JP2016516765A5 - - Google Patents
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- Publication number
- JP2016516765A5 JP2016516765A5 JP2016507106A JP2016507106A JP2016516765A5 JP 2016516765 A5 JP2016516765 A5 JP 2016516765A5 JP 2016507106 A JP2016507106 A JP 2016507106A JP 2016507106 A JP2016507106 A JP 2016507106A JP 2016516765 A5 JP2016516765 A5 JP 2016516765A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- fatty acid
- antifungal
- ester
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims description 60
- 150000004665 fatty acids Chemical class 0.000 claims description 43
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 39
- 239000000194 fatty acid Substances 0.000 claims description 39
- 229930195729 fatty acid Natural products 0.000 claims description 39
- 150000002148 esters Chemical class 0.000 claims description 38
- 239000003921 oil Substances 0.000 claims description 26
- 125000004432 carbon atom Chemical group C* 0.000 claims description 17
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 15
- -1 serum Substances 0.000 claims description 14
- 239000002245 particle Substances 0.000 claims description 13
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 11
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 9
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 8
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 150000005690 diesters Chemical class 0.000 claims description 6
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims description 6
- 229920001983 poloxamer Polymers 0.000 claims description 6
- 229960000502 poloxamer Drugs 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 6
- 229960000541 cetyl alcohol Drugs 0.000 claims description 5
- 239000003995 emulsifying agent Substances 0.000 claims description 5
- ILCOCZBHMDEIAI-UHFFFAOYSA-N 2-(2-octadecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCO ILCOCZBHMDEIAI-UHFFFAOYSA-N 0.000 claims description 4
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 4
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 229960002446 octanoic acid Drugs 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 3
- AWQSAIIDOMEEOD-UHFFFAOYSA-N 5,5-Dimethyl-4-(3-oxobutyl)dihydro-2(3H)-furanone Chemical compound CC(=O)CCC1CC(=O)OC1(C)C AWQSAIIDOMEEOD-UHFFFAOYSA-N 0.000 claims description 3
- XTJFFFGAUHQWII-UHFFFAOYSA-N Dibutyl adipate Chemical compound CCCCOC(=O)CCCCC(=O)OCCCC XTJFFFGAUHQWII-UHFFFAOYSA-N 0.000 claims description 3
- 239000005662 Paraffin oil Substances 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 3
- GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 claims description 3
- ZFMQKOWCDKKBIF-UHFFFAOYSA-N bis(3,5-difluorophenyl)phosphane Chemical compound FC1=CC(F)=CC(PC=2C=C(F)C=C(F)C=2)=C1 ZFMQKOWCDKKBIF-UHFFFAOYSA-N 0.000 claims description 3
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 3
- 229940100539 dibutyl adipate Drugs 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 3
- FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 235000019260 propionic acid Nutrition 0.000 claims description 3
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 3
- 239000002453 shampoo Substances 0.000 claims description 3
- 229920002545 silicone oil Polymers 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- 229940012831 stearyl alcohol Drugs 0.000 claims description 3
- 150000003505 terpenes Chemical class 0.000 claims description 3
- 235000007586 terpenes Nutrition 0.000 claims description 3
- 150000005691 triesters Chemical class 0.000 claims description 3
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 claims description 2
- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 2
- 229920002669 Polyoxyl 20 Cetostearyl Ether Polymers 0.000 claims description 2
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 claims description 2
- 229940063953 ammonium lauryl sulfate Drugs 0.000 claims description 2
- 150000001735 carboxylic acids Chemical class 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 150000002170 ethers Chemical class 0.000 claims description 2
- 229960003511 macrogol Drugs 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 229940098760 steareth-2 Drugs 0.000 claims description 2
- 229940100458 steareth-21 Drugs 0.000 claims description 2
- 239000012871 anti-fungal composition Substances 0.000 claims 14
- 229940121375 antifungal agent Drugs 0.000 claims 8
- 239000003429 antifungal agent Substances 0.000 claims 7
- 239000013543 active substance Substances 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 claims 2
- 239000006185 dispersion Substances 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 238000000265 homogenisation Methods 0.000 claims 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 1
- BLSQLHNBWJLIBQ-OZXSUGGESA-N (2R,4S)-terconazole Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2N=CN=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 BLSQLHNBWJLIBQ-OZXSUGGESA-N 0.000 claims 1
- MQHLMHIZUIDKOO-OKZBNKHCSA-N (2R,6S)-2,6-dimethyl-4-[(2S)-2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine Chemical compound C1=CC(C(C)(C)CC)=CC=C1C[C@H](C)CN1C[C@@H](C)O[C@@H](C)C1 MQHLMHIZUIDKOO-OKZBNKHCSA-N 0.000 claims 1
- CKNOIIXFUKKRIC-HZJYTTRNSA-N (9z,12z)-n,n-bis(2-hydroxyethyl)octadeca-9,12-dienamide Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)N(CCO)CCO CKNOIIXFUKKRIC-HZJYTTRNSA-N 0.000 claims 1
- MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 claims 1
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims 1
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 1
- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 claims 1
- MBRHNTMUYWQHMR-UHFFFAOYSA-N 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one Chemical compound NCCO.ON1C(=O)C=C(C)C=C1C1CCCCC1 MBRHNTMUYWQHMR-UHFFFAOYSA-N 0.000 claims 1
- HUADITLKOCMHSB-AVQIMAJZSA-N 2-butan-2-yl-4-[4-[4-[4-[[(2s,4r)-2-(2,4-difluorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N(C(C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3O[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 HUADITLKOCMHSB-AVQIMAJZSA-N 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 240000007049 Juglans regia Species 0.000 claims 1
- 235000009496 Juglans regia Nutrition 0.000 claims 1
- YTAOBBFIOAEMLL-REQDGWNSSA-N Luliconazole Chemical compound ClC1=CC(Cl)=CC=C1[C@H](CS\1)SC/1=C(\C#N)N1C=NC=C1 YTAOBBFIOAEMLL-REQDGWNSSA-N 0.000 claims 1
- 239000004909 Moisturizer Substances 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- AOMUHOFOVNGZAN-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)dodecanamide Chemical compound CCCCCCCCCCCC(=O)N(CCO)CCO AOMUHOFOVNGZAN-UHFFFAOYSA-N 0.000 claims 1
- QZXSMBBFBXPQHI-UHFFFAOYSA-N N-(dodecanoyl)ethanolamine Chemical compound CCCCCCCCCCCC(=O)NCCO QZXSMBBFBXPQHI-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 claims 1
- 229960003204 amorolfine Drugs 0.000 claims 1
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000001153 anti-wrinkle effect Effects 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 229940089116 arnica extract Drugs 0.000 claims 1
- 239000002199 base oil Substances 0.000 claims 1
- 239000010623 birch oil Substances 0.000 claims 1
- 229960002962 butenafine Drugs 0.000 claims 1
- ABJKWBDEJIDSJZ-UHFFFAOYSA-N butenafine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)CC1=CC=C(C(C)(C)C)C=C1 ABJKWBDEJIDSJZ-UHFFFAOYSA-N 0.000 claims 1
- 229960004375 ciclopirox olamine Drugs 0.000 claims 1
- 229960004022 clotrimazole Drugs 0.000 claims 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims 1
- 239000007957 coemulsifier Substances 0.000 claims 1
- 230000003750 conditioning effect Effects 0.000 claims 1
- 239000004064 cosurfactant Substances 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 claims 1
- SMVRDGHCVNAOIN-UHFFFAOYSA-L disodium;1-dodecoxydodecane;sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC SMVRDGHCVNAOIN-UHFFFAOYSA-L 0.000 claims 1
- 239000000428 dust Substances 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 229960003913 econazole Drugs 0.000 claims 1
- 239000003974 emollient agent Substances 0.000 claims 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims 1
- 229960004884 fluconazole Drugs 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000004088 foaming agent Substances 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 239000012676 herbal extract Substances 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 229960004130 itraconazole Drugs 0.000 claims 1
- 229960004125 ketoconazole Drugs 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 229960000570 luliconazole Drugs 0.000 claims 1
- 229960005040 miconazole nitrate Drugs 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- 239000002324 mouth wash Substances 0.000 claims 1
- 229940051866 mouthwash Drugs 0.000 claims 1
- 229960004313 naftifine Drugs 0.000 claims 1
- OZGNYLLQHRPOBR-DHZHZOJOSA-N naftifine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)C\C=C\C1=CC=CC=C1 OZGNYLLQHRPOBR-DHZHZOJOSA-N 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 229960003483 oxiconazole Drugs 0.000 claims 1
- QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 229940081510 piroctone olamine Drugs 0.000 claims 1
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical group NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000001012 protector Effects 0.000 claims 1
- 238000004064 recycling Methods 0.000 claims 1
- 239000010668 rosemary oil Substances 0.000 claims 1
- 229940058206 rosemary oil Drugs 0.000 claims 1
- 229960004889 salicylic acid Drugs 0.000 claims 1
- 229950005137 saperconazole Drugs 0.000 claims 1
- 229910000338 selenium disulfide Inorganic materials 0.000 claims 1
- JNMWHTHYDQTDQZ-UHFFFAOYSA-N selenium sulfide Chemical compound S=[Se]=S JNMWHTHYDQTDQZ-UHFFFAOYSA-N 0.000 claims 1
- 229960005265 selenium sulfide Drugs 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 229960005349 sulfur Drugs 0.000 claims 1
- 239000000516 sunscreening agent Substances 0.000 claims 1
- 239000000375 suspending agent Substances 0.000 claims 1
- 239000011269 tar Substances 0.000 claims 1
- 239000010677 tea tree oil Substances 0.000 claims 1
- 229940111630 tea tree oil Drugs 0.000 claims 1
- 229960002722 terbinafine Drugs 0.000 claims 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims 1
- 229960000580 terconazole Drugs 0.000 claims 1
- 239000002562 thickening agent Substances 0.000 claims 1
- 239000004034 viscosity adjusting agent Substances 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 239000000341 volatile oil Substances 0.000 claims 1
- 235000020234 walnut Nutrition 0.000 claims 1
- 229930007845 β-thujaplicin Natural products 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 description 8
- 208000015181 infectious disease Diseases 0.000 description 7
- 230000000813 microbial effect Effects 0.000 description 7
- 230000000845 anti-microbial effect Effects 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 229940043810 zinc pyrithione Drugs 0.000 description 4
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 1
- 229940098691 coco monoethanolamide Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- 229960000878 docusate sodium Drugs 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
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| ES2784307T3 (es) * | 2014-01-29 | 2020-09-24 | Vyome Therapeutics Ltd | Besifloxacina para el tratamiento del acné resistente |
| US10772343B2 (en) | 2014-11-19 | 2020-09-15 | Kansas State University Research Foundation | Chemical mitigants in animal feed and feed ingredients |
| WO2016118644A1 (en) * | 2015-01-20 | 2016-07-28 | Plurogen Therapeutics, Llc | Compositions and methods of treating microbes |
| US11684567B2 (en) | 2015-08-05 | 2023-06-27 | Cmpd Licensing, Llc | Compositions and methods for treating an infection |
| US11446236B2 (en) | 2015-08-05 | 2022-09-20 | Cmpd Licensing, Llc | Topical antimicrobial compositions and methods of formulating the same |
| US10898455B2 (en) | 2016-01-07 | 2021-01-26 | Cmpd Licensing, Llc | Urea cream formulations |
| US11690815B2 (en) | 2015-08-05 | 2023-07-04 | Cmpd Licensing Llc | Hyperkeratotic skin condition treatments and compositions |
| US11793783B2 (en) | 2015-08-05 | 2023-10-24 | Cmpd Licensing, Llc | Compositions and methods for treating an infection |
| US20170173063A1 (en) * | 2015-12-18 | 2017-06-22 | Cmpd Licensing, Llc | Compositions and Methods for Treating an Infection |
| CN106377757B (zh) * | 2016-03-04 | 2020-05-19 | 广州英赛特生物技术有限公司 | 含氧碳氢衍生物作为多粘菌素的协同增效剂的应用 |
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| EP3468544A2 (en) * | 2016-06-13 | 2019-04-17 | Vyome Therapeutics Limited | Synergistic antifungal compositions and methods thereof |
| WO2017216722A2 (en) * | 2016-06-13 | 2017-12-21 | Vyome Biosciences Pvt. Ltd. | Synergistic antifungal compositions and methods thereof |
| GB201611365D0 (en) * | 2016-06-30 | 2016-08-17 | Devenish Nutrition Ltd | A composition for use in treating rotavirus infection |
| CN106178024A (zh) * | 2016-07-06 | 2016-12-07 | 安徽智博新材料科技有限公司 | 一种医用器具的长效消毒方法 |
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| EA201992520A1 (ru) * | 2017-07-12 | 2020-06-25 | Юнилевер Н.В. | Масло, улучшающее композицию для кожи |
| TR201714882A2 (tr) * | 2017-10-03 | 2019-04-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Luli̇konazolün topi̇kal farmasöti̇k kompozi̇syonlari |
| US20210393520A1 (en) * | 2018-02-12 | 2021-12-23 | Vyome Therapeutics Limited | Treatment of gram-negative folliculitis or an inflammation thereof with besifloxacin |
| KR101961366B1 (ko) * | 2018-06-25 | 2019-03-25 | (주) 아이나노 | 금 나노 입자가 분산 함유되어 있는 항균제 혹은 소취제 조성물, 및 이를 함유한 금나노 함유 제품 |
| WO2020028319A1 (en) * | 2018-07-30 | 2020-02-06 | Sinica, Academia | Therapeutic nanoparticles by coacervate complexation and their use for treating bacteria |
| US20220175827A1 (en) * | 2019-04-05 | 2022-06-09 | Northeastern University | Biosynthesis of Selenium Nanoparticles Having Antimicrobial Activity |
| WO2021004770A1 (en) * | 2019-07-09 | 2021-01-14 | Unilever N.V. | Hair care composition comprising antidandruff agent |
| KR102241761B1 (ko) * | 2019-08-07 | 2021-04-16 | 고려대학교 산학협력단 | 상온에서 속효성 살균 효과를 갖는 조성물 |
| CN114450010A (zh) * | 2019-10-11 | 2022-05-06 | 皮埃蒙特动物健康公司 | 耳用制剂、方法和装置 |
| CN111000744B (zh) * | 2020-01-07 | 2021-10-15 | 拉芳家化股份有限公司 | 一种含协同增效去屑组合的洗发香波 |
| CN111286274A (zh) * | 2020-03-06 | 2020-06-16 | 南雄市双溪丽盈化工涂料有限公司 | 高闪高透超丰满哑光清面漆 |
| CN115551470A (zh) * | 2020-04-23 | 2022-12-30 | 奥麒英国生物灭杀剂有限公司 | 含有亚烷基二醇酯的协同防腐剂/个人护理组合物 |
| KR102197910B1 (ko) * | 2020-08-06 | 2021-01-05 | 주식회사 씨엘바이오 | 피톤치드 함유 살균 및 살바이러스 조성물 |
| CN112205431A (zh) * | 2020-09-14 | 2021-01-12 | 株洲千金药业股份有限公司 | 一种抑菌组合物和抑菌型婴幼儿衣物洗液及其制备方法 |
| CN112089684A (zh) * | 2020-10-30 | 2020-12-18 | 华东医药（西安）博华制药有限公司 | 左奥硝唑/奥硝唑水包油乳温敏凝胶栓剂及其制备方法 |
| CN112263499B (zh) * | 2020-11-27 | 2023-05-23 | 佛山市南海东方澳龙制药有限公司 | 一种具有抗菌功能的动物香波及制备方法 |
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-
2014
- 2014-04-12 WO PCT/IB2014/060675 patent/WO2014167554A2/en not_active Ceased
- 2014-04-12 US US14/783,658 patent/US20160058775A1/en not_active Abandoned
- 2014-04-12 HK HK16108710.4A patent/HK1220624A1/zh unknown
- 2014-04-12 CN CN201480030144.XA patent/CN105263525A/zh active Pending
- 2014-04-12 EA EA201591954A patent/EA201591954A1/ru unknown
- 2014-04-12 JP JP2016507106A patent/JP6589086B2/ja not_active Expired - Fee Related
- 2014-04-12 EP EP14722767.2A patent/EP2983714A2/en not_active Withdrawn
- 2014-04-12 KR KR1020157031844A patent/KR101862448B1/ko not_active Expired - Fee Related
- 2014-04-12 AU AU2014252157A patent/AU2014252157B2/en not_active Ceased
-
2018
- 2018-11-01 JP JP2018206681A patent/JP2019031561A/ja active Pending
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