JP2016517898A - 多量のuv安定剤を含む剤 - Google Patents
多量のuv安定剤を含む剤 Download PDFInfo
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- JP2016517898A JP2016517898A JP2016512337A JP2016512337A JP2016517898A JP 2016517898 A JP2016517898 A JP 2016517898A JP 2016512337 A JP2016512337 A JP 2016512337A JP 2016512337 A JP2016512337 A JP 2016512337A JP 2016517898 A JP2016517898 A JP 2016517898A
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- PABHEXWDYRTPBQ-UHFFFAOYSA-N methyl 3-[2,5-di(propan-2-yl)phenyl]prop-2-enoate Chemical compound COC(=O)C=CC1=CC(C(C)C)=CC=C1C(C)C PABHEXWDYRTPBQ-UHFFFAOYSA-N 0.000 description 1
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- 229940043348 myristyl alcohol Drugs 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940078812 myristyl myristate Drugs 0.000 description 1
- YWFWDNVOPHGWMX-UHFFFAOYSA-N n,n-dimethyldodecan-1-amine Chemical compound CCCCCCCCCCCCN(C)C YWFWDNVOPHGWMX-UHFFFAOYSA-N 0.000 description 1
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- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000002560 nitrile group Chemical group 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- YZUUTMGDONTGTN-UHFFFAOYSA-N nonaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCO YZUUTMGDONTGTN-UHFFFAOYSA-N 0.000 description 1
- 235000014571 nuts Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- WRPMUZXHQKAAIC-CZIZESTLSA-N octadecyl (e)-octadec-9-enoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C\CCCCCCCC WRPMUZXHQKAAIC-CZIZESTLSA-N 0.000 description 1
- ZFCUBQOYWAZKNO-ZPHPHTNESA-N octadecyl (z)-docos-13-enoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCC\C=C/CCCCCCCC ZFCUBQOYWAZKNO-ZPHPHTNESA-N 0.000 description 1
- GAQPWOABOQGPKA-UHFFFAOYSA-N octadecyl docosanoate Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCC GAQPWOABOQGPKA-UHFFFAOYSA-N 0.000 description 1
- IEDOGKKOPNRRKW-UHFFFAOYSA-N octadecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC IEDOGKKOPNRRKW-UHFFFAOYSA-N 0.000 description 1
- 229960003921 octisalate Drugs 0.000 description 1
- WCJLCOAEJIHPCW-UHFFFAOYSA-N octyl 2-hydroxybenzoate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1O WCJLCOAEJIHPCW-UHFFFAOYSA-N 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-M oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC([O-])=O ZQPPMHVWECSIRJ-KTKRTIGZSA-M 0.000 description 1
- ALSTYHKOOCGGFT-MDZDMXLPSA-N oleyl alcohol Chemical compound CCCCCCCC\C=C\CCCCCCCCO ALSTYHKOOCGGFT-MDZDMXLPSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- AFDXODALSZRGIH-UHFFFAOYSA-N p-coumaric acid methyl ether Natural products COC1=CC=C(C=CC(O)=O)C=C1 AFDXODALSZRGIH-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- LXTZRIBXKVRLOA-UHFFFAOYSA-N padimate a Chemical compound CCCCCOC(=O)C1=CC=C(N(C)C)C=C1 LXTZRIBXKVRLOA-UHFFFAOYSA-N 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- JYTMDBGMUIAIQH-ZPHPHTNESA-N palmityl oleate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC JYTMDBGMUIAIQH-ZPHPHTNESA-N 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
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- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
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- 229910052700 potassium Inorganic materials 0.000 description 1
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- 239000001294 propane Substances 0.000 description 1
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- 230000004224 protection Effects 0.000 description 1
- DQAKJEWZWDQURW-UHFFFAOYSA-N pyrrolidonecarboxylic acid Chemical class OC(=O)N1CCCC1=O DQAKJEWZWDQURW-UHFFFAOYSA-N 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
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- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 1
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- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
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- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
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- 239000012176 shellac wax Substances 0.000 description 1
- KCIKCCHXZMLVDE-UHFFFAOYSA-N silanediol Chemical compound O[SiH2]O KCIKCCHXZMLVDE-UHFFFAOYSA-N 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940057950 sodium laureth sulfate Drugs 0.000 description 1
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
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- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
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- 150000003408 sphingolipids Chemical class 0.000 description 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
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- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 229940094908 stearyl myristate Drugs 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003459 sulfonic acid esters Chemical class 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 229920001897 terpolymer Polymers 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- HBPNTDBLHQHPLH-UHFFFAOYSA-N tetradecyl 16-methylheptadecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C HBPNTDBLHQHPLH-UHFFFAOYSA-N 0.000 description 1
- AVKVDDQTHIQFSC-UHFFFAOYSA-N tetradecyl docosanoate Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC AVKVDDQTHIQFSC-UHFFFAOYSA-N 0.000 description 1
- DHZWALZKPWZSMA-UHFFFAOYSA-N tetradecyl oleate Natural products CCCCCCCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC DHZWALZKPWZSMA-UHFFFAOYSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- JYKSTGLAIMQDRA-UHFFFAOYSA-N tetraglycerol Chemical compound OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO JYKSTGLAIMQDRA-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
- FAGMGMRSURYROS-UHFFFAOYSA-M trihexadecyl(methyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(CCCCCCCCCCCCCCCC)CCCCCCCCCCCCCCCC FAGMGMRSURYROS-UHFFFAOYSA-M 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- OEIXGLMQZVLOQX-UHFFFAOYSA-N trimethyl-[3-(prop-2-enoylamino)propyl]azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCNC(=O)C=C OEIXGLMQZVLOQX-UHFFFAOYSA-N 0.000 description 1
- QXJQHYBHAIHNGG-UHFFFAOYSA-N trimethylolethane Chemical compound OCC(C)(CO)CO QXJQHYBHAIHNGG-UHFFFAOYSA-N 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229920006163 vinyl copolymer Polymers 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 229960003487 xylose Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/415—Aminophenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Abstract
Description
(a)15〜50重量%の油性物質
(b)4〜30重量%のアニオン界面活性剤、
(c)0.5〜25重量%の(b)とは異なる別の共界面活性剤、
(d)25〜75重量%の少なくとも1つのUVフィルター、並びに
(e)場合によって、100重量%までの水及び/又は補助物質
を含む剤によってその目的を達成することが可能であった。
R1、R2及びR3は、互いに独立に、水素又は式(II):R4(OCH2CHR5)nの基
(式中、
R4は、6〜22個の炭素原子を有する直鎖状若しくは分枝状アルキル及び/又はアルケニル基を表し、
R5は、水素又はメチル基を表し、
nは、基R1、R2又はR3の少なくとも1つが水素以外であることを条件として、1から20までの数を表す)
を意味する。]
に対応するクエン酸とアルコキシ化アルコールのモノ-、ジ-及びトリエステルの混合物である。
- 2から50モルまでのエチレンオキシド及び/又は0〜20モルのプロピレンオキシドの8〜40個のC原子を有する直鎖状脂肪族アルコールへの、12〜40個のC原子を有する脂肪酸への及びアルキル基中に8〜15個のC原子を有するアルキルフェノールへの付加生成物、
- 1から50モルまでのエチレンオキシドのグリセロールへの付加生成物のC12/18-脂肪酸モノ-及びジエステル、6〜22個の炭素原子を有する飽和及び不飽和脂肪酸のグリセロールモノ-及びジエステル及びソルビタンモノ-及びジエステル並びにそれらのエチレンオキシド付加生成物、
- アルキル基中に8〜22個の炭素原子を有するアルキルモノグリコシド及びオリゴグリコシド及びそれらのエトキシ化類似物、ヒマシ油及び/又は水添ヒマシ油への7から60モルまでのエチレンオキシドの付加生成物、
- ポリオール及び/又はポリグリセロールエステル、例えばポリグリセロールジイソステアレート又はポリグリセロールダイマレート又はポリグリセロール12-ヒドロキシステアレート、
- ヒマシ油及び/又は水添ヒマシ油への2から15モルまでのエチレンオキシドの付加生成物、
- 直鎖状、分枝状、不飽和若しくは飽和C6-C22-脂肪酸、リシノール酸及び12-ヒドロキシステアリン酸に基づくペンタエリスリトール、ジペンタエリスリトール、糖アルコール(例えばソルビトール)、アルキルグルコシド(例えば、メチルグルコシド、ブチルグルコシド、ラウリルグルコシド)及びポリグルコシド(例えばセルロース)による部分エステル、又は混合されたエステル、例えばグリセリルステアレートシトレート及びグリセリルステアレートラクテートなど、
- ウールワックスアルコール、
- ポリシロキサン/ポリアルキルポリエーテルコポリマー及び対応する誘導体、
- ペンタエリスリトール、脂肪酸、クエン酸及び脂肪族アルコールの混合エステル及び/又は6〜22個の炭素原子を有する脂肪酸、メチルグルコース及びポリオール、好ましくはグリセロール若しくはポリグリセロールの混合エステル、及び
- ポリアルキレングリコール
として存在する。
- グリセロール及びポリグリセロール、
- アルキレングリコール、例えば、エチレングリコール、ジエチレングリコール、プロピレングリコールなど、
- メチロール化合物、特に、トリメチロールエタン、トリメチロールプロパン、トリメチロールブタン、ペンタエリスリトール及びジペンタエリスリトールなど、
- アルキル基中に1〜12個、好ましくは1〜8個、特に1〜4個の炭素を有するアルキルオリゴグルコシド、例えば、メチル及びブチルグルコシドなど、
- 5〜12個の炭素原子を有する糖アルコール、例えば、ソルビトール又はマンニトールなど、
- 5〜12個の炭素原子を有する糖、例えば、グルコース又はスクロースなど、
- アミノ糖、例えば、グルカミンなど、
である。
グリセロール:5〜15(15〜30)重量%
ジグリセロール:15〜40(20〜32)重量%
トリグリセロール:10〜15(15〜25)重量%
テトラグリセロール:5〜20(8〜15)重量%
ペンタグリセロール:2〜10(3〜8)重量%
オリゴグリセロール:100重量%まで。
(d1)p-アミノ安息香酸誘導体、
(d2)サリチル酸誘導体、
(d3)ベンゾフェノン誘導体、
(d4)ジベンゾイルメタン誘導体、
(d5)ジフェニルアクリレート、
(d6)3-イミダゾール-4-イル-アクリル酸及びそのエステル、
(d7)ベンゾフラン誘導体、
(d8)ポリマーUV吸収剤、
(d9)ケイ皮酸誘導体、
(d10)ショウノウ誘導体、
(d11)ヒドロキシフェニルトリアジン誘導体、
(d12)ベンゾトリアゾール誘導体、
(d13)トリアニリノ-s-トリアジン誘導体、
(d14)2-フェニルベンゾイミダゾール5-スルホン酸及びその塩、
(d15)メチルo-アミノベンゾエート、
(d16)ホモサレート、
(d17)トリス-ビフェニルトリアジン誘導体、
(d18)TiO2(部分カプセル化)、ZnO及びマイカ、
(d19)ベンジリデンマロネート、
(d20)メロシアニン誘導体、
(d21)フェニレンビスジフェニルトリアジン、
(d22)イミダゾリン誘導体、及び
(d23)ジアリールブタジエン誘導体。
4-アミノ安息香酸(PABA)、式(PABA-01)
R1及びR2は、水素、C1-C20-アルキル、C2-C10-アルケニル、C3-C10-シクロアルキル、C3-C10-シクロアルケニルを表し、そこで置換基R1及びR2は、それらが結合している窒素原子と共に5員環又は6員環を形成することができ、
R3及びR4は、互いに独立に、C1-C20-アルキル、C2-C1O-アルケニル、C3-C10-シクロアルキル、C3-C10-シクロアルケニル、C1-C22-アルコキシ、C1-C20-アルコキシカルボニル、C1-C12-アルキルアミノ、C1-C12-ジアルキルアミノ、場合によって置換されているアリール、ヘタリール、ニトリル基、及びカルボキシレート、スルホネート又はアンモニウム基から成る群から選択される水中での溶解性を授与する置換基であり、
Xは、水素、COOR5、又はCONR6R7を表し、
R5、R6、R7は、互いに独立に、水素、C1-C20-アルキル、C2-C1O-アルケニル、C3-C10-シクロアルキル、C3-C10-シクロアルケニル、(Y-O)o-Z、又はアリールを表し、
Zは、-CH2-CH3、-CH2-CH2-CH3、-CH2-CH2-CH2-CH3、又は-CH(CH3)-CH3を表し、
mは、0〜3を表し、
nは、0〜4を表し、
oは、1〜20を表す)
のベンゾフェノン-3-(2-ヒドロキシ-4-メトキシベンゾフェノン)、ベンゾフェノン-4-(2-ヒドロキシ-4-メトキシベンゾフェノン-5-スルホン酸)、ベンゾフェノン-8-(2,2'-ジヒドロキシ-4-メトキシベンゾフェノン)、又はアミノ-置換ヒドロキシベンゾフェノンである。
R1及びR2は、互いに独立に、C1-C20-アルキル、C2-C20-アルケニル、C3-C10-シクロアルキル、C3-C10-シクロアルケニルを表し、又はR1及びR2は、それらが結合している窒素原子と共に5員又は6員の複素環を形成し、
R3は、カルボニル又はカルボキシル基によって場合によって置換されているアルキレン、シクロアルキレン、アルケニレン又はフェニレン、式(HBP-03a)
n2は、1〜3の数を表し、
Aは、-O-、又は-N(R5)-を表し、
R5 は、水素、C1-C5-アルキル、又はヒドロキシ-C1-C5-アルキルを表す]
に対応する二量体ベンゾフェノン誘導体が、本発明に従って同様に使用され得る。
R1及びR2は、互いに独立に、水素、C1-C18-アルキル、C2-C18-アルケニル、式-CH2-CH(-OH)-CH2-O-T1の基、式(HTP-01a)
R3、R5及びR5は、互いに独立に、ヒドロキシル、非置換若しくは1つ以上のOH基により置換されているC1-C5-アルコキシ、アミノ、モノ-又はジ-C1-C5-アルキルアミノ、M、式(HPT-01b)
R10、R11及びR12は、互いに独立に、非置換又は1つ以上のOH基により置換されているC1-C14-アルキルを表し、
R13は、水素、M、C1-C5-アルキル、又は式-(CH2)m3-O-T1の基を表し、
R6は、直接結合、直鎖若しくは分枝状のC1-C4-アルキレン基、又は式-Cm4H2m4、若しくは-Cm4H2m4-O-の基を表し、
R7、R8及びR9は、互いに独立に、C1-C18-アルキル、C1-C18-アルコキシ又は式(HPT-01m)
R14は、C1-C5-アルキルを表し、
Mは、金属カチオンを表し、
T1は、水素又は(C1-C8)-アルキルを表し、
m1、m2及びm3は、互いに独立に、1〜3を表し、
m4は、2〜14を表し、
p1は、0又は1から5までの数を表す。
- 2-(4’-メトキシフェニル)-4,6-ビス(2’-ヒドロキシ-4’-n-オクチルオキシフェニル)-1,3,5-トリアジン;
- 2,4-ビス{[4-(3-(2-プロピルオキシ)-2-ヒドロキシプロピルオキシ)-2-ヒドロキシ]フェニル}-6-(4-メトキシフェニル)-1,3,5-トリアジン;
- 2,4-ビス{[4-(2-エチルヘキシルオキシ)-2-ヒドロキシ]フェニル}-6-[4-(2-メトキシエチルカルボキシル)-フェニルアミノ]-1,3,5-トリアジン;
- 2,4-ビス{[4-(トリス(トリメチルシロキシシリルプロピルオキシ)-2-ヒドロキシ]フェニル}-6-(4-メトキシフェニル)-1,3,5-トリアジン;
- 2,4-ビス{[4-(2"メチルプロペニルオキシ)-2-ヒドロキシ]フェニル}-6-(4-メトキシフェニル)-1,3,5-トリアジン;
- 2,4-ビス{[4-(1',1',1',3',5',5',5'-ヘプタメチルトリシリル-2"-メチルプロピルオキシ)-2-ヒドロキシ]フェニル}-6-(4-メトキシフェニル)-1,3,5-トリアジン;
- 2,4-ビス{[4-(3-(2-プロピルオキシ)-2-ヒドロキシプロピルオキシ)-2-ヒドロキシ]フェニル}-6-[4-エチルカルボキシル)-フェニルアミノ]-1,3,5-トリアジン;
- 2,4-ビス{[4-(2-エチルヘキシルオキシ)-2-ヒドロキシ]フェニル}-6-(1-メチルピロール-2-yl)-1,3,5-トリアジン;又は
- 式(BRT-02)
である。
R1は、水素、C1-C12-アルキル、C1-C12-アルコキシ、C1-C12-アルコキシカルボニル、C5-C10-シクロアルキル又は-S03Mを表し、
R3は、水素、C1-C18-アルキル、C1-C12-アルコキシ、又はハロゲンを表し、
nは、1又は2を表し、
n=1の場合、
R2は、C1-C20-アルキル、C5-C10-シクロ-C1-C5-アルキル、C1-C12-アルコキシ-C1-C5-アルキル、C5-C10-シクロアルキル-C1-C5-アルキル、C6-C10-アリール、C6-C10-アリール-C1-C5-アルキルを表し、
n=2の場合、
R2は、直接結合、又は-(CH2)p-を表し、
pは、1から3までの整数である)
に対応する。
R1が、C1-C12-アルキル、又は-S03Mを表し、
R3が、水素、ハロゲン、好ましくはClを表し、
nが、1を表し、
R2が、C1-C12-アルキルを表し、
pが、1〜3を表す
式(BT-01)の化合物が可能である。
R1が、水素を表し、
R3が、C1-C18-アルキルを表し、
n=2であり、
R2が、-CH2-を表す
ものである。
R1、R2及びR3は、互いに独立に、場合によって置換されているC1-C20-アルキル、アリール又はヘタリールを表し、
Xは、O又はNR4を表し、
R4は、水素、又は場合によって置換されているC1-C20-アルキル、アリール又はヘタリールを表す)
に対応する。
R6、R7、R8、R9及びR10は、互いに独立に、水素;ヒドロキシル;ハロゲン;C1〜C18-アルキル;C1〜C18-アルコキシ;C6〜C12-アリール;ビフェニリル;C6〜C12-アリールオキシ;C1〜C18-アルキルチオ;カルボキシル;-COOM;C1〜C18-アルキルカルボキシル;アミノカルボニル;又はモノ-又はジ-C1〜C18-アルキルアミノ;C1〜C10-アシルアミノ;-COOHを表し、
Mは、アルカリ金属イオンを表し、
xは、1又は2を表し、
yは、2から10までの整数を表す。
R2及びR3は、互いに独立に、水素、又はメチルであり、
R4は、メチル、エチル、又はn-プロピルであり、
R5及びR6は、互いに独立に、水素、又はC1-C3-アルキルであり、
R1が、エチル、プロピル、又はn-ブチルを表す場合、
Rは、イソプロピルを表す。
(d1)p-アミノ安息香酸誘導体、
(d2)サリチル酸誘導体、
(d3)ベンゾフェノン誘導体、
(d4)ジベンゾイルメタン誘導体、
(d5)ジフェニルアクリレート、
(d6)3-イミダゾール-4-イル-アクリル酸及びそのエステル、
(d7)ベンゾフラン誘導体、
(d9)ケイ皮酸誘導体、
(d10)ショウノウ誘導体、
(d11)ヒドロキシフェニルトリアジン誘導体、
(d12)ベンゾトリアゾール誘導体、
(d13)トリアニリノ-s-トリアジン誘導体、
(d14)2-フェニルベンゾイミダゾール5-スルホン酸及びその塩、
(d15)o-アミノ安息香酸メンチル、
(d16)ホモサレート、
(d19)ベンジリデンマロネート、及び
(d20)メロシアニン誘導体。
(dSOL-1)ベンゾフェノン-3(BP3)、
(dSOL-2)ベンゾフェノン-4(BP4)、
(dSOL-3)3-ベンジリデンカンファー(3BC)、
(dSOL-4)ビス-エチルヘキシルオキシフェノールメトキシフェニルトリアジン(BEMT)、
(dSOL-5)ブチルメトキシジベンゾイルメタン(BMBM)、
(dSOL-6)ジエチルヘキシルブタミドトリアゾン(DBT)、
(dSOL-7)ドロメトリゾールトリシロキサン(DTS)、
(dSOL-8)エチルヘキシルトリアゾン(EHT)、
(dSOL-9)メトキシケイ皮酸エチルヘキシル、
(dSOL-10)ベンジリデンマロネート(BM)、
(dSOL-11)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル(DHHB)、
(dSOL-12)オクトクリレン、
(dSOL-13)ポリシリコーン1-15、
(dSOL-14)ホモサレート、及び
(dSOL-15)サリチル酸エチルヘキシル。
(d9a)メトキシケイ皮酸エチルヘキシル、
(d11a)ビス-エチルヘキシルオキシフェノールメトキシフェニルトリアジン、
(d13a)エチルヘキシルトリアゾン、及び
(d3a)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル
の油溶性フィルター混合物である。
(a)20〜35重量%の油性物質、
(b)7〜17重量%のアニオン界面活性剤、
(c)3〜18重量%の共界面活性剤、
(d)35〜65重量%のUVフィルター、並びに
(e)0.01〜5重量%の水及び場合によって0.5〜5重量%の補助物質
を、全ての構成成分が合計100重量%になる条件下で含むものである。
(a)直鎖状及び分枝状脂肪族アルコールカーボネート、特に炭酸ジカプリリル及び/又はC2-C12-ジカルボン酸のエステルから選択される20〜35重量%の油性物質、
(b)アルキルポリアルキレングリコールエーテルシトレート、特にラウリルアルコールのポリエチレングリコールエーテルから選択される7〜17重量%のアニオン界面活性剤、
(c)非イオン界面活性剤、好ましくはポリオール及び/又はポリグリセロールエステルから選択される3〜18重量%の共界面活性剤、
(d)(d9a)メトキシケイ皮酸エチルヘキシル、
(d11a)ビス-エチルヘキシルオキシフェノールメトキシフェニルトリアジン、
(d13a)エチルヘキシルトリアゾン、及び
(d3a)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル
から選択される35〜65重量%のUVフィルター、並びに
(e)0.01〜5重量%の水及び場合によって0.5〜5重量%の補助物質
を含み、成分(d9a)、(d11a)、(d13a)及び(d3a)が、前記剤中に個々の化合物又は2成分、3成分若しくは4成分の混合物として存在することができるものである。
活性物質として重量%で計算されたデータ
Claims (21)
- 日焼け止め最終製剤の調製のための高濃度の剤であって、
(a)15〜50重量%の油性物質、
(b)4〜30重量%のアニオン界面活性剤、
(c)0.5〜25重量%の(b)とは異なる別の共界面活性剤、
(d)25〜75重量%の少なくとも1つのUVフィルター、並びに
(e)場合によって、100重量%までの水及び/又は補助物質
を含む剤。 - 油性物質として、中極性の油、好ましくはC2-C12-ジカルボン酸と1から22個の炭素原子を有する直鎖状若しくは分枝状アルコールとのエステル及び/又は直鎖状及び分枝状C6-C22-脂肪族アルコールカーボネート、特に1から22個の炭素原子を有する直鎖状若しくは分枝状アルコールのアジピン酸エステルを含むことを特徴とする請求項1に記載の剤。
- 油性物質(a)として直鎖状及び分枝状脂肪族アルコールカーボネート、特に炭酸ジカプリリルを含むことを特徴とする請求項1に記載の剤。
- アジピン酸ジブチルが、油性物質(a)として使用されることを特徴とする請求項1から3のいずれか一項に記載の剤。
- 20から35重量%の量で油性物質(a)を含むことを特徴とする請求項1から4のいずれか一項に記載の剤。
- 18から25℃で液体であり、アニオン界面活性剤に基づいて好ましくは最大で10重量%、特に0.1から5重量%の水分含有量を有するアニオン界面活性剤(b)を含むことを特徴とする請求項1から5のいずれか一項に記載の剤。
- アニオン界面活性剤(b)としてアルキルポリアルキレングリコールエーテルシトレート、特にラウリルアルコールのポリエチレングリコールエーテルを含むことを特徴とする請求項1から6のいずれか一項に記載の剤。
- 7から17重量%の量でアニオン界面活性剤を含むことを特徴とする請求項1から7のいずれか一項に記載の剤。
- 別の共界面活性剤(c)として、非イオン界面活性剤、好ましくはポリオール及び/又はポリグリセロールエステルを含むことを特徴とする請求項1から8のいずれか一項に記載の剤。
- 成分(d)として、
(d1)p-アミノ安息香酸誘導体、
(d2)サリチル酸誘導体、
(d3)ベンゾフェノン誘導体、
(d4)ジベンゾイルメタン誘導体、
(d5)ジフェニルアクリレート、
(d6)3-イミダゾール-4-イル-アクリル酸及びそのエステル、
(d7)ベンゾフラン誘導体、
(d8)ポリマーUV吸収剤、
(d9)ケイ皮酸誘導体、
(d10)ショウノウ誘導体、
(d11)ヒドロキシフェニルトリアジン誘導体、
(d12)ベンゾトリアゾール誘導体、
(d13)トリアニリノ-s-トリアジン誘導体、
(d14)2-フェニルベンゾイミダゾール-5-スルホン酸及びその塩、
(d15)o-アミノ安息香酸メンチル、
(d16)ホモサレート、
(d17)トリス-ビフェニル-トリアジン誘導体、
(d18)TiO2(部分カプセル化)、ZnO及びマイカ、
(d19)ベンジリデンマロネート、
(d20)メロシアニン誘導体、
(d21)フェニレンビスジフェニルトリアジン、
(d22)イミダゾリン誘導体、及び
(d23)ジアリールブタジエン誘導体
から選択されるUVフィルター物質の種類が使用されることを特徴とする請求項1から9のいずれか一項に記載の剤。 - 油溶性UVフィルターが成分(d)として使用されることを特徴とする請求項1から10のいずれか一項に記載の剤。
- 油溶性UVフィルター(d)が、
(dSOL-1)ベンゾフェノン-3(BP3)、
(dSOL-2)ベンゾフェノン-4(BP4)、
(dSOL-3)3-ベンジリデンカンファー(3BC)、
(dSOL-4)ビス-エチルヘキシルオキシフェノールメトキシフェニルトリアジン(BEMT)、
(dSOL-5)ブチルメトキシジベンゾイルメタン(BMBM)、
(dSOL-6)ジエチルヘキシルブタミドトリアゾン(DBT)、
(dSOL-7)ドロメトリゾールトリシロキサン(DTS)、
(dSOL-8)エチルヘキシルトリアゾン(EHT)、
(dSOL-9)メトキシケイ皮酸エチルヘキシル、
(dSOL-10)ベンジリデンマロネート(BM)、
(dSOL-11)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル(DHHB)、
(dSOL-12)オクトクリレン、
(dSOL-13)ポリシリコーン1-15、
(dSOL-14)ホモサレート、及び
(dSOL-15)サリチル酸エチルヘキシル
から選択されることを特徴とする請求項11に記載の剤。 - 油溶性UVフィルター(d)が、
(d9a)メトキシケイ皮酸エチルヘキシル、
(d11a)ビス-エチルヘキシルオキシフェノールメトキシフェニルトリアジン、
(d13a)エチルヘキシルトリアゾン、及び
(d3a)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル
から選択されることを特徴とする請求項11又は12に記載の剤。 - UVフィルター(d)を35から65重量%、好ましくは40から60重量%の量で含むことを特徴とする請求項11から13のいずれか一項に記載の剤。
- 水を含まないか、又は10重量%未満、好ましくは0.1から8重量%、特に0.01〜5重量%の少量の水しか含まないことを特徴とする請求項1から14のいずれか一項に記載の剤。
- (a)20〜35重量%の油性物質、
(b)7〜17重量%のアニオン界面活性剤、
(c)3〜18重量%の共界面活性剤、
(d)35〜65重量%のUVフィルター、並びに
(e)0.01〜5重量%の水及び場合によって0.5〜5重量%の補助物質
を、全ての構成成分が合計100重量%になる条件下で含むことを特徴とする請求項1に記載の剤。 - (a)直鎖状及び分枝状脂肪族アルコールカーボネート、特に炭酸ジカプリリル及びC2-C12ジカルボン酸と直鎖状又は分枝状アルコールとのエステルから選択される20〜35重量%の油性物質、
(b)アルキルポリアルキレングリコールエーテルシトレート、特にラウリルアルコールのポリエチレングリコールエーテルから選択される7〜17重量%のアニオン界面活性剤、
(c)非イオン界面活性剤、好ましくはポリオール及び/又はポリグリセロールエステルから選択される3〜18重量%の共界面活性剤、
(d)(d9a)メトキシケイ皮酸エチルヘキシル、
(d11a)ビス-エチルヘキシルオキシフェノールメトキシフェニルトリアジン、
(d13a)エチルヘキシルトリアゾン、及び
(d3a)ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル
から選択される35〜65重量%のUVフィルター、並びに
(e)0.01〜5重量%の水及び場合によって0.5〜5重量%の補助物質
を含み、成分(d9a)、(d11a)、(d13a)及び(d3a)が、剤の中に個々の化合物又は2成分、3成分若しくは4成分の混合物として存在することができることを特徴とする請求項16に記載の剤。 - 請求項1〜17のいずれか一項に記載の剤を含む日焼け止め最終製剤の調製方法であって、前記の剤を、5から30℃の範囲の温度で、水、場合によって別のUVフィルター及び場合によって通常の別の補助物質により希釈することを特徴とする方法。
- 請求項1に記載の高濃度の剤を、場合によって補助物質としての増粘剤の存在下で、水により、日焼け止め最終製剤に基づいて6から50重量%の量に希釈することを特徴とする請求項18に記載の方法。
- 日焼け止め最終製剤が、O/Wエマルジョン、W/Oエマルジョン、ゲル、ゲルクリーム、W/Siエマルジョン、噴霧剤、クリーム及びローションの形態であることを特徴とする請求項19に記載の方法。
- 最高50+の日焼け防止指数及びUVA-PF/SPF>1/3を有する化粧品最終製剤の調製のための、請求項1から17のいずれか一項に記載の剤の使用。
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PCT/EP2014/059187 WO2014180818A1 (de) | 2013-05-10 | 2014-05-06 | Mittel mit hohen mengen an uv-stabilisatoren |
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WO2019042999A1 (en) * | 2017-09-01 | 2019-03-07 | Basf Se | FORMS OF CONCENTRATED WATER-BASED PRODUCT OF OIL-SOLUBLE ORGANIC UV-ABSORBS |
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ES2663478T3 (es) | 2018-04-12 |
KR102239036B1 (ko) | 2021-04-13 |
CN105358221A (zh) | 2016-02-24 |
RU2677885C2 (ru) | 2019-01-22 |
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EP2994201B1 (de) | 2017-12-20 |
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