018-10-24 | Bellicum Pharmaceuticals, Inc. | Dual controls for therapeutic cell activation or elimination |
| CN109153975A (zh) | 2015-12-28 | 2019-01-04 | 诺华股份有限公司 | 制备嵌合抗原受体表达细胞的方法 |
| EA201891589A1 (ru) | 2016-01-08 | 2019-01-31 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Условно активные гетеродимерные полипептиды и способы их применения |
| US11111505B2 (en) | 2016-03-19 | 2021-09-07 | Exuma Biotech, Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| US11325948B2 (en) | 2016-03-19 | 2022-05-10 | Exuma Biotech Corp. | Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL |
| PE20190201A1 (es) | 2016-04-01 | 2019-02-05 | Amgen Inc | Receptores quimericos de flt3 y metodos de uso de los mismos |
| US10689450B2 (en) | 2016-04-01 | 2020-06-23 | Kite Pharma, Inc | BCMA binding molecules and methods of use thereof |
| PL3436079T3 (pl) | 2016-04-01 | 2021-12-20 | Kite Pharma, Inc. | Antygen chimeryczny i receptory komórek t oraz sposoby ich stosowania |
| PE20190356A1 (es) | 2016-04-01 | 2019-03-07 | Kite Pharma Inc | Receptores quimericos y metodos de uso de los mismos |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Ｃａｒ ｔ細胞療法のための方法および組成物 |
| EP3458077A4 (en) | 2016-05-17 | 2020-04-01 | Chimera Bioengineering Inc. | METHODS OF MANUFACTURING NEW AREAS OF ANTIGEN BINDING |
| EP3464375A2 (en) | 2016-06-02 | 2019-04-10 | Novartis AG | Therapeutic regimens for chimeric antigen receptor (car)- expressing cells |
| US11384156B2 (en) * | 2016-07-25 | 2022-07-12 | The Nemours Foundation | Adoptive T-cell therapy using EMPD-specific chimeric antigen receptors for treating IgE-mediated allergic diseases |
| CN112481217A (zh) | 2016-09-01 | 2021-03-12 | 嵌合体生物工程公司 | Gold优化的car t-细胞 |
| EP3523331A1 (en) | 2016-10-07 | 2019-08-14 | Novartis AG | Chimeric antigen receptors for the treatment of cancer |
| EP3579870A4 (en) | 2017-02-07 | 2020-12-30 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| JOP20180027A1 (ar) * | 2017-03-28 | 2019-01-30 | Cell Design Labs Inc | بوليبيبتيدات مخلطة و طرق لتغيير موضع الغشاء فيها |
| EP3391914B1 (en) * | 2017-04-21 | 2021-07-14 | Safe Implant Technology ApS | Gold particles for use in therapy to prevent or reduce capsular contracture |
| JOP20180042A1 (ar) | 2017-04-24 | 2019-01-30 | Kite Pharma Inc | نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام |
| US20210147507A1 (en) * | 2017-05-09 | 2021-05-20 | Bellicum Pharmaceuticals, Inc. | Methods to augment or alter signal transduction |
| AU2018270515A1 (en) | 2017-05-19 | 2019-12-05 | The Regents Of The University Of California | Antibody chemically induced dimerizer (abCID) as molecular switches for regulating cellular therapies |
| US20200306303A1 (en) * | 2017-09-29 | 2020-10-01 | Chiou Hwa YUH | Methods and compositions enhancing survival and functionality of anti-tumor and anti-viral t cells |
| MX2020004229A (es) | 2017-10-25 | 2020-07-22 | Novartis Ag | Metodos de produccion de celulas que expresan receptores antigenicos quimericos. |
| US11390655B2 (en) | 2017-11-16 | 2022-07-19 | Kite Pharma, Inc. | Modified chimeric antigen receptors and methods of use |
| EP3720479A2 (en) | 2017-12-08 | 2020-10-14 | Bellicum Pharmaceuticals, Inc. | Methods for enhancing and maintaining car-t cell efficacy |
| EP3728189A1 (en) | 2017-12-20 | 2020-10-28 | Bellicum Pharmaceuticals, Inc. | Multimeric piperidine derivatives |
| US12365733B2 (en) | 2017-12-29 | 2025-07-22 | Cellectis | Method for improving production of car T cells |
| AU2019209432A1 (en) | 2018-01-22 | 2020-08-06 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for CAR T cells |
| CN111936518A (zh) | 2018-02-06 | 2020-11-13 | 西雅图儿童医院（Dba西雅图儿童研究所） | 对fl-ple标记的肿瘤表现出最佳的t细胞功能的荧光素特异性car |
| CN111989108B (zh) | 2018-02-13 | 2024-07-16 | 嵌合体生物工程公司 | 利用rna去稳定元件协调基因表达 |
| WO2019165237A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| WO2019169290A1 (en) | 2018-03-02 | 2019-09-06 | Allogene Therapeutics, Inc. | Inducible chimeric cytokine receptors |
| UY38182A (es) | 2018-04-10 | 2019-10-31 | Amgen Inc | Receptores quiméricos de dll3 y métodos para su uso |
| US20210396739A1 (en) | 2018-05-01 | 2021-12-23 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| US20210213063A1 (en) | 2018-05-25 | 2021-07-15 | Novartis Ag | Combination therapy with chimeric antigen receptor (car) therapies |
| WO2020018695A1 (en) | 2018-07-18 | 2020-01-23 | Amgen Inc. | Chimeric receptors to steap1 and methods of use thereof |
| EP3833742A2 (en) | 2018-08-09 | 2021-06-16 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| WO2020047449A2 (en) | 2018-08-31 | 2020-03-05 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| ES3042082T3 (en) | 2018-08-31 | 2025-11-18 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| EP3856782A1 (en) | 2018-09-28 | 2021-08-04 | Novartis AG | Cd19 chimeric antigen receptor (car) and cd22 car combination therapies |
| US20220047633A1 (en) | 2018-09-28 | 2022-02-17 | Novartis Ag | Cd22 chimeric antigen receptor (car) therapies |
| IL283734B2 (en) | 2018-12-12 | 2025-03-01 | Kite Pharma Inc | Chimeric antigen receptors and CAR-T cells and methods of use |
| PH12021551861A1 (en) | 2019-03-01 | 2022-05-30 | Allogene Therapeutics Inc | Constitutively active chimeric cytokine receptors |
| KR20210138574A (ko) | 2019-03-01 | 2021-11-19 | 알로젠 테라퓨틱스 인코포레이티드 | Dll3 표적화 키메라 항원 수용체 및 결합제 |
| US11786553B2 (en) | 2019-03-01 | 2023-10-17 | Allogene Therapeuctics, Inc. | Chimeric cytokine receptors bearing a PD-1 ectodomain |
| WO2020210678A1 (en) | 2019-04-12 | 2020-10-15 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| WO2020219848A1 (en) | 2019-04-26 | 2020-10-29 | Allogene Therapeutics, Inc. | Rituximab-resistant chimeric antigen receptors and uses thereof |
| WO2020219812A1 (en) | 2019-04-26 | 2020-10-29 | Allogene Therapeutics, Inc. | Methods of manufacturing allogeneic car t cells |
| KR20220016474A (ko) | 2019-05-01 | 2022-02-09 | 주노 쎄러퓨티크스 인코퍼레이티드 | 변형된 ｃｄ247 유전자 자리로부터 키메라 수용체를 발현하는 세포, 관련 폴리뉴클레오타이드 및 방법 |
| BR112021021075A2 (pt) | 2019-05-01 | 2021-12-14 | Editas Medicine Inc | Células que expressam um receptor recombinante de um locus de tgfbr2 modificado, polinucleotídeos relacionados e métodos |
| JP2019170393A (ja) * | 2019-06-19 | 2019-10-10 | 国立大学法人九州大学 | ｉＰＳ細胞の作製方法 |
| CN114786686A (zh) | 2019-08-18 | 2022-07-22 | 嵌合体生物工程公司 | Gold控制的转基因的联合疗法 |
| EP4104187A1 (en) | 2020-02-14 | 2022-12-21 | Novartis AG | Method of predicting response to chimeric antigen receptor therapy |
| AU2021227191A1 (en) | 2020-02-24 | 2022-08-25 | Allogene Therapeutics, Inc. | BCMA car-T cells with enhanced activities |
| US20230256017A1 (en) | 2020-02-27 | 2023-08-17 | Jennifer Brogdon | Methods of making chimeric antigen receptor-expressing cells |
| EP4171616A1 (en) | 2020-06-26 | 2023-05-03 | Juno Therapeutics GmbH | Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods |
| US20240279353A1 (en) | 2020-07-06 | 2024-08-22 | Kiromic BioPharma, Inc. | Mesothelin isoform binding molecules and chimeric pd1 receptor molecules, cells containing the same and uses thereof |
| IL299886A (en) | 2020-07-17 | 2023-03-01 | Instil Bio Uk Ltd | Receptors that provide targeted costimulation for host cell therapy |
| CA3198447A1 (en) | 2020-11-13 | 2022-05-19 | Novartis Ag | Combination therapies with chimeric antigen receptor (car)-expressing cells |
| WO2022108627A1 (en) | 2020-11-18 | 2022-05-27 | Kiromic Biopharma, Inc.Kiromic Biopharma, Inc. | Gamma-delta t cell manufacturing processes and chimeric pd1 receptor molecules |
| WO2022115492A1 (en) | 2020-11-24 | 2022-06-02 | Lyell Immunopharma, Inc. | Methods for making, compositions comprising, and methods of using rejuvenated t cells |
| JP2024500189A (ja) | 2020-12-21 | 2024-01-04 | アロジーン セラピューティクス，インコーポレイテッド | プロテアーゼ活性化ｃｄ４５ゲートｃａｒ |
| EP4355340A4 (en) | 2021-06-16 | 2025-05-21 | Instil Bio, Inc. | RECEPTORS FOR TARGETED COSTIMULATION FOR ADOPTIVE CELL THERAPY |
| WO2023288278A1 (en) * | 2021-07-16 | 2023-01-19 | Instil Bio (Uk) Limited | Chimeric molecules providing targeted costimulation for adoptive cell therapy |
| EP4376876A1 (en) | 2021-07-26 | 2024-06-05 | Kite Pharma, Inc. | Split chimeric antigen receptors and methods of use |
| CN114410689B (zh) * | 2022-03-29 | 2022-06-17 | 北京循生生物医学研究有限公司 | 一种增强肿瘤浸润淋巴细胞杀伤力的制备方法 |
| CA3266372A1 (en) | 2022-09-15 | 2024-03-21 | Novartis Ag | TREATMENT OF AUTOIMMUNE DISORDERS USING CHIMERIC ANTIGEN RECEPTOR THERAPY |
| TW202440623A (zh) | 2022-11-28 | 2024-10-16 | 美商艾洛基因醫療公司 | 靶向密連蛋白１８﹒２之嵌合抗原受體及結合劑以及其用途 |
| CN116179495B (zh) * | 2022-11-28 | 2025-06-06 | 上海恩凯细胞技术有限公司 | 转基因免疫细胞及其应用 |
| WO2024182539A1 (en) | 2023-02-28 | 2024-09-06 | Lyell Immunopharma, Inc. | Methods of culturing reprogrammed cells |
| WO2024196796A1 (en) * | 2023-03-17 | 2024-09-26 | Cartesian Therapeutics, Inc. | Intracellular signaling and costimulatory domains adapted for prolonged expression of chimeric antigen receptors |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4514506A (en) | 1982-02-23 | 1985-04-30 | The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services | Method for the identification and purification of human lung tumor-associated antigens (hLTAA) and clinical detection and determination of these antigens |
| EP0273085A1 (en) | 1986-12-29 | 1988-07-06 | IntraCel Corporation | A method for internalizing nucleic acids into eukaryotic cells |
| FR2610631B1 (fr) | 1987-02-09 | 1989-11-24 | Pasteur Institut | Molecules comportant au moins une sequence peptidique porteuse d'un ou plusieurs, epitope caracteristique d'une proteine produite par p. falciparum dans les hepatocytes, et leurs utilisations, notamment pour le diagnostic du paludisme ou dans des compositions de vaccins contre le paludisme |
| US5869608A (en) | 1989-03-17 | 1999-02-09 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and amino acid sequences of the four variable domains of the major outer membrane proteins of Chlamydia trachomatis |
| US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| GB9105383D0 (en) | 1991-03-14 | 1991-05-01 | Immunology Ltd | An immunotherapeutic for cervical cancer |
| DE69233441T2 (de) | 1991-04-26 | 2005-10-13 | Osaka Bioscience Institute, Suita | Menschliches Zelloberflächen-Antigen codierende DNA |
| US5780036A (en) | 1991-08-26 | 1998-07-14 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepattis B virus |
| US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
| DE4228457A1 (de) | 1992-08-27 | 1994-04-28 | Beiersdorf Ag | Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen |
| GB9222888D0 (en) | 1992-10-30 | 1992-12-16 | British Tech Group | Tomography |
| US5869337A (en) | 1993-02-12 | 1999-02-09 | President And Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
| US5830462A (en) | 1993-02-12 | 1998-11-03 | President & Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
| US5834266A (en) | 1993-02-12 | 1998-11-10 | President & Fellows Of Harvard College | Regulated apoptosis |
| PL310327A1 (en) | 1993-02-12 | 1995-12-11 | Univ Leland Stanford Junior | Adjustable transcription of target genes and other biological processes |
| US5426027A (en) | 1993-05-20 | 1995-06-20 | The Government Of The United States Of America As Represented By The Secretary | Nucleic acid probes and methods for detecting Candida DNA cells in blood |
| US5648226A (en) | 1993-07-22 | 1997-07-15 | Ludwig Institute For Cancer Research | Isolated peptides derived from tumor rejection antigens, and their use |
| EP0721341A4 (en) | 1993-08-06 | 1998-04-22 | Cytel Corp | CLONING AND DESCRIPTION OF FULL MAGE-1 GENE CHARACTERISTICS |
| US5550214A (en) | 1994-02-10 | 1996-08-27 | Brigham And Women's Hospital | Isolated antigenic oncogene peptide fragments and uses |
| US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
| FR2722208B1 (fr) | 1994-07-05 | 1996-10-04 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique |
| EP0785992A4 (en) | 1994-10-25 | 1999-12-22 | Univ Leland Stanford Junior | TRANSFORMATION OF THE STATE OF CELLS PRODUCED BY GENETIC ENGINEERING |
| US5837544A (en) | 1995-02-02 | 1998-11-17 | Cell Genesys, Inc. | Method of inducing a cell to proliferate using a chimeric receptor comprising janus kinase |
| US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
| US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| AU705647B2 (en) | 1996-07-10 | 1999-05-27 | Immunex Corporation | Method of activating dendritic cells |
| US5955596A (en) | 1996-07-26 | 1999-09-21 | American Cyanamid Company | NucA protein of Haemophilus influenzae and the gene encoding that protein |
| US6046158A (en) | 1996-12-20 | 2000-04-04 | Board Of Regents The University Of Texas Systems | Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof |
| US5965242A (en) | 1997-02-19 | 1999-10-12 | Eastman Kodak Company | Glow-in-the-dark medium and method of making |
| US6969609B1 (en) | 1998-12-09 | 2005-11-29 | The United States Of America As Represented By The Department Of Health And Human Serivces | Recombinant vector expressing multiple costimulatory molecules and uses thereof |
| US6558951B1 (en) | 1999-02-11 | 2003-05-06 | 3M Innovative Properties Company | Maturation of dendritic cells with immune response modifying compounds |
| GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| WO2001048154A1 (en) | 1999-12-28 | 2001-07-05 | Toyoshima, Kumao | Maturation-promoting agent for immature dendritic cells |
| US7435585B2 (en) | 2000-01-03 | 2008-10-14 | University Of Pennsylvania | Auto-stimulating cells and methods for making and using the same |
| SE0001642D0 (sv) | 2000-05-04 | 2000-05-04 | Sahltech Ab | Reagent for detection of biomolecules, and use thereof |
| US20030232055A1 (en) | 2000-07-31 | 2003-12-18 | Ruslan Medzhitov | Innate immune system-directed vaccines |
| US6943245B2 (en) | 2000-08-10 | 2005-09-13 | Board Of Regents, The University Of Texas System | Tumor suppressor CAR-1 |
| US7666424B2 (en) * | 2001-10-17 | 2010-02-23 | Sloan-Kettering Institute For Cancer Research | Methods of preparing and using single chain anti-tumor antibodies |
| WO2002036769A2 (en) | 2000-10-31 | 2002-05-10 | F. Hoffmann-La Roche Ag | Nucleic acids encoding cd40/cd40l chimeric polypeptides, methods for their production and uses thereof |
| US6965023B2 (en) | 2000-11-17 | 2005-11-15 | The Burnham Institute | Death domain proteins |
| US6838263B2 (en) | 2001-07-09 | 2005-01-04 | Oklahoma Medical Research Foundation | Targeted fusion proteins and methods for the characterization of cellular membrane domains |
| US20040116333A1 (en) | 2001-08-03 | 2004-06-17 | Rong-Hwa Lin | Modulators of P-selectin glycoprotein ligand 1 |
| EP1425040A2 (en) | 2001-09-14 | 2004-06-09 | Cytos Biotechnology AG | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
| AU2002353890A1 (en) | 2001-10-26 | 2003-05-06 | Cleveland Clinic Foundation | Fused cells, methods of forming same, and therapie utilizing same |
| GB0225279D0 (en) | 2002-10-30 | 2002-12-11 | Celltech R&D Ltd | Biological products |
| EP2557164A1 (en) | 2003-02-18 | 2013-02-13 | Kevin M. Slawin | Induced activation in dendritic cells |
| US20050113564A1 (en) * | 2003-11-05 | 2005-05-26 | St. Jude Children's Research Hospital | Chimeric receptors with 4-1BB stimulatory signaling domain |
| US20080274140A1 (en) | 2004-11-19 | 2008-11-06 | David B Weiner | Vaccines and Methods for Using the Same |
| US8088908B2 (en) | 2005-05-10 | 2012-01-03 | City Of Hope | Humanized anti-prostate stem cell antigen monoclonal antibody |
| KR100705981B1 (ko) | 2005-10-12 | 2007-04-10 | 주식회사 리제론 | 인간 성장호르몬을 포함하는 탈모방지 또는 발모촉진용조성물 |
| WO2007137300A2 (en) | 2006-05-23 | 2007-11-29 | Bellicum Pharmaceuticals, Inc. | Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods |
| WO2008045437A2 (en) * | 2006-10-09 | 2008-04-17 | The General Hospital Corporation | Chimeric t-cell receptors and t-cells targeting egfrviii on tumors |
| EP2076272B1 (en) | 2006-10-19 | 2015-07-29 | Baylor College Of Medicine | Generating an immune response by inducing cd40 and pattern recognition receptors |
| BRPI0820270A2 (pt) | 2007-11-07 | 2015-06-16 | Celldex Therapeutics Inc | Anticorpo monoclonal, vetor de expressão, célula, conjugado molecular, composição, uso da composição, método para detectar a presença ou ausência de dec-205 em uma amostra biológica, e, uso de um conjugado molecular. |
| AU2009221915A1 (en) | 2008-03-03 | 2009-09-11 | Dyax Corp. | Metalloproteinase 12 binding proteins |
| PL3006459T3 (pl) * | 2008-08-26 | 2022-01-17 | City Of Hope | Sposób i kompozycje dla wzmocnionego działania efektorowego komórek t przeciw guzowi nowotworowemu |
| DK2331680T3 (en) | 2008-09-22 | 2017-08-21 | Baylor College Medicine | Methods and Compositions for Generating an Immune Response by Induction of CD-40 as well as Pattern Recognition Receptor Adapters |
| EP2558109A4 (en) | 2010-04-16 | 2014-09-24 | Bellicum Pharmaceuticals Inc | METHOD FOR TREATING HARD TUMORS |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP2651442B1 (en) * | 2010-12-14 | 2020-04-22 | University of Maryland, Baltimore | Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer |
| WO2012127464A2 (en) | 2011-03-23 | 2012-09-27 | Gavish-Galilee Bio Applications Ltd | Constitutively activated t cells for use in adoptive cell therapy |
| US20130071414A1 (en) * | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
| US20140255363A1 (en) * | 2011-09-16 | 2014-09-11 | Baylor College Of Medicine | Targeting the tumor microenvironment using manipulated nkt cells |
| EP2773651B1 (en) * | 2011-11-03 | 2020-12-23 | The Trustees of the University of Pennsylvania | Isolated b7-h4 specific compositions and methods of use thereof |
| WO2013078433A1 (en) | 2011-11-23 | 2013-05-30 | University Of Hawaii | Auto-processing domains for polypeptide expression |
| WO2013126720A2 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for the assessment of target cancer cell resistance to car engineered t cell killing |
| WO2013154760A1 (en) | 2012-04-11 | 2013-10-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors targeting b-cell maturation antigen |
| US20130280220A1 (en) * | 2012-04-20 | 2013-10-24 | Nabil Ahmed | Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes |
| NZ701324A (en) | 2012-05-04 | 2016-09-30 | Pfizer | Prostate-associated antigens and vaccine-based immunotherapy regimens |
| CA3133545C (en) * | 2012-05-25 | 2023-08-08 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| ES2824024T3 (es) * | 2012-10-10 | 2021-05-11 | Sangamo Therapeutics Inc | Compuestos modificadores de células T y usos de los mismos |
| LT2956175T (lt) | 2013-02-15 | 2017-12-11 | The Regents Of The University Of California | Chimerinis antigeno receptorius ir jo panaudojimo būdai |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| KR20150131218A (ko) | 2013-03-14 | 2015-11-24 | 벨리쿰 파마슈티컬스, 인크. | T 세포 증식의 제어 방법 |
| CA2912172A1 (en) | 2013-06-05 | 2014-12-11 | Bellicum Pharmaceuticals, Inc. | Methods for inducing partial apoptosis using caspase polypeptides |
| US10144770B2 (en) | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| CN106132423B (zh) | 2014-02-14 | 2020-07-31 | 贝里坤制药股份有限公司 | 用诱导型嵌合多肽活化t细胞的方法 |
| WO2015134877A1 (en) | 2014-03-07 | 2015-09-11 | Bellicum Pharmaceuticals, Inc. | Caspase polypeptides having modified activity and uses thereof |
| JP6868554B2 (ja) | 2014-09-02 | 2021-05-12 | ベリカム ファーマシューティカルズ， インコーポレイテッド | ＭｙＤ８８およびＣＤ４０ポリペプチドによるキメラ抗原受容体の共刺激 |
-
2014
- 2014-03-13 KR KR1020157028844A patent/KR20150131218A/ko not_active Ceased
- 2014-03-13 US US14/210,034 patent/US9944690B2/en active Active
- 2014-03-13 EP EP14770399.5A patent/EP2968502B1/en active Active
- 2014-03-13 CN CN201480028439.3A patent/CN105209065B/zh active Active
- 2014-03-13 JP JP2016502228A patent/JP6541639B2/ja active Active
- 2014-03-13 SG SG11201506974XA patent/SG11201506974XA/en unknown
- 2014-03-13 AU AU2014236726A patent/AU2014236726A1/en not_active Abandoned
- 2014-03-13 CA CA2905352A patent/CA2905352A1/en not_active Abandoned
- 2014-03-13 HK HK16105044.7A patent/HK1217000A1/zh unknown
- 2014-03-13 WO PCT/US2014/026734 patent/WO2014151960A2/en not_active Ceased
-
2018
- 2018-03-02 US US15/910,380 patent/US20180265566A1/en not_active Abandoned
- 2018-05-31 JP JP2018105044A patent/JP2018145194A/ja not_active Withdrawn
-
2019
- 2019-03-07 AU AU2019201586A patent/AU2019201586A1/en not_active Abandoned
- 2019-12-13 JP JP2019225565A patent/JP2020055863A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016519068A5 (enExample) | ||
| US20240417481A1 (en) | Bcma chimeric antigen receptors | |
| Weinkove et al. | Selecting costimulatory domains for chimeric antigen receptors: functional and clinical considerations | |
| AU2018203687B2 (en) | Improved methods for manufacturing adoptive cell therapies | |
| AU2014259675B2 (en) | CS1-specific chimeric antigen receptor engineered immune effector cells | |
| JP7288503B2 (ja) | 改変された抗ｃｄ１９ ｃａｒ－ｔ細胞 | |
| JP2016521709A5 (enExample) | ||
| JP2018501786A5 (enExample) | ||
| RS62733B1 (sr) | Mnd promoter himernih antigenskih receptora | |
| JP2019525898A (ja) | ヒト白血球抗原拘束ガンマデルタｔ細胞受容体及びその使用方法 | |
| CN108137670A (zh) | Ny-eso-1特异性tcr及其使用方法 | |
| CN107074929A (zh) | 嵌合自身抗体受体t细胞的组合物和方法 | |
| EA036379B1 (ru) | Химерные антигенные рецепторы к bcma | |
| US20240101616A1 (en) | Dap10/12 based cars adapted for rush | |
| CN112154204A (zh) | 基因工程化的细胞及应用 | |
| US20230192848A1 (en) | Engineered cell compositions and methods of use thereof | |
| KR20250005572A (ko) | Cd4 특이적 항체 작제물과 조성물 및 이의 용도 | |
| KR20250111218A (ko) | 혈액학적 암의 치료에 사용하기 위한 키트 | |
| JP2025512407A (ja) | Ｃｍｖ－ｈｉｖ特異的キメラ抗原受容体ｔ細胞 | |
| EA045264B1 (ru) | Способ лечения гемобластоза с помощью иммунных эффекторных клеток, содержащих химерные антигенные рецепторы к bcma |