JP2016517409A5 - - Google Patents

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Publication number
JP2016517409A5
JP2016517409A5 JP2016500472A JP2016500472A JP2016517409A5 JP 2016517409 A5 JP2016517409 A5 JP 2016517409A5 JP 2016500472 A JP2016500472 A JP 2016500472A JP 2016500472 A JP2016500472 A JP 2016500472A JP 2016517409 A5 JP2016517409 A5 JP 2016517409A5
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JP
Japan
Prior art keywords
optionally substituted
alkyl
hydrogen
linear
hydroxymethyl
Prior art date
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Granted
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JP2016500472A
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English (en)
Japanese (ja)
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JP6407951B2 (ja
JP2016517409A (ja
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Priority claimed from PCT/US2014/019126 external-priority patent/WO2014158654A1/en
Publication of JP2016517409A publication Critical patent/JP2016517409A/ja
Publication of JP2016517409A5 publication Critical patent/JP2016517409A5/ja
Application granted granted Critical
Publication of JP6407951B2 publication Critical patent/JP6407951B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2016500472A 2013-03-14 2014-02-27 Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法 Expired - Fee Related JP6407951B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361786020P 2013-03-14 2013-03-14
US61/786,020 2013-03-14
PCT/US2014/019126 WO2014158654A1 (en) 2013-03-14 2014-02-27 Ship1 modulators and methods related thereto

Publications (3)

Publication Number Publication Date
JP2016517409A JP2016517409A (ja) 2016-06-16
JP2016517409A5 true JP2016517409A5 (enExample) 2017-02-09
JP6407951B2 JP6407951B2 (ja) 2018-10-17

Family

ID=50288307

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016500472A Expired - Fee Related JP6407951B2 (ja) 2013-03-14 2014-02-27 Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法

Country Status (14)

Country Link
US (2) US9765085B2 (enExample)
EP (1) EP2970122B1 (enExample)
JP (1) JP6407951B2 (enExample)
KR (3) KR20220110337A (enExample)
CN (2) CN108892637A (enExample)
AU (1) AU2014242041B2 (enExample)
BR (1) BR112015023009A2 (enExample)
CA (1) CA2902768A1 (enExample)
ES (1) ES2740779T3 (enExample)
IL (1) IL240968A0 (enExample)
MX (1) MX2015012111A (enExample)
RU (1) RU2679805C2 (enExample)
WO (1) WO2014158654A1 (enExample)
ZA (1) ZA201506674B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108752236A (zh) 2013-01-09 2018-11-06 阿奎诺克斯药物（加拿大）公司 Ship1调节剂和与其相关的方法
ES2740779T3 (es) 2013-03-14 2020-02-06 Aquinox Pharmaceuticals Canada Inc Moduladores de SHIP1
EP2970100A1 (en) 2013-03-14 2016-01-20 Aquinox Pharmaceuticals (Canada) Inc. Ship1 modulators and methods related thereto
WO2016210146A1 (en) 2015-06-26 2016-12-29 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
AU2017209430A1 (en) 2016-01-20 2018-07-12 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
WO2017149052A1 (en) * 2016-03-02 2017-09-08 Patheon Austria Gmbh Co. & Kg Process and intermediates for the production of 17(20)-ene b-seco steroids
WO2018126040A1 (en) 2016-12-28 2018-07-05 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol
IL277904B2 (en) * 2018-04-06 2024-05-01 Aquinox Pharmaceuticals Canada Inc History of indan for use in the treatment of pain and inflammation
EP4292655A2 (en) 2018-04-06 2023-12-20 Taro Pharmaceuticals Inc. Hexadecahydro-1h-cyclopenta[a]phenanthrene derivatives useful in treating pain and inflammation
CN112533905A (zh) * 2018-04-06 2021-03-19 塔罗制药公司 可用于治疗疼痛和炎症的茚衍生物
CN112940062B (zh) * 2021-02-23 2022-09-06 浙江神洲药业有限公司 一种16-去氢黄体酮的制备方法
CN117024374A (zh) * 2023-08-08 2023-11-10 安庆百谊生物科技有限公司 一种3-甲基-1，2，4-噻二唑-5-碳酰肼或其盐的合成方法

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CA2463136A1 (en) 2001-10-17 2003-04-24 Raymond Andersen Ship 1 modulators
JP4753581B2 (ja) 2002-10-17 2011-08-24 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア Ｓｈｉｐ１モデュレーター
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WO2008038965A1 (en) * 2006-09-26 2008-04-03 Kyungpook National University Industry-Academic Cooperation Foundation 7alpha-aminosteroid derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for anticancer or antibiotics containing the same as an active ingredient
CA2781661A1 (en) 2009-12-04 2011-06-09 Aquinox Pharmaceuticals Inc. Ship1 modulators and methods related thereto
US9000050B2 (en) 2010-08-20 2015-04-07 The University Of British Columbia SHIP1 modulators and related methods
JP2013545809A (ja) * 2010-12-13 2013-12-26 ラトガース ユニバーシティ 骨格筋および皮膚の成長、修復、および維持を促進するようにブラシノステロイドを産生および使用する方法
EP2970100A1 (en) 2013-03-14 2016-01-20 Aquinox Pharmaceuticals (Canada) Inc. Ship1 modulators and methods related thereto
ES2740779T3 (es) 2013-03-14 2020-02-06 Aquinox Pharmaceuticals Canada Inc Moduladores de SHIP1
WO2016210146A1 (en) 2015-06-26 2016-12-29 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
AU2017209430A1 (en) 2016-01-20 2018-07-12 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative
WO2018058144A1 (en) 2016-09-26 2018-03-29 Aquinox Pharmaceuticals (Canada) Inc. Ship1 activator for treating prostatis

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