JP2016516719A5 - - Google Patents

Info

Publication number

JP2016516719A5

JP2016516719A5 JP2016502840A JP2016502840A JP2016516719A5 JP 2016516719 A5 JP2016516719 A5 JP 2016516719A5 JP 2016502840 A JP2016502840 A JP 2016502840A JP 2016502840 A JP2016502840 A JP 2016502840A JP 2016516719 A5 JP2016516719 A5 JP 2016516719A5

Authority

JP

Japan

Prior art keywords

arg

phe

cys

trp

cyclo

Prior art date

2014-03-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229920001184 polypeptide Polymers 0.000 claims 25
• 102000004196 processed proteins & peptides Human genes 0.000 claims 25
• 108090000765 processed proteins & peptides Proteins 0.000 claims 25
• 150000003839 salts Chemical class 0.000 claims 14
• 125000000539 amino acid group Chemical group 0.000 claims 10
• 150000001413 amino acids Chemical class 0.000 claims 9
• 125000003118 aryl group Chemical group 0.000 claims 7
• 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 6
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
• 125000001072 heteroaryl group Chemical group 0.000 claims 6
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
• XUJNEKJLAYXESH-UHFFFAOYSA-N Cysteine Chemical compound SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
• 101000978418 Homo sapiens Melanocortin receptor 4 Proteins 0.000 claims 3
• 102100023724 Melanocortin receptor 4 Human genes 0.000 claims 3
• 125000000217 alkyl group Chemical group 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 208000035475 disorder Diseases 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 125000006823 (C1-C6) acyl group Chemical group 0.000 claims 2
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
• COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims 2
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
• -1 R 34 Chemical compound 0.000 claims 2
• 150000001412 amines Chemical class 0.000 claims 2
• 125000004475 heteroaralkyl group Chemical group 0.000 claims 2
• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 2
• 125000001424 substituent group Chemical group 0.000 claims 2
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 150000008574 D-amino acids Chemical class 0.000 claims 1
• 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
• 206010057671 Female sexual dysfunction Diseases 0.000 claims 1
• 206010022489 Insulin Resistance Diseases 0.000 claims 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
• 125000003710 aryl alkyl group Chemical group 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 201000001881 impotence Diseases 0.000 claims 1
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1