JP2016515536A5 - - Google Patents
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- Publication number
- JP2016515536A5 JP2016515536A5 JP2016503448A JP2016503448A JP2016515536A5 JP 2016515536 A5 JP2016515536 A5 JP 2016515536A5 JP 2016503448 A JP2016503448 A JP 2016503448A JP 2016503448 A JP2016503448 A JP 2016503448A JP 2016515536 A5 JP2016515536 A5 JP 2016515536A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- substituted
- unsubstituted
- ethoxycarbonylamino
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- -1 R C is —F Chemical group 0.000 claims 5
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 125000002993 cycloalkylene group Chemical group 0.000 claims 3
- FMNGLFKMWOZMJZ-MZNJEOGPSA-N (2r)-3-(4-bromophenyl)-2-[[4-[4-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]benzoyl]amino]propanoic acid Chemical compound C([C@@H](NC(=O)C1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C(=CC=CC=1)Cl)C(O)=O)C1=CC=C(Br)C=C1 FMNGLFKMWOZMJZ-MZNJEOGPSA-N 0.000 claims 2
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 2
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 2
- 150000000022 5-membered heteroarenes Chemical class 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- DNTASSMVWDKGEL-KBMIEXCESA-N (2r)-2-[[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]methylamino]-3-[4-(trifluoromethyl)phenyl]propanoic acid Chemical compound C([C@@H](NCC1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C=CC=CC=1)C(O)=O)C1=CC=C(C(F)(F)F)C=C1 DNTASSMVWDKGEL-KBMIEXCESA-N 0.000 claims 1
- DVQWHRUNKRFWKU-CJFMBICVSA-N (2r)-2-[[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]methylamino]-3-phenylpropanoic acid Chemical compound C([C@@H](NCC1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 DVQWHRUNKRFWKU-CJFMBICVSA-N 0.000 claims 1
- ITTQHEXJRGBDRV-MZNJEOGPSA-N (2r)-2-[[4-[4-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]benzoyl]amino]-3-(2-fluorophenyl)propanoic acid Chemical compound C([C@@H](NC(=O)C1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C(=CC=CC=1)Cl)C(O)=O)C1=CC=CC=C1F ITTQHEXJRGBDRV-MZNJEOGPSA-N 0.000 claims 1
- SQFCAGDNKYIPQF-VOIUYBSRSA-N (2r)-2-[[4-[4-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]benzoyl]amino]-3-(3,4-difluorophenyl)propanoic acid Chemical compound C([C@@H](NC(=O)C1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C(=CC=CC=1)Cl)C(O)=O)C1=CC=C(F)C(F)=C1 SQFCAGDNKYIPQF-VOIUYBSRSA-N 0.000 claims 1
- BIWJMEMDKAXHNL-MZNJEOGPSA-N (2r)-2-[[4-[4-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]benzoyl]amino]-3-(4-fluorophenyl)propanoic acid Chemical compound C([C@@H](NC(=O)C1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C(=CC=CC=1)Cl)C(O)=O)C1=CC=C(F)C=C1 BIWJMEMDKAXHNL-MZNJEOGPSA-N 0.000 claims 1
- FVGWGHOSJIRUFY-KBMIEXCESA-N (2r)-2-[[4-[4-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]benzoyl]amino]-3-(4-methylphenyl)propanoic acid Chemical compound C([C@@H](NC(=O)C1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C(=CC=CC=1)Cl)C(O)=O)C1=CC=C(C)C=C1 FVGWGHOSJIRUFY-KBMIEXCESA-N 0.000 claims 1
- JEACLEXWCNRNKN-HOYKHHGWSA-N (2r)-2-[[4-[4-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]benzoyl]amino]-3-phenylpropanoic acid Chemical compound C([C@@H](NC(=O)C1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C(=CC=CC=1)Cl)C(O)=O)C1=CC=CC=C1 JEACLEXWCNRNKN-HOYKHHGWSA-N 0.000 claims 1
- XCLWZCYDJNBLCW-IQGLISFBSA-N (2r)-2-[[4-[4-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]phenyl]methylamino]-3-[4-(trifluoromethyl)phenyl]propanoic acid Chemical compound C([C@@H](NCC1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C(=CC=CC=1)Cl)C(O)=O)C1=CC=C(C(F)(F)F)C=C1 XCLWZCYDJNBLCW-IQGLISFBSA-N 0.000 claims 1
- FXGHIICVGOZMMB-OPAMFIHVSA-N (2r)-2-[[4-[4-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]phenyl]methylamino]-3-cyclopropylpropanoic acid Chemical compound C([C@@H](NCC1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C(=CC=CC=1)Cl)C(O)=O)C1CC1 FXGHIICVGOZMMB-OPAMFIHVSA-N 0.000 claims 1
- WBYQMFJYFSEDBU-KBMIEXCESA-N (2r)-2-[[4-[4-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]phenyl]methylamino]-3-phenylpropanoic acid Chemical compound C([C@@H](NCC1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C(=CC=CC=1)Cl)C(O)=O)C1=CC=CC=C1 WBYQMFJYFSEDBU-KBMIEXCESA-N 0.000 claims 1
- ARXHIRFXSXLYHD-KBMIEXCESA-N (2r)-3-(2-chlorophenyl)-2-[[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]methylamino]propanoic acid Chemical compound C([C@@H](NCC1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1Cl ARXHIRFXSXLYHD-KBMIEXCESA-N 0.000 claims 1
- ZAJATRVMUICHSW-MZNJEOGPSA-N (2r)-3-(2-chlorophenyl)-2-[[4-[4-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]benzoyl]amino]propanoic acid Chemical compound C([C@@H](NC(=O)C1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C(=CC=CC=1)Cl)C(O)=O)C1=CC=CC=C1Cl ZAJATRVMUICHSW-MZNJEOGPSA-N 0.000 claims 1
- XPFZMUSJNQAECK-IQGLISFBSA-N (2r)-3-(2-chlorophenyl)-2-[[4-[4-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]phenyl]methylamino]propanoic acid Chemical compound C([C@@H](NCC1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C(=CC=CC=1)Cl)C(O)=O)C1=CC=CC=C1Cl XPFZMUSJNQAECK-IQGLISFBSA-N 0.000 claims 1
- IMIXACYBJVVYOY-KBMIEXCESA-N (2r)-3-(2-fluorophenyl)-2-[[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]methylamino]propanoic acid Chemical compound C([C@@H](NCC1=CC=C(C=C1)C=1ON=C(C)C=1NC(=O)O[C@H](C)C=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1F IMIXACYBJVVYOY-KBMIEXCESA-N 0.000 claims 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- BYOMTTIAEXZFDJ-MRXNPFEDSA-N 1-[4-[4-[5-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-4-fluoropyrazol-1-yl]phenyl]-2-fluorophenyl]cyclopropane-1-carboxylic acid Chemical compound O([C@H](C)C=1C(=CC=CC=1)Cl)C(=O)NC1=C(F)C=NN1C(C=C1)=CC=C1C(C=C1F)=CC=C1C1(C(O)=O)CC1 BYOMTTIAEXZFDJ-MRXNPFEDSA-N 0.000 claims 1
- XVNWTGXJZLFDKA-MRXNPFEDSA-N 1-[4-[4-[5-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-4-fluoropyrazol-1-yl]phenyl]-3-fluorophenyl]cyclopropane-1-carboxylic acid Chemical compound O([C@H](C)C=1C(=CC=CC=1)Cl)C(=O)NC1=C(F)C=NN1C(C=C1)=CC=C1C(C(=C1)F)=CC=C1C1(C(O)=O)CC1 XVNWTGXJZLFDKA-MRXNPFEDSA-N 0.000 claims 1
- LGXDKSKWIVKEQA-GOSISDBHSA-N 1-[4-[4-[5-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-4-fluoropyrazol-1-yl]phenyl]-3-methylphenyl]cyclopropane-1-carboxylic acid Chemical compound O([C@H](C)C=1C(=CC=CC=1)Cl)C(=O)NC1=C(F)C=NN1C(C=C1)=CC=C1C(C(=C1)C)=CC=C1C1(C(O)=O)CC1 LGXDKSKWIVKEQA-GOSISDBHSA-N 0.000 claims 1
- KGBNHXHOPVUASI-QGZVFWFLSA-N 1-[4-[4-[5-[[(1r)-1-(2-chlorophenyl)ethoxy]carbonylamino]-4-fluoropyrazol-1-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid Chemical compound O([C@H](C)C=1C(=CC=CC=1)Cl)C(=O)NC1=C(F)C=NN1C(C=C1)=CC=C1C(C=C1)=CC=C1C1(C(O)=O)CC1 KGBNHXHOPVUASI-QGZVFWFLSA-N 0.000 claims 1
- NXDMYFBKUGPDMK-GOSISDBHSA-N 1-[4-[4-[5-[[(1r)-1-phenylethoxy]carbonylamino]-4-(trifluoromethyl)pyrazol-1-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid Chemical compound O([C@H](C)C=1C=CC=CC=1)C(=O)NC1=C(C(F)(F)F)C=NN1C(C=C1)=CC=C1C(C=C1)=CC=C1C1(C(O)=O)CC1 NXDMYFBKUGPDMK-GOSISDBHSA-N 0.000 claims 1
- ZMBYEYYGLMMXFD-VGOKPJQXSA-N 2-[[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]methoxy]-3-phenylpropanoic acid Chemical compound O([C@H](C)C=1C=CC=CC=1)C(=O)NC=1C(C)=NOC=1C(C=C1)=CC=C1COC(C(O)=O)CC1=CC=CC=C1 ZMBYEYYGLMMXFD-VGOKPJQXSA-N 0.000 claims 1
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 1
- BBDSWHRPUYCMKX-PLEWWHCXSA-N 3-cyclopropyl-2-[[4-[3-methyl-4-[[(1r)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]methoxy]propanoic acid Chemical compound O([C@H](C)C=1C=CC=CC=1)C(=O)NC=1C(C)=NOC=1C(C=C1)=CC=C1COC(C(O)=O)CC1CC1 BBDSWHRPUYCMKX-PLEWWHCXSA-N 0.000 claims 1
- 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- YMGUBTXCNDTFJI-UHFFFAOYSA-N cyclopropanecarboxylic acid Chemical compound OC(=O)C1CC1 YMGUBTXCNDTFJI-UHFFFAOYSA-N 0.000 claims 1
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000004304 oxazol-5-yl group Chemical group O1C=NC=C1* 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361801231P | 2013-03-15 | 2013-03-15 | |
| US201361801426P | 2013-03-15 | 2013-03-15 | |
| US61/801,231 | 2013-03-15 | ||
| US61/801,426 | 2013-03-15 | ||
| US201361827409P | 2013-05-24 | 2013-05-24 | |
| US61/827,409 | 2013-05-24 | ||
| PCT/US2014/030712 WO2014145873A2 (en) | 2013-03-15 | 2014-03-17 | Heterocyclic compounds useful in the treatment of disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019020553A Division JP6843903B2 (ja) | 2013-03-15 | 2019-02-07 | 疾患の治療に有用な複素環化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016515536A JP2016515536A (ja) | 2016-05-30 |
| JP2016515536A5 true JP2016515536A5 (https=) | 2017-04-20 |
| JP6482086B2 JP6482086B2 (ja) | 2019-03-13 |
Family
ID=51538557
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503448A Active JP6482086B2 (ja) | 2013-03-15 | 2014-03-17 | 疾患の治療に有用な複素環化合物 |
| JP2019020553A Active JP6843903B2 (ja) | 2013-03-15 | 2019-02-07 | 疾患の治療に有用な複素環化合物 |
| JP2024059851A Active JP7754979B2 (ja) | 2013-03-15 | 2024-04-03 | 疾患の治療に有用な複素環化合物 |
| JP2025166007A Pending JP2026004456A (ja) | 2013-03-15 | 2025-10-02 | 疾患の治療に有用な複素環化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019020553A Active JP6843903B2 (ja) | 2013-03-15 | 2019-02-07 | 疾患の治療に有用な複素環化合物 |
| JP2024059851A Active JP7754979B2 (ja) | 2013-03-15 | 2024-04-03 | 疾患の治療に有用な複素環化合物 |
| JP2025166007A Pending JP2026004456A (ja) | 2013-03-15 | 2025-10-02 | 疾患の治療に有用な複素環化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US10000459B2 (https=) |
| EP (1) | EP2988743B1 (https=) |
| JP (4) | JP6482086B2 (https=) |
| KR (1) | KR102090231B1 (https=) |
| CN (3) | CN105142635B (https=) |
| AU (3) | AU2014232383B2 (https=) |
| BR (2) | BR112015023267B1 (https=) |
| CA (1) | CA2906931C (https=) |
| DK (1) | DK2988743T3 (https=) |
| EA (1) | EA033923B1 (https=) |
| ES (1) | ES2855173T3 (https=) |
| MX (3) | MX382748B (https=) |
| PT (1) | PT2988743T (https=) |
| SG (3) | SG11201507459YA (https=) |
| WO (1) | WO2014145873A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2988743T3 (da) * | 2013-03-15 | 2021-03-01 | Epigen Biosciences Inc | Heterocykliske forbindelser, der kan anvendes til behandling af sygdom |
| KR20180082564A (ko) * | 2015-11-20 | 2018-07-18 | 우베 고산 가부시키가이샤 | Nash의 치료 또는 예방을 위한 의약 조성물 |
| KR102292989B1 (ko) * | 2017-03-29 | 2021-08-26 | 재단법인 아산사회복지재단 | S1pr4를 타겟으로 하는 비알코올성 지방간염 예방 또는 치료용 조성물 |
| JP7212047B2 (ja) * | 2017-12-19 | 2023-01-24 | ブリストル－マイヤーズ スクイブ カンパニー | Ｌｐａアンタゴニストとしてのシクロヘキシル酸ピラゾールアゾール |
| EP3728209B1 (en) * | 2017-12-19 | 2025-12-24 | Bristol-Myers Squibb Company | Cyclohexyl acid isoxazole azines as lpa antagonists |
| US11180488B2 (en) | 2017-12-19 | 2021-11-23 | Bristol-Myers Squibb Company | Isoxazole o-linked carbamoyl cyclohexyl acids as LPA antagonists |
| WO2019126089A1 (en) * | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Cyclohexyl acid pyrazole azines as lpa antagonists |
| KR102756639B1 (ko) * | 2017-12-19 | 2025-01-16 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 시클로헥실 산 이속사졸 아졸 |
| CN112041302B (zh) * | 2017-12-19 | 2024-11-19 | 百时美施贵宝公司 | 作为lpa拮抗剂的吡唑o-连接的氨基甲酰基环己基酸 |
| CN111699180B (zh) * | 2017-12-19 | 2024-11-29 | 百时美施贵宝公司 | 作为lpa拮抗剂的吡唑n-连接的氨基甲酰基环己基酸 |
| EP4011875A1 (en) | 2017-12-19 | 2022-06-15 | Bristol-Myers Squibb Company | Triazole n-linked carbamoyl cyclohexyl acids as lpa antagonists |
| US11447475B2 (en) | 2017-12-19 | 2022-09-20 | Bristol-Myers Squibb Company | Isoxazole N-linked carbamoyl cyclohexyl acids as LPA antagonists |
| KR102831570B1 (ko) | 2018-05-04 | 2025-07-10 | 레미디 플랜, 인크. | 암 줄기 세포를 표적화하는 암 치료 |
| CA3046894A1 (en) * | 2018-06-18 | 2019-12-18 | Epigen Biosciences, Inc. | Heterocyclic compounds useful in the treatment of disease |
| KR102788997B1 (ko) | 2018-09-18 | 2025-03-28 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 옥사비시클로 산 |
| ES2946657T3 (es) | 2018-09-18 | 2023-07-24 | Bristol Myers Squibb Co | Acidos ciclopentílicos como antagonistas de LPA |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| IL322315A (en) | 2019-05-14 | 2025-09-01 | Provention Bio Inc | Methods and preparations for preventing type 1 diabetes |
| WO2021076961A1 (en) * | 2019-10-16 | 2021-04-22 | University Of South Florida | Compositions and methods of treatment for inhibiting capillary tube regression |
| AU2020384883B2 (en) | 2019-11-15 | 2023-11-16 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof |
| CN115867556B (zh) | 2020-06-03 | 2025-05-06 | 吉利德科学公司 | Lpa受体拮抗剂及其用途 |
| TWI843503B (zh) | 2020-06-03 | 2024-05-21 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| AU2021287998B2 (en) | 2020-06-11 | 2026-03-12 | Benaroya Research Institute At Virginia Mason | Methods and compositions for preventing type 1 diabetes |
| US12383547B2 (en) | 2020-07-01 | 2025-08-12 | Vanderbilt University | Methods of treatment for a kidney disease |
| WO2022013378A1 (en) * | 2020-07-16 | 2022-01-20 | Chiesi Farmaceutici S.P.A. | Amido cyclohexane acid derivatives as lpa receptor inhibitors |
| EP4196220A1 (en) * | 2020-08-11 | 2023-06-21 | Viva Star Biosciences Limited | Triazole-pyridinyl substituted azacyclohexyl acetic acid compounds as lpa receptor antagonists |
| TWI853704B (zh) | 2021-05-11 | 2024-08-21 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| KR20240007233A (ko) * | 2021-05-13 | 2024-01-16 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제 및 이의 용도 |
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