AU2014229561B2 - Self-assembling synthetic proteins - Google Patents

Self-assembling synthetic proteins Download PDF

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Publication number
AU2014229561B2
AU2014229561B2 AU2014229561A AU2014229561A AU2014229561B2 AU 2014229561 B2 AU2014229561 B2 AU 2014229561B2 AU 2014229561 A AU2014229561 A AU 2014229561A AU 2014229561 A AU2014229561 A AU 2014229561A AU 2014229561 B2 AU2014229561 B2 AU 2014229561B2
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AU
Australia
Prior art keywords
recombinant
synthetic
protein according
synthetic protein
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2014229561A
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English (en)
Other versions
AU2014229561A1 (en
Inventor
Keith Alan Charlton
Erik D'hondt
Daniel T. Verhamme
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
In3bio Ltd
Original Assignee
Dhondt Erik
In3bio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dhondt Erik, In3bio Ltd filed Critical Dhondt Erik
Publication of AU2014229561A1 publication Critical patent/AU2014229561A1/en
Application granted granted Critical
Publication of AU2014229561B2 publication Critical patent/AU2014229561B2/en
Assigned to D'HONDT, ERIK, CHARLTON, KEITH, VERHAMME, DANIEL, IN3BIO LTD. reassignment D'HONDT, ERIK Request to Amend Deed and Register Assignors: BIOVEN 3 LIMITED, CHARLTON, KEITH, D'HONDT, ERIK, VERHAMME, DANIEL
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
AU2014229561A 2013-03-15 2014-03-17 Self-assembling synthetic proteins Active AU2014229561B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361791268P 2013-03-15 2013-03-15
US61/791,268 2013-03-15
PCT/IB2014/001125 WO2014140894A2 (en) 2013-03-15 2014-03-17 Self-assembling synthetic proteins

Publications (2)

Publication Number Publication Date
AU2014229561A1 AU2014229561A1 (en) 2015-10-29
AU2014229561B2 true AU2014229561B2 (en) 2018-06-07

Family

ID=51225849

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014229561A Active AU2014229561B2 (en) 2013-03-15 2014-03-17 Self-assembling synthetic proteins

Country Status (14)

Country Link
US (3) US10736948B2 (enExample)
EP (1) EP2970409A2 (enExample)
JP (1) JP6873530B2 (enExample)
KR (2) KR102391734B1 (enExample)
CN (2) CN111978409B (enExample)
AU (1) AU2014229561B2 (enExample)
BR (1) BR112015023402A2 (enExample)
CA (1) CA2904506A1 (enExample)
HK (1) HK1214606A1 (enExample)
IL (3) IL286537B (enExample)
MX (2) MX385451B (enExample)
MY (1) MY187936A (enExample)
RU (1) RU2747857C2 (enExample)
WO (1) WO2014140894A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160333087A1 (en) 2015-05-12 2016-11-17 Bioven 3 Limited Methods and compositions for inhibition of egf/egfr pathway in combination with tyrosine kinase inhibitors
JP7751357B2 (ja) * 2017-07-18 2025-10-08 イン３バイオ・リミテッド 合成タンパク質およびその治療学的用途
WO2020257317A1 (en) * 2019-06-18 2020-12-24 Citranvi Biosciences, Llc Rationally engineered carrier proteins for vaccines
KR20220058527A (ko) * 2019-06-25 2022-05-09 인3바이오 리미티드 안정화된 키메라 합성 단백질 및 그 치료 용도
KR20220099990A (ko) 2019-11-07 2022-07-14 인3바이오 리미티드 비티로신 표적화 키나아제 억제제와 병용하여 성장 인자 항체를 사용하기 위한 방법 및 조성물
CN114019166B (zh) * 2021-09-27 2024-02-27 浙江省食品药品检验研究院 一种检测龙葵素的试纸条及其应用

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238190A (en) 1963-10-23 1966-03-01 Madaus & Co K G Fa Dr Aescin recovery
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
CA1331443C (en) 1987-05-29 1994-08-16 Charlotte A. Kensil Saponin adjuvant
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US6153203A (en) 1993-10-08 2000-11-28 Duotol Ab Immunological tolerance-inducing agent
ES2237750T3 (es) * 1993-12-09 2005-08-01 Centro De Inmunologia Molecular Vacuna que comprende factor de crecimiento epidermico autologo humano y su uso.
CA2261433A1 (en) * 1993-12-09 1995-06-10 Belinda Sanchez Ramirez Composition comprising autologous epidermal growth factor
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
BR9712852A (pt) * 1996-10-23 1999-11-16 Univ Pennsylvania Plasmìdeo, composição, processo de imunização de um indivìduo contra um patógeno, vacina recombinante, patógeno vivo atenuado, proteìna bl-1 substancialmente pura, vetor recombinante de expressão, e, anticorpo isolado
ES2500490T3 (es) 1997-08-29 2014-09-30 Antigenics Inc. Composiciones que comprenden el adyuvante QS-21 y polisorbato o ciclodextrina como excipiente
US20080249019A1 (en) * 1998-08-25 2008-10-09 Syntaxin, Ltd. Treatment of mucus hypersecretion
CN1227030C (zh) 1999-04-19 2005-11-16 史密丝克莱恩比彻姆生物有限公司 包含皂甙和免疫刺激寡核苷酸的佐剂组合物
SK782002A3 (en) * 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
WO2001027144A2 (en) 1999-10-08 2001-04-19 Active Biotech Ab Ab5 toxin b subunit mutants with altered chemical conjugation characteristics
PE20020572A1 (es) * 2000-12-06 2002-07-31 Centro Inmunologia Molecular Preparaciones para potenciar la inmunogenicidad de antigenos poco inmunogenicos
US6991849B2 (en) 2001-06-21 2006-01-31 Teijin Limited Near infrared ray shielding film
GB0115382D0 (en) 2001-06-22 2001-08-15 Univ Bristol Mutant
JP2005512538A (ja) * 2001-12-14 2005-05-12 セントカー・インコーポレーテツド 無血清培地中でタンパク質を製造するのに有用なクローン性骨髄腫細胞系
ATE372379T1 (de) * 2002-03-15 2007-09-15 Cellectis Hybride and einzelkettige meganukleasen und deren anwendungen
DE602004031341D1 (de) * 2003-07-21 2011-03-24 Transgene Sa Multifunktionelle cytokine
JP4623625B2 (ja) 2003-07-24 2011-02-02 株式会社AMBiS ヘテロ型５量体組換えワクチン
US7320795B2 (en) * 2003-07-30 2008-01-22 Vaccine Research Institute Of San Diego Rodent hepatitis B virus core proteins as vaccine platforms and methods of use thereof
ATE541580T1 (de) * 2003-12-05 2012-02-15 Univ Northwestern Selbst anordnende peptid-amphiphile und relevante verfahren für die abgabe von wachstumsfaktor
NZ549048A (en) 2004-02-11 2009-04-30 Angeletti P Ist Richerche Bio Carcinoembryonic antigen fusion proteins and uses thereof
EP1921149A1 (en) * 2006-11-13 2008-05-14 AEterna Zentaris GmbH Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof
US7946815B2 (en) 2007-03-27 2011-05-24 Siemens Energy, Inc. Airfoil for a gas turbine engine
CN101970498A (zh) 2007-10-25 2011-02-09 维文蒂阿生物技术公司 针对变体HnRNPG的癌相关表位的抗体及其应用
WO2009078796A1 (en) 2007-12-19 2009-06-25 Mivac Development Aktiebolag Compositions and methods for treatment of autoimmune and allergic diseases
AU2009265095B2 (en) 2008-06-09 2014-09-11 Bharat Biotech International Limited Vaccine composition useful for HPV and Hepatitis B infections and a method for preparing the same
JP2010050586A (ja) 2008-08-20 2010-03-04 Nec Corp 通信装置及びそれに用いる装置コンポーネント複合冗長化方法
JPWO2010050586A1 (ja) * 2008-10-31 2012-03-29 ディナベック株式会社 組み換え蛋白質の発現を増強する方法
KR20110104032A (ko) * 2008-12-19 2011-09-21 마크로제닉스, 인크. 공유결합형 디아바디 및 이의 용도
JP2011097930A (ja) * 2009-10-07 2011-05-19 Hokkaido Univ 光活性化生理機能センサータンパク質
RU2480524C2 (ru) * 2010-09-13 2013-04-27 Учреждение Российской академии наук Институт биоорганической химии им. академии М.М. Шемякина и Ю.А. Овчинникова РАН Конструкция на основе белковой пары барназа-барстар и способ ее получения
ES2676878T3 (es) * 2011-03-03 2018-07-25 Zymeworks Inc. Diseño de armazón de heteromultímero multivalente y constructos
CN102604993B (zh) 2012-01-10 2013-03-20 天津耀宇生物技术有限公司 免疫佐剂与幽门螺杆菌抗原融合蛋白口服疫苗及其制备方法

Also Published As

Publication number Publication date
JP2016517402A (ja) 2016-06-16
AU2014229561A1 (en) 2015-10-29
CA2904506A1 (en) 2014-09-18
MX2015012461A (es) 2016-08-08
CN111978409B (zh) 2024-01-26
WO2014140894A3 (en) 2015-02-19
RU2747857C2 (ru) 2021-05-17
MX2021010021A (es) 2021-12-10
MX385451B (es) 2025-03-18
US20160095910A1 (en) 2016-04-07
RU2015143217A (ru) 2017-04-27
IL273051B (en) 2021-10-31
US10736948B2 (en) 2020-08-11
US11419923B2 (en) 2022-08-23
IL286537A (en) 2021-10-31
CN111978409A (zh) 2020-11-24
CN105209481B (zh) 2020-08-25
KR20150139513A (ko) 2015-12-11
IL241116B (en) 2020-03-31
IL273051A (en) 2020-04-30
CN105209481A (zh) 2015-12-30
US20200297827A1 (en) 2020-09-24
RU2019109120A (ru) 2019-06-13
JP6873530B2 (ja) 2021-05-19
KR20210005294A (ko) 2021-01-13
KR102427429B1 (ko) 2022-08-01
WO2014140894A2 (en) 2014-09-18
BR112015023402A2 (pt) 2017-08-22
EP2970409A2 (en) 2016-01-20
MY187936A (en) 2021-10-29
US20230042534A1 (en) 2023-02-09
KR102391734B1 (ko) 2022-04-29
IL286537B (en) 2022-07-01
IL241116A0 (en) 2015-11-30
US12433939B2 (en) 2025-10-07
HK1214606A1 (zh) 2016-07-29

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
HB Alteration of name in register

Owner name: D'HONDT, E.

Free format text: FORMER NAME(S): BIOVEN 3 LIMITED; VERHAMME, DANIEL; D'HONDT, ERIK; CHARLTON, KEITH

Owner name: VERHAMME, D.

Free format text: FORMER NAME(S): BIOVEN 3 LIMITED; VERHAMME, DANIEL; D'HONDT, ERIK; CHARLTON, KEITH

Owner name: IN3BIO LTD.

Free format text: FORMER NAME(S): BIOVEN 3 LIMITED; VERHAMME, DANIEL; D'HONDT, ERIK; CHARLTON, KEITH

Owner name: CHARLTON, K.

Free format text: FORMER NAME(S): BIOVEN 3 LIMITED; VERHAMME, DANIEL; D'HONDT, ERIK; CHARLTON, KEITH