RU2725150C2 - Пептидные композиции - Google Patents

Пептидные композиции Download PDF

Info

Publication number
RU2725150C2
RU2725150C2 RU2015145593A RU2015145593A RU2725150C2 RU 2725150 C2 RU2725150 C2 RU 2725150C2 RU 2015145593 A RU2015145593 A RU 2015145593A RU 2015145593 A RU2015145593 A RU 2015145593A RU 2725150 C2 RU2725150 C2 RU 2725150C2
Authority
RU
Russia
Prior art keywords
arg
phe
cys
trp
ala
Prior art date
Application number
RU2015145593A
Other languages
English (en)
Russian (ru)
Other versions
RU2015145593A (ru
Inventor
Шубх ШАРМА
ДЕР ПЛУГ Леонардус Х.Т. ВАН
Барт ХЕНДЕРСОН
Original Assignee
Ритм Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ритм Фармасьютикалз, Инк. filed Critical Ритм Фармасьютикалз, Инк.
Publication of RU2015145593A publication Critical patent/RU2015145593A/ru
Application granted granted Critical
Publication of RU2725150C2 publication Critical patent/RU2725150C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68—Melanocyte-stimulating hormone [MSH]
    • C07K14/685—Alpha-melanotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
RU2015145593A 2013-03-15 2014-03-14 Пептидные композиции RU2725150C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361790469P 2013-03-15 2013-03-15
US61/790,469 2013-03-15
PCT/US2014/028590 WO2014144260A1 (en) 2013-03-15 2014-03-14 Peptide compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2020120797A Division RU2020120797A (ru) 2013-03-15 2014-03-14 Пептидные композиции

Publications (2)

Publication Number Publication Date
RU2015145593A RU2015145593A (ru) 2017-04-24
RU2725150C2 true RU2725150C2 (ru) 2020-06-30

Family

ID=50588892

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2015145593A RU2725150C2 (ru) 2013-03-15 2014-03-14 Пептидные композиции
RU2020120797A RU2020120797A (ru) 2013-03-15 2014-03-14 Пептидные композиции

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2020120797A RU2020120797A (ru) 2013-03-15 2014-03-14 Пептидные композиции

Country Status (10)

Country Link
US (4) US10196425B2 (enExample)
EP (2) EP3450449A3 (enExample)
JP (4) JP6622690B2 (enExample)
CN (3) CN118271400A (enExample)
AU (5) AU2014227712B2 (enExample)
CA (1) CA2906694A1 (enExample)
ES (1) ES2693761T3 (enExample)
RU (2) RU2725150C2 (enExample)
TR (1) TR201815173T4 (enExample)
WO (1) WO2014144260A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3539551T3 (pl) 2011-12-29 2022-02-21 Rhythm Pharmaceuticals, Inc. Sposób leczenia zaburzeń związanych z receptorem melanokortyny 4 u heterozygotycznych nosicieli
EP2970389B1 (en) 2013-03-15 2020-08-19 Rhythm Pharmaceuticals, Inc. Pharmaceutical compositions
AU2014227712B2 (en) 2013-03-15 2018-08-02 Rhythm Pharmaceuticals, Inc. Peptide compositions
WO2016168388A2 (en) 2015-04-14 2016-10-20 Palatin Technologies, Inc. Therapies for obesity, diabetes and related indications
FI3356386T3 (fi) * 2015-09-30 2024-05-16 Rhythm Pharmaceuticals Inc Melanokortiini-4-reseptoripolkuun liittyvien häiriöiden hoitamismenetelmä
US11591367B2 (en) * 2016-10-04 2023-02-28 Dsm Ip Assets B.V. Melanocortin-1-receptor agonists
WO2018167194A1 (en) * 2017-03-15 2018-09-20 Novo Nordisk A/S Bicyclic compounds capable of binding to melanocortin 4 receptor
CA3096055A1 (en) 2018-04-06 2019-10-10 Rhythm Pharmaceuticals, Inc. Compositions for treating kidney disease
WO2020053414A1 (en) * 2018-09-14 2020-03-19 Novo Nordisk A/S Bicyclic compounds capable of acting as melanocortin 4 receptor agonists
TW202228760A (zh) * 2020-09-24 2022-08-01 美商律森製藥股份有限公司 治療黑素皮質素-4受體路徑相關病症之方法
CN113209270B (zh) * 2021-05-17 2022-02-22 宁波大学 丙谷二肽在制备防治急性肝衰竭药物中的应用
CN113332416B (zh) * 2021-05-17 2022-02-22 宁波大学 丙谷二肽在制备治疗非酒精性脂肪肝药物中的应用
CN116789802A (zh) * 2023-06-25 2023-09-22 湖北省农业科学院畜牧兽医研究所 一种山羊mc4r增强型突变体及其应用
CN120192363A (zh) * 2023-12-22 2025-06-24 上海多米瑞生物技术有限公司 多肽化合物、其药物组合物及其用途

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5731408A (en) * 1995-04-10 1998-03-24 Arizona Board Of Regents On Behalf Of The University Of Arizona Peptides having potent antagonist and agonist bioactivities at melanocortin receptors
WO2003006620A2 (en) * 2001-07-11 2003-01-23 Palatin Technologies, Inc. Linear and cyclic melanocortin receptor-specific peptides
WO2005014617A2 (en) * 2003-08-08 2005-02-17 Palatin Technologies, Inc. Cyclic peptide compositions and methods for treatment of sexual dysfunction
EA200600055A1 (ru) * 2003-06-19 2006-08-25 Эли Лилли Энд Компани Агонисты рецептора меланокортина 4 (мк4 ) и их применение
WO2007008704A2 (en) * 2005-07-08 2007-01-18 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Melanocortin receptor ligands
WO2009151383A1 (en) * 2008-06-09 2009-12-17 Palatin Technologies, Inc. Melanocortin receptor-specific peptides for the treatment of obesity and other diseases associated with melanocortin receptor function
WO2010144344A2 (en) * 2009-06-08 2010-12-16 Palatin Technologies, Inc. Melanocortin receptor-specific peptides
WO2010144038A1 (en) * 2009-06-08 2010-12-16 Astrazeneca Ab Melanocortin receptor-specific peptides

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3851002T2 (de) * 1987-05-22 1995-02-02 University Patents, Inc., Westport, Conn. Lineare und zyklische Analoge von alpha-MSH-Fragmenten mit ausserordentlicher Wirkung.
GB9827500D0 (en) * 1998-12-14 1999-02-10 Wapharm Ab Compounds for control of eating, growth and body weight
EP1315750B1 (en) * 2000-08-30 2007-02-14 F. Hoffmann-La Roche Ag Cyclic peptides having melanocortin-4 receptor agonist activity
US7345144B2 (en) * 2001-07-11 2008-03-18 Palatin Technologies, Inc. Cyclic peptides for treatment of cachexia
US7342089B2 (en) * 2001-07-11 2008-03-11 Palatin Technologies, Inc. Cyclic peptides for treatment for cachexia
US7034004B2 (en) * 2002-05-07 2006-04-25 University Of Florida Peptides and methods for the control of obesity
FR2851563B1 (fr) 2003-02-26 2005-04-22 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament
FR2852957B1 (fr) 2003-03-31 2005-06-10 Sod Conseils Rech Applic Nouveaux derives d'imidazo-pyridine et leur utilisation en tant que medicament
JP2006527772A (ja) * 2003-06-19 2006-12-07 イーライ リリー アンド カンパニー メラノコルチン３受容体（ｍｃ３ｒ）作用薬ペプチドの用途
FR2862971B1 (fr) 2003-11-28 2006-03-24 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament
US8343031B2 (en) * 2004-03-23 2013-01-01 Michael Gertner Obesity treatment systems
FR2872165B1 (fr) 2004-06-24 2006-09-22 Sod Conseils Rech Applic Nouveaux derives de pyrimido-benzimidazole
WO2007008684A2 (en) 2005-07-08 2007-01-18 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Ligands of melanocortin receptors
RU2450017C2 (ru) 2007-05-25 2012-05-10 Ипсен Фарма С.А.С. Лиганды меланокортиновых рецепторов, модифицированные гидантоином
WO2008156677A2 (en) 2007-06-15 2008-12-24 Ipsen Pharma S.A.S. Cyclic peptide melanocortin receptor ligands
CN103316345B (zh) 2007-11-05 2016-05-18 益普生制药股份有限公司 黑皮质素治疗胰岛素敏感的应用
AU2010279719A1 (en) * 2009-08-05 2012-03-01 Ipsen Pharma S.A.S. Use of melanocortins to treat dyslipidemia
RU2012125033A (ru) 2009-11-16 2014-01-20 Ипсен Фарма С.А.С. СПОСОБ СИНТЕЗА Ас-Arg-ЦИКЛО(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2
CN102665401A (zh) 2009-11-16 2012-09-12 益普生制药股份有限公司 黑皮质素受体配体的药物组合物
BR112013027222B1 (pt) 2011-06-14 2022-07-12 Ipsen Pharma S.A.S. Composição de liberação sustentada que contém peptídeos como ingrediente ativo
EP2705835A1 (en) 2012-06-08 2014-03-12 Ipsen Pharma S.A.S. Aqueous gelling compositions of soluble active pharmaceutical peptides providing modified release
EP2970389B1 (en) * 2013-03-15 2020-08-19 Rhythm Pharmaceuticals, Inc. Pharmaceutical compositions
AU2014227712B2 (en) 2013-03-15 2018-08-02 Rhythm Pharmaceuticals, Inc. Peptide compositions

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5731408A (en) * 1995-04-10 1998-03-24 Arizona Board Of Regents On Behalf Of The University Of Arizona Peptides having potent antagonist and agonist bioactivities at melanocortin receptors
WO2003006620A2 (en) * 2001-07-11 2003-01-23 Palatin Technologies, Inc. Linear and cyclic melanocortin receptor-specific peptides
EA200600055A1 (ru) * 2003-06-19 2006-08-25 Эли Лилли Энд Компани Агонисты рецептора меланокортина 4 (мк4 ) и их применение
WO2005014617A2 (en) * 2003-08-08 2005-02-17 Palatin Technologies, Inc. Cyclic peptide compositions and methods for treatment of sexual dysfunction
WO2007008704A2 (en) * 2005-07-08 2007-01-18 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Melanocortin receptor ligands
WO2009151383A1 (en) * 2008-06-09 2009-12-17 Palatin Technologies, Inc. Melanocortin receptor-specific peptides for the treatment of obesity and other diseases associated with melanocortin receptor function
WO2010144344A2 (en) * 2009-06-08 2010-12-16 Palatin Technologies, Inc. Melanocortin receptor-specific peptides
WO2010144038A1 (en) * 2009-06-08 2010-12-16 Astrazeneca Ab Melanocortin receptor-specific peptides

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AL-OBEIDI F ET AL, "POTENT AND PROLONGED ACTING CYCLIC LACTAM ANALOGUES OF ALPHA MELANOTROPIN DESIGN BASED ON MOLECULAR DYNAMICS", JOURNAL OF MEDICINAL CHEMISTRY, 1989, vol. 32, no. 12, pages 2555 - 2561 *
AL-OBEIDI F ET AL, "POTENT AND PROLONGED ACTING CYCLIC LACTAM ANALOGUES OF ALPHA MELANOTROPIN DESIGN BASED ON MOLECULAR DYNAMICS", JOURNAL OF MEDICINAL CHEMISTRY, 1989, vol. 32, no. 12, pages 2555 - 2561. BEDNAREK M A ET AL, "ANALOGS OF MTII, LACTAM DERIVATIVES OF ALPHA-MELANOTROPIN, MODIFIED AT THE N-TERMINUS, AND THEIR SELECTIVITY AT HUMAN MELANOCORTIN RECEPTORS 3, 4, AND 5", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, vol. 261, no. 1, pages 209 - 213. BEDNAREK M A ET AL, "Structure-function studies on the cyclic peptide MT-II, lactam derivative of alpha-melanotropin", PEPTIDES, 1999, vol. 20, no. 3, pages 401 - 409. PAOLO GRIECO ET AL, "Structure-Activity Studies of the Melanocortin Peptides: Discovery of Potent and Selective Affinity Antagonists for the h MC3 and h MC4 Receptors +", JOURNAL OF MEDICINAL CHEMISTRY, 2002vol. 45, no. 24, pages 5287 - 5294. GRIECO ET AL, "Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: Their activity and s *
BEDNAREK M A ET AL, "ANALOGS OF MTII, LACTAM DERIVATIVES OF ALPHA-MELANOTROPIN, MODIFIED AT THE N-TERMINUS, AND THEIR SELECTIVITY AT HUMAN MELANOCORTIN RECEPTORS 3, 4, AND 5", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, vol. 261, no. 1, pages 209 - 213. *
BEDNAREK M A ET AL, "Structure-function studies on the cyclic peptide MT-II, lactam derivative of alpha-melanotropin", PEPTIDES, 1999, vol. 20, no. 3, pages 401 - 409. *
GRIECO ET AL, "Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: Their activity and selectivity at human melanocortin receptors 3, 4, and 5", PEPTIDES, 2007, vol. 28, no. 6, pages 1191 - 1196. *
PAOLO GRIECO ET AL, "Structure-Activity Studies of the Melanocortin Peptides: Discovery of Potent and Selective Affinity Antagonists for the h MC3 and h MC4 Receptors +", JOURNAL OF MEDICINAL CHEMISTRY, 2002vol. 45, no. 24, pages 5287 - 5294 *

Also Published As

Publication number Publication date
EP3450449A3 (en) 2019-06-12
AU2024200528A1 (en) 2024-02-15
HK1220697A1 (en) 2017-05-12
US20210040155A1 (en) 2021-02-11
AU2014227712A1 (en) 2015-10-01
JP2016516719A (ja) 2016-06-09
EP2970388A1 (en) 2016-01-20
RU2020120797A (ru) 2020-07-02
JP2025102830A (ja) 2025-07-08
CN105492456B (zh) 2024-11-01
US20160017001A1 (en) 2016-01-21
US20250188124A1 (en) 2025-06-12
US20190092815A1 (en) 2019-03-28
AU2021269411A1 (en) 2021-12-16
EP3450449A2 (en) 2019-03-06
US10858399B2 (en) 2020-12-08
CN105492456A (zh) 2016-04-13
AU2018256493A1 (en) 2018-11-22
JP2019172693A (ja) 2019-10-10
US10196425B2 (en) 2019-02-05
US12077612B2 (en) 2024-09-03
JP6622690B2 (ja) 2019-12-18
ES2693761T3 (es) 2018-12-13
TR201815173T4 (tr) 2018-11-21
AU2014227712B2 (en) 2018-08-02
CA2906694A1 (en) 2014-09-18
JP7654587B2 (ja) 2025-04-01
AU2020203353A1 (en) 2020-06-11
CN118240012A (zh) 2024-06-25
CN118271400A (zh) 2024-07-02
EP2970388B1 (en) 2018-07-25
WO2014144260A1 (en) 2014-09-18
JP7046871B2 (ja) 2022-04-04
JP2022084844A (ja) 2022-06-07
RU2015145593A (ru) 2017-04-24

Similar Documents

Publication Publication Date Title
RU2725150C2 (ru) Пептидные композиции
RU2690377C2 (ru) Фармацевтические композиции
HK40006194A (en) Peptide compositions
HK1220697B (en) Peptide compositions
HK40046859A (en) Pharmaceutical compositions