JP2016517409A5 - - Google Patents
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- Publication number
- JP2016517409A5 JP2016517409A5 JP2016500472A JP2016500472A JP2016517409A5 JP 2016517409 A5 JP2016517409 A5 JP 2016517409A5 JP 2016500472 A JP2016500472 A JP 2016500472A JP 2016500472 A JP2016500472 A JP 2016500472A JP 2016517409 A5 JP2016517409 A5 JP 2016517409A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- linear
- hydroxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[C@]1(C(*)CC(*)C(*)C1)C(CC1)C(*)C2C1(*)C(*)(*)C(*)C2 Chemical compound C[C@]1(C(*)CC(*)C(*)C1)C(CC1)C(*)C2C1(*)C(*)(*)C(*)C2 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361786020P | 2013-03-14 | 2013-03-14 | |
| US61/786,020 | 2013-03-14 | ||
| PCT/US2014/019126 WO2014158654A1 (en) | 2013-03-14 | 2014-02-27 | Ship1 modulators and methods related thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517409A JP2016517409A (ja) | 2016-06-16 |
| JP2016517409A5 true JP2016517409A5 (enExample) | 2017-02-09 |
| JP6407951B2 JP6407951B2 (ja) | 2018-10-17 |
Family
ID=50288307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500472A Expired - Fee Related JP6407951B2 (ja) | 2013-03-14 | 2014-02-27 | Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9765085B2 (enExample) |
| EP (1) | EP2970122B1 (enExample) |
| JP (1) | JP6407951B2 (enExample) |
| KR (3) | KR20220110337A (enExample) |
| CN (2) | CN108892637A (enExample) |
| AU (1) | AU2014242041B2 (enExample) |
| BR (1) | BR112015023009A2 (enExample) |
| CA (1) | CA2902768A1 (enExample) |
| ES (1) | ES2740779T3 (enExample) |
| IL (1) | IL240968A0 (enExample) |
| MX (1) | MX2015012111A (enExample) |
| RU (1) | RU2679805C2 (enExample) |
| WO (1) | WO2014158654A1 (enExample) |
| ZA (1) | ZA201506674B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2015133177A (ru) | 2013-01-09 | 2017-02-14 | Экуинокс Фармасьютикалз (Кэнэда) Инк. | Модуляторы ship1 и связанные с ними способы |
| US10100056B2 (en) | 2013-03-14 | 2018-10-16 | Aquinox Pharmaceuticals (Canada) Inc. | SHIP1 modulators and methods related thereto |
| EP2970122B1 (en) | 2013-03-14 | 2019-05-08 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 modulators |
| EP3313811A1 (en) * | 2015-06-26 | 2018-05-02 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| WO2017127753A1 (en) | 2016-01-20 | 2017-07-27 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| JP2019508424A (ja) * | 2016-03-02 | 2019-03-28 | パセオン オーストリア ゲーエムベーハー ウント ツェーオー カーゲー | １７（２０）−エン ｂ−セコステロイドの生産のためのプロセスと中間体 |
| WO2018126040A1 (en) | 2016-12-28 | 2018-07-05 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol |
| JP2021526545A (ja) * | 2018-04-06 | 2021-10-07 | アキノックス ファーマシューティカルス（カナダ）インク． | 疼痛及び炎症を治療するのに有用なインデン誘導体 |
| JP2021526546A (ja) * | 2018-04-06 | 2021-10-07 | アキノックス ファーマシューティカルス（カナダ）インク． | 疼痛及び炎症を治療するのに有用なインデン誘導体 |
| WO2019195692A1 (en) * | 2018-04-06 | 2019-10-10 | Aquinox Pharmaceuticals (Canada) Inc. | Hexadecahydro-1h-cyclopenta[a]phenanthrene derivatives useful in treating pain and inflammation |
| CN112940062B (zh) * | 2021-02-23 | 2022-09-06 | 浙江神洲药业有限公司 | 一种16-去氢黄体酮的制备方法 |
| CN117024374A (zh) * | 2023-08-08 | 2023-11-10 | 安庆百谊生物科技有限公司 | 一种3-甲基-1，2，4-噻二唑-5-碳酰肼或其盐的合成方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1084718B (de) | 1958-07-08 | 1960-07-07 | Bayer Ag | Verfahren zur Herstellung von Secosteroiden |
| SE345995B (enExample) | 1969-01-31 | 1972-06-19 | Bristol Myers Co | |
| US3682983A (en) | 1969-11-12 | 1972-08-08 | Klaus Prezewowsky | Preparation of {66 {11 {11 -17 ethinyl steroids |
| US3869467A (en) | 1972-06-05 | 1975-03-04 | Hoffmann La Roche | 17-{62 -Hydroxy-17-{60 -methyl-5-{60 -androstano{9 3,2-c{9 or{8 2,3-d{9 isoxazoles |
| US3962275A (en) | 1972-06-05 | 1976-06-08 | Hoffmann-La Roche Inc. | 7-oxa steroids |
| JPH01290624A (ja) | 1988-05-16 | 1989-11-22 | Shiono Chem Kk | ５，６―セコ―ステロール誘導体血清脂質低下剤 |
| JPH07502511A (ja) | 1991-12-20 | 1995-03-16 | グラクソ、インコーポレーテッド | ５‐α‐テストステロンレダクターゼ阻害剤 |
| JPH05221924A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール化合物 |
| JPH05221901A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール誘導体 |
| US5464866A (en) | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
| AP459A (en) | 1992-12-18 | 1996-02-14 | Glaxo Wellcome Inc | Substituted 6-azaandrostenones. |
| AU699200B2 (en) | 1993-07-09 | 1998-11-26 | Roger Bouillon | Novel structural analogues of vitamin D |
| US5541322A (en) | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
| US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
| EP1118654A4 (en) | 1999-04-16 | 2007-03-07 | Nippon Mitsubishi Oil Corp | TRANSMISSION FLUID |
| SK15692002A3 (sk) | 2000-04-28 | 2003-11-04 | Inflazyme Pharmaceuticals Limited | 3-Amino-6,7-dioxygénované steroidy a s nimi súvisiace použitie |
| US6696580B2 (en) | 2001-05-22 | 2004-02-24 | Inflazyme Pharmaceuticals Ltd. | Process for the production of 6,7-diols of steroidal compounds |
| CA2463136A1 (en) | 2001-10-17 | 2003-04-24 | Raymond Andersen | Ship 1 modulators |
| JP4753581B2 (ja) | 2002-10-17 | 2011-08-24 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | Ｓｈｉｐ１モデュレーター |
| CN1805915A (zh) | 2003-04-15 | 2006-07-19 | 茵弗莱采姆药物有限公司 | 作为药物活性剂的茚衍生物 |
| WO2007147252A1 (en) | 2006-06-21 | 2007-12-27 | The University Of British Columbia | Ship 1 modulator prodrugs |
| WO2008038965A1 (en) * | 2006-09-26 | 2008-04-03 | Kyungpook National University Industry-Academic Cooperation Foundation | 7alpha-aminosteroid derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for anticancer or antibiotics containing the same as an active ingredient |
| US8101605B2 (en) * | 2009-12-04 | 2012-01-24 | Aquinox Pharmaceuticals Inc. | SHIP1 modulators and methods related thereto |
| EP2605767B1 (en) | 2010-08-20 | 2016-07-27 | The University Of British Columbia | Ship1 modulators and related methods |
| WO2012082750A1 (en) * | 2010-12-13 | 2012-06-21 | Rutgers University | Methods of producing and using brassinosteroids to promote growth, repair and maintenance of skeletal muscle and skin |
| US10100056B2 (en) | 2013-03-14 | 2018-10-16 | Aquinox Pharmaceuticals (Canada) Inc. | SHIP1 modulators and methods related thereto |
| EP2970122B1 (en) | 2013-03-14 | 2019-05-08 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 modulators |
| EP3313811A1 (en) | 2015-06-26 | 2018-05-02 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| WO2017127753A1 (en) | 2016-01-20 | 2017-07-27 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| WO2018058144A1 (en) | 2016-09-26 | 2018-03-29 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 activator for treating prostatis |
-
2014
- 2014-02-27 EP EP14710727.0A patent/EP2970122B1/en active Active
- 2014-02-27 CA CA2902768A patent/CA2902768A1/en not_active Abandoned
- 2014-02-27 US US14/772,731 patent/US9765085B2/en not_active Expired - Fee Related
- 2014-02-27 BR BR112015023009A patent/BR112015023009A2/pt not_active Application Discontinuation
- 2014-02-27 KR KR1020227025934A patent/KR20220110337A/ko not_active Abandoned
- 2014-02-27 CN CN201810634778.6A patent/CN108892637A/zh active Pending
- 2014-02-27 ES ES14710727T patent/ES2740779T3/es active Active
- 2014-02-27 AU AU2014242041A patent/AU2014242041B2/en not_active Ceased
- 2014-02-27 WO PCT/US2014/019126 patent/WO2014158654A1/en not_active Ceased
- 2014-02-27 KR KR1020217030879A patent/KR102427491B1/ko not_active Expired - Fee Related
- 2014-02-27 CN CN201480024563.2A patent/CN105164108B/zh not_active Expired - Fee Related
- 2014-02-27 KR KR1020157028154A patent/KR102308319B1/ko not_active Expired - Fee Related
- 2014-02-27 JP JP2016500472A patent/JP6407951B2/ja not_active Expired - Fee Related
- 2014-02-27 RU RU2015143676A patent/RU2679805C2/ru active
- 2014-02-27 MX MX2015012111A patent/MX2015012111A/es unknown
-
2015
- 2015-08-31 IL IL240968A patent/IL240968A0/en unknown
- 2015-09-09 ZA ZA2015/06674A patent/ZA201506674B/en unknown
-
2017
- 2017-08-14 US US15/676,726 patent/US10174046B2/en active Active
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