RU2725150C2 - Пептидные композиции - Google Patents

Пептидные композиции Download PDF

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Publication number
RU2725150C2
RU2725150C2 RU2015145593A RU2015145593A RU2725150C2 RU 2725150 C2 RU2725150 C2 RU 2725150C2 RU 2015145593 A RU2015145593 A RU 2015145593A RU 2015145593 A RU2015145593 A RU 2015145593A RU 2725150 C2 RU2725150 C2 RU 2725150C2
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Russia
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arg
phe
cys
trp
ala
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RU2015145593A
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English (en)
Russian (ru)
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RU2015145593A (ru
Inventor
Шубх ШАРМА
ДЕР ПЛУГ Леонардус Х.Т. ВАН
Барт ХЕНДЕРСОН
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Ритм Фармасьютикалз, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68—Melanocyte-stimulating hormone [MSH]
    • C07K14/685—Alpha-melanotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
RU2015145593A 2013-03-15 2014-03-14 Пептидные композиции RU2725150C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361790469P 2013-03-15 2013-03-15
US61/790,469 2013-03-15
PCT/US2014/028590 WO2014144260A1 (en) 2013-03-15 2014-03-14 Peptide compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2020120797A Division RU2020120797A (ru) 2013-03-15 2014-03-14 Пептидные композиции

Publications (2)

Publication Number Publication Date
RU2015145593A RU2015145593A (ru) 2017-04-24
RU2725150C2 true RU2725150C2 (ru) 2020-06-30

Family

ID=50588892

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2015145593A RU2725150C2 (ru) 2013-03-15 2014-03-14 Пептидные композиции
RU2020120797A RU2020120797A (ru) 2013-03-15 2014-03-14 Пептидные композиции

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2020120797A RU2020120797A (ru) 2013-03-15 2014-03-14 Пептидные композиции

Country Status (10)

Country Link
US (4) US10196425B2 (enExample)
EP (2) EP2970388B1 (enExample)
JP (4) JP6622690B2 (enExample)
CN (3) CN118240012A (enExample)
AU (6) AU2014227712B2 (enExample)
CA (1) CA2906694A1 (enExample)
ES (1) ES2693761T3 (enExample)
RU (2) RU2725150C2 (enExample)
TR (1) TR201815173T4 (enExample)
WO (1) WO2014144260A1 (enExample)

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SMT202100734T1 (it) 2011-12-29 2022-03-21 Rhythm Pharmaceuticals Inc Metodo di trattamento di disturbi associati al recettore di melanocortina 4 in portatori eterozigoti
JP6538025B2 (ja) 2013-03-15 2019-07-03 リズム・ファーマシューティカルズ・インコーポレイテッド 医薬組成物
JP6622690B2 (ja) * 2013-03-15 2019-12-18 リズム・ファーマシューティカルズ・インコーポレイテッド ペプチド組成物
WO2016168388A2 (en) 2015-04-14 2016-10-20 Palatin Technologies, Inc. Therapies for obesity, diabetes and related indications
MX2018003983A (es) * 2015-09-30 2018-11-09 Rhythm Pharmaceuticals Inc Metodo de tratamiento de trastornos asociados a la via del receptor de melanocortina-4.
WO2018065345A1 (en) * 2016-10-04 2018-04-12 Dsm Ip Assets B.V. Melanocortin-1-receptor agonists
US20200223889A1 (en) * 2017-03-15 2020-07-16 Novo Nordisk A/S Bicyclic Compounds Capable of Binding to Melanocortin 4 Receptor
CA3096055A1 (en) 2018-04-06 2019-10-10 Rhythm Pharmaceuticals, Inc. Compositions for treating kidney disease
WO2020053414A1 (en) * 2018-09-14 2020-03-19 Novo Nordisk A/S Bicyclic compounds capable of acting as melanocortin 4 receptor agonists
JP2023542985A (ja) * 2020-09-24 2023-10-12 リズム ファーマシューティカルズ， インコーポレイテッド メラノコルチン－４受容体経路関連障害の治療方法
CN113209270B (zh) * 2021-05-17 2022-02-22 宁波大学 丙谷二肽在制备防治急性肝衰竭药物中的应用
CN113332416B (zh) * 2021-05-17 2022-02-22 宁波大学 丙谷二肽在制备治疗非酒精性脂肪肝药物中的应用
JP2024532294A (ja) * 2021-08-24 2024-09-05 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Ｍｃ４ｒアゴニストペプチド
CN116789802A (zh) * 2023-06-25 2023-09-22 湖北省农业科学院畜牧兽医研究所 一种山羊mc4r增强型突变体及其应用
WO2025131101A1 (zh) * 2023-12-22 2025-06-26 上海多米瑞生物技术有限公司 多肽化合物、其药物组合物及其用途

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WO2003006620A2 (en) * 2001-07-11 2003-01-23 Palatin Technologies, Inc. Linear and cyclic melanocortin receptor-specific peptides
WO2005014617A2 (en) * 2003-08-08 2005-02-17 Palatin Technologies, Inc. Cyclic peptide compositions and methods for treatment of sexual dysfunction
EA200600055A1 (ru) * 2003-06-19 2006-08-25 Эли Лилли Энд Компани Агонисты рецептора меланокортина 4 (мк4 ) и их применение
WO2007008704A2 (en) * 2005-07-08 2007-01-18 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Melanocortin receptor ligands
WO2009151383A1 (en) * 2008-06-09 2009-12-17 Palatin Technologies, Inc. Melanocortin receptor-specific peptides for the treatment of obesity and other diseases associated with melanocortin receptor function
WO2010144038A1 (en) * 2009-06-08 2010-12-16 Astrazeneca Ab Melanocortin receptor-specific peptides
WO2010144344A2 (en) * 2009-06-08 2010-12-16 Palatin Technologies, Inc. Melanocortin receptor-specific peptides

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WO2009151383A1 (en) * 2008-06-09 2009-12-17 Palatin Technologies, Inc. Melanocortin receptor-specific peptides for the treatment of obesity and other diseases associated with melanocortin receptor function
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AL-OBEIDI F ET AL, "POTENT AND PROLONGED ACTING CYCLIC LACTAM ANALOGUES OF ALPHA MELANOTROPIN DESIGN BASED ON MOLECULAR DYNAMICS", JOURNAL OF MEDICINAL CHEMISTRY, 1989, vol. 32, no. 12, pages 2555 - 2561. BEDNAREK M A ET AL, "ANALOGS OF MTII, LACTAM DERIVATIVES OF ALPHA-MELANOTROPIN, MODIFIED AT THE N-TERMINUS, AND THEIR SELECTIVITY AT HUMAN MELANOCORTIN RECEPTORS 3, 4, AND 5", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, vol. 261, no. 1, pages 209 - 213. BEDNAREK M A ET AL, "Structure-function studies on the cyclic peptide MT-II, lactam derivative of alpha-melanotropin", PEPTIDES, 1999, vol. 20, no. 3, pages 401 - 409. PAOLO GRIECO ET AL, "Structure-Activity Studies of the Melanocortin Peptides: Discovery of Potent and Selective Affinity Antagonists for the h MC3 and h MC4 Receptors +", JOURNAL OF MEDICINAL CHEMISTRY, 2002vol. 45, no. 24, pages 5287 - 5294. GRIECO ET AL, "Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: Their activity and s *
BEDNAREK M A ET AL, "ANALOGS OF MTII, LACTAM DERIVATIVES OF ALPHA-MELANOTROPIN, MODIFIED AT THE N-TERMINUS, AND THEIR SELECTIVITY AT HUMAN MELANOCORTIN RECEPTORS 3, 4, AND 5", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, vol. 261, no. 1, pages 209 - 213. *
BEDNAREK M A ET AL, "Structure-function studies on the cyclic peptide MT-II, lactam derivative of alpha-melanotropin", PEPTIDES, 1999, vol. 20, no. 3, pages 401 - 409. *
GRIECO ET AL, "Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: Their activity and selectivity at human melanocortin receptors 3, 4, and 5", PEPTIDES, 2007, vol. 28, no. 6, pages 1191 - 1196. *
PAOLO GRIECO ET AL, "Structure-Activity Studies of the Melanocortin Peptides: Discovery of Potent and Selective Affinity Antagonists for the h MC3 and h MC4 Receptors +", JOURNAL OF MEDICINAL CHEMISTRY, 2002vol. 45, no. 24, pages 5287 - 5294 *

Also Published As

Publication number Publication date
JP7654587B2 (ja) 2025-04-01
EP2970388B1 (en) 2018-07-25
CA2906694A1 (en) 2014-09-18
AU2014227712A1 (en) 2015-10-01
US10858399B2 (en) 2020-12-08
EP2970388A1 (en) 2016-01-20
CN118271400A (zh) 2024-07-02
JP6622690B2 (ja) 2019-12-18
JP2016516719A (ja) 2016-06-09
US20190092815A1 (en) 2019-03-28
AU2021269411A1 (en) 2021-12-16
TR201815173T4 (tr) 2018-11-21
AU2024200528A1 (en) 2024-02-15
AU2026204118A1 (en) 2026-06-11
CN105492456B (zh) 2024-11-01
EP3450449A3 (en) 2019-06-12
RU2020120797A (ru) 2020-07-02
AU2018256493A1 (en) 2018-11-22
US20210040155A1 (en) 2021-02-11
JP2019172693A (ja) 2019-10-10
AU2020203353A1 (en) 2020-06-11
US10196425B2 (en) 2019-02-05
CN118240012A (zh) 2024-06-25
JP7046871B2 (ja) 2022-04-04
US20250188124A1 (en) 2025-06-12
CN105492456A (zh) 2016-04-13
US12077612B2 (en) 2024-09-03
ES2693761T3 (es) 2018-12-13
RU2015145593A (ru) 2017-04-24
US20160017001A1 (en) 2016-01-21
EP3450449A2 (en) 2019-03-06
AU2014227712B2 (en) 2018-08-02
JP2025102830A (ja) 2025-07-08
HK1220697A1 (en) 2017-05-12
JP2022084844A (ja) 2022-06-07
WO2014144260A1 (en) 2014-09-18

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