JP2016514709A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016514709A5 JP2016514709A5 JP2016503521A JP2016503521A JP2016514709A5 JP 2016514709 A5 JP2016514709 A5 JP 2016514709A5 JP 2016503521 A JP2016503521 A JP 2016503521A JP 2016503521 A JP2016503521 A JP 2016503521A JP 2016514709 A5 JP2016514709 A5 JP 2016514709A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- dihydro
- amino
- pyrazolo
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2013/072873 | 2013-03-19 | ||
| PCT/CN2013/072873 WO2014146249A1 (en) | 2013-03-19 | 2013-03-19 | Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors |
| PCT/CN2014/000297 WO2014146491A1 (en) | 2013-03-19 | 2014-03-19 | Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016514709A JP2016514709A (ja) | 2016-05-23 |
| JP2016514709A5 true JP2016514709A5 (https=) | 2017-04-06 |
Family
ID=51579271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503521A Pending JP2016514709A (ja) | 2013-03-19 | 2014-03-19 | ヤヌスキナーゼ阻害剤としてのジェミナル置換シアノエチルピラゾロピリドン |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9957264B2 (https=) |
| EP (1) | EP2976339B1 (https=) |
| JP (1) | JP2016514709A (https=) |
| AU (1) | AU2014234907B2 (https=) |
| BR (1) | BR112015023858A2 (https=) |
| CA (1) | CA2901765A1 (https=) |
| RU (1) | RU2664533C2 (https=) |
| WO (2) | WO2014146249A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014146246A1 (en) * | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors |
| WO2016061751A1 (en) | 2014-10-22 | 2016-04-28 | Merck Sharp & Dohme Corp. | Ethyl n-boc piperidinyl pyrazolo pyridones as janus kinase inhibitors |
| CN110291090A (zh) * | 2017-01-20 | 2019-09-27 | 利奥制药有限公司 | 作为新型jak激酶抑制剂的双环胺 |
| WO2020155931A1 (zh) | 2019-01-30 | 2020-08-06 | 格格巫（珠海）生物科技有限公司 | 一种jak抑制剂及其制备方法 |
| EP3982954A4 (en) * | 2019-06-14 | 2024-01-03 | The Trustees of Columbia University in the City of New York | NT5C2 INHIBITORS FOR THE TREATMENT OF CHEMOTHERAPY-RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA |
| TW202208355A (zh) * | 2020-05-04 | 2022-03-01 | 美商安進公司 | 作為骨髓細胞觸發受體2促效劑之雜環化合物及使用方法 |
| PE20230609A1 (es) | 2020-05-04 | 2023-04-13 | Amgen Inc | Compuestos heterociclicos como agonistas del receptor de activacion expresado en las celulas mieloides 2 y metodos de uso |
| JP7023026B1 (ja) | 2021-05-18 | 2022-02-21 | 株式会社アイビー化粧品 | Ｊａｋ阻害剤 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
| EP2123651A4 (en) * | 2007-01-12 | 2011-05-04 | Astellas Pharma Inc | CONDENSED PYRIDINE COMPOUND |
| WO2009064835A1 (en) * | 2007-11-16 | 2009-05-22 | Incyte Corporation | 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors |
| US8158616B2 (en) * | 2008-03-11 | 2012-04-17 | Incyte Corporation | Azetidine and cyclobutane derivatives as JAK inhibitors |
| TW201111385A (en) * | 2009-08-27 | 2011-04-01 | Biocryst Pharm Inc | Heterocyclic compounds as janus kinase inhibitors |
| PT3354652T (pt) * | 2010-03-10 | 2020-07-20 | Incyte Holdings Corp | Derivados de piperidin-4-ilazetidina como inibidores de jak1 |
| KR20130094710A (ko) | 2010-04-14 | 2013-08-26 | 어레이 바이오파마 인크. | Ｊａｋ 키나아제의 억제제로서 5,7-치환된-이미다조［1,2-ｃ］피리미딘 |
| WO2012030924A1 (en) * | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Azolopyridine and azolopyrimidine compounds and methods of use thereof |
| MX2013005445A (es) * | 2010-11-19 | 2013-07-29 | Hoffmann La Roche | Pirazolopiridinas y el uso de pirazolopiridinas como inhibidores de tirosina cinasa 2 (tyk2). |
| BR112013025142A2 (pt) * | 2011-04-01 | 2019-09-24 | Univ Utah Res Found | análogos de 3-(1h-benzo{d}imidazol-2-il)-1h-indazol substituído como inibidores da cinase pdk1 |
| UA111854C2 (uk) * | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| WO2013041042A1 (en) * | 2011-09-22 | 2013-03-28 | Merck Sharp & Dohme Corp. | Pyrazole carboxamides as janus kinase inhibitors |
| WO2013180265A1 (ja) | 2012-06-01 | 2013-12-05 | 武田薬品工業株式会社 | 複素環化合物 |
| EP2863914B1 (en) * | 2012-06-20 | 2018-10-03 | Merck Sharp & Dohme Corp. | Pyrazolyl derivatives as syk inhibitors |
-
2013
- 2013-03-19 WO PCT/CN2013/072873 patent/WO2014146249A1/en not_active Ceased
-
2014
- 2014-03-19 US US14/778,046 patent/US9957264B2/en active Active
- 2014-03-19 WO PCT/CN2014/000297 patent/WO2014146491A1/en not_active Ceased
- 2014-03-19 CA CA2901765A patent/CA2901765A1/en not_active Abandoned
- 2014-03-19 BR BR112015023858A patent/BR112015023858A2/pt not_active Application Discontinuation
- 2014-03-19 EP EP14770170.0A patent/EP2976339B1/en active Active
- 2014-03-19 JP JP2016503521A patent/JP2016514709A/ja active Pending
- 2014-03-19 AU AU2014234907A patent/AU2014234907B2/en not_active Ceased
- 2014-03-19 RU RU2015144485A patent/RU2664533C2/ru not_active IP Right Cessation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016514709A5 (https=) | ||
| RU2015144485A (ru) | Геминально-замещенные цианоэтилпиразолопиридоны в качестве ингибиторов janus киназ | |
| JP6735330B2 (ja) | Ｔｒｐａ１調節因子として有用な置換複素環式スルホンアミド化合物 | |
| US11065231B2 (en) | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides | |
| RU2497813C2 (ru) | 4-(4-циано-2-тиоарил)-дигидропиримидиноны и их применение | |
| KR102491308B1 (ko) | Cyp11a1 (시토크롬 p450 모노옥시게나제 11a1) 억제제로서 피란 유도체 | |
| JPWO2021055744A5 (https=) | ||
| JP2014062093A5 (https=) | ||
| RU2011107437A (ru) | Ингибиторы кинуренин-3-моноксигеназы | |
| HRP20140252T1 (hr) | Derivati imidazola kao inhibitori kazeinske kinaze | |
| JP2011503194A5 (https=) | ||
| JP2018513107A (ja) | １−（ｈｅｔ）アリールスルホニル−（ピロリジン又はピペリジン）−２−カルボキサミド誘導体、及びｔｒｐａ１拮抗薬としてのそれらの使用 | |
| JP2021511363A5 (https=) | ||
| TR201807973T4 (tr) | Janus kinaz inhibitörleri olarak siyanometilpirazol karboksamidler. | |
| JP2006500348A5 (https=) | ||
| AU2004305079A1 (en) | 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors | |
| JP2011518836A5 (https=) | ||
| HRP20140030T1 (hr) | Derivati prolina kao inhibitori katepsina | |
| RU2015144386A (ru) | Циклоалкилнитрилпиразолопиридоны в качестве ингибиторов янус-киназы | |
| CN106715419A (zh) | 用作tank‑结合激酶抑制剂化合物的氨基三嗪衍生物 | |
| HRP20250104T1 (hr) | Novi supstituirani derivati sulfonilureje | |
| HRP20240297T1 (hr) | Derivati alfa-d-galaktopiranozida | |
| JP2016518344A5 (https=) | ||
| CA2905530A1 (en) | Pyrrolo[2,3-b]pyridine cdk9 kinase inhibitors | |
| RU2010106974A (ru) | Ариловые эфиры пирролидина в качестве антагонистов рецепторов nk3 |