JP2016517409A5 - - Google Patents

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Publication number
JP2016517409A5
JP2016517409A5 JP2016500472A JP2016500472A JP2016517409A5 JP 2016517409 A5 JP2016517409 A5 JP 2016517409A5 JP 2016500472 A JP2016500472 A JP 2016500472A JP 2016500472 A JP2016500472 A JP 2016500472A JP 2016517409 A5 JP2016517409 A5 JP 2016517409A5
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JP
Japan
Prior art keywords
optionally substituted
alkyl
hydrogen
linear
hydroxymethyl
Prior art date
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JP2016500472A
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English (en)
Japanese (ja)
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JP6407951B2 (ja
JP2016517409A (ja
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Priority claimed from PCT/US2014/019126 external-priority patent/WO2014158654A1/en
Publication of JP2016517409A publication Critical patent/JP2016517409A/ja
Publication of JP2016517409A5 publication Critical patent/JP2016517409A5/ja
Application granted granted Critical
Publication of JP6407951B2 publication Critical patent/JP6407951B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2016500472A 2013-03-14 2014-02-27 Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法 Expired - Fee Related JP6407951B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361786020P 2013-03-14 2013-03-14
US61/786,020 2013-03-14
PCT/US2014/019126 WO2014158654A1 (en) 2013-03-14 2014-02-27 Ship1 modulators and methods related thereto

Publications (3)

Publication Number Publication Date
JP2016517409A JP2016517409A (ja) 2016-06-16
JP2016517409A5 true JP2016517409A5 (enExample) 2017-02-09
JP6407951B2 JP6407951B2 (ja) 2018-10-17

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ID=50288307

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016500472A Expired - Fee Related JP6407951B2 (ja) 2013-03-14 2014-02-27 Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法

Country Status (14)

Country Link
US (2) US9765085B2 (enExample)
EP (1) EP2970122B1 (enExample)
JP (1) JP6407951B2 (enExample)
KR (3) KR20220110337A (enExample)
CN (2) CN105164108B (enExample)
AU (1) AU2014242041B2 (enExample)
BR (1) BR112015023009A2 (enExample)
CA (1) CA2902768A1 (enExample)
ES (1) ES2740779T3 (enExample)
IL (1) IL240968A0 (enExample)
MX (1) MX2015012111A (enExample)
RU (1) RU2679805C2 (enExample)
WO (1) WO2014158654A1 (enExample)
ZA (1) ZA201506674B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105026375B (zh) 2013-01-09 2018-06-05 阿奎诺克斯药物（加拿大）公司 Ship1调节剂和与其相关的方法
CA2902768A1 (en) 2013-03-14 2014-10-02 Aquinox Pharmaceuticals (Canada) Inc. Ship1 modulators and methods related thereto
CN105209429B (zh) 2013-03-14 2018-05-29 阿奎诺克斯药物（加拿大）公司 Ship1调节剂和与其相关的方法
EP3313811A1 (en) 2015-06-26 2018-05-02 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
US10053415B2 (en) 2016-01-20 2018-08-21 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
WO2017149052A1 (en) * 2016-03-02 2017-09-08 Patheon Austria Gmbh Co. & Kg Process and intermediates for the production of 17(20)-ene b-seco steroids
WO2018126040A1 (en) 2016-12-28 2018-07-05 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol
EP3774738A1 (en) * 2018-04-06 2021-02-17 Aquinox Pharmaceuticals (Canada) Inc. Indene derivatives useful in treating pain and inflammation
ES2960542T3 (es) * 2018-04-06 2024-03-05 Taro Pharmaceuticals Inc Derivados de hexadecahidro-1H-ciclopenta[a]fenantreno útiles en el tratamiento del dolor y la inflamación
JP2021526545A (ja) * 2018-04-06 2021-10-07 アキノックス ファーマシューティカルス（カナダ）インク． 疼痛及び炎症を治療するのに有用なインデン誘導体
CN112940062B (zh) * 2021-02-23 2022-09-06 浙江神洲药业有限公司 一种16-去氢黄体酮的制备方法
CN117024374A (zh) * 2023-08-08 2023-11-10 安庆百谊生物科技有限公司 一种3-甲基-1，2，4-噻二唑-5-碳酰肼或其盐的合成方法

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CA2463136A1 (en) 2001-10-17 2003-04-24 Raymond Andersen Ship 1 modulators
DE60327936D1 (de) 2002-10-17 2009-07-23 Univ British Columbia Modulatoren von ship-1
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WO2008038965A1 (en) * 2006-09-26 2008-04-03 Kyungpook National University Industry-Academic Cooperation Foundation 7alpha-aminosteroid derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for anticancer or antibiotics containing the same as an active ingredient
JP5769726B2 (ja) * 2009-12-04 2015-08-26 アキノックス・ファーマシューティカルズ・（カナダ）・インコーポレイテッドＡｑｕｉｎｏｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ （Ｃａｎａｄａ） Ｉｎｃ． Ｓｈｉｐ１モジュレーターおよびそれに関連する方法
WO2012024682A1 (en) 2010-08-20 2012-02-23 The University Of British Columbia Ship1 modulators and related methods
MX2013006658A (es) * 2010-12-13 2013-11-04 Univ Rutgers Métodos para producir y usar brasinoesteroides para promover el crecimiento, la reparación y mantenimiento del músculo esquelético y la piel.
CN105209429B (zh) 2013-03-14 2018-05-29 阿奎诺克斯药物（加拿大）公司 Ship1调节剂和与其相关的方法
CA2902768A1 (en) 2013-03-14 2014-10-02 Aquinox Pharmaceuticals (Canada) Inc. Ship1 modulators and methods related thereto
EP3313811A1 (en) 2015-06-26 2018-05-02 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
US10053415B2 (en) 2016-01-20 2018-08-21 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
WO2018058144A1 (en) 2016-09-26 2018-03-29 Aquinox Pharmaceuticals (Canada) Inc. Ship1 activator for treating prostatis

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