JP2016517409A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016517409A5 JP2016517409A5 JP2016500472A JP2016500472A JP2016517409A5 JP 2016517409 A5 JP2016517409 A5 JP 2016517409A5 JP 2016500472 A JP2016500472 A JP 2016500472A JP 2016500472 A JP2016500472 A JP 2016500472A JP 2016517409 A5 JP2016517409 A5 JP 2016517409A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- linear
- hydroxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[C@]1(C(*)CC(*)C(*)C1)C(CC1)C(*)C2C1(*)C(*)(*)C(*)C2 Chemical compound C[C@]1(C(*)CC(*)C(*)C1)C(CC1)C(*)C2C1(*)C(*)(*)C(*)C2 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361786020P | 2013-03-14 | 2013-03-14 | |
| US61/786,020 | 2013-03-14 | ||
| PCT/US2014/019126 WO2014158654A1 (en) | 2013-03-14 | 2014-02-27 | Ship1 modulators and methods related thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517409A JP2016517409A (ja) | 2016-06-16 |
| JP2016517409A5 true JP2016517409A5 (enExample) | 2017-02-09 |
| JP6407951B2 JP6407951B2 (ja) | 2018-10-17 |
Family
ID=50288307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500472A Expired - Fee Related JP6407951B2 (ja) | 2013-03-14 | 2014-02-27 | Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9765085B2 (enExample) |
| EP (1) | EP2970122B1 (enExample) |
| JP (1) | JP6407951B2 (enExample) |
| KR (3) | KR20220110337A (enExample) |
| CN (2) | CN105164108B (enExample) |
| AU (1) | AU2014242041B2 (enExample) |
| BR (1) | BR112015023009A2 (enExample) |
| CA (1) | CA2902768A1 (enExample) |
| ES (1) | ES2740779T3 (enExample) |
| IL (1) | IL240968A0 (enExample) |
| MX (1) | MX2015012111A (enExample) |
| RU (1) | RU2679805C2 (enExample) |
| WO (1) | WO2014158654A1 (enExample) |
| ZA (1) | ZA201506674B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1216886A1 (zh) | 2013-01-09 | 2016-12-09 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1调节剂和与其相关的方法 |
| BR112015022577A2 (pt) | 2013-03-14 | 2017-07-18 | Aquinox Pharmaceuticals Canada Inc | moduladores ship1 e métodos relacionados a esse |
| EP2970122B1 (en) | 2013-03-14 | 2019-05-08 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 modulators |
| US9944590B2 (en) | 2015-06-26 | 2018-04-17 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| WO2017127753A1 (en) | 2016-01-20 | 2017-07-27 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| US20190047939A1 (en) * | 2016-03-02 | 2019-02-14 | Patheon Austria Gmbh & Co Kg | Process and intermediates for the production of 17(20)-ene b-seco steroids |
| WO2018126040A1 (en) | 2016-12-28 | 2018-07-05 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol |
| ES2960542T3 (es) * | 2018-04-06 | 2024-03-05 | Taro Pharmaceuticals Inc | Derivados de hexadecahidro-1H-ciclopenta[a]fenantreno útiles en el tratamiento del dolor y la inflamación |
| CN112543753A (zh) * | 2018-04-06 | 2021-03-23 | 塔罗制药公司 | 可用于治疗疼痛和炎症的茚衍生物 |
| AU2019247496A1 (en) * | 2018-04-06 | 2020-10-22 | Taro Pharmaceuticals Inc. | Indene derivatives useful in treating pain and inflammation |
| CN112940062B (zh) * | 2021-02-23 | 2022-09-06 | 浙江神洲药业有限公司 | 一种16-去氢黄体酮的制备方法 |
| CN117024374A (zh) * | 2023-08-08 | 2023-11-10 | 安庆百谊生物科技有限公司 | 一种3-甲基-1，2，4-噻二唑-5-碳酰肼或其盐的合成方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1084718B (de) | 1958-07-08 | 1960-07-07 | Bayer Ag | Verfahren zur Herstellung von Secosteroiden |
| SE345995B (enExample) | 1969-01-31 | 1972-06-19 | Bristol Myers Co | |
| US3682983A (en) | 1969-11-12 | 1972-08-08 | Klaus Prezewowsky | Preparation of {66 {11 {11 -17 ethinyl steroids |
| US3869467A (en) | 1972-06-05 | 1975-03-04 | Hoffmann La Roche | 17-{62 -Hydroxy-17-{60 -methyl-5-{60 -androstano{9 3,2-c{9 or{8 2,3-d{9 isoxazoles |
| US3962275A (en) | 1972-06-05 | 1976-06-08 | Hoffmann-La Roche Inc. | 7-oxa steroids |
| JPH01290624A (ja) | 1988-05-16 | 1989-11-22 | Shiono Chem Kk | ５，６―セコ―ステロール誘導体血清脂質低下剤 |
| EP0641356B1 (en) | 1991-12-20 | 1998-04-22 | Glaxo Wellcome Inc. | Inhibitors of 5-alpha-testosterone reductase |
| JPH05221901A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール誘導体 |
| JPH05221924A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール化合物 |
| US5464866A (en) | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
| AP459A (en) | 1992-12-18 | 1996-02-14 | Glaxo Wellcome Inc | Substituted 6-azaandrostenones. |
| ATE191712T1 (de) | 1993-07-09 | 2000-04-15 | Theramex | Neue strukturelle vitamin d derivate |
| US5541322A (en) | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
| US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
| WO2000063323A1 (en) | 1999-04-16 | 2000-10-26 | Nippon Mitsubishi Oil Corporation | Fluids for traction drive |
| RU2291873C2 (ru) | 2000-04-28 | 2007-01-20 | Инфлазим Фармасьютикалз Лимитед | 3-амино-6,7-дикислородсодержащие стероиды, фармацевтическая композиция, способы лечения |
| US6696580B2 (en) | 2001-05-22 | 2004-02-24 | Inflazyme Pharmaceuticals Ltd. | Process for the production of 6,7-diols of steroidal compounds |
| WO2003033517A1 (en) | 2001-10-17 | 2003-04-24 | The University Of British Columbia | Ship 1 modulators |
| DE60327936D1 (de) | 2002-10-17 | 2009-07-23 | Univ British Columbia | Modulatoren von ship-1 |
| CA2521883C (en) | 2003-04-15 | 2013-09-17 | Inflazyme Pharmaceuticals Ltd. | Indene derivatives as pharmaceutical agents |
| CA2656339A1 (en) | 2006-06-21 | 2007-12-27 | The University Of British Columbia | Ship 1 modulator prodrugs |
| WO2008038965A1 (en) * | 2006-09-26 | 2008-04-03 | Kyungpook National University Industry-Academic Cooperation Foundation | 7alpha-aminosteroid derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for anticancer or antibiotics containing the same as an active ingredient |
| WO2011069118A1 (en) | 2009-12-04 | 2011-06-09 | Aquinox Pharmaceuticals Inc. | Ship1 modulators and methods related thereto |
| US9000050B2 (en) | 2010-08-20 | 2015-04-07 | The University Of British Columbia | SHIP1 modulators and related methods |
| CA2821501A1 (en) * | 2010-12-13 | 2012-06-21 | Rutgers University | Methods of producing and using brassinosteroids to promote growth, repair, and maintenance of skeletal muscle and skin |
| BR112015022577A2 (pt) | 2013-03-14 | 2017-07-18 | Aquinox Pharmaceuticals Canada Inc | moduladores ship1 e métodos relacionados a esse |
| EP2970122B1 (en) | 2013-03-14 | 2019-05-08 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 modulators |
| US9944590B2 (en) | 2015-06-26 | 2018-04-17 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| WO2017127753A1 (en) | 2016-01-20 | 2017-07-27 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| WO2018058144A1 (en) | 2016-09-26 | 2018-03-29 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 activator for treating prostatis |
-
2014
- 2014-02-27 EP EP14710727.0A patent/EP2970122B1/en active Active
- 2014-02-27 CA CA2902768A patent/CA2902768A1/en not_active Abandoned
- 2014-02-27 KR KR1020227025934A patent/KR20220110337A/ko not_active Abandoned
- 2014-02-27 AU AU2014242041A patent/AU2014242041B2/en not_active Ceased
- 2014-02-27 ES ES14710727T patent/ES2740779T3/es active Active
- 2014-02-27 CN CN201480024563.2A patent/CN105164108B/zh not_active Expired - Fee Related
- 2014-02-27 KR KR1020217030879A patent/KR102427491B1/ko not_active Expired - Fee Related
- 2014-02-27 US US14/772,731 patent/US9765085B2/en not_active Expired - Fee Related
- 2014-02-27 JP JP2016500472A patent/JP6407951B2/ja not_active Expired - Fee Related
- 2014-02-27 KR KR1020157028154A patent/KR102308319B1/ko not_active Expired - Fee Related
- 2014-02-27 BR BR112015023009A patent/BR112015023009A2/pt not_active Application Discontinuation
- 2014-02-27 WO PCT/US2014/019126 patent/WO2014158654A1/en not_active Ceased
- 2014-02-27 CN CN201810634778.6A patent/CN108892637A/zh active Pending
- 2014-02-27 RU RU2015143676A patent/RU2679805C2/ru active
- 2014-02-27 MX MX2015012111A patent/MX2015012111A/es unknown
-
2015
- 2015-08-31 IL IL240968A patent/IL240968A0/en unknown
- 2015-09-09 ZA ZA2015/06674A patent/ZA201506674B/en unknown
-
2017
- 2017-08-14 US US15/676,726 patent/US10174046B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015143676A (ru) | Модулятолры ship1 и относящиеся к ним способы | |
| JP7834721B2 (ja) | 急速進行性線維肉腫タンパク質分解化合物及び関連する使用方法 | |
| JP7626722B2 (ja) | アミノピリミジンアミドオートファジー阻害剤およびその使用方法 | |
| US20220002313A1 (en) | Hpk1 inhibitors and methods of using same | |
| US10913727B2 (en) | Modulators of the integrated stress pathway | |
| JP5805763B2 (ja) | Ｃ型肝炎ウイルス阻害剤 | |
| KR102534028B1 (ko) | 트리아졸로피리미딘 화합물 및 그의 용도 | |
| RU2718917C2 (ru) | Комбинированное лечение агонистом толл-подобного рецептора (tlr7) и ингибитором сборки капсида вируса гепатита в | |
| SG11202111918PA (en) | Substituted cycloalkyls as modulators of the integrated stress pathway | |
| CN108434149B (zh) | 针对Rb阳性异常细胞增殖的HSPC节制性治疗 | |
| JP6213564B2 (ja) | キノリン誘導体 | |
| JP2020518561A (ja) | Ｐｄ−１／ｐｄ−ｌ１阻害剤 | |
| CN112312904A (zh) | 螺环化合物 | |
| JP2020517667A (ja) | 抗ウイルス剤としての融合インダゾールピリドン化合物 | |
| AU2018346597A1 (en) | Inhibiting Ubiquitin Specific Peptidase 30 | |
| RU2018103944A (ru) | Производные этинила как модуляторы метаботропного рецептора глутамата | |
| AR079840A2 (es) | Receptor nicotinico de acetilcolina, subtipo selectivo de amidas de diazabicicloalcanos | |
| JP2018522034A5 (enExample) | ||
| TW201630891A (zh) | 三環性螺化合物 | |
| AU2018240031A1 (en) | Compounds and methods for the treatment of parasitic diseases | |
| US20220064123A1 (en) | (--)-Huperzine A Processes and Related Compositions and Methods of Treatment | |
| EA036318B1 (ru) | 6-аминопиридин-3-илтиазолы в качестве модуляторов rort | |
| AU2019286531A1 (en) | Pyrazole and imidazole compounds for inhibition of IL-17 and rorgamma | |
| JPWO2006137527A1 (ja) | チアゾール誘導体 | |
| JP2017516772A5 (enExample) |