JP2016517409A5 - - Google Patents
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- Publication number
- JP2016517409A5 JP2016517409A5 JP2016500472A JP2016500472A JP2016517409A5 JP 2016517409 A5 JP2016517409 A5 JP 2016517409A5 JP 2016500472 A JP2016500472 A JP 2016500472A JP 2016500472 A JP2016500472 A JP 2016500472A JP 2016517409 A5 JP2016517409 A5 JP 2016517409A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- linear
- hydroxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[C@]1(C(*)CC(*)C(*)C1)C(CC1)C(*)C2C1(*)C(*)(*)C(*)C2 Chemical compound C[C@]1(C(*)CC(*)C(*)C1)C(CC1)C(*)C2C1(*)C(*)(*)C(*)C2 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361786020P | 2013-03-14 | 2013-03-14 | |
| US61/786,020 | 2013-03-14 | ||
| PCT/US2014/019126 WO2014158654A1 (en) | 2013-03-14 | 2014-02-27 | Ship1 modulators and methods related thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517409A JP2016517409A (ja) | 2016-06-16 |
| JP2016517409A5 true JP2016517409A5 (enExample) | 2017-02-09 |
| JP6407951B2 JP6407951B2 (ja) | 2018-10-17 |
Family
ID=50288307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500472A Expired - Fee Related JP6407951B2 (ja) | 2013-03-14 | 2014-02-27 | Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9765085B2 (enExample) |
| EP (1) | EP2970122B1 (enExample) |
| JP (1) | JP6407951B2 (enExample) |
| KR (3) | KR20220110337A (enExample) |
| CN (2) | CN105164108B (enExample) |
| AU (1) | AU2014242041B2 (enExample) |
| BR (1) | BR112015023009A2 (enExample) |
| CA (1) | CA2902768A1 (enExample) |
| ES (1) | ES2740779T3 (enExample) |
| IL (1) | IL240968A0 (enExample) |
| MX (1) | MX2015012111A (enExample) |
| RU (1) | RU2679805C2 (enExample) |
| WO (1) | WO2014158654A1 (enExample) |
| ZA (1) | ZA201506674B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9540353B2 (en) | 2013-01-09 | 2017-01-10 | Aquinox Pharmaceuticals (Canada) Inc. | SHIP1 modulators and methods related thereto |
| RU2679805C2 (ru) | 2013-03-14 | 2019-02-13 | Экуинокс Фармасьютикалз (Кэнэда) Инк. | Модуляторы ship1 и относящиеся к ним способы |
| HK1220173A1 (zh) | 2013-03-14 | 2017-04-28 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1调节剂和与其相关的方法 |
| US9944590B2 (en) | 2015-06-26 | 2018-04-17 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| WO2017127753A1 (en) | 2016-01-20 | 2017-07-27 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| US20190047939A1 (en) * | 2016-03-02 | 2019-02-14 | Patheon Austria Gmbh & Co Kg | Process and intermediates for the production of 17(20)-ene b-seco steroids |
| WO2018126040A1 (en) | 2016-12-28 | 2018-07-05 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol |
| EP4292655A2 (en) | 2018-04-06 | 2023-12-20 | Taro Pharmaceuticals Inc. | Hexadecahydro-1h-cyclopenta[a]phenanthrene derivatives useful in treating pain and inflammation |
| CN112533905A (zh) * | 2018-04-06 | 2021-03-19 | 塔罗制药公司 | 可用于治疗疼痛和炎症的茚衍生物 |
| WO2019195777A1 (en) | 2018-04-06 | 2019-10-10 | Aquinox Pharmaceuticals (Canada) Inc. | Indene derivatives useful in treating pain and inflammation |
| CN112940062B (zh) * | 2021-02-23 | 2022-09-06 | 浙江神洲药业有限公司 | 一种16-去氢黄体酮的制备方法 |
| CN117024374A (zh) * | 2023-08-08 | 2023-11-10 | 安庆百谊生物科技有限公司 | 一种3-甲基-1，2，4-噻二唑-5-碳酰肼或其盐的合成方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1084718B (de) | 1958-07-08 | 1960-07-07 | Bayer Ag | Verfahren zur Herstellung von Secosteroiden |
| SE345995B (enExample) | 1969-01-31 | 1972-06-19 | Bristol Myers Co | |
| US3682983A (en) | 1969-11-12 | 1972-08-08 | Klaus Prezewowsky | Preparation of {66 {11 {11 -17 ethinyl steroids |
| US3962275A (en) | 1972-06-05 | 1976-06-08 | Hoffmann-La Roche Inc. | 7-oxa steroids |
| US3869467A (en) | 1972-06-05 | 1975-03-04 | Hoffmann La Roche | 17-{62 -Hydroxy-17-{60 -methyl-5-{60 -androstano{9 3,2-c{9 or{8 2,3-d{9 isoxazoles |
| JPH01290624A (ja) | 1988-05-16 | 1989-11-22 | Shiono Chem Kk | ５，６―セコ―ステロール誘導体血清脂質低下剤 |
| US5543406A (en) | 1991-12-20 | 1996-08-06 | Glaxo Wellcome, Inc. | Inhibitors of 5-α-testosterone reductase |
| JPH05221924A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール化合物 |
| JPH05221901A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール誘導体 |
| US5464866A (en) | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
| AP459A (en) | 1992-12-18 | 1996-02-14 | Glaxo Wellcome Inc | Substituted 6-azaandrostenones. |
| DE69433220T2 (de) | 1993-07-09 | 2004-08-19 | Laboratoire Theramex | Neue strukturelle Vitamin D Derivate |
| US5541322A (en) | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
| US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
| WO2000063323A1 (en) | 1999-04-16 | 2000-10-26 | Nippon Mitsubishi Oil Corporation | Fluids for traction drive |
| AP1825A (en) | 2000-04-28 | 2008-02-03 | Inflazyme Pharm Ltd | 3-Nitrogen-6, 7-dioxygen steroids and uses related thereto. |
| NZ546612A (en) | 2001-05-22 | 2007-08-31 | Inflazyme Pharm Ltd | Process for the production of 6,7-dihydroxy steroid compounds by allylic oxidation of steroid-5-ene compounds to steroid-5-ene-7-one compounds followed by hydroboration and oxidation intermediates of this process |
| CA2463136A1 (en) | 2001-10-17 | 2003-04-24 | Raymond Andersen | Ship 1 modulators |
| WO2004035601A1 (en) | 2002-10-17 | 2004-04-29 | The University Of British Columbia | Ship 1 modulators |
| NZ542962A (en) | 2003-04-15 | 2008-08-29 | Inflazyme Pharm Ltd | Indene derivatives as pharmaceutical agents |
| US20100323990A1 (en) | 2006-06-21 | 2010-12-23 | The University Of British Columbia | Ship 1 modulator prodrugs |
| KR100950204B1 (ko) * | 2006-09-26 | 2010-03-29 | 경북대학교 산학협력단 | 7α-아미노스테로이드 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로함유하는 항암용 또는 항생제 조성물 |
| EP2507221A1 (en) | 2009-12-04 | 2012-10-10 | Aquinox Pharmaceuticals Inc. | Ship1 modulators and methods related thereto |
| ES2594980T3 (es) | 2010-08-20 | 2016-12-27 | The University Of British Columbia | Moduladores de SHIP1 y métodos relacionados |
| JP2013545809A (ja) * | 2010-12-13 | 2013-12-26 | ラトガース ユニバーシティ | 骨格筋および皮膚の成長、修復、および維持を促進するようにブラシノステロイドを産生および使用する方法 |
| RU2679805C2 (ru) | 2013-03-14 | 2019-02-13 | Экуинокс Фармасьютикалз (Кэнэда) Инк. | Модуляторы ship1 и относящиеся к ним способы |
| HK1220173A1 (zh) | 2013-03-14 | 2017-04-28 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1调节剂和与其相关的方法 |
| US9944590B2 (en) | 2015-06-26 | 2018-04-17 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| WO2017127753A1 (en) | 2016-01-20 | 2017-07-27 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| US20180085460A1 (en) | 2016-09-26 | 2018-03-29 | Aquinox Pharmaceuticals (Canada) Inc. | Methods of treating prostatitis |
-
2014
- 2014-02-27 RU RU2015143676A patent/RU2679805C2/ru active
- 2014-02-27 JP JP2016500472A patent/JP6407951B2/ja not_active Expired - Fee Related
- 2014-02-27 US US14/772,731 patent/US9765085B2/en not_active Expired - Fee Related
- 2014-02-27 KR KR1020227025934A patent/KR20220110337A/ko not_active Abandoned
- 2014-02-27 CN CN201480024563.2A patent/CN105164108B/zh not_active Expired - Fee Related
- 2014-02-27 CN CN201810634778.6A patent/CN108892637A/zh active Pending
- 2014-02-27 AU AU2014242041A patent/AU2014242041B2/en not_active Ceased
- 2014-02-27 BR BR112015023009A patent/BR112015023009A2/pt not_active Application Discontinuation
- 2014-02-27 EP EP14710727.0A patent/EP2970122B1/en active Active
- 2014-02-27 MX MX2015012111A patent/MX2015012111A/es unknown
- 2014-02-27 ES ES14710727T patent/ES2740779T3/es active Active
- 2014-02-27 KR KR1020157028154A patent/KR102308319B1/ko not_active Expired - Fee Related
- 2014-02-27 CA CA2902768A patent/CA2902768A1/en not_active Abandoned
- 2014-02-27 KR KR1020217030879A patent/KR102427491B1/ko active Active
- 2014-02-27 WO PCT/US2014/019126 patent/WO2014158654A1/en not_active Ceased
-
2015
- 2015-08-31 IL IL240968A patent/IL240968A0/en unknown
- 2015-09-09 ZA ZA2015/06674A patent/ZA201506674B/en unknown
-
2017
- 2017-08-14 US US15/676,726 patent/US10174046B2/en active Active
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