JP2016518109A5 - - Google Patents
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- JP2016518109A5 JP2016518109A5 JP2016501590A JP2016501590A JP2016518109A5 JP 2016518109 A5 JP2016518109 A5 JP 2016518109A5 JP 2016501590 A JP2016501590 A JP 2016501590A JP 2016501590 A JP2016501590 A JP 2016501590A JP 2016518109 A5 JP2016518109 A5 JP 2016518109A5
- Authority
- JP
- Japan
- Prior art keywords
- microvesicles
- fluid
- isolated
- tissue
- promote
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 15
- 238000002360 preparation method Methods 0.000 claims 7
- 210000001519 tissue Anatomy 0.000 claims 7
- 239000013060 biological fluid Substances 0.000 claims 4
- 239000012530 fluid Substances 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- -1 ammonium ions Chemical class 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000001914 filtration Methods 0.000 claims 2
- 238000005191 phase separation Methods 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 230000008929 regeneration Effects 0.000 claims 2
- 238000011069 regeneration method Methods 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 206010003445 Ascites Diseases 0.000 claims 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 1
- 206010050337 Cerumen impaction Diseases 0.000 claims 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims 1
- 208000005228 Pericardial Effusion Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010407 ammonium alginate Nutrition 0.000 claims 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims 1
- 235000011130 ammonium sulphate Nutrition 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000001640 apoptogenic effect Effects 0.000 claims 1
- 210000001742 aqueous humor Anatomy 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000002533 bulbourethral gland Anatomy 0.000 claims 1
- 229910001424 calcium ion Inorganic materials 0.000 claims 1
- 239000012930 cell culture fluid Substances 0.000 claims 1
- 230000012292 cell migration Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 210000002583 cell-derived microparticle Anatomy 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 210000002939 cerumen Anatomy 0.000 claims 1
- 210000003756 cervix mucus Anatomy 0.000 claims 1
- 210000001268 chyle Anatomy 0.000 claims 1
- 238000009295 crossflow filtration Methods 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 210000003981 ectoderm Anatomy 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000001808 exosome Anatomy 0.000 claims 1
- 210000003722 extracellular fluid Anatomy 0.000 claims 1
- 210000000416 exudates and transudate Anatomy 0.000 claims 1
- 210000003608 fece Anatomy 0.000 claims 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims 1
- 210000004209 hair Anatomy 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 210000004251 human milk Anatomy 0.000 claims 1
- 235000020256 human milk Nutrition 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 230000028709 inflammatory response Effects 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 229910001425 magnesium ion Inorganic materials 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000002175 menstrual effect Effects 0.000 claims 1
- 210000003716 mesoderm Anatomy 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 210000003097 mucus Anatomy 0.000 claims 1
- 210000000944 nerve tissue Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 230000008520 organization Effects 0.000 claims 1
- 210000001819 pancreatic juice Anatomy 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 210000004912 pericardial fluid Anatomy 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000004910 pleural fluid Anatomy 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 210000004909 pre-ejaculatory fluid Anatomy 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 210000004908 prostatic fluid Anatomy 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 230000036573 scar formation Effects 0.000 claims 1
- 210000002374 sebum Anatomy 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 229910001415 sodium ion Inorganic materials 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000004243 sweat Anatomy 0.000 claims 1
- 210000001179 synovial fluid Anatomy 0.000 claims 1
- 210000001138 tear Anatomy 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 230000037373 wrinkle formation Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019105087A JP7405389B2 (ja) | 2013-03-13 | 2019-06-05 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361778591P | 2013-03-13 | 2013-03-13 | |
| US61/778,591 | 2013-03-13 | ||
| PCT/US2014/024629 WO2014159662A1 (en) | 2013-03-13 | 2014-03-12 | Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019105087A Division JP7405389B2 (ja) | 2013-03-13 | 2019-06-05 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518109A JP2016518109A (ja) | 2016-06-23 |
| JP2016518109A5 true JP2016518109A5 (enExample) | 2017-04-13 |
| JP6562897B2 JP6562897B2 (ja) | 2019-08-21 |
Family
ID=51625222
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501590A Active JP6562897B2 (ja) | 2013-03-13 | 2014-03-12 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
| JP2019105087A Active JP7405389B2 (ja) | 2013-03-13 | 2019-06-05 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
| JP2022027857A Active JP7417301B2 (ja) | 2013-03-13 | 2022-02-25 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019105087A Active JP7405389B2 (ja) | 2013-03-13 | 2019-06-05 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
| JP2022027857A Active JP7417301B2 (ja) | 2013-03-13 | 2022-02-25 | 細胞培養上清および生体液からの微小胞の単離および精製のための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10500231B2 (enExample) |
| EP (3) | EP2972193B1 (enExample) |
| JP (3) | JP6562897B2 (enExample) |
| CN (2) | CN105209881B (enExample) |
| AU (4) | AU2014244618A1 (enExample) |
| CA (1) | CA2906502A1 (enExample) |
| DK (2) | DK3677271T3 (enExample) |
| ES (2) | ES2778098T3 (enExample) |
| FI (1) | FI3677271T3 (enExample) |
| HU (2) | HUE049003T2 (enExample) |
| PL (2) | PL2972193T3 (enExample) |
| PT (2) | PT2972193T (enExample) |
| WO (1) | WO2014159662A1 (enExample) |
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| US9687511B2 (en) * | 2015-03-06 | 2017-06-27 | Vivex Biomedical, Inc. | Acellular biologic composition and method of manufacture |
| US10596123B2 (en) | 2015-03-11 | 2020-03-24 | Mayo Foundation For Medical Education And Research | Exosome delivery technology |
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| KR102418785B1 (ko) * | 2015-09-25 | 2022-07-08 | (주)프로스테믹스 | 식물 착즙물 유래 세포 외 소포체를 포함하는 피부 개선 및 탈모 방지용 조성물 |
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| JP2020528766A (ja) * | 2017-07-26 | 2020-10-01 | ロゼッタ エクソソーム | 陽イオンを利用した細胞外小胞体の分離方法 |
| CN111183354B (zh) * | 2017-07-27 | 2023-09-15 | 康奈尔大学 | 细胞外囊泡的固定和保留 |
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