JP2021511363A5 - - Google Patents
Info
- Publication number
- JP2021511363A5 JP2021511363A5 JP2020540798A JP2020540798A JP2021511363A5 JP 2021511363 A5 JP2021511363 A5 JP 2021511363A5 JP 2020540798 A JP2020540798 A JP 2020540798A JP 2020540798 A JP2020540798 A JP 2020540798A JP 2021511363 A5 JP2021511363 A5 JP 2021511363A5
- Authority
- JP
- Japan
- Prior art keywords
- triazine
- amino
- pyrrolo
- trifluoromethyl
- fluoro
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862622415P | 2018-01-26 | 2018-01-26 | |
| US62/622,415 | 2018-01-26 | ||
| PCT/US2019/014918 WO2019147782A1 (en) | 2018-01-26 | 2019-01-24 | Aminopyrrolotriazines as kinase inhibitors |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021511363A JP2021511363A (ja) | 2021-05-06 |
| JP2021511363A5 true JP2021511363A5 (https=) | 2022-01-28 |
| JPWO2019147782A5 JPWO2019147782A5 (https=) | 2022-01-28 |
| JP7307734B2 JP7307734B2 (ja) | 2023-07-12 |
Family
ID=65363405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020540798A Active JP7307734B2 (ja) | 2018-01-26 | 2019-01-24 | キナーゼ阻害剤としてのアミノピロロトリアジン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US11618753B2 (https=) |
| EP (1) | EP3743430B1 (https=) |
| JP (1) | JP7307734B2 (https=) |
| KR (1) | KR102759231B1 (https=) |
| CN (1) | CN112262139B (https=) |
| AR (1) | AR114186A1 (https=) |
| AU (1) | AU2019211382B2 (https=) |
| BR (1) | BR112020014516A2 (https=) |
| CA (1) | CA3088548A1 (https=) |
| EA (1) | EA202091777A1 (https=) |
| ES (1) | ES2959399T3 (https=) |
| IL (1) | IL276269A (https=) |
| MX (1) | MX2020007531A (https=) |
| SG (1) | SG11202007035YA (https=) |
| TW (1) | TW201940485A (https=) |
| WO (1) | WO2019147782A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA47460A (fr) | 2017-02-13 | 2019-12-18 | Bristol Myers Squibb Co | Aminotriazolopyridines utilisées en tant qu'inhibiteurs de kinase |
| HUE058292T2 (hu) | 2017-10-30 | 2022-07-28 | Bristol Myers Squibb Co | Aminoimidazopiridazinok mint kináz inhibitorok |
| AU2019339355A1 (en) | 2018-09-13 | 2021-05-13 | Bristol-Myers Squibb Company | Indazole carboxamides as kinase inhibitors |
| KR102906523B1 (ko) | 2018-09-13 | 2025-12-30 | 브리스톨-마이어스 스큅 컴퍼니 | 수용체-상호작용 단백질 키나제 1 (ripk1) 억제제로서의 1h-인다졸 카르복스아미드 |
| ES2969756T3 (es) | 2019-10-03 | 2024-05-22 | Bristol Myers Squibb Co | Indazol carboxamidas como inhibidores de cinasas |
| JPWO2021157596A1 (https=) * | 2020-02-07 | 2021-08-12 | ||
| WO2022007921A1 (zh) * | 2020-07-10 | 2022-01-13 | 北京范恩柯尔生物科技有限公司 | 三嗪类化合物及其组合物和用途 |
| CN111925345B (zh) * | 2020-08-21 | 2023-09-29 | 上海科利生物医药有限公司 | 一种手性2-氨甲基四氢呋喃的制备方法 |
| AR123793A1 (es) | 2020-10-19 | 2023-01-11 | Bristol Myers Squibb Co | Compuestos de triazolopiridinilo como inhibidores de quinasas |
| JPWO2022172889A1 (https=) * | 2021-02-10 | 2022-08-18 | ||
| CN113563214B (zh) * | 2021-07-06 | 2024-02-02 | 山东鲁泰控股集团有限公司石墨烯高分子复合材料研发中心 | 一种氨基乙酸的合成方法 |
| CN113527220A (zh) * | 2021-07-26 | 2021-10-22 | 京博农化科技有限公司 | 一种脱硫丙硫菌唑异构体的合成方法 |
| CN116574053B (zh) * | 2022-06-21 | 2026-04-14 | 中国药科大学 | Ripk1激酶靶点抑制剂及其医药用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2627839C (en) | 2005-11-02 | 2014-08-19 | Bayer Healthcare Ag | Pyrrolo[2,1-f] [1,2,4] triazin-4-ylamines igf-1r kinase inhibitors for the treatment of cancer and other hyperproliferative diseases |
| EP2385053B1 (en) * | 2005-11-17 | 2013-10-02 | OSI Pharmaceuticals, Inc. | Intermediates for the preparation of fused bicyclic mTOR inhibitors |
| KR101461680B1 (ko) | 2005-12-02 | 2014-11-19 | 바이엘 헬스케어 엘엘씨 | 과다-증식성 장애 및 맥관형성과 관련된 질환의 치료에유용한 치환된 4-아미노-피롤로트리아진 유도체 |
| PE20070855A1 (es) | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
| GB2467670B (en) * | 2007-10-04 | 2012-08-01 | Intellikine Inc | Chemical entities and therapeutic uses thereof |
| EP2424368B1 (en) | 2009-04-29 | 2014-12-31 | Locus Pharmaceuticals, Inc. | Pyrrolotriazine compounds |
| TW201107329A (en) | 2009-07-30 | 2011-03-01 | Oncotherapy Science Inc | Fused imidazole derivative having ttk inhibitory action |
| HRP20160967T1 (hr) | 2009-10-06 | 2016-10-07 | Millennium Pharmaceuticals, Inc. | Heterociklički spojevi korisni kao pdk1 inhibitori |
| CN102918045A (zh) | 2010-03-31 | 2013-02-06 | 百时美施贵宝公司 | 作为蛋白激酶抑制剂的取代的吡咯并三嗪 |
| WO2014047024A1 (en) | 2012-09-18 | 2014-03-27 | Bristol-Myers Squibb Company | Iap antagonists |
| WO2015054358A1 (en) | 2013-10-11 | 2015-04-16 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US10023576B2 (en) * | 2014-10-22 | 2018-07-17 | Bristol-Myers Squibb Company | Heteroaryl substituted pyrrolotriazine amine compounds as PI3K inhibitors |
| US10214537B2 (en) * | 2014-10-22 | 2019-02-26 | Bristol-Myers Squibb Company | Bicyclic heteroaryl amine compounds |
| MD3436461T2 (ro) | 2016-03-28 | 2024-05-31 | Incyte Corp | Compuși pirolotriazină ca inhibitori TAM |
| WO2018017435A1 (en) | 2016-07-22 | 2018-01-25 | Accro Bioscience Inc. | Heteroaryl compounds as inhibitors of necrosis, composition and application thereof |
| MA47460A (fr) | 2017-02-13 | 2019-12-18 | Bristol Myers Squibb Co | Aminotriazolopyridines utilisées en tant qu'inhibiteurs de kinase |
| HUE058292T2 (hu) | 2017-10-30 | 2022-07-28 | Bristol Myers Squibb Co | Aminoimidazopiridazinok mint kináz inhibitorok |
| AU2019339355A1 (en) | 2018-09-13 | 2021-05-13 | Bristol-Myers Squibb Company | Indazole carboxamides as kinase inhibitors |
| KR102906523B1 (ko) | 2018-09-13 | 2025-12-30 | 브리스톨-마이어스 스큅 컴퍼니 | 수용체-상호작용 단백질 키나제 1 (ripk1) 억제제로서의 1h-인다졸 카르복스아미드 |
-
2019
- 2019-01-24 CN CN201980019863.4A patent/CN112262139B/zh active Active
- 2019-01-24 EA EA202091777A patent/EA202091777A1/ru unknown
- 2019-01-24 CA CA3088548A patent/CA3088548A1/en active Pending
- 2019-01-24 AR ARP190100156A patent/AR114186A1/es unknown
- 2019-01-24 JP JP2020540798A patent/JP7307734B2/ja active Active
- 2019-01-24 SG SG11202007035YA patent/SG11202007035YA/en unknown
- 2019-01-24 WO PCT/US2019/014918 patent/WO2019147782A1/en not_active Ceased
- 2019-01-24 MX MX2020007531A patent/MX2020007531A/es unknown
- 2019-01-24 AU AU2019211382A patent/AU2019211382B2/en not_active Ceased
- 2019-01-24 ES ES19704524T patent/ES2959399T3/es active Active
- 2019-01-24 KR KR1020207024141A patent/KR102759231B1/ko active Active
- 2019-01-24 US US16/963,886 patent/US11618753B2/en active Active
- 2019-01-24 BR BR112020014516-5A patent/BR112020014516A2/pt not_active Application Discontinuation
- 2019-01-24 EP EP19704524.8A patent/EP3743430B1/en active Active
- 2019-01-25 TW TW108102873A patent/TW201940485A/zh unknown
-
2020
- 2020-07-24 IL IL276269A patent/IL276269A/en unknown
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