JP2016517402A5 - - Google Patents

Info

Publication number

JP2016517402A5

JP2016517402A5 JP2015562395A JP2015562395A JP2016517402A5 JP 2016517402 A5 JP2016517402 A5 JP 2016517402A5 JP 2015562395 A JP2015562395 A JP 2015562395A JP 2015562395 A JP2015562395 A JP 2015562395A JP 2016517402 A5 JP2016517402 A5 JP 2016517402A5

Authority

JP

Japan

Prior art keywords

recombinant

growth factor

protein according

synthetic protein

vegf

Prior art date

2014-03-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000003102 growth factor Substances 0.000 claims 25
• 102000004169 proteins and genes Human genes 0.000 claims 23
• 108090000623 proteins and genes Proteins 0.000 claims 23
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 15
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 15
• 108090000765 processed proteins & peptides Proteins 0.000 claims 13
• 229920001184 polypeptide Polymers 0.000 claims 12
• 102000004196 processed proteins & peptides Human genes 0.000 claims 12
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 239000000427 antigen Substances 0.000 claims 5
• 102000036639 antigens Human genes 0.000 claims 5
• 108091007433 antigens Proteins 0.000 claims 5
• 238000006386 neutralization reaction Methods 0.000 claims 5
• 125000006850 spacer group Chemical group 0.000 claims 4
• 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims 3
• 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 3
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 3
• 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 3
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 3
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 3
• 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 3
• 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 3
• 102000006747 Transforming Growth Factor alpha Human genes 0.000 claims 3
• 108010009583 Transforming Growth Factors Proteins 0.000 claims 3
• 102000009618 Transforming Growth Factors Human genes 0.000 claims 3
• 101800004564 Transforming growth factor alpha Proteins 0.000 claims 3
• 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 claims 3
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 3
• 108010073925 Vascular Endothelial Growth Factor B Proteins 0.000 claims 3
• 102000009520 Vascular Endothelial Growth Factor C Human genes 0.000 claims 3
• 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 claims 3
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
• 102100038217 Vascular endothelial growth factor B Human genes 0.000 claims 3
• 230000002163 immunogen Effects 0.000 claims 3
• 230000003472 neutralizing effect Effects 0.000 claims 3
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000000178 monomer Substances 0.000 claims 2
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
• 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 1
• 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 229940031348 multivalent vaccine Drugs 0.000 claims 1
• 230000011664 signaling Effects 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1