JP6407951B2 - Ship1モジュレーターおよびそれに関連する組成物および方法 - Google Patents
Ship1モジュレーターおよびそれに関連する組成物および方法 Download PDFInfo
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- JP6407951B2 JP6407951B2 JP2016500472A JP2016500472A JP6407951B2 JP 6407951 B2 JP6407951 B2 JP 6407951B2 JP 2016500472 A JP2016500472 A JP 2016500472A JP 2016500472 A JP2016500472 A JP 2016500472A JP 6407951 B2 JP6407951 B2 JP 6407951B2
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- 0 C[C@]1(C(*)CC(*)C(*)C1)C(CC1)C(*)C2C1(*)C1=CCC=CC=C1C2 Chemical compound C[C@]1(C(*)CC(*)C(*)C1)C(CC1)C(*)C2C1(*)C1=CCC=CC=C1C2 0.000 description 14
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- FAHWCRGYXVNIJO-PPULCKLOSA-N C[C@@]1(CC2)C(c3ccccc3)=CC[C@H]1C(CO)[C@H]2[C@@](C)(CC1)[C@@H](CO)C[C@H]1OC(C)=O Chemical compound C[C@@]1(CC2)C(c3ccccc3)=CC[C@H]1C(CO)[C@H]2[C@@](C)(CC1)[C@@H](CO)C[C@H]1OC(C)=O FAHWCRGYXVNIJO-PPULCKLOSA-N 0.000 description 1
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- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
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| EP2970100A1 (en) | 2013-03-14 | 2016-01-20 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 modulators and methods related thereto |
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| AU2017209430A1 (en) | 2016-01-20 | 2018-07-12 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| WO2017149052A1 (en) * | 2016-03-02 | 2017-09-08 | Patheon Austria Gmbh Co. & Kg | Process and intermediates for the production of 17(20)-ene b-seco steroids |
| WO2018126040A1 (en) | 2016-12-28 | 2018-07-05 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol |
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| CN112533905A (zh) * | 2018-04-06 | 2021-03-19 | 塔罗制药公司 | 可用于治疗疼痛和炎症的茚衍生物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1084718B (de) | 1958-07-08 | 1960-07-07 | Bayer Ag | Verfahren zur Herstellung von Secosteroiden |
| SE345995B (enExample) | 1969-01-31 | 1972-06-19 | Bristol Myers Co | |
| US3682983A (en) | 1969-11-12 | 1972-08-08 | Klaus Prezewowsky | Preparation of {66 {11 {11 -17 ethinyl steroids |
| US3869467A (en) | 1972-06-05 | 1975-03-04 | Hoffmann La Roche | 17-{62 -Hydroxy-17-{60 -methyl-5-{60 -androstano{9 3,2-c{9 or{8 2,3-d{9 isoxazoles |
| US3962275A (en) | 1972-06-05 | 1976-06-08 | Hoffmann-La Roche Inc. | 7-oxa steroids |
| JPH01290624A (ja) | 1988-05-16 | 1989-11-22 | Shiono Chem Kk | 5,6―セコ―ステロール誘導体血清脂質低下剤 |
| WO1993013124A1 (en) | 1991-12-20 | 1993-07-08 | Glaxo Inc. | Inhibitors of 5-alpha-testosterone reductase |
| JPH05221901A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール誘導体 |
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| US5464866A (en) | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
| AP459A (en) | 1992-12-18 | 1996-02-14 | Glaxo Wellcome Inc | Substituted 6-azaandrostenones. |
| DK0707566T3 (da) | 1993-07-09 | 2000-09-04 | Theramex | Hidtil ukendte strukturelle analoger til vitamin D |
| US5541322A (en) | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
| US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
| WO2000063323A1 (en) | 1999-04-16 | 2000-10-26 | Nippon Mitsubishi Oil Corporation | Fluids for traction drive |
| BR0110419A (pt) | 2000-04-28 | 2004-02-25 | Inflazyme Pharm Ltd | Esteróides de 3-nitrogênio-6,7-dioxigênio e usos relacionados aos mesmos |
| AU2002257453B2 (en) | 2001-05-22 | 2008-04-10 | Inflazyme Pharmaceuticals Limited | Process for the production of 6, 7 - dihydroxy steroid compounds by allylic oxidation of steroid - 5 - ene compounds to steroid - 5 - ene - 7 - one compounds followed by hydroboration and oxidation and intermediates of this process |
| CA2463136A1 (en) | 2001-10-17 | 2003-04-24 | Raymond Andersen | Ship 1 modulators |
| JP4753581B2 (ja) | 2002-10-17 | 2011-08-24 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | Ship1モデュレーター |
| DE602004031410D1 (de) | 2003-04-15 | 2011-03-31 | Aquinox Pharmaceuticals Inc | Inden derivate als pharmazeutika |
| US20110263539A1 (en) | 2006-06-21 | 2011-10-27 | The University Of British Columbia | Ship 1 modulator compounds |
| WO2008038965A1 (en) * | 2006-09-26 | 2008-04-03 | Kyungpook National University Industry-Academic Cooperation Foundation | 7alpha-aminosteroid derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for anticancer or antibiotics containing the same as an active ingredient |
| CA2781661A1 (en) | 2009-12-04 | 2011-06-09 | Aquinox Pharmaceuticals Inc. | Ship1 modulators and methods related thereto |
| US9000050B2 (en) | 2010-08-20 | 2015-04-07 | The University Of British Columbia | SHIP1 modulators and related methods |
| JP2013545809A (ja) * | 2010-12-13 | 2013-12-26 | ラトガース ユニバーシティ | 骨格筋および皮膚の成長、修復、および維持を促進するようにブラシノステロイドを産生および使用する方法 |
| EP2970100A1 (en) | 2013-03-14 | 2016-01-20 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 modulators and methods related thereto |
| ES2740779T3 (es) | 2013-03-14 | 2020-02-06 | Aquinox Pharmaceuticals Canada Inc | Moduladores de SHIP1 |
| WO2016210146A1 (en) | 2015-06-26 | 2016-12-29 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| AU2017209430A1 (en) | 2016-01-20 | 2018-07-12 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| WO2018058144A1 (en) | 2016-09-26 | 2018-03-29 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 activator for treating prostatis |
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2014
- 2014-02-27 ES ES14710727T patent/ES2740779T3/es active Active
- 2014-02-27 RU RU2015143676A patent/RU2679805C2/ru active
- 2014-02-27 CN CN201810634778.6A patent/CN108892637A/zh active Pending
- 2014-02-27 MX MX2015012111A patent/MX2015012111A/es unknown
- 2014-02-27 EP EP14710727.0A patent/EP2970122B1/en active Active
- 2014-02-27 US US14/772,731 patent/US9765085B2/en not_active Expired - Fee Related
- 2014-02-27 AU AU2014242041A patent/AU2014242041B2/en not_active Ceased
- 2014-02-27 KR KR1020227025934A patent/KR20220110337A/ko not_active Abandoned
- 2014-02-27 WO PCT/US2014/019126 patent/WO2014158654A1/en not_active Ceased
- 2014-02-27 KR KR1020157028154A patent/KR102308319B1/ko not_active Expired - Fee Related
- 2014-02-27 BR BR112015023009A patent/BR112015023009A2/pt not_active Application Discontinuation
- 2014-02-27 CN CN201480024563.2A patent/CN105164108B/zh not_active Expired - Fee Related
- 2014-02-27 JP JP2016500472A patent/JP6407951B2/ja not_active Expired - Fee Related
- 2014-02-27 KR KR1020217030879A patent/KR102427491B1/ko active Active
- 2014-02-27 CA CA2902768A patent/CA2902768A1/en not_active Abandoned
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- 2015-09-09 ZA ZA2015/06674A patent/ZA201506674B/en unknown
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|---|---|
| CN105164108A (zh) | 2015-12-16 |
| US10174046B2 (en) | 2019-01-08 |
| WO2014158654A1 (en) | 2014-10-02 |
| US20180155359A9 (en) | 2018-06-07 |
| US20160031899A1 (en) | 2016-02-04 |
| US20170247389A2 (en) | 2017-08-31 |
| ES2740779T3 (es) | 2020-02-06 |
| EP2970122A1 (en) | 2016-01-20 |
| KR20220110337A (ko) | 2022-08-05 |
| KR20150127205A (ko) | 2015-11-16 |
| HK1220180A1 (en) | 2017-04-28 |
| IL240968A0 (en) | 2015-11-30 |
| AU2014242041B2 (en) | 2018-07-26 |
| RU2015143676A (ru) | 2017-04-27 |
| BR112015023009A2 (pt) | 2017-08-22 |
| EP2970122B1 (en) | 2019-05-08 |
| KR102308319B1 (ko) | 2021-10-06 |
| US9765085B2 (en) | 2017-09-19 |
| AU2014242041A1 (en) | 2015-09-24 |
| CN108892637A (zh) | 2018-11-27 |
| CA2902768A1 (en) | 2014-10-02 |
| RU2679805C2 (ru) | 2019-02-13 |
| US20170362250A1 (en) | 2017-12-21 |
| HK1217704A1 (zh) | 2017-01-20 |
| ZA201506674B (en) | 2016-11-30 |
| JP2016517409A (ja) | 2016-06-16 |
| CN105164108B (zh) | 2018-07-17 |
| KR20210120137A (ko) | 2021-10-06 |
| KR102427491B1 (ko) | 2022-08-01 |
| MX2015012111A (es) | 2016-05-05 |
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