KR102391734B1 - 자기조립형 합성 단백질 - Google Patents

자기조립형 합성 단백질 Download PDF

Info

Publication number
KR102391734B1
KR102391734B1 KR1020157026975A KR20157026975A KR102391734B1 KR 102391734 B1 KR102391734 B1 KR 102391734B1 KR 1020157026975 A KR1020157026975 A KR 1020157026975A KR 20157026975 A KR20157026975 A KR 20157026975A KR 102391734 B1 KR102391734 B1 KR 102391734B1
Authority
KR
South Korea
Prior art keywords
seq
protein
delete delete
growth factor
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020157026975A
Other languages
English (en)
Korean (ko)
Other versions
KR20150139513A (ko
Inventor
키이스 알란 찰톤
에릭 돈트
다니엘 티. 베르함
Original Assignee
인3바이오 리미티드
다니엘 티. 베르함
에릭 돈트
키이스 알란 찰톤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 인3바이오 리미티드, 다니엘 티. 베르함, 에릭 돈트, 키이스 알란 찰톤 filed Critical 인3바이오 리미티드
Priority to KR1020207037800A priority Critical patent/KR102427429B1/ko
Publication of KR20150139513A publication Critical patent/KR20150139513A/ko
Application granted granted Critical
Publication of KR102391734B1 publication Critical patent/KR102391734B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
KR1020157026975A 2013-03-15 2014-03-17 자기조립형 합성 단백질 Active KR102391734B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020207037800A KR102427429B1 (ko) 2013-03-15 2014-03-17 자기조립형 합성 단백질

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361791268P 2013-03-15 2013-03-15
US61/791,268 2013-03-15
PCT/IB2014/001125 WO2014140894A2 (en) 2013-03-15 2014-03-17 Self-assembling synthetic proteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020207037800A Division KR102427429B1 (ko) 2013-03-15 2014-03-17 자기조립형 합성 단백질

Publications (2)

Publication Number Publication Date
KR20150139513A KR20150139513A (ko) 2015-12-11
KR102391734B1 true KR102391734B1 (ko) 2022-04-29

Family

ID=51225849

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020157026975A Active KR102391734B1 (ko) 2013-03-15 2014-03-17 자기조립형 합성 단백질
KR1020207037800A Active KR102427429B1 (ko) 2013-03-15 2014-03-17 자기조립형 합성 단백질

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020207037800A Active KR102427429B1 (ko) 2013-03-15 2014-03-17 자기조립형 합성 단백질

Country Status (14)

Country Link
US (3) US10736948B2 (enExample)
EP (1) EP2970409A2 (enExample)
JP (1) JP6873530B2 (enExample)
KR (2) KR102391734B1 (enExample)
CN (2) CN111978409B (enExample)
AU (1) AU2014229561B2 (enExample)
BR (1) BR112015023402A2 (enExample)
CA (1) CA2904506A1 (enExample)
HK (1) HK1214606A1 (enExample)
IL (3) IL286537B (enExample)
MX (2) MX385451B (enExample)
MY (1) MY187936A (enExample)
RU (1) RU2747857C2 (enExample)
WO (1) WO2014140894A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160333087A1 (en) 2015-05-12 2016-11-17 Bioven 3 Limited Methods and compositions for inhibition of egf/egfr pathway in combination with tyrosine kinase inhibitors
JP7751357B2 (ja) * 2017-07-18 2025-10-08 イン３バイオ・リミテッド 合成タンパク質およびその治療学的用途
WO2020257317A1 (en) * 2019-06-18 2020-12-24 Citranvi Biosciences, Llc Rationally engineered carrier proteins for vaccines
KR20220058527A (ko) * 2019-06-25 2022-05-09 인3바이오 리미티드 안정화된 키메라 합성 단백질 및 그 치료 용도
KR20220099990A (ko) 2019-11-07 2022-07-14 인3바이오 리미티드 비티로신 표적화 키나아제 억제제와 병용하여 성장 인자 항체를 사용하기 위한 방법 및 조성물
CN114019166B (zh) * 2021-09-27 2024-02-27 浙江省食品药品检验研究院 一种检测龙葵素的试纸条及其应用

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238190A (en) 1963-10-23 1966-03-01 Madaus & Co K G Fa Dr Aescin recovery
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
CA1331443C (en) 1987-05-29 1994-08-16 Charlotte A. Kensil Saponin adjuvant
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US6153203A (en) 1993-10-08 2000-11-28 Duotol Ab Immunological tolerance-inducing agent
ES2237750T3 (es) * 1993-12-09 2005-08-01 Centro De Inmunologia Molecular Vacuna que comprende factor de crecimiento epidermico autologo humano y su uso.
CA2261433A1 (en) * 1993-12-09 1995-06-10 Belinda Sanchez Ramirez Composition comprising autologous epidermal growth factor
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
BR9712852A (pt) * 1996-10-23 1999-11-16 Univ Pennsylvania Plasmìdeo, composição, processo de imunização de um indivìduo contra um patógeno, vacina recombinante, patógeno vivo atenuado, proteìna bl-1 substancialmente pura, vetor recombinante de expressão, e, anticorpo isolado
ES2500490T3 (es) 1997-08-29 2014-09-30 Antigenics Inc. Composiciones que comprenden el adyuvante QS-21 y polisorbato o ciclodextrina como excipiente
US20080249019A1 (en) * 1998-08-25 2008-10-09 Syntaxin, Ltd. Treatment of mucus hypersecretion
CN1227030C (zh) 1999-04-19 2005-11-16 史密丝克莱恩比彻姆生物有限公司 包含皂甙和免疫刺激寡核苷酸的佐剂组合物
SK782002A3 (en) * 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
WO2001027144A2 (en) 1999-10-08 2001-04-19 Active Biotech Ab Ab5 toxin b subunit mutants with altered chemical conjugation characteristics
PE20020572A1 (es) * 2000-12-06 2002-07-31 Centro Inmunologia Molecular Preparaciones para potenciar la inmunogenicidad de antigenos poco inmunogenicos
US6991849B2 (en) 2001-06-21 2006-01-31 Teijin Limited Near infrared ray shielding film
GB0115382D0 (en) 2001-06-22 2001-08-15 Univ Bristol Mutant
JP2005512538A (ja) * 2001-12-14 2005-05-12 セントカー・インコーポレーテツド 無血清培地中でタンパク質を製造するのに有用なクローン性骨髄腫細胞系
ATE372379T1 (de) * 2002-03-15 2007-09-15 Cellectis Hybride and einzelkettige meganukleasen und deren anwendungen
DE602004031341D1 (de) * 2003-07-21 2011-03-24 Transgene Sa Multifunktionelle cytokine
JP4623625B2 (ja) 2003-07-24 2011-02-02 株式会社AMBiS ヘテロ型５量体組換えワクチン
US7320795B2 (en) * 2003-07-30 2008-01-22 Vaccine Research Institute Of San Diego Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof
ATE541580T1 (de) * 2003-12-05 2012-02-15 Univ Northwestern Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor
NZ549048A (en) 2004-02-11 2009-04-30 Angeletti P Ist Richerche Bio Carcinoembryonic antigen fusion proteins and uses thereof
EP1921149A1 (en) * 2006-11-13 2008-05-14 AEterna Zentaris GmbH Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof
US7946815B2 (en) 2007-03-27 2011-05-24 Siemens Energy, Inc. Airfoil for a gas turbine engine
CN101970498A (zh) 2007-10-25 2011-02-09 维文蒂阿生物技术公司 针对变体HnRNPG的癌相关表位的抗体及其应用
WO2009078796A1 (en) 2007-12-19 2009-06-25 Mivac Development Aktiebolag Compositions and methods for treatment of autoimmune and allergic diseases
AU2009265095B2 (en) 2008-06-09 2014-09-11 Bharat Biotech International Limited Vaccine composition useful for HPV and Hepatitis B infections and a method for preparing the same
JP2010050586A (ja) 2008-08-20 2010-03-04 Nec Corp 通信装置及びそれに用いる装置コンポーネント複合冗長化方法
JPWO2010050586A1 (ja) * 2008-10-31 2012-03-29 ディナベック株式会社 組み換え蛋白質の発現を増強する方法
KR20110104032A (ko) * 2008-12-19 2011-09-21 마크로제닉스, 인크. 공유결합형 디아바디 및 이의 용도
JP2011097930A (ja) * 2009-10-07 2011-05-19 Hokkaido Univ 光活性化生理機能センサータンパク質
RU2480524C2 (ru) * 2010-09-13 2013-04-27 Учреждение Российской академии наук Институт биоорганической химии им. академии М.М. Шемякина и Ю.А. Овчинникова РАН Конструкция на основе белковой пары барназа-барстар и способ ее получения
ES2676878T3 (es) * 2011-03-03 2018-07-25 Zymeworks Inc. Diseño de armazón de heteromultímero multivalente y constructos
CN102604993B (zh) 2012-01-10 2013-03-20 天津耀宇生物技术有限公司 免疫佐剂与幽门螺杆菌抗原融合蛋白口服疫苗及其制备方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Li S. et al, Molecular Immunology 46:PP.1718~1726 (2009.)*
Molecular Immunology, Vol. 46, pp. 1718-1726 (2009.03.09.)
Molecular Immunology, Vol. 46, pp. 1718-1726(2009.03.09.)*
Vaccine, Vol. 21, pp. 514-520 (2003.)

Also Published As

Publication number Publication date
JP2016517402A (ja) 2016-06-16
AU2014229561A1 (en) 2015-10-29
CA2904506A1 (en) 2014-09-18
MX2015012461A (es) 2016-08-08
CN111978409B (zh) 2024-01-26
WO2014140894A3 (en) 2015-02-19
RU2747857C2 (ru) 2021-05-17
MX2021010021A (es) 2021-12-10
MX385451B (es) 2025-03-18
US20160095910A1 (en) 2016-04-07
RU2015143217A (ru) 2017-04-27
IL273051B (en) 2021-10-31
US10736948B2 (en) 2020-08-11
AU2014229561B2 (en) 2018-06-07
US11419923B2 (en) 2022-08-23
IL286537A (en) 2021-10-31
CN111978409A (zh) 2020-11-24
CN105209481B (zh) 2020-08-25
KR20150139513A (ko) 2015-12-11
IL241116B (en) 2020-03-31
IL273051A (en) 2020-04-30
CN105209481A (zh) 2015-12-30
US20200297827A1 (en) 2020-09-24
RU2019109120A (ru) 2019-06-13
JP6873530B2 (ja) 2021-05-19
KR20210005294A (ko) 2021-01-13
KR102427429B1 (ko) 2022-08-01
WO2014140894A2 (en) 2014-09-18
BR112015023402A2 (pt) 2017-08-22
EP2970409A2 (en) 2016-01-20
MY187936A (en) 2021-10-29
US20230042534A1 (en) 2023-02-09
IL286537B (en) 2022-07-01
IL241116A0 (en) 2015-11-30
US12433939B2 (en) 2025-10-07
HK1214606A1 (zh) 2016-07-29

Similar Documents

Publication Publication Date Title
US12433939B2 (en) Self-assembling synthetic proteins comprising cholera toxin beta subunit
US12030920B2 (en) Recombinant proteins and their therapeutic uses
RU2801230C9 (ru) Самособирающиеся синтетические белки
RU2801230C2 (ru) Самособирающиеся синтетические белки
HK40041859A (en) Self-assembling synthetic proteins
CN114269792B (zh) 稳定的嵌合合成蛋白及其治疗用途

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

A107 Divisional application of patent
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

E90F Notification of reason for final refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 4