KR102759231B1 - 키나제 억제제로서의 아미노피롤로트리아진 - Google Patents

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Publication number

KR102759231B1

KR102759231B1 KR1020207024141A KR20207024141A KR102759231B1 KR 102759231 B1 KR102759231 B1 KR 102759231B1 KR 1020207024141 A KR1020207024141 A KR 1020207024141A KR 20207024141 A KR20207024141 A KR 20207024141A KR 102759231 B1 KR102759231 B1 KR 102759231B1

Authority

KR

South Korea

Prior art keywords

trifluoromethyl

amino

triazin

pyrrolo

fluoro

Prior art date

2018-01-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• VPTRWECDZZUXIF-UHFFFAOYSA-N N1=NNC2=CC=NC2=C1N Chemical compound N1=NNC2=CC=NC2=C1N VPTRWECDZZUXIF-UHFFFAOYSA-N 0.000 title description 4
• 229940043355 kinase inhibitor Drugs 0.000 title description 3
• 239000003757 phosphotransferase inhibitor Substances 0.000 title description 3
• 150000001875 compounds Chemical class 0.000 claims abstract description 201
• 125000000217 alkyl group Chemical group 0.000 claims description 237
• 125000003545 alkoxy group Chemical group 0.000 claims description 108
• 150000003839 salts Chemical class 0.000 claims description 100
• -1 2 -cyclopropyl Chemical group 0.000 claims description 95
• 229910052739 hydrogen Inorganic materials 0.000 claims description 85
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 83
• 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims description 81
• 239000001257 hydrogen Substances 0.000 claims description 75
• 125000005345 deuteroalkyl group Chemical group 0.000 claims description 71
• 125000004438 haloalkoxy group Chemical group 0.000 claims description 63
• 150000002431 hydrogen Chemical group 0.000 claims description 52
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 51
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 45
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 42
• 229910052757 nitrogen Inorganic materials 0.000 claims description 38
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 36
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 36
• 125000006559 (C1-C3) alkylamino group Chemical group 0.000 claims description 34
• 125000004663 dialkyl amino group Chemical group 0.000 claims description 34
• 229910052799 carbon Inorganic materials 0.000 claims description 26
• 125000001475 halogen functional group Chemical group 0.000 claims description 25
• 125000004076 pyridyl group Chemical group 0.000 claims description 25
• 229910052760 oxygen Inorganic materials 0.000 claims description 22
• 125000003884 phenylalkyl group Chemical group 0.000 claims description 21
• 125000004429 atom Chemical group 0.000 claims description 19
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 18
• 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 18
• 125000000335 thiazolyl group Chemical group 0.000 claims description 18
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims description 17
• 125000001188 haloalkyl group Chemical group 0.000 claims description 16
• 229910002091 carbon monoxide Inorganic materials 0.000 claims description 13
• 125000002883 imidazolyl group Chemical group 0.000 claims description 12
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 12
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 11
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 11
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 10
• 125000003386 piperidinyl group Chemical group 0.000 claims description 10
• 125000003831 tetrazolyl group Chemical group 0.000 claims description 10
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 9
• 206010009900 Colitis ulcerative Diseases 0.000 claims description 9
• 201000006704 Ulcerative Colitis Diseases 0.000 claims description 9
• 229910052731 fluorine Inorganic materials 0.000 claims description 9
• 125000005347 halocycloalkyl group Chemical group 0.000 claims description 9
• 208000011231 Crohn disease Diseases 0.000 claims description 8
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 8
• 201000004681 Psoriasis Diseases 0.000 claims description 8
• 239000003937 drug carrier Substances 0.000 claims description 8
• 125000003373 pyrazinyl group Chemical group 0.000 claims description 8
• 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 7
• 125000001786 isothiazolyl group Chemical group 0.000 claims description 7
• 125000000842 isoxazolyl group Chemical group 0.000 claims description 7
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
• 125000001624 naphthyl group Chemical group 0.000 claims description 7
• 125000001715 oxadiazolyl group Chemical group 0.000 claims description 7
• 125000002971 oxazolyl group Chemical group 0.000 claims description 7
• 125000003566 oxetanyl group Chemical group 0.000 claims description 7
• 239000008194 pharmaceutical composition Substances 0.000 claims description 7
• 125000002098 pyridazinyl group Chemical group 0.000 claims description 7
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 7
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 7
• 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 7
• 125000001113 thiadiazolyl group Chemical group 0.000 claims description 7
• KRNSYSYRLQDHDK-UHFFFAOYSA-N 6,7-dihydro-5h-cyclopenta[b]pyridine Chemical compound C1=CN=C2CCCC2=C1 KRNSYSYRLQDHDK-UHFFFAOYSA-N 0.000 claims description 6
• 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims description 6
• 125000001425 triazolyl group Chemical group 0.000 claims description 6
• 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 5
• YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 5
• 206010019280 Heart failures Diseases 0.000 claims description 5
• 125000002393 azetidinyl group Chemical group 0.000 claims description 5
• 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 5
• 229910052805 deuterium Inorganic materials 0.000 claims description 5
• 125000000532 dioxanyl group Chemical group 0.000 claims description 5
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
• 125000003507 tetrahydrothiofenyl group Chemical group 0.000 claims description 5
• CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 claims description 5
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 4
• 125000003282 alkyl amino group Chemical group 0.000 claims description 4
• 125000005350 hydroxycycloalkyl group Chemical group 0.000 claims description 4
• MAFNBBNBKPJWEQ-UHFFFAOYSA-N 2,3,4,9-tetrahydro-1h-benzo[7]annulene Chemical compound C1C=CC=CC2=C1CCCC2 MAFNBBNBKPJWEQ-UHFFFAOYSA-N 0.000 claims description 3
• WWPHBASFEQISGX-CABCVRRESA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3S,4R)-1-(3,3-difluorocyclobutanecarbonyl)-4-fluoropyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@H]1CN(C[C@H]1F)C(=O)C1CC(C1)(F)F)C(F)(F)F WWPHBASFEQISGX-CABCVRRESA-N 0.000 claims description 3
• WWPHBASFEQISGX-UHFFFAOYSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[1-(3,3-difluorocyclobutanecarbonyl)-4-fluoropyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)NC2CN(CC2F)C(=O)C2CC(C2)(F)F)C=1)OC)C(F)(F)F WWPHBASFEQISGX-UHFFFAOYSA-N 0.000 claims description 3
• ROLHHIOLMNNZLG-UHFFFAOYSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[1-(cyclohexanecarbonyl)-4-methylpyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1C)C(=O)C1CCCCC1)C(F)(F)F ROLHHIOLMNNZLG-UHFFFAOYSA-N 0.000 claims description 3
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 3
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 3
• FZDXZWCWTKYJJY-ZDUSSCGKSA-N tert-butyl (3S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]pyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(CC1)C(=O)OC(C)(C)C)C(F)(F)F FZDXZWCWTKYJJY-ZDUSSCGKSA-N 0.000 claims description 3
• XBVXZUOLCYRGRZ-KRWDZBQOSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxy-N-[(3S)-1-(4-methylbenzoyl)pyrrolidin-3-yl]pyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(CC1)C(C1=CC=C(C=C1)C)=O)C(F)(F)F XBVXZUOLCYRGRZ-KRWDZBQOSA-N 0.000 claims description 2
• WRKRUTZUTQXSTI-UHFFFAOYSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-(1-benzoyl-4-methylpyrrolidin-3-yl)-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1C)C(C1=CC=CC=C1)=O)C(F)(F)F WRKRUTZUTQXSTI-UHFFFAOYSA-N 0.000 claims description 2
• WWPHBASFEQISGX-LSDHHAIUSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-1-(3,3-difluorocyclobutanecarbonyl)-4-fluoropyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(C1)(F)F)C(F)(F)F WWPHBASFEQISGX-LSDHHAIUSA-N 0.000 claims description 2
• SDMWFJRWEWWAJL-JNMIHDSVSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-1-(3,3-difluorocyclopentanecarbonyl)-4-fluoropyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(CC1)(F)F)C(F)(F)F SDMWFJRWEWWAJL-JNMIHDSVSA-N 0.000 claims description 2
• XEKZSVZVLDUMPS-ZWKOTPCHSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-1-(4,4-difluorocyclohexanecarbonyl)-4-fluoropyrrolidin-3-yl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCC(CC1)(F)F)C(F)(F)F XEKZSVZVLDUMPS-ZWKOTPCHSA-N 0.000 claims description 2
• BGBXWKANTNLERJ-MSFQCOKLSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3S,4S)-1-(3,3-difluorocyclopentanecarbonyl)-4-(fluoromethyl)pyrrolidin-3-yl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1CF)C(=O)C1CC(CC1)(F)F)C(F)(F)F BGBXWKANTNLERJ-MSFQCOKLSA-N 0.000 claims description 2
• WHIRULNAWOFNFA-QRUKAPELSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3S,4S)-1-(3,3-difluorocyclopentanecarbonyl)-4-methylpyrrolidin-3-yl]-2-(trifluoromethyl)pyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C(F)(F)F)C(=O)N[C@@H]1CN(C[C@@H]1C)C(=O)C1CC(CC1)(F)F)C(F)(F)F WHIRULNAWOFNFA-QRUKAPELSA-N 0.000 claims description 2
• CKIUAESIKKPBSF-YVEFUNNKSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3S,4S)-1-(4,4-difluorocyclohexanecarbonyl)-4-methylpyrrolidin-3-yl]-2-(trifluoromethyl)pyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C(F)(F)F)C(=O)N[C@@H]1CN(C[C@@H]1C)C(=O)C1CCC(CC1)(F)F)C(F)(F)F CKIUAESIKKPBSF-YVEFUNNKSA-N 0.000 claims description 2
• AGEOFOWZHRNCCN-VBKZILBWSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3S,4S)-1-(cyclohexanecarbonyl)-4-methylpyrrolidin-3-yl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1C)C(=O)C1CCCCC1)C(F)(F)F AGEOFOWZHRNCCN-VBKZILBWSA-N 0.000 claims description 2
• GIIQJUCRJOCKRK-SCLBCKFNSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3S,4S)-1-(cyclopentanecarbonyl)-4-methylpyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1C)C(=O)C1CCCC1)C(F)(F)F GIIQJUCRJOCKRK-SCLBCKFNSA-N 0.000 claims description 2
• VFZJNQOWWJKYDL-UHFFFAOYSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[1-(3,3-dimethylbutanoyl)-4-methylpyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1C)C(CC(C)(C)C)=O)C(F)(F)F VFZJNQOWWJKYDL-UHFFFAOYSA-N 0.000 claims description 2
• WQLUFPFCSKOEDI-UHFFFAOYSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[4-fluoro-1-(4-fluorobenzoyl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)C(C1=CC=C(C=C1)F)=O)C(F)(F)F WQLUFPFCSKOEDI-UHFFFAOYSA-N 0.000 claims description 2
• PWHCCKUKNSUYIK-ZIOBHTBHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)C(C(F)(F)F)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)C(C(F)(F)F)O)C(F)(F)F PWHCCKUKNSUYIK-ZIOBHTBHSA-N 0.000 claims 4
• DLLMKTPKYJZFRN-ZIOBHTBHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)C(C(F)F)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)C(C(F)F)O)C(F)(F)F DLLMKTPKYJZFRN-ZIOBHTBHSA-N 0.000 claims 4
• XMXVZIHFOYKJGS-PXWJKWRZSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)C)F)C(F)(F)F XMXVZIHFOYKJGS-PXWJKWRZSA-N 0.000 claims 3
• KHUCAQJAGQIKPG-OTLVQASYSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)C)F)C(F)(F)F KHUCAQJAGQIKPG-OTLVQASYSA-N 0.000 claims 3
• GQJRMUNZVOLGAB-AJMWJVNWSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)Cl)F)C(F)(F)F GQJRMUNZVOLGAB-AJMWJVNWSA-N 0.000 claims 3
• NDJMEHRBAVETTG-AZGGKPGBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)Cl)F)C(F)(F)F NDJMEHRBAVETTG-AZGGKPGBSA-N 0.000 claims 3
• HTBBRNBXLQGCIW-SXODRGRHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)Cl)F)C(F)(F)F HTBBRNBXLQGCIW-SXODRGRHSA-N 0.000 claims 3
• PSBMDJORISGBGY-JWAGFEDZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C(C)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C(C)O)C(F)(F)F PSBMDJORISGBGY-JWAGFEDZSA-N 0.000 claims 3
• XBMYAUUMYXTKCS-OKQVYOHESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC=CC=C1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC=CC=C1)C(F)(F)F XBMYAUUMYXTKCS-OKQVYOHESA-N 0.000 claims 3
• FJDHTVGOVJSLNV-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(C(F)(F)F)(O)C2CC2)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(C(F)(F)F)(O)C2CC2)C=1)OC)C(F)(F)F FJDHTVGOVJSLNV-OKFXBHNASA-N 0.000 claims 3
• DOZNBIZFXHSLMP-YUIIUQSRSA-N (2,2-difluorocyclopropyl)methyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OCC1C(C1)(F)F)C(F)(F)F DOZNBIZFXHSLMP-YUIIUQSRSA-N 0.000 claims 2
• WZMSQXWHDMNIEZ-IHGBKINDSA-N N-[(3R,4S)-1-[2-amino-2-(trifluoromethyl)pentanoyl]-4-fluoropyrrolidin-3-yl]-5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC(C(=O)N1C[C@H]([C@H](C1)F)NC(C1=C(N=CC(=C1)C1=CC(=C2C(=NC=NN21)N)C(F)(F)F)OC)=O)(CCC)C(F)(F)F WZMSQXWHDMNIEZ-IHGBKINDSA-N 0.000 claims 2
• XXHBQYPKBLBNBF-OEZHTOCISA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C(=CC=1)F)F)C(F)(F)F XXHBQYPKBLBNBF-OEZHTOCISA-N 0.000 claims 2
• BKBLCDAVBHYDBU-BDHCGPDFSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)C)C)C(F)(F)F BKBLCDAVBHYDBU-BDHCGPDFSA-N 0.000 claims 2
• LSRRYIVQMWYCDP-XHEDQKCFSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)C)F)C(F)(F)F LSRRYIVQMWYCDP-XHEDQKCFSA-N 0.000 claims 2
• CVTRFYHCZBHDEO-TUAHZWSISA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)Cl)F)C(F)(F)F CVTRFYHCZBHDEO-TUAHZWSISA-N 0.000 claims 2
• GZHLOVIVQKBUDX-KBUGRDCFSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)CC)F)C(F)(F)F GZHLOVIVQKBUDX-KBUGRDCFSA-N 0.000 claims 2
• XFZOJURETRCXQU-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)NC1CN(CC1F)C(=O)C1C(C1)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)NC1CN(CC1F)C(=O)C1C(C1)(F)F)C(F)(F)F XFZOJURETRCXQU-UHFFFAOYSA-N 0.000 claims 2
• FZOILCCSLITRSX-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)NC1CN(CC1F)C(=O)C1CC(C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)NC1CN(CC1F)C(=O)C1CC(C1)F)C(F)(F)F FZOILCCSLITRSX-UHFFFAOYSA-N 0.000 claims 2
• GHOWBTPXULAJJV-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)NC1CN(CC1F)C(=O)C1CCC(CC1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)NC1CN(CC1F)C(=O)C1CCC(CC1)F)C(F)(F)F GHOWBTPXULAJJV-UHFFFAOYSA-N 0.000 claims 2
• DKQFRXRCWKQBNC-CRRZLINXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(CC1)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(CC1)(F)F)C(F)(F)F DKQFRXRCWKQBNC-CRRZLINXSA-N 0.000 claims 2
• GRUPVRDSWOQMRQ-NNKZFNQJSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)CC(C(F)(F)F)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)CC(C(F)(F)F)O)C(F)(F)F GRUPVRDSWOQMRQ-NNKZFNQJSA-N 0.000 claims 2
• BFMZLFKLDSQECV-FFPFEORLSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)CC1C(C1)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)CC1C(C1)(F)F)C(F)(F)F BFMZLFKLDSQECV-FFPFEORLSA-N 0.000 claims 2
• BUIIQHYYJKDUIX-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)C(=O)C1CCC(CC1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)C(=O)C1CCC(CC1)F)C(F)(F)F BUIIQHYYJKDUIX-UHFFFAOYSA-N 0.000 claims 2
• VTINOCMWIFPQKA-VOPCEASESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OC(C)C(C(F)(F)F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OC(C)C(C(F)(F)F)(F)F)C(F)(F)F VTINOCMWIFPQKA-VOPCEASESA-N 0.000 claims 2
• ASTBRBIIWWEMKJ-MOUIRZPISA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(CC)(C(F)(F)F)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(CC)(C(F)(F)F)O)=O)C(F)(F)F ASTBRBIIWWEMKJ-MOUIRZPISA-N 0.000 claims 2
• ARADQEJMNYAUGQ-JNMIHDSVSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C(C)(C)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C(C)(C)O)C(F)(F)F ARADQEJMNYAUGQ-JNMIHDSVSA-N 0.000 claims 2
• UKBKLCPNQKOHLO-IWSJWDQHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C=C(C=C1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C=C(C=C1)F)F)C(F)(F)F UKBKLCPNQKOHLO-IWSJWDQHSA-N 0.000 claims 2
• WZLYSTLFKVFFOY-YYUCZDELSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C=CC=C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C=CC=C1)F)C(F)(F)F WZLYSTLFKVFFOY-YYUCZDELSA-N 0.000 claims 2
• HLKPMMKCMJDOET-OKQVYOHESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C=CC=C1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C=CC=C1)OC)C(F)(F)F HLKPMMKCMJDOET-OKQVYOHESA-N 0.000 claims 2
• YGGAFHLKCJOGAW-FVHARNBYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C=NC=C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C=NC=C1)F)C(F)(F)F YGGAFHLKCJOGAW-FVHARNBYSA-N 0.000 claims 2
• QOONEFLZVPULQV-IWSJWDQHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC(=C(C=C1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC(=C(C=C1)F)F)C(F)(F)F QOONEFLZVPULQV-IWSJWDQHSA-N 0.000 claims 2
• JTQYBSQODSYLKH-IWSJWDQHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC(=CC(=C1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC(=CC(=C1)F)F)C(F)(F)F JTQYBSQODSYLKH-IWSJWDQHSA-N 0.000 claims 2
• FLIWLHVFCZBKKP-WCWOBGJUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC(=CC=C1)C#N)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC(=CC=C1)C#N)C(F)(F)F FLIWLHVFCZBKKP-WCWOBGJUSA-N 0.000 claims 2
• GWJMZICZJUJAON-YYUCZDELSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC=C(C=C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC=C(C=C1)F)C(F)(F)F GWJMZICZJUJAON-YYUCZDELSA-N 0.000 claims 2
• IXTPBBOLGPDVND-WFELRXAXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC=NC=C1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC=NC=C1)C(F)(F)F IXTPBBOLGPDVND-WFELRXAXSA-N 0.000 claims 2
• WRCIYXSTZKXNJZ-JNMIHDSVSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CN=CS1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CN=CS1)C(F)(F)F WRCIYXSTZKXNJZ-JNMIHDSVSA-N 0.000 claims 2
• IVFTXCDJMKDGNQ-IQHYPMEHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=NC=NC=C1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=NC=NC=C1)C(F)(F)F IVFTXCDJMKDGNQ-IQHYPMEHSA-N 0.000 claims 2
• CVIUGPVEGFHESQ-DJQNDVTLSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1CC(CC1)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1CC(CC1)(F)F)C(F)(F)F CVIUGPVEGFHESQ-DJQNDVTLSA-N 0.000 claims 2
• QPZQJUUTPVRGSP-OTLVQASYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1C(=NOC=1C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1C(=NOC=1C)C)C(F)(F)F QPZQJUUTPVRGSP-OTLVQASYSA-N 0.000 claims 2
• DYGZPNWHSKAVDN-FVHARNBYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1C=NC=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1C=NC=C(C=1)F)C(F)(F)F DYGZPNWHSKAVDN-FVHARNBYSA-N 0.000 claims 2
• YQYOIDVKZRLEMR-WFELRXAXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1C=NC=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1C=NC=CC=1)C(F)(F)F YQYOIDVKZRLEMR-WFELRXAXSA-N 0.000 claims 2
• LLUUSUYBMJRZPU-OTLVQASYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1C=NC=NC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1C=NC=NC=1)C(F)(F)F LLUUSUYBMJRZPU-OTLVQASYSA-N 0.000 claims 2
• WOILNFXVWOTUPW-DZLJAHQNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1N=C(SC=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1N=C(SC=1)C)C(F)(F)F WOILNFXVWOTUPW-DZLJAHQNSA-N 0.000 claims 2
• DREFOKCKQORHNO-MDMLBXLCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)CC(C(F)(F)F)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)CC(C(F)(F)F)O)C(F)(F)F DREFOKCKQORHNO-MDMLBXLCSA-N 0.000 claims 2
• OIUQSLYYIVMEFV-KTVLMBSMSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(F)(F)F)C1=CC=CC=C1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(F)(F)F)C1=CC=CC=C1)C(F)(F)F OIUQSLYYIVMEFV-KTVLMBSMSA-N 0.000 claims 2
• AKADPTZNLZPVJW-PZEDNMLSSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)(C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)(C)C)C(F)(F)F AKADPTZNLZPVJW-PZEDNMLSSA-N 0.000 claims 2
• MDSHJDCATIEXBV-HWUOMESGSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)(C)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)(C)O)C(F)(F)F MDSHJDCATIEXBV-HWUOMESGSA-N 0.000 claims 2
• LRCWZUPOEQJBTJ-PGSGCPMZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)C)C(F)(F)F LRCWZUPOEQJBTJ-PGSGCPMZSA-N 0.000 claims 2
• JHDZVZPJIYWXFX-QLIZNUPZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCCC1)(C)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCCC1)(C)O)C(F)(F)F JHDZVZPJIYWXFX-QLIZNUPZSA-N 0.000 claims 2
• BTHJTWOIIIWLIT-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C=1C=NC=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C=1C=NC=CC=1)C(F)(F)F BTHJTWOIIIWLIT-DLBZAZTESA-N 0.000 claims 2
• HXNGJTFOHNCXTI-DTLDGVLPSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1C(C1)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1C(C1)(F)F)C(F)(F)F HXNGJTFOHNCXTI-DTLDGVLPSA-N 0.000 claims 2
• GKEBGNBWEFPNTA-IGSBVAHGSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(C1)F)C(F)(F)F GKEBGNBWEFPNTA-IGSBVAHGSA-N 0.000 claims 2
• JGSWAFXHIQJGCR-DJQNDVTLSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(C1)F)C(F)(F)F JGSWAFXHIQJGCR-DJQNDVTLSA-N 0.000 claims 2
• CUYLRWPQOOVIEO-UGGKNOJYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(CC1)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(CC1)(F)F)C(F)(F)F CUYLRWPQOOVIEO-UGGKNOJYSA-N 0.000 claims 2
• YTRMRRUJHLVZTN-CVVKNMAHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(C1)F)C(F)(F)F YTRMRRUJHLVZTN-CVVKNMAHSA-N 0.000 claims 2
• CHDQIQKSKCBZCM-QZAYROHHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(CC1)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(CC1)(F)F)C(F)(F)F CHDQIQKSKCBZCM-QZAYROHHSA-N 0.000 claims 2
• RGTIKHGWUFTTMC-MPCAOIJTSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=C(C=1)F)C(F)(F)F RGTIKHGWUFTTMC-MPCAOIJTSA-N 0.000 claims 2
• YUSRXEYDGDVAPK-JOCCRWCTSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=C(C=1)OC)C(F)(F)F YUSRXEYDGDVAPK-JOCCRWCTSA-N 0.000 claims 2
• GETXFAXCILCMRK-YQEWQEHLSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=CC=1)C(F)(F)F GETXFAXCILCMRK-YQEWQEHLSA-N 0.000 claims 2
• HNSFQOTZPJDEID-LQVSYIOISA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)F)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)F)C=CC=1)C(F)(F)F HNSFQOTZPJDEID-LQVSYIOISA-N 0.000 claims 2
• NKBSBOBSFBAGTR-SEDVZULUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)F)C(F)(F)F NKBSBOBSFBAGTR-SEDVZULUSA-N 0.000 claims 2
• AOORCMHZHCUEKS-JOCCRWCTSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OCC)C(F)(F)F AOORCMHZHCUEKS-JOCCRWCTSA-N 0.000 claims 2
• GKEBGNBWEFPNTA-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)NC2CN(CC2F)C(=O)C2CC(C2)F)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)NC2CN(CC2F)C(=O)C2CC(C2)F)C=1)OC)C(F)(F)F GKEBGNBWEFPNTA-UHFFFAOYSA-N 0.000 claims 2
• BPNPBQGTCNBUDX-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(CC)(C(F)(F)F)O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(CC)(C(F)(F)F)O)C=1)OC)C(F)(F)F BPNPBQGTCNBUDX-ZOMUKPOZSA-N 0.000 claims 2
• GUVVTTOPGBIPOO-LQVSYIOISA-N NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)C(F)(F)F)C=1)OC)C#N Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)C(F)(F)F)C=1)OC)C#N GUVVTTOPGBIPOO-LQVSYIOISA-N 0.000 claims 2
• LQTRTXMROFTBCB-LSDHHAIUSA-N (1-methylcyclopropyl) (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OC1(CC1)C)C(F)(F)F LQTRTXMROFTBCB-LSDHHAIUSA-N 0.000 claims 1
• OLJJRCFMYUFKTO-IKCIUXDWSA-N (2,2,3,3-tetrafluorocyclobutyl) (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)OC2C(C(C2)(F)F)(F)F)C=1)OC)C(F)(F)F OLJJRCFMYUFKTO-IKCIUXDWSA-N 0.000 claims 1
• KJNASSOHUUYDMO-LSDHHAIUSA-N (3,3-difluorocyclobutyl) (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OC1CC(C1)(F)F)C(F)(F)F KJNASSOHUUYDMO-LSDHHAIUSA-N 0.000 claims 1
• ITWQBFUJIFHHAR-NWDGAFQWSA-N (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylic acid Chemical compound COc1ncc(cc1C(=O)N[C@@H]1CN(C[C@@H]1F)C(O)=O)-c1cc(c2c(N)ncnn12)C(F)(F)F ITWQBFUJIFHHAR-NWDGAFQWSA-N 0.000 claims 1
• ZMXLVRXVTTVUFD-QWHCGFSZSA-N 2,2,2-trifluoroethyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OCC(F)(F)F)C(F)(F)F ZMXLVRXVTTVUFD-QWHCGFSZSA-N 0.000 claims 1
• UQCJGZVZNJXTMC-QWHCGFSZSA-N 2,2-difluoroethyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OCC(F)F)C(F)(F)F UQCJGZVZNJXTMC-QWHCGFSZSA-N 0.000 claims 1
• QGXMDKJPVCATFK-JKSUJKDBSA-N 2,2-dimethylpropyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OCC(C)(C)C)C(F)(F)F QGXMDKJPVCATFK-JKSUJKDBSA-N 0.000 claims 1
• MZNZJSABICYLKI-JKSUJKDBSA-N 2-ethoxyethyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OCCOCC)C(F)(F)F MZNZJSABICYLKI-JKSUJKDBSA-N 0.000 claims 1
• QKOUEGWUFQUFNM-UONOGXRCSA-N 2-hydroxyethyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OCCO)C(F)(F)F QKOUEGWUFQUFNM-UONOGXRCSA-N 0.000 claims 1
• LDZFEAOWUTUGFX-LSDHHAIUSA-N 2-methoxyethyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OCCOC)C(F)(F)F LDZFEAOWUTUGFX-LSDHHAIUSA-N 0.000 claims 1
• ASLHLSBWGOJXAC-JKSUJKDBSA-N 2-methylpropyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OCC(C)C)C(F)(F)F ASLHLSBWGOJXAC-JKSUJKDBSA-N 0.000 claims 1
• PEWXBWQVUWKYBB-UONOGXRCSA-N 3,3,3-trifluoropropyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OCCC(F)(F)F)C(F)(F)F PEWXBWQVUWKYBB-UONOGXRCSA-N 0.000 claims 1
• UYYOQAKQFOWVDZ-UONOGXRCSA-N 3-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-6-ethyl-2-fluoro-N-[(3R,4S)-4-fluoro-1-[4,4,4-trifluoro-3-hydroxy-3-(trifluoromethyl)butanoyl]pyrrolidin-3-yl]benzamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C(=CC=1)CC)F)C(F)(F)F UYYOQAKQFOWVDZ-UONOGXRCSA-N 0.000 claims 1
• NDQONWYLHRWFIP-LSDHHAIUSA-N 3-fluoropropyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OCCCF)C(F)(F)F NDQONWYLHRWFIP-LSDHHAIUSA-N 0.000 claims 1
• 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
• NBZZWIDLQXSTTN-LSDHHAIUSA-N 5-(4-amino-5-fluoropyrrolo[2,1-f][1,2,4]triazin-7-yl)-N-[(3R,4S)-1-(3,3-difluorocyclobutanecarbonyl)-4-fluoropyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(C1)(F)F)F NBZZWIDLQXSTTN-LSDHHAIUSA-N 0.000 claims 1
• RRTUDLDXKQHDMS-PXIJXODZSA-N 5-(4-amino-6-cyanopyrrolo[2,1-f][1,2,4]triazin-7-yl)-N-[(3R,4S)-4-fluoro-1-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)C#N RRTUDLDXKQHDMS-PXIJXODZSA-N 0.000 claims 1
• LRDFERVEEOQWOY-LSDHHAIUSA-N 5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-N-[(3R,4S)-1-(3,3-difluorocyclobutanecarbonyl)-4-fluoropyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=CC=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC LRDFERVEEOQWOY-LSDHHAIUSA-N 0.000 claims 1
• OOUOJIXMFZGSHW-INHYXYHNSA-N 5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-N-[(3R,4S)-4-fluoro-1-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]pyrrolidin-3-yl]-2-(trideuteriomethoxy)pyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=CC=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC([2H])([2H])[2H] OOUOJIXMFZGSHW-INHYXYHNSA-N 0.000 claims 1
• SDMWFJRWEWWAJL-TXJQLGKLSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-(deuteriomethoxy)-N-[(3R,4S)-1-(3,3-difluorocyclopentanecarbonyl)-4-fluoropyrrolidin-3-yl]pyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(CC1)(F)F)C(F)(F)F SDMWFJRWEWWAJL-TXJQLGKLSA-N 0.000 claims 1
• RGMASPUJFVIQNT-HJHUTUBVSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-(deuteriomethoxy)-N-[(3R,4S)-4-fluoro-1-(4-fluorobenzoyl)pyrrolidin-3-yl]-6-methylpyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=CC=C(C=C1)F)=O)C(F)(F)F RGMASPUJFVIQNT-HJHUTUBVSA-N 0.000 claims 1
• IFQVKYUQDSXJJP-JKSUJKDBSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-ethyl-3-fluoro-N-[(3R,4S)-4-fluoro-1-[4,4,4-trifluoro-3-hydroxy-3-(trifluoromethyl)butanoyl]pyrrolidin-3-yl]benzamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)CC)F)C(F)(F)F IFQVKYUQDSXJJP-JKSUJKDBSA-N 0.000 claims 1
• AAIGMIKDAZIWHZ-LSDHHAIUSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-3-fluoro-2-(fluoromethyl)-N-[(3R,4S)-4-fluoro-1-[4,4,4-trifluoro-3-hydroxy-3-(trifluoromethyl)butanoyl]pyrrolidin-3-yl]benzamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)CF)F)C(F)(F)F AAIGMIKDAZIWHZ-LSDHHAIUSA-N 0.000 claims 1
• HFNKBXCVLMQXSW-PDSXEYIOSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-3-fluoro-N-[(3R,4S)-4-fluoro-1-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]pyrrolidin-3-yl]-2-methylbenzamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)C)F)C(F)(F)F HFNKBXCVLMQXSW-PDSXEYIOSA-N 0.000 claims 1
• LJIRRZZRZJHVQO-LSDHHAIUSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-3-fluoro-N-[(3R,4S)-4-fluoro-1-[4,4,4-trifluoro-3-hydroxy-3-(trifluoromethyl)butanoyl]pyrrolidin-3-yl]-2-methylbenzamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)C)F)C(F)(F)F LJIRRZZRZJHVQO-LSDHHAIUSA-N 0.000 claims 1
• YTPZGWVJDMJIKT-UONOGXRCSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-4-fluoro-N-[(3R,4S)-4-fluoro-1-[4,4,4-trifluoro-3-hydroxy-3-(trifluoromethyl)butanoyl]pyrrolidin-3-yl]-2-methoxybenzamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OC)F)C(F)(F)F YTPZGWVJDMJIKT-UONOGXRCSA-N 0.000 claims 1
• PBFFYHMOOBPITC-DOTOQJQBSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-1-(3,3-difluorocyclobutanecarbonyl)-4-fluoropyrrolidin-3-yl]-2-(methylamino)benzamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)NC)C(F)(F)F PBFFYHMOOBPITC-DOTOQJQBSA-N 0.000 claims 1
• GSYWLQXHVHJEJC-JKSUJKDBSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-1-(3,3-difluorocyclobutanecarbonyl)-4-fluoropyrrolidin-3-yl]-4-fluoro-2-methoxybenzamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC)F)C(F)(F)F GSYWLQXHVHJEJC-JKSUJKDBSA-N 0.000 claims 1
• HNBUTGRKSJFNCL-DLBZAZTESA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-1-(3,3-difluorocyclobutanecarbonyl)-4-fluoropyrrolidin-3-yl]-4-fluoro-2-methylbenzamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)C)F)C(F)(F)F HNBUTGRKSJFNCL-DLBZAZTESA-N 0.000 claims 1
• XRVUYPVNHWCABY-LSDHHAIUSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-1-(3,3-difluoropyrrolidine-1-carbonyl)-4-fluoropyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)N2CC(CC2)(F)F)C=1)OC)C(F)(F)F XRVUYPVNHWCABY-LSDHHAIUSA-N 0.000 claims 1
• YICXZGALSVCDQO-ZWKOTPCHSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-1-(cyclohexylcarbamoyl)-4-fluoropyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(NC2CCCCC2)=O)C=1)OC)C(F)(F)F YICXZGALSVCDQO-ZWKOTPCHSA-N 0.000 claims 1
• SEFZGFQGJHHDCY-DLBZAZTESA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-1-(cyclopentylcarbamoyl)-4-fluoropyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(NC2CCCC2)=O)C=1)OC)C(F)(F)F SEFZGFQGJHHDCY-DLBZAZTESA-N 0.000 claims 1
• OUCJONTXUYLAKQ-LSDHHAIUSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-1-(tert-butylcarbamoyl)-4-fluoropyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(NC(C)(C)C)=O)C=1)OC)C(F)(F)F OUCJONTXUYLAKQ-LSDHHAIUSA-N 0.000 claims 1
• FDOQYEAXZLPSPH-LSDHHAIUSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-1-[ethyl(methyl)carbamoyl]-4-fluoropyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(N(C)CC)=O)C=1)OC)C(F)(F)F FDOQYEAXZLPSPH-LSDHHAIUSA-N 0.000 claims 1
• AKHPHEHGVXFQNH-UONOGXRCSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-(1,3-thiazole-5-carbonyl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=CN=CS2)C=1)OC)C(F)(F)F AKHPHEHGVXFQNH-UONOGXRCSA-N 0.000 claims 1
• SVTGHFHIZUKACG-QWHCGFSZSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-(2,2,2-trifluoroethylcarbamoyl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(NCC(F)(F)F)=O)C=1)OC)C(F)(F)F SVTGHFHIZUKACG-QWHCGFSZSA-N 0.000 claims 1
• KISLZOXTUAYFJO-JKSUJKDBSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-(2-methyl-3-oxobutan-2-yl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C)(C(C)=O)C)C=1)OC)C(F)(F)F KISLZOXTUAYFJO-JKSUJKDBSA-N 0.000 claims 1
• NFSVVQWFAMWHIT-IODPJOFQSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(C(F)(F)F)(C)O)C=1)OC)C(F)(F)F NFSVVQWFAMWHIT-IODPJOFQSA-N 0.000 claims 1
• VBNQBUHOEGMKHB-JKSUJKDBSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-(3-hydroxy-2,3-dimethylbutan-2-yl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C)(C(C)(C)O)C)C=1)OC)C(F)(F)F VBNQBUHOEGMKHB-JKSUJKDBSA-N 0.000 claims 1
• VOBLUUOQIIZNKF-ZVZXRCORSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-(3-methyl-2,3-dihydro-1H-inden-1-yl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C2CC(C3=CC=CC=C23)C)C=1)OC)C(F)(F)F VOBLUUOQIIZNKF-ZVZXRCORSA-N 0.000 claims 1
• AYECPAXBVRLMSY-YUIIUQSRSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-(4,4,4-trifluoro-2-hydroxybutyl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(CC(F)(F)F)O)C=1)OC)C(F)(F)F AYECPAXBVRLMSY-YUIIUQSRSA-N 0.000 claims 1
• WQLUFPFCSKOEDI-ZWKOTPCHSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-(4-fluorobenzoyl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=CC=C(C=C1)F)=O)C(F)(F)F WQLUFPFCSKOEDI-ZWKOTPCHSA-N 0.000 claims 1
• LYMLKMDDQRAQHH-RBUKOAKNSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-(4-fluorobenzoyl)pyrrolidin-3-yl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=CC=C(C=C1)F)=O)C(F)(F)F LYMLKMDDQRAQHH-RBUKOAKNSA-N 0.000 claims 1
• NJFMHCYTPMJSKU-DLBZAZTESA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-(pentylcarbamoyl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(NCCCCC)=O)C=1)OC)C(F)(F)F NJFMHCYTPMJSKU-DLBZAZTESA-N 0.000 claims 1
• WFVVVEYFJFOBSE-DLBZAZTESA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-(piperidine-1-carbonyl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)N2CCCCC2)C=1)OC)C(F)(F)F WFVVVEYFJFOBSE-DLBZAZTESA-N 0.000 claims 1
• URNDKZTZTGVSDL-LSDHHAIUSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-(propan-2-ylcarbamoyl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(NC(C)C)=O)C=1)OC)C(F)(F)F URNDKZTZTGVSDL-LSDHHAIUSA-N 0.000 claims 1
• ARXQCFWNXAWCQD-QDUSTFBWSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]pyrrolidin-3-yl]-2-methoxy-N-methylpyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N(C)[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)C(F)(F)F ARXQCFWNXAWCQD-QDUSTFBWSA-N 0.000 claims 1
• GUNXJZVXHXONMK-GZWGPKMKSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-[(2R)-3,3,3-trifluoro-2-methoxy-2-methylpropanoyl]pyrrolidin-3-yl]-2-methoxy-N-methylpyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N(C)[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)OC)=O)C=1)OC)C(F)(F)F GUNXJZVXHXONMK-GZWGPKMKSA-N 0.000 claims 1
• DFJMYIBJXYATKF-XJCOFJLPSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-[3-hydroxy-3-(trifluoromethyl)cyclobutanecarbonyl]pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(C(F)(F)F)O)C=1)OC)C(F)(F)F DFJMYIBJXYATKF-XJCOFJLPSA-N 0.000 claims 1
• NUGCALPYPUOSDI-LSDHHAIUSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-propan-2-ylsulfonylpyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)S(=O)(=O)C(C)C)C=1)OC)C(F)(F)F NUGCALPYPUOSDI-LSDHHAIUSA-N 0.000 claims 1
• LYMLKMDDQRAQHH-MOPGFXCFSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3S,4R)-4-fluoro-1-(4-fluorobenzoyl)pyrrolidin-3-yl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@H]1CN(C[C@H]1F)C(C1=CC=C(C=C1)F)=O)C(F)(F)F LYMLKMDDQRAQHH-MOPGFXCFSA-N 0.000 claims 1
• SDCQLSKVRQBCTC-HKZYLEAXSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3S,4R)-4-fluoro-1-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]piperidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@H]1CN(CC[C@H]1F)C([C@@](C(F)(F)F)(C)O)=O)C(F)(F)F SDCQLSKVRQBCTC-HKZYLEAXSA-N 0.000 claims 1
• MHCUMFPLMMZEOW-SFTDATJTSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3S,5S)-1-(3,3-difluorocyclobutanecarbonyl)-5-(phenylmethoxymethyl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN([C@@H](C2)COCC2=CC=CC=C2)C(=O)C2CC(C2)(F)F)C=1)OC)C(F)(F)F MHCUMFPLMMZEOW-SFTDATJTSA-N 0.000 claims 1
• FOCFLYMBNRSKID-UHFFFAOYSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[1-(2,2-difluorocyclopropanecarbonyl)-4-fluoropiperidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CCC1F)C(=O)C1C(C1)(F)F)C(F)(F)F FOCFLYMBNRSKID-UHFFFAOYSA-N 0.000 claims 1
• MOYQNBUEWFYUSO-UHFFFAOYSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[1-(3,3-difluorocyclobutanecarbonyl)-4,4-difluoropyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1(F)F)C(=O)C1CC(C1)(F)F)C(F)(F)F MOYQNBUEWFYUSO-UHFFFAOYSA-N 0.000 claims 1
• STTUTQFCLKMVOF-UHFFFAOYSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[1-(3,3-difluorocyclobutanecarbonyl)-5-(methoxymethyl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)NC2CN(C(C2)COC)C(=O)C2CC(C2)(F)F)C=1)OC)C(F)(F)F STTUTQFCLKMVOF-UHFFFAOYSA-N 0.000 claims 1
• XWWVFKQABQRTOZ-GAGCMDECSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[4,4-difluoro-1-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)NC2CN(CC2(F)F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)C(F)(F)F XWWVFKQABQRTOZ-GAGCMDECSA-N 0.000 claims 1
• HEWKLTJNNNRXAH-UHFFFAOYSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[4,4-difluoro-1-[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propanoyl]pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)NC2CN(CC2(F)F)C(C(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OC)C(F)(F)F HEWKLTJNNNRXAH-UHFFFAOYSA-N 0.000 claims 1
• MOVFJZJIEQDTAL-UHFFFAOYSA-N 5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[4-fluoro-1-(3,3,3-trifluoro-2-hydroxypropyl)pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC(C(F)(F)F)O)C(F)(F)F MOVFJZJIEQDTAL-UHFFFAOYSA-N 0.000 claims 1
• PEPZEKNKLYYYPH-DJEJFTSGSA-N 5-[4-amino-6-(1-methyltetrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)C1=NN=NN1C PEPZEKNKLYYYPH-DJEJFTSGSA-N 0.000 claims 1
• QCFWQZYGWOMUQJ-DJEJFTSGSA-N 5-[4-amino-6-(2-methyltetrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)C=1N=NN(N=1)C QCFWQZYGWOMUQJ-DJEJFTSGSA-N 0.000 claims 1
• MSEOURRMOMBKIG-OSRJUQGESA-N 5-[4-amino-6-(2H-tetrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-N-[(3R,4S)-4-fluoro-1-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]pyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)C1=NN=NN1 MSEOURRMOMBKIG-OSRJUQGESA-N 0.000 claims 1
• PLHUXOHOIVBZSC-UHFFFAOYSA-N C(C1=CC=CC=C1)C1CN(CC1)C(=O)C=1C=C(C=NC=1OC)C1=CC(=C2C(=NC=NN21)N)C(F)(F)F Chemical compound C(C1=CC=CC=C1)C1CN(CC1)C(=O)C=1C=C(C=NC=1OC)C1=CC(=C2C(=NC=NN21)N)C(F)(F)F PLHUXOHOIVBZSC-UHFFFAOYSA-N 0.000 claims 1
• KXECRILAULBHHV-OVNXLKRTSA-N N-[(3R,4S)-1-(2-amino-3,3,3-trifluoro-2-methylpropanoyl)-4-fluoropyrrolidin-3-yl]-5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC(C(=O)N1C[C@H]([C@H](C1)F)NC(C1=C(N=CC(=C1)C1=CC(=C2C(=NC=NN21)N)C(F)(F)F)OC)=O)(C(F)(F)F)C KXECRILAULBHHV-OVNXLKRTSA-N 0.000 claims 1
• YMSOUKXFTGNZBQ-PLRGMUQMSA-N NC(C(=O)N1C[C@H]([C@H](C1)F)NC(C1=C(N=CC(=C1)C1=CC(=C2C(=NC=NN21)N)C(F)(F)F)OC)=O)(CC(C)C)C(F)(F)F Chemical compound NC(C(=O)N1C[C@H]([C@H](C1)F)NC(C1=C(N=CC(=C1)C1=CC(=C2C(=NC=NN21)N)C(F)(F)F)OC)=O)(CC(C)C)C(F)(F)F YMSOUKXFTGNZBQ-PLRGMUQMSA-N 0.000 claims 1
• YWJGMVBXTZDIGQ-VPUIJTBTSA-N NC(C(=O)N1C[C@H]([C@H](C1)F)NC(C1=C(N=CC(=C1)C1=CC(=C2C(=NC=NN21)N)C(F)(F)F)OC)=O)C(F)(F)F Chemical compound NC(C(=O)N1C[C@H]([C@H](C1)F)NC(C1=C(N=CC(=C1)C1=CC(=C2C(=NC=NN21)N)C(F)(F)F)OC)=O)C(F)(F)F YWJGMVBXTZDIGQ-VPUIJTBTSA-N 0.000 claims 1
• BHTWETZNJFWBFF-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C(=CC=1)C)F)C(F)(F)F BHTWETZNJFWBFF-UONOGXRCSA-N 0.000 claims 1
• ZERWKWDUNIEGOV-KFTPUPIBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C(=CC=1)C)F)C(F)(F)F ZERWKWDUNIEGOV-KFTPUPIBSA-N 0.000 claims 1
• YMHVTPPRSMZONZ-NOYMGPGASA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C(=CC=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C(=CC=1)CC)F)C(F)(F)F YMHVTPPRSMZONZ-NOYMGPGASA-N 0.000 claims 1
• OWKWGTKYDSBWMR-HEVMSJOKSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C(=CC=1)F)F)C(F)(F)F OWKWGTKYDSBWMR-HEVMSJOKSA-N 0.000 claims 1
• FEMKHWCKZVWZPL-KFTPUPIBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=CC=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=CC=1)F)C(F)(F)F FEMKHWCKZVWZPL-KFTPUPIBSA-N 0.000 claims 1
• XIAYLTPPOKNHKF-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C(=CC=1)C)F)C(F)(F)F XIAYLTPPOKNHKF-LSDHHAIUSA-N 0.000 claims 1
• YAAPLFAOSNCKTR-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C(=CC=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C(=CC=1)CC)F)C(F)(F)F YAAPLFAOSNCKTR-JKSUJKDBSA-N 0.000 claims 1
• WJSKDEQKZKBXQT-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C(=CC=1)F)F)C(F)(F)F WJSKDEQKZKBXQT-UONOGXRCSA-N 0.000 claims 1
• XVOOYHLPANETSM-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=CC=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=CC=1)F)C(F)(F)F XVOOYHLPANETSM-LSDHHAIUSA-N 0.000 claims 1
• PYDMKXLVKRRZGG-UQZDFYISSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C(=CC=1)C)F)C(F)(F)F PYDMKXLVKRRZGG-UQZDFYISSA-N 0.000 claims 1
• CNHBAGQFRAJDMJ-CXMPNGEBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C(=CC=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C(=CC=1)CC)F)C(F)(F)F CNHBAGQFRAJDMJ-CXMPNGEBSA-N 0.000 claims 1
• DXQXLTFNYYIGNT-JWAGFEDZSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=CC=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=CC=1)F)C(F)(F)F DXQXLTFNYYIGNT-JWAGFEDZSA-N 0.000 claims 1
• SSFGNAIRPNEVKE-FFPFEORLSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C(=CC=1)C)F)C(F)(F)F SSFGNAIRPNEVKE-FFPFEORLSA-N 0.000 claims 1
• ASOPYMVADQASEW-ZMKYACIDSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C(=CC=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C(=CC=1)CC)F)C(F)(F)F ASOPYMVADQASEW-ZMKYACIDSA-N 0.000 claims 1
• DTJJYTDNDMTONK-XVDHHWJWSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C(=CC=1)F)F)C(F)(F)F DTJJYTDNDMTONK-XVDHHWJWSA-N 0.000 claims 1
• UEQDZACYTKTEIL-JNMIHDSVSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=CC=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=CC=1)F)C(F)(F)F UEQDZACYTKTEIL-JNMIHDSVSA-N 0.000 claims 1
• NUARSUGTYRWUPP-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C(=CC=1)C)F)C(F)(F)F NUARSUGTYRWUPP-DLBZAZTESA-N 0.000 claims 1
• UFPXBCOXJAZKBP-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C(=CC=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C(=CC=1)CC)F)C(F)(F)F UFPXBCOXJAZKBP-ZWKOTPCHSA-N 0.000 claims 1
• QTJTUGLCNSDPJH-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C(=CC=1)F)F)C(F)(F)F QTJTUGLCNSDPJH-JKSUJKDBSA-N 0.000 claims 1
• LBQDNDPIHBOEJG-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC2)C=CC=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC2)C=CC=1)F)C(F)(F)F LBQDNDPIHBOEJG-JKSUJKDBSA-N 0.000 claims 1
• DALGYNJKVHYCNG-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)C)=O)C=CC=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)C)=O)C=CC=1)F)C(F)(F)F DALGYNJKVHYCNG-UONOGXRCSA-N 0.000 claims 1
• AYIXFUQAQRVPKQ-INPHSSGZSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C(=CC=1)C)F)C(F)(F)F AYIXFUQAQRVPKQ-INPHSSGZSA-N 0.000 claims 1
• QROVWJLHAMPTEF-LFOGUXLASA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C(=CC=1)F)F)C(F)(F)F QROVWJLHAMPTEF-LFOGUXLASA-N 0.000 claims 1
• IMSPAHBUPPYPLW-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)C)=O)C=CC=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)C)=O)C=CC=1)F)C(F)(F)F IMSPAHBUPPYPLW-LSDHHAIUSA-N 0.000 claims 1
• GXQOPPXDFSTILG-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C(=CC=1)C)F)C(F)(F)F GXQOPPXDFSTILG-UONOGXRCSA-N 0.000 claims 1
• NLHJHUBMFXFKDY-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=CC=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=CC=1)F)C(F)(F)F NLHJHUBMFXFKDY-UONOGXRCSA-N 0.000 claims 1
• GLJZMBIUXZJCHZ-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C(=CC=1)C)F)C(F)(F)F GLJZMBIUXZJCHZ-UONOGXRCSA-N 0.000 claims 1
• HBOUMKUOSYTEJV-DXZWUPATSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C(=CC=1)C)F)C(F)(F)F HBOUMKUOSYTEJV-DXZWUPATSA-N 0.000 claims 1
• NUWREQFGVSGLHB-WWHFTOCKSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C(=CC=1)F)F)C(F)(F)F NUWREQFGVSGLHB-WWHFTOCKSA-N 0.000 claims 1
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• ACLIDMQRZRPNIQ-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C(=CC=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C(=CC=1)CC)F)C(F)(F)F ACLIDMQRZRPNIQ-RBUKOAKNSA-N 0.000 claims 1
• WSUQAMISGNBPSK-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C(=CC=1)F)F)C(F)(F)F WSUQAMISGNBPSK-DLBZAZTESA-N 0.000 claims 1
• NFYPDARAPQGKBR-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=CC=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=CC=1)F)C(F)(F)F NFYPDARAPQGKBR-ZWKOTPCHSA-N 0.000 claims 1
• UPSDYQWANBNFOW-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=CC=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=CC=1)F)C(F)(F)F UPSDYQWANBNFOW-ZWKOTPCHSA-N 0.000 claims 1
• ZQAWTOMMLVGISZ-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C(=CC=1)C)F)C(F)(F)F ZQAWTOMMLVGISZ-QWHCGFSZSA-N 0.000 claims 1
• GJYVPZAJJYEAQU-NWDGAFQWSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C(=CC=1)F)F)C(F)(F)F GJYVPZAJJYEAQU-NWDGAFQWSA-N 0.000 claims 1
• LUUNXQKFFQTXGZ-DXZWUPATSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C(=CC=1)C)F)C(F)(F)F LUUNXQKFFQTXGZ-DXZWUPATSA-N 0.000 claims 1
• XYSTUXYYNGWTPW-KYFQQJHYSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C(=CC=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C(=CC=1)CC)F)C(F)(F)F XYSTUXYYNGWTPW-KYFQQJHYSA-N 0.000 claims 1
• PWRCTUDBEOPWJH-WWHFTOCKSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C(=CC=1)F)F)C(F)(F)F PWRCTUDBEOPWJH-WWHFTOCKSA-N 0.000 claims 1
• HKHFIXVTVNINDZ-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C(=CC=1)C)F)C(F)(F)F HKHFIXVTVNINDZ-QWHCGFSZSA-N 0.000 claims 1
• XERBXTSIMTYFNK-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C(=CC=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C(=CC=1)CC)F)C(F)(F)F XERBXTSIMTYFNK-UONOGXRCSA-N 0.000 claims 1
• UHZOVNQVZIZNOV-NWDGAFQWSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C(=CC=1)F)F)C(F)(F)F UHZOVNQVZIZNOV-NWDGAFQWSA-N 0.000 claims 1
• MQFYVJYTZWXGSL-YUIIUQSRSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C(=CC=1)C)F)C(F)(F)F MQFYVJYTZWXGSL-YUIIUQSRSA-N 0.000 claims 1
• ROMMUUNIVYFPHY-VOPCEASESA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C(=CC=1)F)F)C(F)(F)F ROMMUUNIVYFPHY-VOPCEASESA-N 0.000 claims 1
• VEBGSXRMXMOUNJ-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C(=CC=1)C)F)C(F)(F)F VEBGSXRMXMOUNJ-JKSUJKDBSA-N 0.000 claims 1
• YCOVGBZXPBKWAH-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C(=CC=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C(=CC=1)CC)F)C(F)(F)F YCOVGBZXPBKWAH-DLBZAZTESA-N 0.000 claims 1
• WNRHYRASODLGMB-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C(=CC=1)F)F)C(F)(F)F WNRHYRASODLGMB-LSDHHAIUSA-N 0.000 claims 1
• MAONMVLPPNVFNT-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=CC=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=CC=1)F)C(F)(F)F MAONMVLPPNVFNT-JKSUJKDBSA-N 0.000 claims 1
• UOMXHECPMCFJKU-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C(=CC=1)C)F)C(F)(F)F UOMXHECPMCFJKU-QWHCGFSZSA-N 0.000 claims 1
• XMMWZBFSTMWKFM-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C(=CC=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C(=CC=1)CC)F)C(F)(F)F XMMWZBFSTMWKFM-UONOGXRCSA-N 0.000 claims 1
• HKDXDYQRDPCFIY-OSRJUQGESA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C(=CC=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C(=CC=1)C)F)C(F)(F)F HKDXDYQRDPCFIY-OSRJUQGESA-N 0.000 claims 1
• OKZKDYOTSLNJQQ-DJEJFTSGSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C(=CC=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C(=CC=1)CC)F)C(F)(F)F OKZKDYOTSLNJQQ-DJEJFTSGSA-N 0.000 claims 1
• RALAURUMBBYCHS-XXRNEEKGSA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C(=CC=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C(=CC=1)F)F)C(F)(F)F RALAURUMBBYCHS-XXRNEEKGSA-N 0.000 claims 1
• QEQQXHKIWNMAEQ-MRRFBWAASA-N NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=CC=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=CC=1)F)C(F)(F)F QEQQXHKIWNMAEQ-MRRFBWAASA-N 0.000 claims 1
• JMYGENNWHWHGOO-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=1)F)F)C(F)(F)F JMYGENNWHWHGOO-LSDHHAIUSA-N 0.000 claims 1
• ULIUSVJPOGVNBE-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)C(F)(F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)C(F)(F)F)C=1)C)F)C(F)(F)F ULIUSVJPOGVNBE-DLBZAZTESA-N 0.000 claims 1
• JTCAWUIPYRXAFK-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)F)C=1)C)F)C(F)(F)F JTCAWUIPYRXAFK-DLBZAZTESA-N 0.000 claims 1
• XYPALKDMSVDACD-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)O)C=1)C)F)C(F)(F)F XYPALKDMSVDACD-DLBZAZTESA-N 0.000 claims 1
• KBKRLXDTIVGPGR-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)O)C=1)Cl)F)C(F)(F)F KBKRLXDTIVGPGR-JKSUJKDBSA-N 0.000 claims 1
• SODHAQJJDROVFK-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCCC2)O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCCC2)O)C=1)C)F)C(F)(F)F SODHAQJJDROVFK-ZWKOTPCHSA-N 0.000 claims 1
• JTRXLFVALQLQDR-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCCC2)O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCCC2)O)C=1)Cl)F)C(F)(F)F JTRXLFVALQLQDR-DLBZAZTESA-N 0.000 claims 1
• YHQKIUBQAAPAIE-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2)Cl)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2)Cl)C=1)C)F)C(F)(F)F YHQKIUBQAAPAIE-RBUKOAKNSA-N 0.000 claims 1
• ITJYDAZBRLGZNY-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2)F)C=1)C)F)C(F)(F)F ITJYDAZBRLGZNY-RBUKOAKNSA-N 0.000 claims 1
• DYSRHNRWMPTNBK-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2F)F)C=1)C)F)C(F)(F)F DYSRHNRWMPTNBK-ZWKOTPCHSA-N 0.000 claims 1
• UCBNHAJDSVMQDA-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=CC(=NC=C2)C)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=CC(=NC=C2)C)C=1)C)F)C(F)(F)F UCBNHAJDSVMQDA-VQTJNVASSA-N 0.000 claims 1
• CXGRIKDBCXNBPL-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=CC(=NC=C2F)C)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=CC(=NC=C2F)C)C=1)C)F)C(F)(F)F CXGRIKDBCXNBPL-VQTJNVASSA-N 0.000 claims 1
• TYWOVUJXHRMXKD-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=CC=NC=C2)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=CC=NC=C2)C=1)C)F)C(F)(F)F TYWOVUJXHRMXKD-RBUKOAKNSA-N 0.000 claims 1
• SOBQBLMWXHEHDQ-FUHWJXTLSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC(=C(C=C2)F)Br)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC(=C(C=C2)F)Br)C=1)C)F)C(F)(F)F SOBQBLMWXHEHDQ-FUHWJXTLSA-N 0.000 claims 1
• XJMMZFYRJKJFOM-FUHWJXTLSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC(=CC=C2)Br)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC(=CC=C2)Br)C=1)C)F)C(F)(F)F XJMMZFYRJKJFOM-FUHWJXTLSA-N 0.000 claims 1
• OSAAEEXTNOHVQS-FUHWJXTLSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC(=CC=C2)C(F)(F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC(=CC=C2)C(F)(F)F)C=1)C)F)C(F)(F)F OSAAEEXTNOHVQS-FUHWJXTLSA-N 0.000 claims 1
• MTWDAYFAKAORPZ-AZUAARDMSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC(=CC=C2)C)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC(=CC=C2)C)C=1)C)F)C(F)(F)F MTWDAYFAKAORPZ-AZUAARDMSA-N 0.000 claims 1
• UMGQEZCNIKKZNG-FUHWJXTLSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC(=CC=C2)Cl)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC(=CC=C2)Cl)C=1)C)F)C(F)(F)F UMGQEZCNIKKZNG-FUHWJXTLSA-N 0.000 claims 1
• ILKGMUYWSALXHU-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC(=CC=C2C(F)(F)F)Cl)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC(=CC=C2C(F)(F)F)Cl)C=1)C)F)C(F)(F)F ILKGMUYWSALXHU-DLBZAZTESA-N 0.000 claims 1
• SWWMMWQSRBSWJW-PKOBYXMFSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2)Cl)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2)Cl)C=1)C)F)C(F)(F)F SWWMMWQSRBSWJW-PKOBYXMFSA-N 0.000 claims 1
• XOKMOSZTVLSDMC-PKOBYXMFSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2)F)C=1)C)F)C(F)(F)F XOKMOSZTVLSDMC-PKOBYXMFSA-N 0.000 claims 1
• UIVGHUZTWJMZCQ-PKOBYXMFSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2)OC(F)(F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2)OC(F)(F)F)C=1)C)F)C(F)(F)F UIVGHUZTWJMZCQ-PKOBYXMFSA-N 0.000 claims 1
• OKRFHQWROMTGOW-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2F)Br)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2F)Br)C=1)C)F)C(F)(F)F OKRFHQWROMTGOW-ZWKOTPCHSA-N 0.000 claims 1
• NHEGCCWDTPMIDO-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2F)C(F)(F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2F)C(F)(F)F)C=1)C)F)C(F)(F)F NHEGCCWDTPMIDO-ZWKOTPCHSA-N 0.000 claims 1
• KVBNKRZEZOQRCD-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2F)F)C=1)C)F)C(F)(F)F KVBNKRZEZOQRCD-ZWKOTPCHSA-N 0.000 claims 1
• GTOOWUGYLBSKSI-AZUAARDMSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)C)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)C)C=1)C)F)C(F)(F)F GTOOWUGYLBSKSI-AZUAARDMSA-N 0.000 claims 1
• RWVBLQWRXKSESX-PKOBYXMFSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)Cl)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)Cl)C=1)C)F)C(F)(F)F RWVBLQWRXKSESX-PKOBYXMFSA-N 0.000 claims 1
• GPWCSQDIVGMCBN-PKOBYXMFSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)F)C=1)C)F)C(F)(F)F GPWCSQDIVGMCBN-PKOBYXMFSA-N 0.000 claims 1
• LKKJZYZLPCKIQM-PKOBYXMFSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2)C=1)C)F)C(F)(F)F LKKJZYZLPCKIQM-PKOBYXMFSA-N 0.000 claims 1
• XNSRNPGHBUSJPN-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2Br)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2Br)C=1)C)F)C(F)(F)F XNSRNPGHBUSJPN-ZWKOTPCHSA-N 0.000 claims 1
• HZWDNGZAHVMLRF-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2C(F)(F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2C(F)(F)F)C=1)C)F)C(F)(F)F HZWDNGZAHVMLRF-ZWKOTPCHSA-N 0.000 claims 1
• ZHYOKOGHBGKHBN-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2Cl)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2Cl)C=1)C)F)C(F)(F)F ZHYOKOGHBGKHBN-ZWKOTPCHSA-N 0.000 claims 1
• RNVCMEBVOIRQJX-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2F)C=1)C)F)C(F)(F)F RNVCMEBVOIRQJX-ZWKOTPCHSA-N 0.000 claims 1
• HKTLGCOTCIQHLV-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2F)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2F)C=1)Cl)F)C(F)(F)F HKTLGCOTCIQHLV-DLBZAZTESA-N 0.000 claims 1
• KNWRBWSPOZIJME-LRUHZDSUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)C)C)C(F)(F)F KNWRBWSPOZIJME-LRUHZDSUSA-N 0.000 claims 1
• JXSFRAFAKBTJKH-YUIIUQSRSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)Cl)F)C(F)(F)F JXSFRAFAKBTJKH-YUIIUQSRSA-N 0.000 claims 1
• JYRMDUQVVPKSSK-YUIIUQSRSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)F)F)C(F)(F)F JYRMDUQVVPKSSK-YUIIUQSRSA-N 0.000 claims 1
• DFEPFIDZRGRBIQ-JQXSQYPDSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OC)F)C(F)(F)F DFEPFIDZRGRBIQ-JQXSQYPDSA-N 0.000 claims 1
• NMARSLSXGRJUPI-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)C)C)C(F)(F)F NMARSLSXGRJUPI-ZWKOTPCHSA-N 0.000 claims 1
• ZQJWIEABSXBHOV-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)Cl)F)C(F)(F)F ZQJWIEABSXBHOV-JKSUJKDBSA-N 0.000 claims 1
• BCCXLVLRUMVXJM-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)F)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)F)Cl)C(F)(F)F BCCXLVLRUMVXJM-JKSUJKDBSA-N 0.000 claims 1
• LNJCBJNINKKZIF-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)F)F)C(F)(F)F LNJCBJNINKKZIF-JKSUJKDBSA-N 0.000 claims 1
• KGMCUFXQFBHRLB-TUAHZWSISA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)F)F)C(F)(F)F KGMCUFXQFBHRLB-TUAHZWSISA-N 0.000 claims 1
• WQKXDJJZXQZLDW-JRIFGSMTSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OC)F)C(F)(F)F WQKXDJJZXQZLDW-JRIFGSMTSA-N 0.000 claims 1
• XBQRXLLTNCYWCN-GGUZCGDUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)C)C)C(F)(F)F XBQRXLLTNCYWCN-GGUZCGDUSA-N 0.000 claims 1
• HRVILQXRSVVQFD-OTLVQASYSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)F)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)F)C)C(F)(F)F HRVILQXRSVVQFD-OTLVQASYSA-N 0.000 claims 1
• XBJKRGHAOQFQPY-AJMWJVNWSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)F)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)F)Cl)C(F)(F)F XBJKRGHAOQFQPY-AJMWJVNWSA-N 0.000 claims 1
• XVGADRLMMLARKC-AJMWJVNWSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)F)F)C(F)(F)F XVGADRLMMLARKC-AJMWJVNWSA-N 0.000 claims 1
• HEWOLTHFJUEDOW-DZLJAHQNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OC)F)C(F)(F)F HEWOLTHFJUEDOW-DZLJAHQNSA-N 0.000 claims 1
• ZYQAPBIPLBQFAL-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)C)C)C(F)(F)F ZYQAPBIPLBQFAL-VQTJNVASSA-N 0.000 claims 1
• PRSWVLILAUOBMJ-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)C)F)C(F)(F)F PRSWVLILAUOBMJ-RBUKOAKNSA-N 0.000 claims 1
• VFZSFVJUSSVPSQ-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)Cl)F)C(F)(F)F VFZSFVJUSSVPSQ-ZWKOTPCHSA-N 0.000 claims 1
• COJGKEOTIFOCJP-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC2)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC2)C=1)C)F)C(F)(F)F COJGKEOTIFOCJP-ZWKOTPCHSA-N 0.000 claims 1
• QHMRPMQPLKIQHH-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCCC2)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCCC2)C=1)C)F)C(F)(F)F QHMRPMQPLKIQHH-RBUKOAKNSA-N 0.000 claims 1
• ADUQUJOFBXUEIH-GGUZCGDUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2COCC2)C=1)C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2COCC2)C=1)C)C)C(F)(F)F ADUQUJOFBXUEIH-GGUZCGDUSA-N 0.000 claims 1
• VODDLHLYGBAXMM-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=CC=2Cl)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=CC=2Cl)C=1)C)F)C(F)(F)F VODDLHLYGBAXMM-RBUKOAKNSA-N 0.000 claims 1
• NQUISIGRVANIJR-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=C(SC=2)C)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=C(SC=2)C)C=1)C)F)C(F)(F)F NQUISIGRVANIJR-DLBZAZTESA-N 0.000 claims 1
• DNOFTGIVTICVCW-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=C(SC=2C)C)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=C(SC=2C)C)C=1)C)F)C(F)(F)F DNOFTGIVTICVCW-ZWKOTPCHSA-N 0.000 claims 1
• GTYKPHWBMBHEDO-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=CSC=2)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=CSC=2)C=1)C)F)C(F)(F)F GTYKPHWBMBHEDO-JKSUJKDBSA-N 0.000 claims 1
• FLHSQOUALOPLNR-PKOBYXMFSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=NC(=CC=2)C)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=NC(=CC=2)C)C=1)C)F)C(F)(F)F FLHSQOUALOPLNR-PKOBYXMFSA-N 0.000 claims 1
• QZJLCILFHXTEAX-DOTOQJQBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=NC(=CC=2)Cl)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=NC(=CC=2)Cl)C=1)C)F)C(F)(F)F QZJLCILFHXTEAX-DOTOQJQBSA-N 0.000 claims 1
• JBIIMNDMNKLMSR-FUHWJXTLSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=NC=CC=2)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=NC=CC=2)C=1)C)F)C(F)(F)F JBIIMNDMNKLMSR-FUHWJXTLSA-N 0.000 claims 1
• ROMNLKSJLPEVRO-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2SC=C(N=2)C)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2SC=C(N=2)C)C=1)C)F)C(F)(F)F ROMNLKSJLPEVRO-DLBZAZTESA-N 0.000 claims 1
• MQNCGUDUCFAICB-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)C)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)C)=O)C=1)C)F)C(F)(F)F MQNCGUDUCFAICB-JKSUJKDBSA-N 0.000 claims 1
• FWIPANOTFXXLAA-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)C)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)C)=O)C=1)OC)F)C(F)(F)F FWIPANOTFXXLAA-LSDHHAIUSA-N 0.000 claims 1
• LMIYWMDOGKALJA-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)F)=O)C=1)C)F)C(F)(F)F LMIYWMDOGKALJA-ZOMUKPOZSA-N 0.000 claims 1
• MEURYGOXKSGQMD-YFZPJLNOSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)C)F)C(F)(F)F MEURYGOXKSGQMD-YFZPJLNOSA-N 0.000 claims 1
• JAGKZQDVKKKURV-AQNUZEJVSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)Cl)F)C(F)(F)F JAGKZQDVKKKURV-AQNUZEJVSA-N 0.000 claims 1
• HBYQKJIAQNKWOE-AQNUZEJVSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)F)F)C(F)(F)F HBYQKJIAQNKWOE-AQNUZEJVSA-N 0.000 claims 1
• ABHQESATNWJMNG-SXODRGRHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OC)F)C(F)(F)F ABHQESATNWJMNG-SXODRGRHSA-N 0.000 claims 1
• NPESGCSBPZOWIF-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)C)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)C)=O)C=1)C)F)C(F)(F)F NPESGCSBPZOWIF-DLBZAZTESA-N 0.000 claims 1
• MRMVLGXKRNGOMG-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)Cl)F)C(F)(F)F MRMVLGXKRNGOMG-LSDHHAIUSA-N 0.000 claims 1
• HNGQQDVTLGDSOR-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)F)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)F)Cl)C(F)(F)F HNGQQDVTLGDSOR-LSDHHAIUSA-N 0.000 claims 1
• KLPMMVUXUKBCDE-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)F)F)C(F)(F)F KLPMMVUXUKBCDE-LSDHHAIUSA-N 0.000 claims 1
• HDOIEETYRADWNQ-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OC)F)C(F)(F)F HDOIEETYRADWNQ-LSDHHAIUSA-N 0.000 claims 1
• XPLZMTXEMKYZBX-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)C)F)C(F)(F)F XPLZMTXEMKYZBX-JKSUJKDBSA-N 0.000 claims 1
• VBBMXMNKXHBARD-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)F)F)C(F)(F)F VBBMXMNKXHBARD-LSDHHAIUSA-N 0.000 claims 1
• SZCWATDANZNJHI-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)C)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)C)=O)C=1)C)F)C(F)(F)F SZCWATDANZNJHI-DLBZAZTESA-N 0.000 claims 1
• MESJCMJGYGFFEO-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)C)F)C(F)(F)F MESJCMJGYGFFEO-OKFXBHNASA-N 0.000 claims 1
• WMKSHNPNMMHINB-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)Cl)F)C(F)(F)F WMKSHNPNMMHINB-ZOMUKPOZSA-N 0.000 claims 1
• FUVKRUGECVUVBS-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)F)F)C(F)(F)F FUVKRUGECVUVBS-ZOMUKPOZSA-N 0.000 claims 1
• MLXUGRZIYGOJHS-IHGBKINDSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OC)F)C(F)(F)F MLXUGRZIYGOJHS-IHGBKINDSA-N 0.000 claims 1
• FZKLYCIZCCLCCM-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C(=CC=C2)F)Cl)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C(=CC=C2)F)Cl)=O)C=1)C)F)C(F)(F)F FZKLYCIZCCLCCM-RBUKOAKNSA-N 0.000 claims 1
• MHTYQXYGPWFZAP-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C(=CC=C2)F)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C(=CC=C2)F)F)=O)C=1)C)F)C(F)(F)F MHTYQXYGPWFZAP-RBUKOAKNSA-N 0.000 claims 1
• WWXXUZXFTULIPT-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C(=C2)F)F)Cl)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C(=C2)F)F)Cl)=O)C=1)C)F)C(F)(F)F WWXXUZXFTULIPT-VQTJNVASSA-N 0.000 claims 1
• ZKMGXZJDQXRCFD-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C(=C2)F)F)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C(=C2)F)F)F)=O)C=1)C)F)C(F)(F)F ZKMGXZJDQXRCFD-VQTJNVASSA-N 0.000 claims 1
• VRTCOPMJVFLQMV-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2)F)Cl)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2)F)Cl)=O)C=1)C)F)C(F)(F)F VRTCOPMJVFLQMV-VQTJNVASSA-N 0.000 claims 1
• MCLVKWBNKWNCRN-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2)F)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2)F)F)=O)C=1)C)F)C(F)(F)F MCLVKWBNKWNCRN-VQTJNVASSA-N 0.000 claims 1
• KILNBKMTNPPCTO-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2F)F)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2F)F)F)=O)C=1)C)F)C(F)(F)F KILNBKMTNPPCTO-RBUKOAKNSA-N 0.000 claims 1
• DPVJWNFPUJQHKA-LEWJYISDSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC(=C2)C#N)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC(=C2)C#N)F)=O)C=1)C)F)C(F)(F)F DPVJWNFPUJQHKA-LEWJYISDSA-N 0.000 claims 1
• ANKJVNBVQVRLHO-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC(=C2)F)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC(=C2)F)F)=O)C=1)C)F)C(F)(F)F ANKJVNBVQVRLHO-VQTJNVASSA-N 0.000 claims 1
• TXCOQEUEDTVJAF-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)Cl)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)Cl)=O)C=1)C)F)C(F)(F)F TXCOQEUEDTVJAF-VQTJNVASSA-N 0.000 claims 1
• ZYOHQGXCAKISKU-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)C)F)C(F)(F)F ZYOHQGXCAKISKU-VQTJNVASSA-N 0.000 claims 1
• BSLBICBOZBAVCG-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)Cl)F)C(F)(F)F BSLBICBOZBAVCG-RBUKOAKNSA-N 0.000 claims 1
• FUBOKKNPQYJUPJ-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2F)Cl)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2F)Cl)=O)C=1)C)F)C(F)(F)F FUBOKKNPQYJUPJ-RBUKOAKNSA-N 0.000 claims 1
• ZUHFJPXOGSCVEN-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2F)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2F)F)=O)C=1)C)F)C(F)(F)F ZUHFJPXOGSCVEN-RBUKOAKNSA-N 0.000 claims 1
• CONOTIATFIBJNL-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=C(C=C2)F)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=C(C=C2)F)F)=O)C=1)C)F)C(F)(F)F CONOTIATFIBJNL-VQTJNVASSA-N 0.000 claims 1
• CLABVSOPNKARAJ-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=CC(=C2)F)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=CC(=C2)F)F)=O)C=1)C)F)C(F)(F)F CLABVSOPNKARAJ-VQTJNVASSA-N 0.000 claims 1
• HILCSBUFGRCWFL-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=CC=C2)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=CC=C2)F)=O)C=1)C)F)C(F)(F)F HILCSBUFGRCWFL-VQTJNVASSA-N 0.000 claims 1
• UDFMANNCQIBYPJ-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)Cl)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)Cl)=O)C=1)C)F)C(F)(F)F UDFMANNCQIBYPJ-VQTJNVASSA-N 0.000 claims 1
• GUHRWXSOVJKNRB-LEWJYISDSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)C)C)C(F)(F)F GUHRWXSOVJKNRB-LEWJYISDSA-N 0.000 claims 1
• PWOUHFFPTMICKJ-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)C)F)C(F)(F)F PWOUHFFPTMICKJ-VQTJNVASSA-N 0.000 claims 1
• BFCAIQGORJJMSA-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)Cl)F)C(F)(F)F BFCAIQGORJJMSA-RBUKOAKNSA-N 0.000 claims 1
• DECZTBROOZHZSI-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)OC)F)C(F)(F)F DECZTBROOZHZSI-RBUKOAKNSA-N 0.000 claims 1
• AEXJFFACFWGEHP-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)C)F)C(F)(F)F AEXJFFACFWGEHP-LSDHHAIUSA-N 0.000 claims 1
• MQAVROLLMVCMGT-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)Cl)F)C(F)(F)F MQAVROLLMVCMGT-UONOGXRCSA-N 0.000 claims 1
• ZFDXUMLKDGGKAM-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)F)F)C(F)(F)F ZFDXUMLKDGGKAM-UONOGXRCSA-N 0.000 claims 1
• VRXMPPAWKOGZFG-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)C)F)C(F)(F)F VRXMPPAWKOGZFG-OKFXBHNASA-N 0.000 claims 1
• VSJOTNMIPWMXMT-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)Cl)F)C(F)(F)F VSJOTNMIPWMXMT-ZOMUKPOZSA-N 0.000 claims 1
• QIWYMGBNXXGLRY-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)F)F)C(F)(F)F QIWYMGBNXXGLRY-ZOMUKPOZSA-N 0.000 claims 1
• VMLMOZZNZRCQHG-IHGBKINDSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OC)F)C(F)(F)F VMLMOZZNZRCQHG-IHGBKINDSA-N 0.000 claims 1
• OHZTWWYZURBWTN-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)C)F)C(F)(F)F OHZTWWYZURBWTN-LSDHHAIUSA-N 0.000 claims 1
• BZARZINGMZPDDY-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)Cl)F)C(F)(F)F BZARZINGMZPDDY-UONOGXRCSA-N 0.000 claims 1
• XRYZHJZDJYKQQH-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)F)F)C(F)(F)F XRYZHJZDJYKQQH-UONOGXRCSA-N 0.000 claims 1
• PGTBPZJHRQKCAB-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OC)F)C(F)(F)F PGTBPZJHRQKCAB-UONOGXRCSA-N 0.000 claims 1
• DDPASLFWGYOGBU-DZLJAHQNSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)C)F)C(F)(F)F DDPASLFWGYOGBU-DZLJAHQNSA-N 0.000 claims 1
• GVSKRUBFHPACTE-BZRNNEMISA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)Cl)F)C(F)(F)F GVSKRUBFHPACTE-BZRNNEMISA-N 0.000 claims 1
• UCTVCSRZZGVVAM-BZRNNEMISA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)F)F)C(F)(F)F UCTVCSRZZGVVAM-BZRNNEMISA-N 0.000 claims 1
• LGFBVDZWEDOWNL-YFZPJLNOSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OC)F)C(F)(F)F LGFBVDZWEDOWNL-YFZPJLNOSA-N 0.000 claims 1
• MEBZSNHJDLHDSQ-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)(C)O)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)(C)O)=O)C=1)C)F)C(F)(F)F MEBZSNHJDLHDSQ-DLBZAZTESA-N 0.000 claims 1
• JZNACIZMQIJQRP-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)(C)O)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)(C)O)=O)C=1)Cl)F)C(F)(F)F JZNACIZMQIJQRP-JKSUJKDBSA-N 0.000 claims 1
• IQPRGSKGRRYUEN-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)C)F)C(F)(F)F IQPRGSKGRRYUEN-ZWKOTPCHSA-N 0.000 claims 1
• JPAVZQKTFJRPRU-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)Cl)F)C(F)(F)F JPAVZQKTFJRPRU-DLBZAZTESA-N 0.000 claims 1
• NHZHAFACLIUPIE-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)F)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)F)C)C(F)(F)F NHZHAFACLIUPIE-ZWKOTPCHSA-N 0.000 claims 1
• ROBOJTFJPWNFBR-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)F)F)C(F)(F)F ROBOJTFJPWNFBR-DLBZAZTESA-N 0.000 claims 1
• OMJXDEZRULAYFL-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)C)F)C(F)(F)F OMJXDEZRULAYFL-LSDHHAIUSA-N 0.000 claims 1
• JDFPOPKIBNJIPW-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)Cl)F)C(F)(F)F JDFPOPKIBNJIPW-UONOGXRCSA-N 0.000 claims 1
• AYJJTMMKQDUVST-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)F)F)C(F)(F)F AYJJTMMKQDUVST-UONOGXRCSA-N 0.000 claims 1
• LNDBBXBJXKQGCW-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)OC)F)C(F)(F)F LNDBBXBJXKQGCW-UONOGXRCSA-N 0.000 claims 1
• ONIJUAMQQHVTII-PDSXEYIOSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)C)F)C(F)(F)F ONIJUAMQQHVTII-PDSXEYIOSA-N 0.000 claims 1
• FGKUAOYCEOJFQE-LRDNONRASA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)Cl)F)C(F)(F)F FGKUAOYCEOJFQE-LRDNONRASA-N 0.000 claims 1
• VGGXXHSZXVEEJR-PDSXEYIOSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)F)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)F)C)C(F)(F)F VGGXXHSZXVEEJR-PDSXEYIOSA-N 0.000 claims 1
• YCZIEUOYPOUGCY-LRDNONRASA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)F)F)C(F)(F)F YCZIEUOYPOUGCY-LRDNONRASA-N 0.000 claims 1
• AYUHAMNBZSWUDI-PXIJXODZSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)F)C(F)(F)F AYUHAMNBZSWUDI-PXIJXODZSA-N 0.000 claims 1
• AUODBCDBQNCWEI-JJRVBVJISA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@H](C(F)(F)F)O)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@H](C(F)(F)F)O)=O)C=1)C)F)C(F)(F)F AUODBCDBQNCWEI-JJRVBVJISA-N 0.000 claims 1
• QQSGSWIGOIFTPR-WOSRLPQWSA-N NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@H](C(F)(F)F)O)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@H](C(F)(F)F)O)=O)C=1)Cl)F)C(F)(F)F QQSGSWIGOIFTPR-WOSRLPQWSA-N 0.000 claims 1
• YUAIJNXQUNPHHO-MVLOVYDUSA-N NC1=NC=NN2C1=C(C=C2C=1C(=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC([2H])([2H])[2H])C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C(=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC([2H])([2H])[2H])C)C(F)(F)F YUAIJNXQUNPHHO-MVLOVYDUSA-N 0.000 claims 1
• NOCYWMUVOVXBND-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=1)CC)F)C(F)(F)F NOCYWMUVOVXBND-DLBZAZTESA-N 0.000 claims 1
• AZSCSGMJNPTLTC-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=1)CF)F)C(F)(F)F AZSCSGMJNPTLTC-JKSUJKDBSA-N 0.000 claims 1
• PEIOBBSWGMAWLM-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=1)Cl)C)C(F)(F)F PEIOBBSWGMAWLM-LSDHHAIUSA-N 0.000 claims 1
• VJLBWVICDGTHNQ-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=1)Cl)F)C(F)(F)F VJLBWVICDGTHNQ-UONOGXRCSA-N 0.000 claims 1
• UUNIKHYTJCCPJI-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=1)OC)F)C(F)(F)F UUNIKHYTJCCPJI-LSDHHAIUSA-N 0.000 claims 1
• ANQPFBHDACUITF-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)O)C=1)C)F)C(F)(F)F ANQPFBHDACUITF-DLBZAZTESA-N 0.000 claims 1
• XIPFQPPELQPCQC-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2)F)C=1)C)F)C(F)(F)F XIPFQPPELQPCQC-RBUKOAKNSA-N 0.000 claims 1
• MRTNKDWJSYRFDR-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2F)F)C=1)C)F)C(F)(F)F MRTNKDWJSYRFDR-ZWKOTPCHSA-N 0.000 claims 1
• OBBVADGJQFIUHS-PXWJKWRZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)C)F)C(F)(F)F OBBVADGJQFIUHS-PXWJKWRZSA-N 0.000 claims 1
• XYYWXMSRQPHNKP-MWSTZMHHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)CC)F)C(F)(F)F XYYWXMSRQPHNKP-MWSTZMHHSA-N 0.000 claims 1
• KDRUSVBHAWRVCS-PXWJKWRZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)CF)F)C(F)(F)F KDRUSVBHAWRVCS-PXWJKWRZSA-N 0.000 claims 1
• OUSRDIVFCYZNNG-NOYMGPGASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)Cl)C)C(F)(F)F OUSRDIVFCYZNNG-NOYMGPGASA-N 0.000 claims 1
• ZKAGSZODYIZRJA-SBKAZOPESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)Cl)F)C(F)(F)F ZKAGSZODYIZRJA-SBKAZOPESA-N 0.000 claims 1
• SGGIEWOLBYKWDI-JQXSQYPDSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OC)F)C(F)(F)F SGGIEWOLBYKWDI-JQXSQYPDSA-N 0.000 claims 1
• SOCHLAYNMHLTPL-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)C)F)C(F)(F)F SOCHLAYNMHLTPL-DLBZAZTESA-N 0.000 claims 1
• XNORQRLELRVNGX-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)CC)F)C(F)(F)F XNORQRLELRVNGX-ZWKOTPCHSA-N 0.000 claims 1
• ZPAKMNFVSRVAPA-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)CF)F)C(F)(F)F ZPAKMNFVSRVAPA-DLBZAZTESA-N 0.000 claims 1
• USANMSWSXHCDPP-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)Cl)C)C(F)(F)F USANMSWSXHCDPP-JKSUJKDBSA-N 0.000 claims 1
• HKCZDZKNLDBKJT-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)Cl)F)C(F)(F)F HKCZDZKNLDBKJT-LSDHHAIUSA-N 0.000 claims 1
• UYUNIQAKEFRQDQ-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)F)F)C(F)(F)F UYUNIQAKEFRQDQ-LSDHHAIUSA-N 0.000 claims 1
• TYVCJMNMXISUBU-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC)F)C(F)(F)F TYVCJMNMXISUBU-JKSUJKDBSA-N 0.000 claims 1
• KJTMWDBRFAGBNB-DJQNDVTLSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)C)F)C(F)(F)F KJTMWDBRFAGBNB-DJQNDVTLSA-N 0.000 claims 1
• XMQGYFVCSUBLDQ-XHEDQKCFSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)CF)F)C(F)(F)F XMQGYFVCSUBLDQ-XHEDQKCFSA-N 0.000 claims 1
• PWJYTHOCTRXTEW-CXMPNGEBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)Cl)C)C(F)(F)F PWJYTHOCTRXTEW-CXMPNGEBSA-N 0.000 claims 1
• BIANCZGMQCDMTD-JWAGFEDZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)Cl)F)C(F)(F)F BIANCZGMQCDMTD-JWAGFEDZSA-N 0.000 claims 1
• OADYCYXYBBSFRY-SEDVZULUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OC)F)C(F)(F)F OADYCYXYBBSFRY-SEDVZULUSA-N 0.000 claims 1
• CVVHUMQVDFWAEB-OTLVQASYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)C)F)C(F)(F)F CVVHUMQVDFWAEB-OTLVQASYSA-N 0.000 claims 1
• CXDNTCSLLJLULX-FVHARNBYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)CC)F)C(F)(F)F CXDNTCSLLJLULX-FVHARNBYSA-N 0.000 claims 1
• ZTDLIZVYLIYNES-LHOBAWKSSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)CF)F)C(F)(F)F ZTDLIZVYLIYNES-LHOBAWKSSA-N 0.000 claims 1
• USPQFQLKRDPRKC-CRRZLINXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)Cl)C)C(F)(F)F USPQFQLKRDPRKC-CRRZLINXSA-N 0.000 claims 1
• ZVCMKNQIFHQTKK-YFZPJLNOSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)Cl)F)C(F)(F)F ZVCMKNQIFHQTKK-YFZPJLNOSA-N 0.000 claims 1
• CBLLQEJVZABWBN-YFZPJLNOSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)F)F)C(F)(F)F CBLLQEJVZABWBN-YFZPJLNOSA-N 0.000 claims 1
• KJZWNLXJFGQQOA-DZLJAHQNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OC)F)C(F)(F)F KJZWNLXJFGQQOA-DZLJAHQNSA-N 0.000 claims 1
• MFPZPTYUVKLOCU-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)C)F)C(F)(F)F MFPZPTYUVKLOCU-RBUKOAKNSA-N 0.000 claims 1
• CRFRNMGXBKYWQL-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)CC)F)C(F)(F)F CRFRNMGXBKYWQL-VQTJNVASSA-N 0.000 claims 1
• IKPNXEHGIILSOW-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)CF)F)C(F)(F)F IKPNXEHGIILSOW-RBUKOAKNSA-N 0.000 claims 1
• QXONOBUAWHLQKJ-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)Cl)C)C(F)(F)F QXONOBUAWHLQKJ-ZWKOTPCHSA-N 0.000 claims 1
• IWBMUQDZQWKDCU-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)Cl)F)C(F)(F)F IWBMUQDZQWKDCU-DLBZAZTESA-N 0.000 claims 1
• RRNHYSCNUVHMBR-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)OC)F)C(F)(F)F RRNHYSCNUVHMBR-ZWKOTPCHSA-N 0.000 claims 1
• NNWLZVTUDAUQKO-LCKJDKPRSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)F)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)F)C=1)OC)F)C(F)(F)F NNWLZVTUDAUQKO-LCKJDKPRSA-N 0.000 claims 1
• OANYSKONUARDEV-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC2)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC2)C=1)C)F)C(F)(F)F OANYSKONUARDEV-ZWKOTPCHSA-N 0.000 claims 1
• WEJDYGRKDQHNGU-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC2)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC2)C=1)OC)F)C(F)(F)F WEJDYGRKDQHNGU-DLBZAZTESA-N 0.000 claims 1
• ZHKLIQJULGXXIF-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=C(C=2)F)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=C(C=2)F)C=1)C)F)C(F)(F)F ZHKLIQJULGXXIF-RBUKOAKNSA-N 0.000 claims 1
• WHWNVQUQXBFGEE-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=CC=2)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=CC=2)C=1)C)F)C(F)(F)F WHWNVQUQXBFGEE-RBUKOAKNSA-N 0.000 claims 1
• SNAIDEJVZZBOFG-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)C)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)C)=O)C=1)C)F)C(F)(F)F SNAIDEJVZZBOFG-JKSUJKDBSA-N 0.000 claims 1
• RLWGKBXYRLIXST-YFZPJLNOSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)C)F)C(F)(F)F RLWGKBXYRLIXST-YFZPJLNOSA-N 0.000 claims 1
• AANHHLQYJWQBMJ-AJMWJVNWSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)CC)F)C(F)(F)F AANHHLQYJWQBMJ-AJMWJVNWSA-N 0.000 claims 1
• MYAYIXVQACDODP-BZRNNEMISA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)CF)F)C(F)(F)F MYAYIXVQACDODP-BZRNNEMISA-N 0.000 claims 1
• YMCXZDQKUFYKEU-XVDHHWJWSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)Cl)C)C(F)(F)F YMCXZDQKUFYKEU-XVDHHWJWSA-N 0.000 claims 1
• XDCDJKSTCMOYRZ-AZGGKPGBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)F)F)C(F)(F)F XDCDJKSTCMOYRZ-AZGGKPGBSA-N 0.000 claims 1
• JMFHKRDNXCUZLN-SXODRGRHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OC)F)C(F)(F)F JMFHKRDNXCUZLN-SXODRGRHSA-N 0.000 claims 1
• KMOIFPDZKSAGMC-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)C)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)C)=O)C=1)C)F)C(F)(F)F KMOIFPDZKSAGMC-DLBZAZTESA-N 0.000 claims 1
• WUWBBYPSOJDJNM-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)C)F)C(F)(F)F WUWBBYPSOJDJNM-JKSUJKDBSA-N 0.000 claims 1
• ZSAWTPDLUOPTQD-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)CC)F)C(F)(F)F ZSAWTPDLUOPTQD-DLBZAZTESA-N 0.000 claims 1
• YGURWJKSCIZFJY-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)CF)F)C(F)(F)F YGURWJKSCIZFJY-JKSUJKDBSA-N 0.000 claims 1
• BDCQERAGSMAHTQ-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)Cl)C)C(F)(F)F BDCQERAGSMAHTQ-LSDHHAIUSA-N 0.000 claims 1
• CKQJMSMESYCJJG-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)Cl)F)C(F)(F)F CKQJMSMESYCJJG-UONOGXRCSA-N 0.000 claims 1
• CDPXSXYSFNZJDY-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OC)F)C(F)(F)F CDPXSXYSFNZJDY-LSDHHAIUSA-N 0.000 claims 1
• VZJYVHNVJHNLIQ-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)C)F)C(F)(F)F VZJYVHNVJHNLIQ-JKSUJKDBSA-N 0.000 claims 1
• QPTLTOXZDAGNCO-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)CC)F)C(F)(F)F QPTLTOXZDAGNCO-DLBZAZTESA-N 0.000 claims 1
• AUCJMQOFQDZVOQ-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)CF)F)C(F)(F)F AUCJMQOFQDZVOQ-JKSUJKDBSA-N 0.000 claims 1
• TVLPAZUFNWFKIN-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)Cl)C)C(F)(F)F TVLPAZUFNWFKIN-LSDHHAIUSA-N 0.000 claims 1
• CAXVZUYACNHFPA-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)Cl)F)C(F)(F)F CAXVZUYACNHFPA-UONOGXRCSA-N 0.000 claims 1
• WHGVVVVQIGOJCU-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)OC)F)C(F)(F)F WHGVVVVQIGOJCU-LSDHHAIUSA-N 0.000 claims 1
• OFAYEMYXBQITPG-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)C)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)C)=O)C=1)C)F)C(F)(F)F OFAYEMYXBQITPG-DLBZAZTESA-N 0.000 claims 1
• XVWYMRUNGUHBRB-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)C)F)C(F)(F)F XVWYMRUNGUHBRB-OKFXBHNASA-N 0.000 claims 1
• FJXHVLWOUVREMJ-MSNHYEFBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)CC)F)C(F)(F)F FJXHVLWOUVREMJ-MSNHYEFBSA-N 0.000 claims 1
• GLNXSBHZZNBEOU-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)CF)F)C(F)(F)F GLNXSBHZZNBEOU-OKFXBHNASA-N 0.000 claims 1
• ASRRPSNXHCNMGK-IHGBKINDSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)Cl)C)C(F)(F)F ASRRPSNXHCNMGK-IHGBKINDSA-N 0.000 claims 1
• ROBLBAWLRPPVRE-MOUIRZPISA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)Cl)F)C(F)(F)F ROBLBAWLRPPVRE-MOUIRZPISA-N 0.000 claims 1
• SMPGQWZQWSUIQQ-MOUIRZPISA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)F)F)C(F)(F)F SMPGQWZQWSUIQQ-MOUIRZPISA-N 0.000 claims 1
• QRKHKVGSEYWMLZ-IHGBKINDSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OC)F)C(F)(F)F QRKHKVGSEYWMLZ-IHGBKINDSA-N 0.000 claims 1
• RWWFXXBZMXHPFD-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)C)F)C(F)(F)F RWWFXXBZMXHPFD-VQTJNVASSA-N 0.000 claims 1
• PFROLSBCASYLQC-LEWJYISDSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)CC)F)C(F)(F)F PFROLSBCASYLQC-LEWJYISDSA-N 0.000 claims 1
• RQZAKKUWUMHUCE-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)CF)F)C(F)(F)F RQZAKKUWUMHUCE-VQTJNVASSA-N 0.000 claims 1
• ZUMBFMWYSUJCRT-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)Cl)C)C(F)(F)F ZUMBFMWYSUJCRT-RBUKOAKNSA-N 0.000 claims 1
• KLCUFZGAFGECJZ-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)Cl)F)C(F)(F)F KLCUFZGAFGECJZ-ZWKOTPCHSA-N 0.000 claims 1
• LEFWKTXFNJVHBG-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OC)F)C(F)(F)F LEFWKTXFNJVHBG-RBUKOAKNSA-N 0.000 claims 1
• JXHNLVDXCFIZAU-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OC)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OC)OC)C(F)(F)F JXHNLVDXCFIZAU-RBUKOAKNSA-N 0.000 claims 1
• JFUGXCGYSYRFEE-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)C)F)C(F)(F)F JFUGXCGYSYRFEE-VQTJNVASSA-N 0.000 claims 1
• BHLLLBSMKAJBEX-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)OC)F)C(F)(F)F BHLLLBSMKAJBEX-RBUKOAKNSA-N 0.000 claims 1
• GBJFCHCJZJINIR-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)Cl)C)C(F)(F)F GBJFCHCJZJINIR-UONOGXRCSA-N 0.000 claims 1
• WTIRROZNNYGZKW-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)Cl)F)C(F)(F)F WTIRROZNNYGZKW-QWHCGFSZSA-N 0.000 claims 1
• RCYDDOYKEGCBJX-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OC)F)C(F)(F)F RCYDDOYKEGCBJX-UONOGXRCSA-N 0.000 claims 1
• YSLCRYBKUBNDAX-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OC)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OC)OC)C(F)(F)F YSLCRYBKUBNDAX-UONOGXRCSA-N 0.000 claims 1
• TVDULMSWIXOAHO-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)C)F)C(F)(F)F TVDULMSWIXOAHO-OKFXBHNASA-N 0.000 claims 1
• DEWJEEYMNSYIDZ-MSNHYEFBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)CC)F)C(F)(F)F DEWJEEYMNSYIDZ-MSNHYEFBSA-N 0.000 claims 1
• SVHVVWPKMKDPHZ-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)CF)F)C(F)(F)F SVHVVWPKMKDPHZ-OKFXBHNASA-N 0.000 claims 1
• RNFGEVWGTVTOPS-IHGBKINDSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)Cl)C)C(F)(F)F RNFGEVWGTVTOPS-IHGBKINDSA-N 0.000 claims 1
• ZYMMPBGZQQJBOB-MOUIRZPISA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)Cl)F)C(F)(F)F ZYMMPBGZQQJBOB-MOUIRZPISA-N 0.000 claims 1
• IAFABSXSWNHHEZ-MOUIRZPISA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)F)F)C(F)(F)F IAFABSXSWNHHEZ-MOUIRZPISA-N 0.000 claims 1
• ZTZAKCIAAPYILM-IHGBKINDSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OC)F)C(F)(F)F ZTZAKCIAAPYILM-IHGBKINDSA-N 0.000 claims 1
• RGYJNAPYKFKTLW-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)C)F)C(F)(F)F RGYJNAPYKFKTLW-LSDHHAIUSA-N 0.000 claims 1
• RDDSICVVVAPBAC-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)CC)F)C(F)(F)F RDDSICVVVAPBAC-JKSUJKDBSA-N 0.000 claims 1
• SDMZLNAUFZCKPX-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)CF)F)C(F)(F)F SDMZLNAUFZCKPX-LSDHHAIUSA-N 0.000 claims 1
• YOYLIXDDFVETHR-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)Cl)C)C(F)(F)F YOYLIXDDFVETHR-UONOGXRCSA-N 0.000 claims 1
• JGBCWPZCXTVJFN-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)Cl)F)C(F)(F)F JGBCWPZCXTVJFN-QWHCGFSZSA-N 0.000 claims 1
• OVPANCCVJREYHD-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OC)F)C(F)(F)F OVPANCCVJREYHD-UONOGXRCSA-N 0.000 claims 1
• RXTHABPKSWVESP-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OC)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OC)OC)C(F)(F)F RXTHABPKSWVESP-UONOGXRCSA-N 0.000 claims 1
• YFQBIYXYBCJLMW-AJMWJVNWSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)C)F)C(F)(F)F YFQBIYXYBCJLMW-AJMWJVNWSA-N 0.000 claims 1
• UWNFLRNISMOFLH-LHOBAWKSSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)CC)F)C(F)(F)F UWNFLRNISMOFLH-LHOBAWKSSA-N 0.000 claims 1
• ZDQWPIKYGHUVMB-AJMWJVNWSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)CF)F)C(F)(F)F ZDQWPIKYGHUVMB-AJMWJVNWSA-N 0.000 claims 1
• GOVFBIQIRKRLQO-JNMIHDSVSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)Cl)C)C(F)(F)F GOVFBIQIRKRLQO-JNMIHDSVSA-N 0.000 claims 1
• JIHHAPKQQVNXAE-YFZPJLNOSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OC)F)C(F)(F)F JIHHAPKQQVNXAE-YFZPJLNOSA-N 0.000 claims 1
• WFMFPMOVFMMTPU-JNMIHDSVSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OC)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OC)OC)C(F)(F)F WFMFPMOVFMMTPU-JNMIHDSVSA-N 0.000 claims 1
• NFRAXNTWYUEZTJ-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)C)F)C(F)(F)F NFRAXNTWYUEZTJ-ZWKOTPCHSA-N 0.000 claims 1
• ONCJLJLRGMMEAO-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)CC)F)C(F)(F)F ONCJLJLRGMMEAO-RBUKOAKNSA-N 0.000 claims 1
• WOBHMDVSQCAUDB-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)CF)F)C(F)(F)F WOBHMDVSQCAUDB-ZWKOTPCHSA-N 0.000 claims 1
• RCGUETBHMINSKY-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)Cl)C)C(F)(F)F RCGUETBHMINSKY-DLBZAZTESA-N 0.000 claims 1
• QSRHZXPCGYVCHN-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)Cl)F)C(F)(F)F QSRHZXPCGYVCHN-JKSUJKDBSA-N 0.000 claims 1
• SSNUIHQPNULLAY-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)OC)F)C(F)(F)F SSNUIHQPNULLAY-DLBZAZTESA-N 0.000 claims 1
• LDEQILNJXLIXLZ-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)C)F)C(F)(F)F LDEQILNJXLIXLZ-LSDHHAIUSA-N 0.000 claims 1
• XWZCWBZCOPXIMZ-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)CC)F)C(F)(F)F XWZCWBZCOPXIMZ-JKSUJKDBSA-N 0.000 claims 1
• ZJIWRLVUMOLFNE-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)CF)F)C(F)(F)F ZJIWRLVUMOLFNE-LSDHHAIUSA-N 0.000 claims 1
• MHWYXKCOQASWEQ-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)Cl)C)C(F)(F)F MHWYXKCOQASWEQ-UONOGXRCSA-N 0.000 claims 1
• HETKOCNYZUYJDG-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)Cl)F)C(F)(F)F HETKOCNYZUYJDG-QWHCGFSZSA-N 0.000 claims 1
• VUSHKWCPKVDBDX-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)OC)F)C(F)(F)F VUSHKWCPKVDBDX-UONOGXRCSA-N 0.000 claims 1
• UYDQOLWUGIQNRW-WJONJSRFSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)CC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)CC)F)C(F)(F)F UYDQOLWUGIQNRW-WJONJSRFSA-N 0.000 claims 1
• GOSFONSNXYJOOQ-PDSXEYIOSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)CF)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)CF)F)C(F)(F)F GOSFONSNXYJOOQ-PDSXEYIOSA-N 0.000 claims 1
• OPUMHWNQMVQXKW-PXIJXODZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)Cl)C)C(F)(F)F OPUMHWNQMVQXKW-PXIJXODZSA-N 0.000 claims 1
• CYCNJHFEFRKBIH-MRRFBWAASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)Cl)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)Cl)F)C(F)(F)F CYCNJHFEFRKBIH-MRRFBWAASA-N 0.000 claims 1
• MHELSODYOVBPFJ-MRRFBWAASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)F)F)C(F)(F)F MHELSODYOVBPFJ-MRRFBWAASA-N 0.000 claims 1
• MMRLCDXQFPIDIH-PXIJXODZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)F)C(F)(F)F MMRLCDXQFPIDIH-PXIJXODZSA-N 0.000 claims 1
• SGTZJQIFOYCUDE-DJEJFTSGSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)OC)C(F)(F)F SGTZJQIFOYCUDE-DJEJFTSGSA-N 0.000 claims 1
• ILZITBGMMTXLJD-JJRVBVJISA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@H](C(F)(F)F)O)=O)C=1)C)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@H](C(F)(F)F)O)=O)C=1)C)F)C(F)(F)F ILZITBGMMTXLJD-JJRVBVJISA-N 0.000 claims 1
• XEKZSVZVLDUMPS-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)NC1CN(CC1F)C(=O)C1CCC(CC1)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)NC1CN(CC1F)C(=O)C1CCC(CC1)(F)F)C(F)(F)F XEKZSVZVLDUMPS-UHFFFAOYSA-N 0.000 claims 1
• RLRVWAWDVGOZJC-APPDUMDISA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1C)C(=O)C1CC(C1)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1C)C(=O)C1CC(C1)(F)F)C(F)(F)F RLRVWAWDVGOZJC-APPDUMDISA-N 0.000 claims 1
• RJMQEWCTDJXJIF-QZIJWDRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1C)C(=O)C1CC(CC1)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1C)C(=O)C1CC(CC1)(F)F)C(F)(F)F RJMQEWCTDJXJIF-QZIJWDRCSA-N 0.000 claims 1
• GOYMDSSZNYSEMJ-ORAYPTAESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1C)C(=O)C1CCC(CC1)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1C)C(=O)C1CCC(CC1)(F)F)C(F)(F)F GOYMDSSZNYSEMJ-ORAYPTAESA-N 0.000 claims 1
• SOGGJXPLROIMQT-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1(CC1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1(CC1)F)C(F)(F)F SOGGJXPLROIMQT-LSDHHAIUSA-N 0.000 claims 1
• HFIWZTQOVLRMLD-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1(CCC1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1(CCC1)F)C(F)(F)F HFIWZTQOVLRMLD-JKSUJKDBSA-N 0.000 claims 1
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• XZESPDIZJALOLX-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)(C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)(C)O)=O)C(F)(F)F XZESPDIZJALOLX-ZOMUKPOZSA-N 0.000 claims 1
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• RNWHJJTYUNBYFL-YFZPJLNOSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)C)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)C)=O)C(F)(F)F RNWHJJTYUNBYFL-YFZPJLNOSA-N 0.000 claims 1
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• OFJASRBBUFSHEF-ZENOOKHLSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@H](C(F)(F)F)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@H](C(F)(F)F)O)=O)C(F)(F)F OFJASRBBUFSHEF-ZENOOKHLSA-N 0.000 claims 1
• STMJAENJOKAVFL-YQVWRLOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@H](CC(C)C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@H](CC(C)C)O)=O)C(F)(F)F STMJAENJOKAVFL-YQVWRLOYSA-N 0.000 claims 1
• BOXISHDBLWJHGC-LRDNONRASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@](C(F)(F)F)(C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@](C(F)(F)F)(C)O)=O)C(F)(F)F BOXISHDBLWJHGC-LRDNONRASA-N 0.000 claims 1
• IYNCCIVVWTVVMC-FRQCXROJSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@H](C(C)(C)C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@H](C(C)(C)C)O)=O)C(F)(F)F IYNCCIVVWTVVMC-FRQCXROJSA-N 0.000 claims 1
• OFJASRBBUFSHEF-WOSRLPQWSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@H](C(F)(F)F)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@H](C(F)(F)F)O)=O)C(F)(F)F OFJASRBBUFSHEF-WOSRLPQWSA-N 0.000 claims 1
• STMJAENJOKAVFL-SCTDSRPQSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@H](CC(C)C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@H](CC(C)C)O)=O)C(F)(F)F STMJAENJOKAVFL-SCTDSRPQSA-N 0.000 claims 1
• BOXISHDBLWJHGC-MNVSYLFESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@](C(F)(F)F)(C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@](C(F)(F)F)(C)O)=O)C(F)(F)F BOXISHDBLWJHGC-MNVSYLFESA-N 0.000 claims 1
• CUDLFGKQZMEONU-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)C1CCCC1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)C1CCCC1)C(F)(F)F CUDLFGKQZMEONU-UHFFFAOYSA-N 0.000 claims 1
• GDCNWTKFHCFNST-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1(COC1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1(COC1)C)C(F)(F)F GDCNWTKFHCFNST-UHFFFAOYSA-N 0.000 claims 1
• UJXBSWMMOBLGPH-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=C(C=CC(=C1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=C(C=CC(=C1)F)F)C(F)(F)F UJXBSWMMOBLGPH-UHFFFAOYSA-N 0.000 claims 1
• IEEOTDLRTUXDIV-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=C(C=CC=C1)C#N)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=C(C=CC=C1)C#N)C(F)(F)F IEEOTDLRTUXDIV-UHFFFAOYSA-N 0.000 claims 1
• ZSGXYEQDBGKXRV-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=C(C=CC=C1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=C(C=CC=C1)C(F)(F)F)C(F)(F)F ZSGXYEQDBGKXRV-UHFFFAOYSA-N 0.000 claims 1
• LFKWKHDOBPYGMS-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=C(C=CC=C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=C(C=CC=C1)F)C(F)(F)F LFKWKHDOBPYGMS-UHFFFAOYSA-N 0.000 claims 1
• ZTNOCZVJOPTWFR-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=C(C=CC=C1Cl)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=C(C=CC=C1Cl)Cl)C(F)(F)F ZTNOCZVJOPTWFR-UHFFFAOYSA-N 0.000 claims 1
• XCYXVLIQBLTRLR-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=C(C=C1)F)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=C(C=C1)F)C)C(F)(F)F XCYXVLIQBLTRLR-UHFFFAOYSA-N 0.000 claims 1
• VDYRVPFAMSVYRF-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=C(C=C1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=C(C=C1)F)F)C(F)(F)F VDYRVPFAMSVYRF-UHFFFAOYSA-N 0.000 claims 1
• GEZWKVVATNBLSI-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=C(C=C1)OC(F)(F)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=C(C=C1)OC(F)(F)F)F)C(F)(F)F GEZWKVVATNBLSI-UHFFFAOYSA-N 0.000 claims 1
• KLABISDYGHQJIE-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=CC(=C1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=CC(=C1)F)F)C(F)(F)F KLABISDYGHQJIE-UHFFFAOYSA-N 0.000 claims 1
• FNSKHJPMUQAQRM-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=CC=C1)C#N)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=CC=C1)C#N)C(F)(F)F FNSKHJPMUQAQRM-UHFFFAOYSA-N 0.000 claims 1
• ZQZJIELTKOCPNX-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=CC=C1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=CC=C1)C(F)(F)F)C(F)(F)F ZQZJIELTKOCPNX-UHFFFAOYSA-N 0.000 claims 1
• QHDZYNVCDMFUHD-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=CC=C1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=CC=C1)C)C(F)(F)F QHDZYNVCDMFUHD-UHFFFAOYSA-N 0.000 claims 1
• MISRZMBEMVPHEF-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=NO1)Br)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC(=NO1)Br)C(F)(F)F MISRZMBEMVPHEF-UHFFFAOYSA-N 0.000 claims 1
• FVIPTSZINBTJHQ-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC=C(C=C1)C#N)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC=C(C=C1)C#N)C(F)(F)F FVIPTSZINBTJHQ-UHFFFAOYSA-N 0.000 claims 1
• TXZYDPBGPOKRDX-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC=C(C=C1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC=C(C=C1)C(F)(F)F)C(F)(F)F TXZYDPBGPOKRDX-UHFFFAOYSA-N 0.000 claims 1
• BPYDWBJKTHFANQ-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC=C(C=C1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC=C(C=C1)C)C(F)(F)F BPYDWBJKTHFANQ-UHFFFAOYSA-N 0.000 claims 1
• YSBHJOSMOOANKM-UHFFFAOYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC=C(C=C1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)NC1CN(CC1F)CC1=CC=C(C=C1)Cl)C(F)(F)F YSBHJOSMOOANKM-UHFFFAOYSA-N 0.000 claims 1
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• GNQAWJZDVAWKDQ-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(C)(C)OCC(F)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(C)(C)OCC(F)F)=O)C(F)(F)F GNQAWJZDVAWKDQ-LSDHHAIUSA-N 0.000 claims 1
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• YRPXKWVDXDDHIW-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(C)C)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(C)C)=O)C(F)(F)F YRPXKWVDXDDHIW-LSDHHAIUSA-N 0.000 claims 1
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• XUJIBTUPTAZTIM-NWDGAFQWSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(F)(F)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(F)(F)F)=O)C(F)(F)F XUJIBTUPTAZTIM-NWDGAFQWSA-N 0.000 claims 1
• CYCSLYPSASVRBG-BQDKEWAUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C(=CC(=C1)F)F)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C(=CC(=C1)F)F)O)C(F)(F)F CYCSLYPSASVRBG-BQDKEWAUSA-N 0.000 claims 1
• CTGAOKJCSGYIDE-DZLJAHQNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C(=NC=C1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C(=NC=C1)F)F)C(F)(F)F CTGAOKJCSGYIDE-DZLJAHQNSA-N 0.000 claims 1
• JKAOEPTVFFQAEG-BQDKEWAUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C=C(C=C1F)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C=C(C=C1F)F)F)C(F)(F)F JKAOEPTVFFQAEG-BQDKEWAUSA-N 0.000 claims 1
• WYLIGMNHALIAKN-WFELRXAXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C=CC=C1)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(C=CC=C1)O)C(F)(F)F WYLIGMNHALIAKN-WFELRXAXSA-N 0.000 claims 1
• DWONKOUHHHPAFK-OTLVQASYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(N=C(S1)C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(N=C(S1)C)C)C(F)(F)F DWONKOUHHHPAFK-OTLVQASYSA-N 0.000 claims 1
• DGBZVEKMJCFNDN-JNMIHDSVSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(N=C(S1)Cl)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=C(N=C(S1)Cl)C)C(F)(F)F DGBZVEKMJCFNDN-JNMIHDSVSA-N 0.000 claims 1
• GJAXIPIAJQZULZ-YYUCZDELSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC(=CC=C1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC(=CC=C1)OC(F)(F)F)C(F)(F)F GJAXIPIAJQZULZ-YYUCZDELSA-N 0.000 claims 1
• VHFKZXIQVRNEAM-DZLJAHQNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC(=NC(=C1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CC(=NC(=C1)F)F)C(F)(F)F VHFKZXIQVRNEAM-DZLJAHQNSA-N 0.000 claims 1
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• OQXOUINIOLQVRQ-DZLJAHQNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CN=C(S1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=CN=C(S1)C)C(F)(F)F OQXOUINIOLQVRQ-DZLJAHQNSA-N 0.000 claims 1
• FQCNVPXIZNHHRI-OTLVQASYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=NC=CC=C1F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C1=NC=CC=C1F)C(F)(F)F FQCNVPXIZNHHRI-OTLVQASYSA-N 0.000 claims 1
• VYQIZCUHNCMBIY-YYUCZDELSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1C(=NC(=NC=1)C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1C(=NC(=NC=1)C)C)C(F)(F)F VYQIZCUHNCMBIY-YYUCZDELSA-N 0.000 claims 1
• CZXHNZJXEHHBBD-VOPCEASESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1N=C(SC=1Br)Br)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1N=C(SC=1Br)Br)C(F)(F)F CZXHNZJXEHHBBD-VOPCEASESA-N 0.000 claims 1
• WUUYMPBDVLFHKO-JNMIHDSVSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1N=CSC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1N=CSC=1)C(F)(F)F WUUYMPBDVLFHKO-JNMIHDSVSA-N 0.000 claims 1
• LBSBPXLQJSKQMH-XVDHHWJWSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1SC=C(N=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)C=1SC=C(N=1)Cl)C(F)(F)F LBSBPXLQJSKQMH-XVDHHWJWSA-N 0.000 claims 1
• OCGIKJWJLITVCW-XVDHHWJWSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)CC(C(F)(F)F)(C(F)(F)F)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)CC(C(F)(F)F)(C(F)(F)F)O)C(F)(F)F OCGIKJWJLITVCW-XVDHHWJWSA-N 0.000 claims 1
• KOSDTXXICOWSRQ-BIXAZQCUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)CC(C(F)(F)F)(C1=CC=CC=C1)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C)CC(C(F)(F)F)(C1=CC=CC=C1)O)C(F)(F)F KOSDTXXICOWSRQ-BIXAZQCUSA-N 0.000 claims 1
• RJDQMHMSPMDDQE-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC(=C1)F)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC(=C1)F)F)=O)C(F)(F)F RJDQMHMSPMDDQE-ZWKOTPCHSA-N 0.000 claims 1
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• LFXFSDJUOOYTLZ-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC=C1F)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC=C1F)F)=O)C(F)(F)F LFXFSDJUOOYTLZ-DLBZAZTESA-N 0.000 claims 1
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• PFDCDLBXNOYOOA-MOUIRZPISA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)(C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)(C)O)=O)C(F)(F)F PFDCDLBXNOYOOA-MOUIRZPISA-N 0.000 claims 1
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• OMECNEPDNCGYRS-XVDHHWJWSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)C)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)C)=O)C(F)(F)F OMECNEPDNCGYRS-XVDHHWJWSA-N 0.000 claims 1
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• ZANCLOUUVRKZQI-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC1(CC1)C)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC1(CC1)C)=O)C(F)(F)F ZANCLOUUVRKZQI-JKSUJKDBSA-N 0.000 claims 1
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• FJLSILYVKVUHGH-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC1CC1)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC1CC1)=O)C(F)(F)F FJLSILYVKVUHGH-JKSUJKDBSA-N 0.000 claims 1
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• QYINSAZWIZVSGZ-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(N(C)C)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(N(C)C)=O)C(F)(F)F QYINSAZWIZVSGZ-UONOGXRCSA-N 0.000 claims 1
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• WEPVSYMCBWZYNE-ZOWXZIJZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@H](C(F)(F)F)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@H](C(F)(F)F)O)=O)C(F)(F)F WEPVSYMCBWZYNE-ZOWXZIJZSA-N 0.000 claims 1
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• CJYNFDYEJJHVKB-HDMKZQKVSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@H](C(C)(C)C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@H](C(C)(C)C)O)=O)C(F)(F)F CJYNFDYEJJHVKB-HDMKZQKVSA-N 0.000 claims 1
• WEPVSYMCBWZYNE-YWPYICTPSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@H](C(F)(F)F)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@H](C(F)(F)F)O)=O)C(F)(F)F WEPVSYMCBWZYNE-YWPYICTPSA-N 0.000 claims 1
• NKXPVLIYHFTPTR-JZXOWHBKSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@H](CC(C)C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@H](CC(C)C)O)=O)C(F)(F)F NKXPVLIYHFTPTR-JZXOWHBKSA-N 0.000 claims 1
• HIRUMAGLMGJJJR-RDXCRGQUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@](C(F)(F)F)(C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@](C(F)(F)F)(C)O)=O)C(F)(F)F HIRUMAGLMGJJJR-RDXCRGQUSA-N 0.000 claims 1
• ZCSODZXLUNQUQN-ANSQWYIGSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@](C(F)(F)F)(C1=CC=CC=C1)OC)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@](C(F)(F)F)(C1=CC=CC=C1)OC)=O)C(F)(F)F ZCSODZXLUNQUQN-ANSQWYIGSA-N 0.000 claims 1
• LRSULBBQXAKPOF-ZVZXRCORSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CC2=CC=CC=C12)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CC2=CC=CC=C12)C)C(F)(F)F LRSULBBQXAKPOF-ZVZXRCORSA-N 0.000 claims 1
• KEFDBAUZJQABOW-JDCHQWLXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)C(=O)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)C(=O)OC)C(F)(F)F KEFDBAUZJQABOW-JDCHQWLXSA-N 0.000 claims 1
• LIQJKSBSDVXWRJ-LCMLCXGQSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1C(CCC1)O)C(F)(F)F LIQJKSBSDVXWRJ-LCMLCXGQSA-N 0.000 claims 1
• PRWRSUPBMBJGMI-MVXTZGPJSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCC(C2=CC=CC=C12)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCC(C2=CC=CC=C12)C)C(F)(F)F PRWRSUPBMBJGMI-MVXTZGPJSA-N 0.000 claims 1
• GEDLRNOUEVNDIA-MCOCGALXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCC2=C(C=CC=C12)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCC2=C(C=CC=C12)F)C(F)(F)F GEDLRNOUEVNDIA-MCOCGALXSA-N 0.000 claims 1
• QCDILDQSDDEWRI-MCOCGALXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCC2=CC(=CC=C12)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCC2=CC(=CC=C12)F)C(F)(F)F QCDILDQSDDEWRI-MCOCGALXSA-N 0.000 claims 1
• KXPYRDBVTSDUNK-MCOCGALXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCC2=CC=C(C=C12)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCC2=CC=C(C=C12)F)C(F)(F)F KXPYRDBVTSDUNK-MCOCGALXSA-N 0.000 claims 1
• CDFUEPWONIZXBC-ABZYKWASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCC2=CC=CC(=C12)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCC2=CC=CC(=C12)Cl)C(F)(F)F CDFUEPWONIZXBC-ABZYKWASSA-N 0.000 claims 1
• RJECHUOIZDJRRR-MCOCGALXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCC2=CC=CC=C12)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCC2=CC=CC=C12)C(F)(F)F RJECHUOIZDJRRR-MCOCGALXSA-N 0.000 claims 1
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• OODFIGCAPDFNAI-UGGDCYSXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCCC2=C(C=CC=C12)Br)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCCC2=C(C=CC=C12)Br)C(F)(F)F OODFIGCAPDFNAI-UGGDCYSXSA-N 0.000 claims 1
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• OMUQPSZLHVVDRZ-ZVTBYLAHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCCCC2=C1C=CC=C2)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C1CCCCC2=C1C=CC=C2)C(F)(F)F OMUQPSZLHVVDRZ-ZVTBYLAHSA-N 0.000 claims 1
• YZJIRTFEMBVSCC-KTVLMBSMSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)CC(C1=CC=CC=C1)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)CC(C1=CC=CC=C1)O)C(F)(F)F YZJIRTFEMBVSCC-KTVLMBSMSA-N 0.000 claims 1
• IYKJRCDSQITWBF-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)CC1=NC=C(C=C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)CC1=NC=C(C=C1)F)C(F)(F)F IYKJRCDSQITWBF-ZWKOTPCHSA-N 0.000 claims 1
• CBXYEDJQWZDGLK-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)CC=1NC(C=CC=1)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)CC=1NC(C=CC=1)=O)C(F)(F)F CBXYEDJQWZDGLK-DLBZAZTESA-N 0.000 claims 1
• AZTKHUGVZUFSJX-VOPCEASESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C(C(F)(F)F)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C(C(F)(F)F)C)C(F)(F)F AZTKHUGVZUFSJX-VOPCEASESA-N 0.000 claims 1
• IVXXDMPAMORRFG-GARIHTGFSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C(C(F)(F)F)C1=CC=CC=C1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C(C(F)(F)F)C1=CC=CC=C1)C(F)(F)F IVXXDMPAMORRFG-GARIHTGFSA-N 0.000 claims 1
• CLQGHAZGHFTGKK-CRRZLINXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C(C)C(C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C(C)C(C)C)C(F)(F)F CLQGHAZGHFTGKK-CRRZLINXSA-N 0.000 claims 1
• JYJDYGSUBXRCHD-UGGKNOJYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C(C)CC(C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C(C)CC(C)C)C(F)(F)F JYJDYGSUBXRCHD-UGGKNOJYSA-N 0.000 claims 1
• CBKBOXHTQDJCFM-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=C(C=CC(=C1)C)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=C(C=CC(=C1)C)OC)C(F)(F)F CBKBOXHTQDJCFM-ZWKOTPCHSA-N 0.000 claims 1
• IVHPHQMLTRZLIO-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=C(C=CC(=C1)OC)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=C(C=CC(=C1)OC)OC)C(F)(F)F IVHPHQMLTRZLIO-ZWKOTPCHSA-N 0.000 claims 1
• KVIPWLRURBWDRA-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=C(C=CC=C1)C#N)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=C(C=CC=C1)C#N)C(F)(F)F KVIPWLRURBWDRA-ZWKOTPCHSA-N 0.000 claims 1
• BYEFOYDNZAZYSO-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=C(C=CC=C1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=C(C=CC=C1)C)C(F)(F)F BYEFOYDNZAZYSO-ZWKOTPCHSA-N 0.000 claims 1
• KDMJMGRJQSQBST-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=C(C=CC=C1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=C(C=CC=C1)OC)C(F)(F)F KDMJMGRJQSQBST-DLBZAZTESA-N 0.000 claims 1
• KRVUYAUXNGVEGE-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CC(=C(C=C1)C)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CC(=C(C=C1)C)C)C(F)(F)F KRVUYAUXNGVEGE-VQTJNVASSA-N 0.000 claims 1
• KERFSIQKNQBCFV-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CC(=CC=C1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CC(=CC=C1)C)C(F)(F)F KERFSIQKNQBCFV-RBUKOAKNSA-N 0.000 claims 1
• KAUOVKFOCVRMQR-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CC(=CC=C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CC(=CC=C1)F)C(F)(F)F KAUOVKFOCVRMQR-ZWKOTPCHSA-N 0.000 claims 1
• RJWGWXDIIFLCOK-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CC=C(C=C1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CC=C(C=C1)C)C(F)(F)F RJWGWXDIIFLCOK-RBUKOAKNSA-N 0.000 claims 1
• SSDIXRBNHPUKQS-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CC=C(C=C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CC=C(C=C1)F)C(F)(F)F SSDIXRBNHPUKQS-ZWKOTPCHSA-N 0.000 claims 1
• VKECHEJJDPAVJM-LEWJYISDSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CC=CC2=CC=CC=C12)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CC=CC2=CC=CC=C12)C(F)(F)F VKECHEJJDPAVJM-LEWJYISDSA-N 0.000 claims 1
• ZRZOZWJJDKUSOK-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CCCCC1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CCCCC1)C(F)(F)F ZRZOZWJJDKUSOK-ZWKOTPCHSA-N 0.000 claims 1
• VSEVUGCLZSMDRV-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CN=C(S1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1=CN=C(S1)C)C(F)(F)F VSEVUGCLZSMDRV-LSDHHAIUSA-N 0.000 claims 1
• SKZBRNPTCROWIC-HEZAVNPASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1C(CCCC1)O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1C(CCCC1)O)C(F)(F)F SKZBRNPTCROWIC-HEZAVNPASA-N 0.000 claims 1
• QDYNEWVAFWUZES-CPZKYELCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1C2CCC(C1)C2)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1C2CCC(C1)C2)C(F)(F)F QDYNEWVAFWUZES-CPZKYELCSA-N 0.000 claims 1
• PTIWYVDGEFSTAS-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1CC1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1CC1)C(F)(F)F PTIWYVDGEFSTAS-LSDHHAIUSA-N 0.000 claims 1
• KOZOWSJIAYQPJZ-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1CCCC1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1CCCC1)C(F)(F)F KOZOWSJIAYQPJZ-DLBZAZTESA-N 0.000 claims 1
• FCNRGBLRLVELAG-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1CCCCC1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1CCCCC1)C(F)(F)F FCNRGBLRLVELAG-ZWKOTPCHSA-N 0.000 claims 1
• YNEAFMKAJUUUDC-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1CCOCC1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1CCOCC1)C(F)(F)F YNEAFMKAJUUUDC-DLBZAZTESA-N 0.000 claims 1
• ZVIAFFMBRNHVIO-FFPFEORLSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1COCC1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)C1COCC1)C(F)(F)F ZVIAFFMBRNHVIO-FFPFEORLSA-N 0.000 claims 1
• BPGQXMWVTKJBED-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC(F)(F)F)C(F)(F)F BPGQXMWVTKJBED-QWHCGFSZSA-N 0.000 claims 1
• WHAUJBXVZGMSGF-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=C(C=CC(=C1)F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=C(C=CC(=C1)F)F)C(F)(F)F WHAUJBXVZGMSGF-RBUKOAKNSA-N 0.000 claims 1
• VPWFYVDFMXONML-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=C(C=CC=C1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=C(C=CC=C1)C(F)(F)F)C(F)(F)F VPWFYVDFMXONML-RBUKOAKNSA-N 0.000 claims 1
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• ISOYUGVHAICDCU-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=C(C=CC=C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=C(C=CC=C1)F)C(F)(F)F ISOYUGVHAICDCU-RBUKOAKNSA-N 0.000 claims 1
• WJVHGLAAGNQDLN-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=C(C=CC=C1)[N+](=O)[O-])C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=C(C=CC=C1)[N+](=O)[O-])C(F)(F)F WJVHGLAAGNQDLN-ZWKOTPCHSA-N 0.000 claims 1
• FNJJTADQVUMTBB-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=C(C=CC=C1Cl)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=C(C=CC=C1Cl)Cl)C(F)(F)F FNJJTADQVUMTBB-RBUKOAKNSA-N 0.000 claims 1
• YIDDJVIIQXHEMY-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=CC(=CC=C1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=CC(=CC=C1)C)C(F)(F)F YIDDJVIIQXHEMY-VQTJNVASSA-N 0.000 claims 1
• RRFNOMVHVRLROZ-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=CC(=CC=C1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=CC(=CC=C1)Cl)C(F)(F)F RRFNOMVHVRLROZ-RBUKOAKNSA-N 0.000 claims 1
• MGBDOYIIKCAVEG-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=CC(=CC=C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=CC(=CC=C1)F)C(F)(F)F MGBDOYIIKCAVEG-RBUKOAKNSA-N 0.000 claims 1
• FVYGYBYWXWXPDE-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=CC(=CC=C1)[N+](=O)[O-])C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=CC(=CC=C1)[N+](=O)[O-])C(F)(F)F FVYGYBYWXWXPDE-RBUKOAKNSA-N 0.000 claims 1
• KFVWQAIJCMRAJY-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=CC=C(C=C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=CC=C(C=C1)F)C(F)(F)F KFVWQAIJCMRAJY-RBUKOAKNSA-N 0.000 claims 1
• OUMNUOVEBGWDQP-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=CC=CC=C1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=CC=CC=C1)C(F)(F)F OUMNUOVEBGWDQP-RBUKOAKNSA-N 0.000 claims 1
• SHWBFDYGQQUGLC-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=NC=CC=C1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CC1=NC=CC=C1)C(F)(F)F SHWBFDYGQQUGLC-ZWKOTPCHSA-N 0.000 claims 1
• GFRCDIXHNXHVGD-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CCC(F)(F)F)C(F)(F)F GFRCDIXHNXHVGD-UONOGXRCSA-N 0.000 claims 1
• RXXNOFIRZXSBFE-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CCCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)CCCC)C(F)(F)F RXXNOFIRZXSBFE-JKSUJKDBSA-N 0.000 claims 1
• VBHGIURMMMMNII-KUHFFWNOSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)\C=C/F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)S(=O)(=O)\C=C/F)C(F)(F)F VBHGIURMMMMNII-KUHFFWNOSA-N 0.000 claims 1
• PNCDEXUNJNPDOQ-QGZVFWFLSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@H]1CN(CC1)CC1=CC=CC=C1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@H]1CN(CC1)CC1=CC=CC=C1)C(F)(F)F PNCDEXUNJNPDOQ-QGZVFWFLSA-N 0.000 claims 1
• HHQSFYHZXOIOJG-ZEYABNBXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCC(CC1)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCC(CC1)(F)F)C(F)(F)F HHQSFYHZXOIOJG-ZEYABNBXSA-N 0.000 claims 1
• DOMJSACRQGLIJD-HSGMDBMHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(C)(C)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(C)(C)F)=O)C(F)(F)F DOMJSACRQGLIJD-HSGMDBMHSA-N 0.000 claims 1
• YRPXKWVDXDDHIW-FRJSZVPGSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(C)C)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(C)C)=O)C(F)(F)F YRPXKWVDXDDHIW-FRJSZVPGSA-N 0.000 claims 1
• RJDQMHMSPMDDQE-YTSBPGMMSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC(=C1)F)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC(=C1)F)F)=O)C(F)(F)F RJDQMHMSPMDDQE-YTSBPGMMSA-N 0.000 claims 1
• TUAILWRIRIMCCC-YTSBPGMMSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC=C1)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC=C1)F)=O)C(F)(F)F TUAILWRIRIMCCC-YTSBPGMMSA-N 0.000 claims 1
• WQLUFPFCSKOEDI-YTSBPGMMSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=CC=C(C=C1)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=CC=C(C=C1)F)=O)C(F)(F)F WQLUFPFCSKOEDI-YTSBPGMMSA-N 0.000 claims 1
• IDSCCVCPMPZTFA-VNSMCWBGSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C)(C)C)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C)(C)C)=O)C(F)(F)F IDSCCVCPMPZTFA-VNSMCWBGSA-N 0.000 claims 1
• KXHCATIBJQKEJJ-FRJSZVPGSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C)(C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C)(C)O)=O)C(F)(F)F KXHCATIBJQKEJJ-FRJSZVPGSA-N 0.000 claims 1
• BWRSJNQRECUNKD-DBIBZWINSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C)C)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C)C)=O)C(F)(F)F BWRSJNQRECUNKD-DBIBZWINSA-N 0.000 claims 1
• HIRUMAGLMGJJJR-GTXXMFISSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@](C(F)(F)F)(C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@](C(F)(F)F)(C)O)=O)C(F)(F)F HIRUMAGLMGJJJR-GTXXMFISSA-N 0.000 claims 1
• HIRUMAGLMGJJJR-RKCCVDEJSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@](C(F)(F)F)(C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC[2H])C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@](C(F)(F)F)(C)O)=O)C(F)(F)F HIRUMAGLMGJJJR-RKCCVDEJSA-N 0.000 claims 1
• YGTJGBVLZQCPSK-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1(CC1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1(CC1)F)C(F)(F)F YGTJGBVLZQCPSK-JKSUJKDBSA-N 0.000 claims 1
• OOKGLGTYVFWMEG-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1=C(C=NC=C1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1=C(C=NC=C1)F)C(F)(F)F OOKGLGTYVFWMEG-RBUKOAKNSA-N 0.000 claims 1
• SMIFELWUPHLZJO-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1=C(C=NC=C1F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1=C(C=NC=C1F)F)C(F)(F)F SMIFELWUPHLZJO-ZWKOTPCHSA-N 0.000 claims 1
• OUPJIHNYLVSMNQ-MERJSTESSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1C(C1)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1C(C1)(F)F)C(F)(F)F OUPJIHNYLVSMNQ-MERJSTESSA-N 0.000 claims 1
• IMLJHRPDMNZLBN-BZRNNEMISA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(C(F)(F)F)C)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(C(F)(F)F)C)=O)C(F)(F)F IMLJHRPDMNZLBN-BZRNNEMISA-N 0.000 claims 1
• VKUCZNCOWZPSHE-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(C)(C)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(C)(C)F)=O)C(F)(F)F VKUCZNCOWZPSHE-JKSUJKDBSA-N 0.000 claims 1
• DZVAESFHNNXEOH-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(CC)(C(F)(F)F)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C(CC)(C(F)(F)F)O)=O)C(F)(F)F DZVAESFHNNXEOH-OKFXBHNASA-N 0.000 claims 1
• UANDBLCWINFPBW-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=C(C=C1)F)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=C(C=C1)F)F)=O)C(F)(F)F UANDBLCWINFPBW-VQTJNVASSA-N 0.000 claims 1
• UYWKUZGKEKNHHI-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC(=C1)F)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC(=C1)F)F)=O)C(F)(F)F UYWKUZGKEKNHHI-VQTJNVASSA-N 0.000 claims 1
• BKHBPXJKFCFQQW-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC=C1)Cl)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC=C1)Cl)=O)C(F)(F)F BKHBPXJKFCFQQW-VQTJNVASSA-N 0.000 claims 1
• HOTZTVJMKIRUEF-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC=C1)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=C(C=CC=C1)F)=O)C(F)(F)F HOTZTVJMKIRUEF-VQTJNVASSA-N 0.000 claims 1
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• JWCYPYYMRUMVAE-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=CC(=CC=C1)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=CC(=CC=C1)F)=O)C(F)(F)F JWCYPYYMRUMVAE-VQTJNVASSA-N 0.000 claims 1
• NDTGEKAOVKSRDC-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=CC=CC=C1)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=CC=CC=C1)=O)C(F)(F)F NDTGEKAOVKSRDC-VQTJNVASSA-N 0.000 claims 1
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• FOBYOILPKBUQBZ-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)(C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)(C)O)=O)C(F)(F)F FOBYOILPKBUQBZ-OKFXBHNASA-N 0.000 claims 1
• ITJNCQXOOVQHKO-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)C(F)(F)F)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)C(F)(F)F)=O)C(F)(F)F ITJNCQXOOVQHKO-LSDHHAIUSA-N 0.000 claims 1
• GOUCRKTXZFZYJO-AJMWJVNWSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)C)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C(F)(F)F)C)=O)C(F)(F)F GOUCRKTXZFZYJO-AJMWJVNWSA-N 0.000 claims 1
• NCBKFWASLRUJKU-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C)C)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C(CC(C)C)=O)C(F)(F)F NCBKFWASLRUJKU-ZWKOTPCHSA-N 0.000 claims 1
• ATNSVITZWWXJQJ-PDSXEYIOSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@](C(F)(F)F)(C)O)=O)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1C)C)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@](C(F)(F)F)(C)O)=O)C(F)(F)F ATNSVITZWWXJQJ-PDSXEYIOSA-N 0.000 claims 1
• ROWNZTNYQLXOTG-SFHVURJKSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(CC2)C(C2=CC=CC=C2)=O)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(CC2)C(C2=CC=CC=C2)=O)C=CC=1)C(F)(F)F ROWNZTNYQLXOTG-SFHVURJKSA-N 0.000 claims 1
• YCJPJUTZMYASMI-IBGZPJMESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(CC2)CC2=CC=CC=C2)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(CC2)CC2=CC=CC=C2)C=CC=1)C(F)(F)F YCJPJUTZMYASMI-IBGZPJMESA-N 0.000 claims 1
• KIUDYUPCPXYIRS-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=C(C=1)OC)C(F)(F)F KIUDYUPCPXYIRS-JKSUJKDBSA-N 0.000 claims 1
• LGKRRLQVVDCSHK-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)F)C=CC=1)C(F)(F)F LGKRRLQVVDCSHK-LSDHHAIUSA-N 0.000 claims 1
• MOULAODJJQWLPH-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)C(F)(F)F)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)C(F)(F)F)C=CC=1)C(F)(F)F MOULAODJJQWLPH-JKSUJKDBSA-N 0.000 claims 1
• ONAQDOMJTMWQHU-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)F)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCC2)F)C=CC=1)C(F)(F)F ONAQDOMJTMWQHU-JKSUJKDBSA-N 0.000 claims 1
• OJULAVNIBQYFHZ-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCCC2)C(F)(F)F)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCCC2)C(F)(F)F)C=CC=1)C(F)(F)F OJULAVNIBQYFHZ-DLBZAZTESA-N 0.000 claims 1
• RHDKAVURVLRVSP-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCCC2)O)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCCC2)O)C=CC=1)C(F)(F)F RHDKAVURVLRVSP-DLBZAZTESA-N 0.000 claims 1
• CYIQXZVYBLZLJJ-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCOCC2)O)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCOCC2)O)C=CC=1)C(F)(F)F CYIQXZVYBLZLJJ-DLBZAZTESA-N 0.000 claims 1
• PCVQWOUVFLAUGQ-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2F)F)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2F)F)C=CC=1)C(F)(F)F PCVQWOUVFLAUGQ-DLBZAZTESA-N 0.000 claims 1
• QVHABDFVTJRSDE-NOYMGPGASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=C(C=1)F)C(F)(F)F QVHABDFVTJRSDE-NOYMGPGASA-N 0.000 claims 1
• KLBIDLNRHULZPE-MERJSTESSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=C(C=1)OC)C(F)(F)F KLBIDLNRHULZPE-MERJSTESSA-N 0.000 claims 1
• WHMFJVOHADYRCY-NOYMGPGASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=CC=1)C(F)(F)F WHMFJVOHADYRCY-NOYMGPGASA-N 0.000 claims 1
• ZLKRFXYZKIFCJR-JQXSQYPDSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=CC=1F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=CC=1F)C(F)(F)F ZLKRFXYZKIFCJR-JQXSQYPDSA-N 0.000 claims 1
• MTHZKSBRTKYLAM-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=C(C=1)F)C(F)(F)F MTHZKSBRTKYLAM-JKSUJKDBSA-N 0.000 claims 1
• DZHGEGOFBZTNNC-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=C(C=1)OC)C(F)(F)F DZHGEGOFBZTNNC-DLBZAZTESA-N 0.000 claims 1
• BPMIKSQHQVZZLS-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=CC=1)C(F)(F)F BPMIKSQHQVZZLS-JKSUJKDBSA-N 0.000 claims 1
• YZLSGVXUUGTIGK-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=CC=1F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=CC=1F)C(F)(F)F YZLSGVXUUGTIGK-JKSUJKDBSA-N 0.000 claims 1
• BYEWLYNDYIQCQY-DZLJAHQNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=C(C=1)F)C(F)(F)F BYEWLYNDYIQCQY-DZLJAHQNSA-N 0.000 claims 1
• HHJOXRITWMZAOS-OTLVQASYSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=C(C=1)OC)C(F)(F)F HHJOXRITWMZAOS-OTLVQASYSA-N 0.000 claims 1
• DAVRFWWBLOQCJK-MWSTZMHHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=CC=1)C(F)(F)F DAVRFWWBLOQCJK-MWSTZMHHSA-N 0.000 claims 1
• ZAIHUSLPCUTQEM-CRRZLINXSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=CC=1F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=CC=1F)C(F)(F)F ZAIHUSLPCUTQEM-CRRZLINXSA-N 0.000 claims 1
• CRMYLYXBCNWPSM-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=C(C=1)F)C(F)(F)F CRMYLYXBCNWPSM-ZWKOTPCHSA-N 0.000 claims 1
• SASFIEKASHHGGJ-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=C(C=1)OC)C(F)(F)F SASFIEKASHHGGJ-RBUKOAKNSA-N 0.000 claims 1
• RMJJTUUYKVWZAP-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=CC=1)C(F)(F)F RMJJTUUYKVWZAP-ZWKOTPCHSA-N 0.000 claims 1
• LDWDONIKFOGHJG-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=CC=1F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=CC=1F)C(F)(F)F LDWDONIKFOGHJG-ZWKOTPCHSA-N 0.000 claims 1
• KXRDHSRJMXKUIA-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC2)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC2)C=C(C=1)F)C(F)(F)F KXRDHSRJMXKUIA-DLBZAZTESA-N 0.000 claims 1
• LRMWFYJNIZJJIA-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)C)=O)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)C)=O)C=C(C=1)F)C(F)(F)F LRMWFYJNIZJJIA-LSDHHAIUSA-N 0.000 claims 1
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• SKQDDRPZDMYFHB-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=CC=1F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=CC=1F)C(F)(F)F SKQDDRPZDMYFHB-LSDHHAIUSA-N 0.000 claims 1
• KSUHPQWPPFOFIQ-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)C)=O)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)C)=O)C=C(C=1)F)C(F)(F)F KSUHPQWPPFOFIQ-JKSUJKDBSA-N 0.000 claims 1
• KXRNCSVXVQBVRU-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)C)=O)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)C)=O)C=CC=1)C(F)(F)F KXRNCSVXVQBVRU-JKSUJKDBSA-N 0.000 claims 1
• PZXVCQFBXFQWSK-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)C)=O)C=CC=1F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)C)=O)C=CC=1F)C(F)(F)F PZXVCQFBXFQWSK-JKSUJKDBSA-N 0.000 claims 1
• MWSRKEQGNKWSTC-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=C(C=1)F)C(F)(F)F MWSRKEQGNKWSTC-ZOMUKPOZSA-N 0.000 claims 1
• RXDLNJVELSJZAJ-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=C(C=1)OC)C(F)(F)F RXDLNJVELSJZAJ-OKFXBHNASA-N 0.000 claims 1
• CLWHISPPRUMJGU-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=CC=1)C(F)(F)F CLWHISPPRUMJGU-ZOMUKPOZSA-N 0.000 claims 1
• NGCVPXWREHHPSF-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=CC=1F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=CC=1F)C(F)(F)F NGCVPXWREHHPSF-ZOMUKPOZSA-N 0.000 claims 1
• XVRPQHCYWAZIDU-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CF)(C)C)=O)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CF)(C)C)=O)C=CC=1)C(F)(F)F XVRPQHCYWAZIDU-JKSUJKDBSA-N 0.000 claims 1
• GEZLPUSJUYLWCC-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=C(C=1)F)C(F)(F)F GEZLPUSJUYLWCC-RBUKOAKNSA-N 0.000 claims 1
• BLEMVEWMJDRUMI-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=C(C=1)OC)C(F)(F)F BLEMVEWMJDRUMI-VQTJNVASSA-N 0.000 claims 1
• DZTPZGQZNFIEIJ-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=CC=1)C(F)(F)F DZTPZGQZNFIEIJ-RBUKOAKNSA-N 0.000 claims 1
• FLGZILGVUHORDD-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=C(C=C2)F)F)=O)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=C(C=C2)F)F)=O)C=CC=1)C(F)(F)F FLGZILGVUHORDD-RBUKOAKNSA-N 0.000 claims 1
• JDASQDJJYBLUNN-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=CC=C2)F)=O)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=CC=C2)F)=O)C=CC=1)C(F)(F)F JDASQDJJYBLUNN-RBUKOAKNSA-N 0.000 claims 1
• LQLWYSRHGUDFQW-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=C(C=1)F)C(F)(F)F LQLWYSRHGUDFQW-RBUKOAKNSA-N 0.000 claims 1
• XKFQIOFXRFOEQG-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=CC=1)C(F)(F)F XKFQIOFXRFOEQG-RBUKOAKNSA-N 0.000 claims 1
• WLZQINMLLZBZGO-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=CC=1F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=CC=1F)C(F)(F)F WLZQINMLLZBZGO-RBUKOAKNSA-N 0.000 claims 1
• SCUVEKUHWPVZJA-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=C(C=1)OC)C(F)(F)F SCUVEKUHWPVZJA-LSDHHAIUSA-N 0.000 claims 1
• YMKGFCHDDSNLKF-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=C(C=1)OC)C(F)(F)F YMKGFCHDDSNLKF-OKFXBHNASA-N 0.000 claims 1
• AQBFAHLTXWMKEW-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=C(C=1)OC)C(F)(F)F AQBFAHLTXWMKEW-LSDHHAIUSA-N 0.000 claims 1
• VUEROOHALONXDB-DZLJAHQNSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=C(C=1)OC)C(F)(F)F VUEROOHALONXDB-DZLJAHQNSA-N 0.000 claims 1
• VFZWMPNUTILLHR-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)(C)C)=O)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)(C)C)=O)C=CC=1)C(F)(F)F VFZWMPNUTILLHR-DLBZAZTESA-N 0.000 claims 1
• PVNQXDAHPABWLE-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=C(C=1)F)C(F)(F)F PVNQXDAHPABWLE-DLBZAZTESA-N 0.000 claims 1
• HIYLQKFMAURRPY-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=C(C=1)OC)C(F)(F)F HIYLQKFMAURRPY-ZWKOTPCHSA-N 0.000 claims 1
• XKBPZOZRHNODCP-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=C(C=1)F)C(F)(F)F XKBPZOZRHNODCP-UONOGXRCSA-N 0.000 claims 1
• WGLQXCGYTFDORN-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=C(C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=C(C=1)OC)C(F)(F)F WGLQXCGYTFDORN-LSDHHAIUSA-N 0.000 claims 1
• APWCTLXEZHIYOP-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=CC=1)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=CC=1)C(F)(F)F APWCTLXEZHIYOP-UONOGXRCSA-N 0.000 claims 1
• FLNNZUSJMVZOJF-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=CC=1F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=CC=1F)C(F)(F)F FLNNZUSJMVZOJF-UONOGXRCSA-N 0.000 claims 1
• INSMTHTYDGTPGN-LRDNONRASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=C(C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=C(C=1)F)C(F)(F)F INSMTHTYDGTPGN-LRDNONRASA-N 0.000 claims 1
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• FNXWPGMCROKQIL-LRDNONRASA-N NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=CC=1F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=CC=1F)C(F)(F)F FNXWPGMCROKQIL-LRDNONRASA-N 0.000 claims 1
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• AMWRZGWNXGGJST-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2)F)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2)F)C=1)C)C(F)(F)F AMWRZGWNXGGJST-RBUKOAKNSA-N 0.000 claims 1
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• VYKDJYCWUFRJDT-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2F)F)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=C(C=NC=C2F)F)C=1)C)C(F)(F)F VYKDJYCWUFRJDT-ZWKOTPCHSA-N 0.000 claims 1
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• NWJOHVWFFUEBAL-FUHWJXTLSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2)F)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=C(C=C2)F)C=1)Cl)C(F)(F)F NWJOHVWFFUEBAL-FUHWJXTLSA-N 0.000 claims 1
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• CANFCYFKSDOHOB-PKOBYXMFSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)C(F)(F)F)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)C(F)(F)F)C=1)C)C(F)(F)F CANFCYFKSDOHOB-PKOBYXMFSA-N 0.000 claims 1
• VTZNLMQLTILBPH-FUHWJXTLSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)C(F)(F)F)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)C(F)(F)F)C=1)Cl)C(F)(F)F VTZNLMQLTILBPH-FUHWJXTLSA-N 0.000 claims 1
• CBXARHBBGIYWEI-AZUAARDMSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)C)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)C)C=1)C)C(F)(F)F CBXARHBBGIYWEI-AZUAARDMSA-N 0.000 claims 1
• AZZBLSUJWBKYQV-PKOBYXMFSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)Cl)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC(=C2)Cl)C=1)C)C(F)(F)F AZZBLSUJWBKYQV-PKOBYXMFSA-N 0.000 claims 1
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• SAIWSZUWFIMMMK-PKOBYXMFSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=NC=CC=C2)C=1)C)C(F)(F)F SAIWSZUWFIMMMK-PKOBYXMFSA-N 0.000 claims 1
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• VDPYAQADXIAPMJ-NOYMGPGASA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)C(F)(F)F)C(F)(F)F VDPYAQADXIAPMJ-NOYMGPGASA-N 0.000 claims 1
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• CEUORJHMIANSQX-LRUHZDSUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)CC)C(F)(F)F CEUORJHMIANSQX-LRUHZDSUSA-N 0.000 claims 1
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• UYDAERIUSGMRPB-JQXSQYPDSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)Cl)C(F)(F)F UYDAERIUSGMRPB-JQXSQYPDSA-N 0.000 claims 1
• RCHFDPIMZOQEMH-JQXSQYPDSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)F)C(F)(F)F RCHFDPIMZOQEMH-JQXSQYPDSA-N 0.000 claims 1
• KLNIFLIYOALWJT-KFTPUPIBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OC(F)(F)F)C(F)(F)F KLNIFLIYOALWJT-KFTPUPIBSA-N 0.000 claims 1
• OBQXZZKEHDLDDB-KFTPUPIBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OC(F)F)C(F)(F)F OBQXZZKEHDLDDB-KFTPUPIBSA-N 0.000 claims 1
• FGIGURNXXAPXFD-NOYMGPGASA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OC)C(F)(F)F FGIGURNXXAPXFD-NOYMGPGASA-N 0.000 claims 1
• ILPJFOSCVNLYBQ-NOYMGPGASA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OCC(F)(F)F)C(F)(F)F ILPJFOSCVNLYBQ-NOYMGPGASA-N 0.000 claims 1
• DQCXQWMSYCKUIZ-MERJSTESSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2C(C2)(F)F)C=1)OCC)C(F)(F)F DQCXQWMSYCKUIZ-MERJSTESSA-N 0.000 claims 1
• XYYOKGRAOQUTKJ-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)C(F)(F)F)C(F)(F)F XYYOKGRAOQUTKJ-JKSUJKDBSA-N 0.000 claims 1
• FXFBSAOBHQBRJQ-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)C)C(F)(F)F FXFBSAOBHQBRJQ-DLBZAZTESA-N 0.000 claims 1
• UOEWIKDXLZZXEK-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)CC)C(F)(F)F UOEWIKDXLZZXEK-ZWKOTPCHSA-N 0.000 claims 1
• CMQBQFNIAJFPDZ-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)CF)C(F)(F)F CMQBQFNIAJFPDZ-DLBZAZTESA-N 0.000 claims 1
• LXFSSANKPUZIEG-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)Cl)C(F)(F)F LXFSSANKPUZIEG-JKSUJKDBSA-N 0.000 claims 1
• FOSJZDRGUOODJF-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)F)C(F)(F)F FOSJZDRGUOODJF-JKSUJKDBSA-N 0.000 claims 1
• FMECAOXPXHCMMO-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC(F)(F)F)C(F)(F)F FMECAOXPXHCMMO-LSDHHAIUSA-N 0.000 claims 1
• SKWPRIMUKJANAV-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC(F)F)C(F)(F)F SKWPRIMUKJANAV-LSDHHAIUSA-N 0.000 claims 1
• YYDQTVCKBQTBFU-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC)C(F)(F)F YYDQTVCKBQTBFU-JKSUJKDBSA-N 0.000 claims 1
• OBLCSCTZJXYMNQ-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OCC(F)(F)F)C(F)(F)F OBLCSCTZJXYMNQ-JKSUJKDBSA-N 0.000 claims 1
• OZIQEVFSPUZTJX-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OCC)C(F)(F)F OZIQEVFSPUZTJX-DLBZAZTESA-N 0.000 claims 1
• GNPUITZBVOZHNC-SEDVZULUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)C(F)(F)F)C(F)(F)F GNPUITZBVOZHNC-SEDVZULUSA-N 0.000 claims 1
• VEZLLSUOFJXUIY-JOCCRWCTSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)C)C(F)(F)F VEZLLSUOFJXUIY-JOCCRWCTSA-N 0.000 claims 1
• YTXPDQCNFMTSBN-QIRNKGDASA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)CC)C(F)(F)F YTXPDQCNFMTSBN-QIRNKGDASA-N 0.000 claims 1
• IYHNBCCAGXPXRR-JOCCRWCTSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)CF)C(F)(F)F IYHNBCCAGXPXRR-JOCCRWCTSA-N 0.000 claims 1
• AQFDOAGYMGVPFI-SEDVZULUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)Cl)C(F)(F)F AQFDOAGYMGVPFI-SEDVZULUSA-N 0.000 claims 1
• OCGRPZWSZXMQNB-UQZDFYISSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OC(F)(F)F)C(F)(F)F OCGRPZWSZXMQNB-UQZDFYISSA-N 0.000 claims 1
• JMMXJQWJXFKQRB-UQZDFYISSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OC(F)F)C(F)(F)F JMMXJQWJXFKQRB-UQZDFYISSA-N 0.000 claims 1
• ZJZNUPSOYYRGPM-CXMPNGEBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OC)C(F)(F)F ZJZNUPSOYYRGPM-CXMPNGEBSA-N 0.000 claims 1
• YOYUORHMYHENEV-CXMPNGEBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)F)C=1)OCC(F)(F)F)C(F)(F)F YOYUORHMYHENEV-CXMPNGEBSA-N 0.000 claims 1
• RQORXPXIKDMYIV-CRRZLINXSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)C(F)(F)F)C(F)(F)F RQORXPXIKDMYIV-CRRZLINXSA-N 0.000 claims 1
• HOMGSTGTGGOHTQ-CXRLMVSZSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)C)C(F)(F)F HOMGSTGTGGOHTQ-CXRLMVSZSA-N 0.000 claims 1
• LNCHSDAKVDQNQV-AOWWOYQVSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)CC)C(F)(F)F LNCHSDAKVDQNQV-AOWWOYQVSA-N 0.000 claims 1
• QWDVZMGOQMXVHT-UGGKNOJYSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)CF)C(F)(F)F QWDVZMGOQMXVHT-UGGKNOJYSA-N 0.000 claims 1
• OBQCOYRGPAURFK-CRRZLINXSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)Cl)C(F)(F)F OBQCOYRGPAURFK-CRRZLINXSA-N 0.000 claims 1
• BGGXKVMBBDCQGN-CRRZLINXSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)F)C(F)(F)F BGGXKVMBBDCQGN-CRRZLINXSA-N 0.000 claims 1
• WQNVNAWHVGVNAM-FFPFEORLSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OC(F)(F)F)C(F)(F)F WQNVNAWHVGVNAM-FFPFEORLSA-N 0.000 claims 1
• UEBIAAWMHUARDA-FFPFEORLSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OC(F)F)C(F)(F)F UEBIAAWMHUARDA-FFPFEORLSA-N 0.000 claims 1
• GTMCOTHFZIYIDC-ZMKYACIDSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OC)C(F)(F)F GTMCOTHFZIYIDC-ZMKYACIDSA-N 0.000 claims 1
• SKHRUBWGCLULOB-ZMKYACIDSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OCC(F)(F)F)C(F)(F)F SKHRUBWGCLULOB-ZMKYACIDSA-N 0.000 claims 1
• IWSYYKIGPRTRFV-CXRLMVSZSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(CC2)(F)F)C=1)OCC)C(F)(F)F IWSYYKIGPRTRFV-CXRLMVSZSA-N 0.000 claims 1
• ZCVFAQXYLRFOEE-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)C(F)(F)F)C(F)(F)F ZCVFAQXYLRFOEE-ZWKOTPCHSA-N 0.000 claims 1
• CBZLKIDENLHERJ-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)C)C(F)(F)F CBZLKIDENLHERJ-RBUKOAKNSA-N 0.000 claims 1
• NQERKPSYMDEFRX-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)CC)C(F)(F)F NQERKPSYMDEFRX-VQTJNVASSA-N 0.000 claims 1
• AUMLZHHPEDDINQ-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)CF)C(F)(F)F AUMLZHHPEDDINQ-RBUKOAKNSA-N 0.000 claims 1
• FGWCLLHRSVYKKS-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)Cl)C(F)(F)F FGWCLLHRSVYKKS-ZWKOTPCHSA-N 0.000 claims 1
• ZUHXTSCAVPXMAB-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)F)C(F)(F)F ZUHXTSCAVPXMAB-ZWKOTPCHSA-N 0.000 claims 1
• LWHMUBSRNWGKAK-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)OC(F)(F)F)C(F)(F)F LWHMUBSRNWGKAK-DLBZAZTESA-N 0.000 claims 1
• STOVQVKCMOEETA-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)OC(F)F)C(F)(F)F STOVQVKCMOEETA-DLBZAZTESA-N 0.000 claims 1
• VDQOJWHMYRLWKF-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)OC)C(F)(F)F VDQOJWHMYRLWKF-ZWKOTPCHSA-N 0.000 claims 1
• ITVKGQLQHVTHNF-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)OCC(F)(F)F)C(F)(F)F ITVKGQLQHVTHNF-ZWKOTPCHSA-N 0.000 claims 1
• CDEOXTRWRJZMNC-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(F)F)C=1)OCC)C(F)(F)F CDEOXTRWRJZMNC-RBUKOAKNSA-N 0.000 claims 1
• UIKXMXPIHFBNJP-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCOCC2)C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCOCC2)C=1)F)C(F)(F)F UIKXMXPIHFBNJP-ZWKOTPCHSA-N 0.000 claims 1
• PBNQTVLAXLWTJP-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C(=NC=CC=2)OC)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C(=NC=CC=2)OC)C=1)C)C(F)(F)F PBNQTVLAXLWTJP-RBUKOAKNSA-N 0.000 claims 1
• ASGVNLXPONEGKL-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC(=CC=2)C(F)(F)F)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC(=CC=2)C(F)(F)F)C=1)C)C(F)(F)F ASGVNLXPONEGKL-ZWKOTPCHSA-N 0.000 claims 1
• YTYULGDCZJFLTF-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=CC=2C(F)(F)F)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=CC=2C(F)(F)F)C=1)C)C(F)(F)F YTYULGDCZJFLTF-RBUKOAKNSA-N 0.000 claims 1
• RRRVDBDNJMPZIG-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=CC=2C(F)(F)F)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=CC=2C(F)(F)F)C=1)Cl)C(F)(F)F RRRVDBDNJMPZIG-ZWKOTPCHSA-N 0.000 claims 1
• HOZFVOTYOCVRMK-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=CC=2Cl)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=CC=2Cl)C=1)C)C(F)(F)F HOZFVOTYOCVRMK-RBUKOAKNSA-N 0.000 claims 1
• QMZMAJWCPLCDLW-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=CC=2Cl)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NC=CC=2Cl)C=1)Cl)C(F)(F)F QMZMAJWCPLCDLW-ZWKOTPCHSA-N 0.000 claims 1
• OZUYNQYQJBECQQ-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NN(C=2)C)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2C=NN(C=2)C)C=1)C)C(F)(F)F OZUYNQYQJBECQQ-ZWKOTPCHSA-N 0.000 claims 1
• PUSGTYRDHBPGEJ-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=C(OC=2)C)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=C(OC=2)C)C=1)C)C(F)(F)F PUSGTYRDHBPGEJ-DLBZAZTESA-N 0.000 claims 1
• WZZVXAWECXWTCY-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=CN(C=2)C)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=CN(C=2)C)C=1)C)C(F)(F)F WZZVXAWECXWTCY-DLBZAZTESA-N 0.000 claims 1
• CMRZZORPFUSVCO-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=CSC=2)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=CSC=2)C=1)C)C(F)(F)F CMRZZORPFUSVCO-JKSUJKDBSA-N 0.000 claims 1
• ZPUPZAZKBYZKQE-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=CSC=2)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=CSC=2)C=1)Cl)C(F)(F)F ZPUPZAZKBYZKQE-LSDHHAIUSA-N 0.000 claims 1
• OBASBPIVOCQZBX-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=NN(C=2)C2CC2)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C=2N=NN(C=2)C2CC2)C=1)C)C(F)(F)F OBASBPIVOCQZBX-ZWKOTPCHSA-N 0.000 claims 1
• OLSIRCDINPDLLV-SXODRGRHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)C(F)(F)F)C(F)(F)F OLSIRCDINPDLLV-SXODRGRHSA-N 0.000 claims 1
• KLNDUBKIUVDDJH-JNMIHDSVSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)C)C(F)(F)F KLNDUBKIUVDDJH-JNMIHDSVSA-N 0.000 claims 1
• SWXUGKPWBOTFDM-DZLJAHQNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)CC)C(F)(F)F SWXUGKPWBOTFDM-DZLJAHQNSA-N 0.000 claims 1
• HNUWHMLELPIOHC-YFZPJLNOSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)CF)C(F)(F)F HNUWHMLELPIOHC-YFZPJLNOSA-N 0.000 claims 1
• DBJPNCJOAYVYPK-SXODRGRHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)Cl)C(F)(F)F DBJPNCJOAYVYPK-SXODRGRHSA-N 0.000 claims 1
• YTYXGGPKJOCFON-VOPCEASESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OC(F)(F)F)C(F)(F)F YTYXGGPKJOCFON-VOPCEASESA-N 0.000 claims 1
• DWSDJFZSTFCCNY-VOPCEASESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OC(F)F)C(F)(F)F DWSDJFZSTFCCNY-VOPCEASESA-N 0.000 claims 1
• DSRWSQDKFBDZLN-XVDHHWJWSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OC)C(F)(F)F DSRWSQDKFBDZLN-XVDHHWJWSA-N 0.000 claims 1
• FEVHQQAPSVUMDY-XVDHHWJWSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OCC(F)(F)F)C(F)(F)F FEVHQQAPSVUMDY-XVDHHWJWSA-N 0.000 claims 1
• WPXYTRWFEDQWIF-JNMIHDSVSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)C)=O)C=1)OCC)C(F)(F)F WPXYTRWFEDQWIF-JNMIHDSVSA-N 0.000 claims 1
• NHHQTVUKFIYKAU-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)C(F)(F)F)C(F)(F)F NHHQTVUKFIYKAU-LSDHHAIUSA-N 0.000 claims 1
• ITIDLWMEPOXMMS-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)C)C(F)(F)F ITIDLWMEPOXMMS-JKSUJKDBSA-N 0.000 claims 1
• VQOYBWLZEAFQOQ-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)CC)C(F)(F)F VQOYBWLZEAFQOQ-DLBZAZTESA-N 0.000 claims 1
• VRYNCKWHDPULAI-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)Cl)C(F)(F)F VRYNCKWHDPULAI-LSDHHAIUSA-N 0.000 claims 1
• ISVKPRLUESZBNN-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OC(F)(F)F)C(F)(F)F ISVKPRLUESZBNN-UONOGXRCSA-N 0.000 claims 1
• GQVGWLNWFQEUKA-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OC(F)F)C(F)(F)F GQVGWLNWFQEUKA-UONOGXRCSA-N 0.000 claims 1
• KTFJNCSOXMLQTA-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OC)C(F)(F)F KTFJNCSOXMLQTA-LSDHHAIUSA-N 0.000 claims 1
• CEORJBHQOBVVBY-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OCC(F)(F)F)C(F)(F)F CEORJBHQOBVVBY-LSDHHAIUSA-N 0.000 claims 1
• LCABOOWLVGQIBN-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OCC)C(F)(F)F LCABOOWLVGQIBN-JKSUJKDBSA-N 0.000 claims 1
• KWRUQCQIECFNCX-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)C(F)(F)F)C(F)(F)F KWRUQCQIECFNCX-LSDHHAIUSA-N 0.000 claims 1
• WJTPWBZYPQXCJM-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)C)C(F)(F)F WJTPWBZYPQXCJM-JKSUJKDBSA-N 0.000 claims 1
• OZCHESBRBSPFSL-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)CC)C(F)(F)F OZCHESBRBSPFSL-DLBZAZTESA-N 0.000 claims 1
• QQNVTXOIRAYRQD-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)CF)C(F)(F)F QQNVTXOIRAYRQD-JKSUJKDBSA-N 0.000 claims 1
• JDRIJDXIRTXXIE-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)Cl)C(F)(F)F JDRIJDXIRTXXIE-LSDHHAIUSA-N 0.000 claims 1
• FJTHSSCANPCCOF-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)OC(F)(F)F)C(F)(F)F FJTHSSCANPCCOF-UONOGXRCSA-N 0.000 claims 1
• NRKZBZAKUOUTQF-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)OC(F)F)C(F)(F)F NRKZBZAKUOUTQF-UONOGXRCSA-N 0.000 claims 1
• QXANNQURBSMPBX-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)OC)C(F)(F)F QXANNQURBSMPBX-LSDHHAIUSA-N 0.000 claims 1
• WNPUFFJTIZGSOF-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)O)=O)C=1)OCC)C(F)(F)F WNPUFFJTIZGSOF-JKSUJKDBSA-N 0.000 claims 1
• QDHMVVASCXIXBX-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)C(F)(F)F)C(F)(F)F QDHMVVASCXIXBX-ZOMUKPOZSA-N 0.000 claims 1
• CYBZQSOWCQKXLQ-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)C)C(F)(F)F CYBZQSOWCQKXLQ-OKFXBHNASA-N 0.000 claims 1
• SXGHOUFGFGCJRA-MSNHYEFBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)CC)C(F)(F)F SXGHOUFGFGCJRA-MSNHYEFBSA-N 0.000 claims 1
• SICKBZXLOGKJHQ-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)CF)C(F)(F)F SICKBZXLOGKJHQ-OKFXBHNASA-N 0.000 claims 1
• WRXMRIZDTKPVDA-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)Cl)C(F)(F)F WRXMRIZDTKPVDA-ZOMUKPOZSA-N 0.000 claims 1
• VNBSLOCCYOZLAI-MOUIRZPISA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OC(F)(F)F)C(F)(F)F VNBSLOCCYOZLAI-MOUIRZPISA-N 0.000 claims 1
• UWWPLDIYCGXZGP-DXZWUPATSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OC(F)F)C(F)(F)F UWWPLDIYCGXZGP-DXZWUPATSA-N 0.000 claims 1
• XFQONUFIJNWAHY-IHGBKINDSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OC)C(F)(F)F XFQONUFIJNWAHY-IHGBKINDSA-N 0.000 claims 1
• JBBZFBGJWVALIZ-IHGBKINDSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OCC(F)(F)F)C(F)(F)F JBBZFBGJWVALIZ-IHGBKINDSA-N 0.000 claims 1
• DEOJATLLJXAFMX-PLRGMUQMSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CC)(C(F)(F)F)O)=O)C=1)OCC)C(F)(F)F DEOJATLLJXAFMX-PLRGMUQMSA-N 0.000 claims 1
• PFCOEERWQITFFW-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C(=CC=C2)F)Cl)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C(=CC=C2)F)Cl)=O)C=1)C)C(F)(F)F PFCOEERWQITFFW-RBUKOAKNSA-N 0.000 claims 1
• UKEGSJWYCDJWJZ-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C(=CC=C2)F)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C(=CC=C2)F)F)=O)C=1)C)C(F)(F)F UKEGSJWYCDJWJZ-RBUKOAKNSA-N 0.000 claims 1
• UZSZHMUSQFBCPP-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C(=C2)F)F)Cl)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C(=C2)F)F)Cl)=O)C=1)C)C(F)(F)F UZSZHMUSQFBCPP-VQTJNVASSA-N 0.000 claims 1
• ZUXPIGGDWIJRGX-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C(=C2)F)F)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C(=C2)F)F)F)=O)C=1)C)C(F)(F)F ZUXPIGGDWIJRGX-VQTJNVASSA-N 0.000 claims 1
• OTBZEDQZDJFBBE-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2)F)Cl)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2)F)Cl)=O)C=1)C)C(F)(F)F OTBZEDQZDJFBBE-VQTJNVASSA-N 0.000 claims 1
• DYMMBCRBHBVWHD-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2)F)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2)F)F)=O)C=1)C)C(F)(F)F DYMMBCRBHBVWHD-VQTJNVASSA-N 0.000 claims 1
• BRIWSGLJQITLAM-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2)F)F)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2)F)F)=O)C=1)Cl)C(F)(F)F BRIWSGLJQITLAM-RBUKOAKNSA-N 0.000 claims 1
• RTCNPOJSITZEQN-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2F)F)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=C(C=C2F)F)F)=O)C=1)C)C(F)(F)F RTCNPOJSITZEQN-RBUKOAKNSA-N 0.000 claims 1
• VSEYQHRLZDSJSW-LEWJYISDSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC(=C2)C#N)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC(=C2)C#N)F)=O)C=1)C)C(F)(F)F VSEYQHRLZDSJSW-LEWJYISDSA-N 0.000 claims 1
• KGKIXMUPUSFFNP-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC(=C2)F)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC(=C2)F)F)=O)C=1)C)C(F)(F)F KGKIXMUPUSFFNP-VQTJNVASSA-N 0.000 claims 1
• KSGWWAGJBHVHAY-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC(=C2)F)F)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC(=C2)F)F)=O)C=1)Cl)C(F)(F)F KSGWWAGJBHVHAY-RBUKOAKNSA-N 0.000 claims 1
• IKBRQRBJKGTVKG-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)Cl)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)Cl)=O)C=1)C)C(F)(F)F IKBRQRBJKGTVKG-VQTJNVASSA-N 0.000 claims 1
• FGMIKVWKVPRCMP-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)Cl)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)Cl)=O)C=1)Cl)C(F)(F)F FGMIKVWKVPRCMP-RBUKOAKNSA-N 0.000 claims 1
• OJBYPQKHVOKNOM-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)C(F)(F)F)C(F)(F)F OJBYPQKHVOKNOM-RBUKOAKNSA-N 0.000 claims 1
• GPISTZKGPZPVCL-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)C)C(F)(F)F GPISTZKGPZPVCL-VQTJNVASSA-N 0.000 claims 1
• IBSLITSQILWMCY-LEWJYISDSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)CC)C(F)(F)F IBSLITSQILWMCY-LEWJYISDSA-N 0.000 claims 1
• AKLVISACKLHHAW-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)CF)C(F)(F)F AKLVISACKLHHAW-VQTJNVASSA-N 0.000 claims 1
• ALGXRVXPHWJKFR-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)Cl)C(F)(F)F ALGXRVXPHWJKFR-RBUKOAKNSA-N 0.000 claims 1
• DTJRKHJKCFZZJW-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OC(F)(F)F)C(F)(F)F DTJRKHJKCFZZJW-ZWKOTPCHSA-N 0.000 claims 1
• MMZUMNPNUYZNML-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OC(F)F)C(F)(F)F MMZUMNPNUYZNML-ZWKOTPCHSA-N 0.000 claims 1
• ZLJNOLDSCXGDPB-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OC)C(F)(F)F ZLJNOLDSCXGDPB-RBUKOAKNSA-N 0.000 claims 1
• VOEYISMRZIFPKX-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OCC(F)(F)F)C(F)(F)F VOEYISMRZIFPKX-RBUKOAKNSA-N 0.000 claims 1
• PYAFRPGVRKWYFU-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)F)=O)C=1)OCC)C(F)(F)F PYAFRPGVRKWYFU-VQTJNVASSA-N 0.000 claims 1
• GQKZFZCJCHNJDZ-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)S(=O)(=O)C)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2)S(=O)(=O)C)=O)C=1)C)C(F)(F)F GQKZFZCJCHNJDZ-VQTJNVASSA-N 0.000 claims 1
• GEMZCOHWFXNLNN-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2F)Cl)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2F)Cl)=O)C=1)C)C(F)(F)F GEMZCOHWFXNLNN-RBUKOAKNSA-N 0.000 claims 1
• AQZMYRWUJRZIEU-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2F)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2F)F)=O)C=1)C)C(F)(F)F AQZMYRWUJRZIEU-RBUKOAKNSA-N 0.000 claims 1
• JYUUKSGAQALFGL-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2F)F)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=C(C=CC=C2F)F)=O)C=1)Cl)C(F)(F)F JYUUKSGAQALFGL-ZWKOTPCHSA-N 0.000 claims 1
• VHCKOAJMTHGZTK-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=C(C=C2)F)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=C(C=C2)F)F)=O)C=1)C)C(F)(F)F VHCKOAJMTHGZTK-VQTJNVASSA-N 0.000 claims 1
• ZHKUBOKUDHEGFO-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=C(C=C2)F)F)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=C(C=C2)F)F)=O)C=1)Cl)C(F)(F)F ZHKUBOKUDHEGFO-RBUKOAKNSA-N 0.000 claims 1
• HUSIWSHVTURMRH-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=CC(=C2)F)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=CC(=C2)F)F)=O)C=1)C)C(F)(F)F HUSIWSHVTURMRH-VQTJNVASSA-N 0.000 claims 1
• NHCCZCNFMCRXJX-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=CC=C2)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=CC=C2)F)=O)C=1)C)C(F)(F)F NHCCZCNFMCRXJX-VQTJNVASSA-N 0.000 claims 1
• URVOJTXAFAWVGL-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=CC=C2)F)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC(=CC=C2)F)=O)C=1)Cl)C(F)(F)F URVOJTXAFAWVGL-RBUKOAKNSA-N 0.000 claims 1
• IKQLFIOMBMMGJY-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)Cl)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)Cl)=O)C=1)C)C(F)(F)F IKQLFIOMBMMGJY-VQTJNVASSA-N 0.000 claims 1
• QCQKIPICSKZFMB-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)Cl)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)Cl)=O)C=1)Cl)C(F)(F)F QCQKIPICSKZFMB-RBUKOAKNSA-N 0.000 claims 1
• ZQGZHZXDHABVKP-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)C)C(F)(F)F ZQGZHZXDHABVKP-VQTJNVASSA-N 0.000 claims 1
• LDQHKLVDBRXPII-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)Cl)C(F)(F)F LDQHKLVDBRXPII-RBUKOAKNSA-N 0.000 claims 1
• IDHPEUMQECMTAL-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=C(C=C2)F)=O)C=1)F)C(F)(F)F IDHPEUMQECMTAL-RBUKOAKNSA-N 0.000 claims 1
• PCNFXQFUAYZBRY-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=CC=C2)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=CC=C2)=O)C=1)C)C(F)(F)F PCNFXQFUAYZBRY-VQTJNVASSA-N 0.000 claims 1
• JWBRNJJQMOHSHD-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=CC=C2)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C2=CC=CC=C2)=O)C=1)Cl)C(F)(F)F JWBRNJJQMOHSHD-RBUKOAKNSA-N 0.000 claims 1
• XLNVTADLDKHLGF-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)C(F)(F)F)C(F)(F)F XLNVTADLDKHLGF-UONOGXRCSA-N 0.000 claims 1
• YYQYGBGXRFUMHG-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)C)C(F)(F)F YYQYGBGXRFUMHG-LSDHHAIUSA-N 0.000 claims 1
• NIUNDOOAFABVIR-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)CC)C(F)(F)F NIUNDOOAFABVIR-JKSUJKDBSA-N 0.000 claims 1
• XKCYRZOIMMMDML-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)CF)C(F)(F)F XKCYRZOIMMMDML-LSDHHAIUSA-N 0.000 claims 1
• KHMMCXMBMGGVNB-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)Cl)C(F)(F)F KHMMCXMBMGGVNB-UONOGXRCSA-N 0.000 claims 1
• RCTCLXDSSSVGEP-DZGCQCFKSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)NC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)NC)C(F)(F)F RCTCLXDSSSVGEP-DZGCQCFKSA-N 0.000 claims 1
• FWOCOBBCBSVTTH-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OC(F)(F)F)C(F)(F)F FWOCOBBCBSVTTH-QWHCGFSZSA-N 0.000 claims 1
• WAEIEAMMWFLWIG-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OC(F)F)C(F)(F)F WAEIEAMMWFLWIG-QWHCGFSZSA-N 0.000 claims 1
• LYZRVDZAVZKCEW-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OC)C(F)(F)F LYZRVDZAVZKCEW-UONOGXRCSA-N 0.000 claims 1
• RENADMJREAPQGR-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OCC(F)(F)F)C(F)(F)F RENADMJREAPQGR-UONOGXRCSA-N 0.000 claims 1
• MTQUVDDITXKLQI-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C(F)(F)F)O)=O)C=1)OCC)C(F)(F)F MTQUVDDITXKLQI-LSDHHAIUSA-N 0.000 claims 1
• SQMWNCUKLOMTBR-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)C(F)(F)F)C(F)(F)F SQMWNCUKLOMTBR-ZOMUKPOZSA-N 0.000 claims 1
• ILVRLHGNSICNRK-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)C)C(F)(F)F ILVRLHGNSICNRK-OKFXBHNASA-N 0.000 claims 1
• NXBMPZQGLQKHEX-MSNHYEFBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)CC)C(F)(F)F NXBMPZQGLQKHEX-MSNHYEFBSA-N 0.000 claims 1
• LHHRUTBLQVYSCV-OKFXBHNASA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)CF)C(F)(F)F LHHRUTBLQVYSCV-OKFXBHNASA-N 0.000 claims 1
• IQVWVRNDZVDXJL-ZOMUKPOZSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)Cl)C(F)(F)F IQVWVRNDZVDXJL-ZOMUKPOZSA-N 0.000 claims 1
• SFOXVNXYKZEFFM-MOUIRZPISA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OC(F)(F)F)C(F)(F)F SFOXVNXYKZEFFM-MOUIRZPISA-N 0.000 claims 1
• SLZWJFXFFPCASD-DXZWUPATSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OC(F)F)C(F)(F)F SLZWJFXFFPCASD-DXZWUPATSA-N 0.000 claims 1
• AEDAXJUXRGKUON-IHGBKINDSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OC)C(F)(F)F AEDAXJUXRGKUON-IHGBKINDSA-N 0.000 claims 1
• RKFSIHFBFLICCI-IHGBKINDSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OCC(F)(F)F)C(F)(F)F RKFSIHFBFLICCI-IHGBKINDSA-N 0.000 claims 1
• ZHTNFPRJHLVNEB-PLRGMUQMSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)(C)O)=O)C=1)OCC)C(F)(F)F ZHTNFPRJHLVNEB-PLRGMUQMSA-N 0.000 claims 1
• CLCDHLNIYIGVKJ-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)C(F)(F)F)C(F)(F)F CLCDHLNIYIGVKJ-UONOGXRCSA-N 0.000 claims 1
• AAYJYEAMFJIWTD-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)C)C(F)(F)F AAYJYEAMFJIWTD-LSDHHAIUSA-N 0.000 claims 1
• SALQVFSHPBTJPF-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)CC)C(F)(F)F SALQVFSHPBTJPF-JKSUJKDBSA-N 0.000 claims 1
• XUPHGQOZYQJIJB-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)CF)C(F)(F)F XUPHGQOZYQJIJB-LSDHHAIUSA-N 0.000 claims 1
• GPCGVILUBKYACJ-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)Cl)C(F)(F)F GPCGVILUBKYACJ-UONOGXRCSA-N 0.000 claims 1
• MMMIDOALIXBVMK-DZGCQCFKSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)NC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)NC)C(F)(F)F MMMIDOALIXBVMK-DZGCQCFKSA-N 0.000 claims 1
• NSEFGPBJZBCZRD-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OC(F)F)C(F)(F)F NSEFGPBJZBCZRD-QWHCGFSZSA-N 0.000 claims 1
• ANXHNDWWLAEWKL-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OC)C(F)(F)F ANXHNDWWLAEWKL-UONOGXRCSA-N 0.000 claims 1
• SFYLMCLLECRCPK-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OCC(F)(F)F)C(F)(F)F SFYLMCLLECRCPK-UONOGXRCSA-N 0.000 claims 1
• SPPHTBXQKQBKHQ-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C(F)(F)F)=O)C=1)OCC)C(F)(F)F SPPHTBXQKQBKHQ-LSDHHAIUSA-N 0.000 claims 1
• IDAGZHMXGBVACY-YFZPJLNOSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)C(F)(F)F)C(F)(F)F IDAGZHMXGBVACY-YFZPJLNOSA-N 0.000 claims 1
• QDPUPXTXUJMONL-CRRZLINXSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)C)C(F)(F)F QDPUPXTXUJMONL-CRRZLINXSA-N 0.000 claims 1
• MEQLKXMIOGDKRZ-OTLVQASYSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)CC)C(F)(F)F MEQLKXMIOGDKRZ-OTLVQASYSA-N 0.000 claims 1
• NPHGYCVHEGZZOG-DZLJAHQNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)CF)C(F)(F)F NPHGYCVHEGZZOG-DZLJAHQNSA-N 0.000 claims 1
• ZSWHUYQZNVAWCJ-YFZPJLNOSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)Cl)C(F)(F)F ZSWHUYQZNVAWCJ-YFZPJLNOSA-N 0.000 claims 1
• ILXJCCKJSZOSPF-XVDHHWJWSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OC(F)(F)F)C(F)(F)F ILXJCCKJSZOSPF-XVDHHWJWSA-N 0.000 claims 1
• RHVPJNDFDJRWCQ-XVDHHWJWSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OC(F)F)C(F)(F)F RHVPJNDFDJRWCQ-XVDHHWJWSA-N 0.000 claims 1
• AAZHNHRTTDAUEC-JNMIHDSVSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OC)C(F)(F)F AAZHNHRTTDAUEC-JNMIHDSVSA-N 0.000 claims 1
• XVGWYWPEHXKPDN-JNMIHDSVSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OCC(F)(F)F)C(F)(F)F XVGWYWPEHXKPDN-JNMIHDSVSA-N 0.000 claims 1
• BUIDHINVXDYTLU-CRRZLINXSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C(F)(F)F)C)=O)C=1)OCC)C(F)(F)F BUIDHINVXDYTLU-CRRZLINXSA-N 0.000 claims 1
• OXULLXYUTPVCSE-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)C(F)(F)F)C(F)(F)F OXULLXYUTPVCSE-DLBZAZTESA-N 0.000 claims 1
• NNBIBMDUNOOGCF-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)C)C(F)(F)F NNBIBMDUNOOGCF-ZWKOTPCHSA-N 0.000 claims 1
• LNOPQYQPIOSYAM-RBUKOAKNSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)CC)C(F)(F)F LNOPQYQPIOSYAM-RBUKOAKNSA-N 0.000 claims 1
• HQTVKSAQGOGZMF-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)CF)C(F)(F)F HQTVKSAQGOGZMF-ZWKOTPCHSA-N 0.000 claims 1
• TVWOQRCYNJOFQQ-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)Cl)C(F)(F)F TVWOQRCYNJOFQQ-DLBZAZTESA-N 0.000 claims 1
• LESNJOJAVYYNIX-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)OC(F)(F)F)C(F)(F)F LESNJOJAVYYNIX-JKSUJKDBSA-N 0.000 claims 1
• GRIJGXTXOORDBE-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)OC(F)F)C(F)(F)F GRIJGXTXOORDBE-JKSUJKDBSA-N 0.000 claims 1
• OEOZXCIRGOCFCM-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)OC)C(F)(F)F OEOZXCIRGOCFCM-DLBZAZTESA-N 0.000 claims 1
• HZMLHIVWQHIKBZ-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)OCC(F)(F)F)C(F)(F)F HZMLHIVWQHIKBZ-DLBZAZTESA-N 0.000 claims 1
• ZYDWCJQWLNPNRX-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(C)C)=O)C=1)OCC)C(F)(F)F ZYDWCJQWLNPNRX-ZWKOTPCHSA-N 0.000 claims 1
• ZRWNTBCKCWCKOM-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)C(F)(F)F)C(F)(F)F ZRWNTBCKCWCKOM-UONOGXRCSA-N 0.000 claims 1
• SFGCWNSKMMQZIP-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)C)C(F)(F)F SFGCWNSKMMQZIP-LSDHHAIUSA-N 0.000 claims 1
• NGWZXBQGRSUYCQ-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)CC)C(F)(F)F NGWZXBQGRSUYCQ-JKSUJKDBSA-N 0.000 claims 1
• FLXMYLFXHWSITJ-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)CF)C(F)(F)F FLXMYLFXHWSITJ-LSDHHAIUSA-N 0.000 claims 1
• AQSZFOWMFVVLTI-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)Cl)C(F)(F)F AQSZFOWMFVVLTI-UONOGXRCSA-N 0.000 claims 1
• TWNTZYGKSRVBBZ-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)OC(F)(F)F)C(F)(F)F TWNTZYGKSRVBBZ-QWHCGFSZSA-N 0.000 claims 1
• GGFRAMFIRDTXFP-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)OC(F)F)C(F)(F)F GGFRAMFIRDTXFP-QWHCGFSZSA-N 0.000 claims 1
• XCRNOHNSEAHPND-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)OC)C(F)(F)F XCRNOHNSEAHPND-UONOGXRCSA-N 0.000 claims 1
• JNPFQBSHSFSKPS-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC(F)(F)F)=O)C=1)OCC)C(F)(F)F JNPFQBSHSFSKPS-LSDHHAIUSA-N 0.000 claims 1
• OCBPDUIWLIWBIH-ZWKOTPCHSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC2CC(C2)(F)F)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC2CC(C2)(F)F)=O)C=1)C)C(F)(F)F OCBPDUIWLIWBIH-ZWKOTPCHSA-N 0.000 claims 1
• JBFSLOSBBDTTGQ-VQTJNVASSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC2CCCC2)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(CC2CCCC2)=O)C=1)C)C(F)(F)F JBFSLOSBBDTTGQ-VQTJNVASSA-N 0.000 claims 1
• LIIYFJQZXKBBJS-LRDNONRASA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)C(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)C(F)(F)F)C(F)(F)F LIIYFJQZXKBBJS-LRDNONRASA-N 0.000 claims 1
• FPKPVVNXMVWBTQ-PDSXEYIOSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)C)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)C)C(F)(F)F FPKPVVNXMVWBTQ-PDSXEYIOSA-N 0.000 claims 1
• WYUVOPAICOOVQP-WJONJSRFSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)CC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)CC)C(F)(F)F WYUVOPAICOOVQP-WJONJSRFSA-N 0.000 claims 1
• RKVSYHRETUIOTE-PDSXEYIOSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)CF)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)CF)C(F)(F)F RKVSYHRETUIOTE-PDSXEYIOSA-N 0.000 claims 1
• RJTIHEWNWQBPJP-LRDNONRASA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)Cl)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)Cl)C(F)(F)F RJTIHEWNWQBPJP-LRDNONRASA-N 0.000 claims 1
• NETHTJGYSNPIFM-QDUSTFBWSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)NC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)NC)C(F)(F)F NETHTJGYSNPIFM-QDUSTFBWSA-N 0.000 claims 1
• XLYVZJSMWSEOAZ-MRRFBWAASA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC(F)(F)F)C(F)(F)F XLYVZJSMWSEOAZ-MRRFBWAASA-N 0.000 claims 1
• GHHMZEBIZBTTQW-OSRJUQGESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC(F)F)C(F)(F)F GHHMZEBIZBTTQW-OSRJUQGESA-N 0.000 claims 1
• MNOBPWJCQPNGPH-PXIJXODZSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OC)C(F)(F)F MNOBPWJCQPNGPH-PXIJXODZSA-N 0.000 claims 1
• DTPPJJHEFXQELB-PXIJXODZSA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OCC(F)(F)F)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OCC(F)(F)F)C(F)(F)F DTPPJJHEFXQELB-PXIJXODZSA-N 0.000 claims 1
• MULUADCIZRTYBN-SMASLZHESA-N NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OCC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=CC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C([C@@](C(F)(F)F)(C)O)=O)C=1)OCC)C(F)(F)F MULUADCIZRTYBN-SMASLZHESA-N 0.000 claims 1
• ONBVLVWZGLTWNY-UONOGXRCSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)C(F)(F)F)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)C(F)(F)F)C=1)OC)C(F)(F)F ONBVLVWZGLTWNY-UONOGXRCSA-N 0.000 claims 1
• AQYOYLOAWUBVHD-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCCC2)N)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CCCC2)N)C=1)OC)C(F)(F)F AQYOYLOAWUBVHD-JKSUJKDBSA-N 0.000 claims 1
• JREKJTZXYSPEIX-RIGXQMBPSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CN(CC2)C(=O)OC(C)(C)C)C(F)(F)F)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CN(CC2)C(=O)OC(C)(C)C)C(F)(F)F)C=1)OC)C(F)(F)F JREKJTZXYSPEIX-RIGXQMBPSA-N 0.000 claims 1
• QRAALILZGCNXFS-IHGBKINDSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CNCC2)C(F)(F)F)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CNCC2)C(F)(F)F)C=1)OC)C(F)(F)F QRAALILZGCNXFS-IHGBKINDSA-N 0.000 claims 1
• STEYUDZSPQEBME-DLBZAZTESA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(COC(OC2)(C)C)C)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(COC(OC2)(C)C)C)C=1)OC)C(F)(F)F STEYUDZSPQEBME-DLBZAZTESA-N 0.000 claims 1
• VVQLOBJERQFXCP-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=CN=C(S2)Cl)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2=CN=C(S2)Cl)C=1)OC)C(F)(F)F VVQLOBJERQFXCP-QWHCGFSZSA-N 0.000 claims 1
• WWPHBASFEQISGX-IJNKOPBPSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC([2H])([2H])[2H])C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CC(C2)(F)F)C=1)OC([2H])([2H])[2H])C(F)(F)F WWPHBASFEQISGX-IJNKOPBPSA-N 0.000 claims 1
• GGHWONAEERIPMF-NWDGAFQWSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(O)O)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(O)O)=O)C=1)OC)C(F)(F)F GGHWONAEERIPMF-NWDGAFQWSA-N 0.000 claims 1
• OISYTYCYAMJHFD-JKSUJKDBSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(N2C=NC(=C2)C(F)(F)F)C)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(N2C=NC(=C2)C(F)(F)F)C)=O)C=1)OC)C(F)(F)F OISYTYCYAMJHFD-JKSUJKDBSA-N 0.000 claims 1
• SPVVRXACNGCCTE-LSDHHAIUSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CO)(C)C)=O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(CO)(C)C)=O)C=1)OC)C(F)(F)F SPVVRXACNGCCTE-LSDHHAIUSA-N 0.000 claims 1
• ZSPHTKIRWUPFDL-SWQDIRLTSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(C(C)(C)C)O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(C(C)(C)C)O)C=1)OC)C(F)(F)F ZSPHTKIRWUPFDL-SWQDIRLTSA-N 0.000 claims 1
• UWUIOJBPWWINKF-QWHCGFSZSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(C(F)(F)F)(C(F)(F)F)O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(C(F)(F)F)(C(F)(F)F)O)C=1)OC)C(F)(F)F UWUIOJBPWWINKF-QWHCGFSZSA-N 0.000 claims 1
• XEZDWHOHQRMTOA-HPLQXTBUSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(C(F)(F)F)(C2=CC=CC=C2)O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(C(F)(F)F)(C2=CC=CC=C2)O)C=1)OC)C(F)(F)F XEZDWHOHQRMTOA-HPLQXTBUSA-N 0.000 claims 1
• KJZJYEBNTCAFOR-IHGBKINDSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(C(F)(F)F)(C=2SC=CN=2)O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(C(F)(F)F)(C=2SC=CN=2)O)C=1)OC)C(F)(F)F KJZJYEBNTCAFOR-IHGBKINDSA-N 0.000 claims 1
• TVHQLRSUWGTVRK-YUIIUQSRSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(CF)O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(CF)O)C=1)OC)C(F)(F)F TVHQLRSUWGTVRK-YUIIUQSRSA-N 0.000 claims 1
• FXQACVBBCAUHFX-YUIIUQSRSA-N NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(COC(C(F)F)(F)F)O)C=1)OC)C(F)(F)F Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)CC(COC(C(F)F)(F)F)O)C=1)OC)C(F)(F)F FXQACVBBCAUHFX-YUIIUQSRSA-N 0.000 claims 1
• FHGKYLGNZNACQI-SBKAZOPESA-N NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1C(C1)(F)F)F Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1C(C1)(F)F)F FHGKYLGNZNACQI-SBKAZOPESA-N 0.000 claims 1
• QSNLWMXRVRZXCE-LSDHHAIUSA-N NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(C1)(F)F)F Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(C1)(F)F)F QSNLWMXRVRZXCE-LSDHHAIUSA-N 0.000 claims 1
• YEQUWZVAXHNAMR-JNMIHDSVSA-N NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(CC1)(F)F)F Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(CC1)(F)F)F YEQUWZVAXHNAMR-JNMIHDSVSA-N 0.000 claims 1
• WASNXDYOQKEKOH-DLBZAZTESA-N NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCC(CC1)(F)F)F Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCC(CC1)(F)F)F WASNXDYOQKEKOH-DLBZAZTESA-N 0.000 claims 1
• GNBFWEJVVDKSHL-BCPDWATNSA-N NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCC(CC1)F)F Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCC(CC1)F)F GNBFWEJVVDKSHL-BCPDWATNSA-N 0.000 claims 1
• QVWUBNLKHZJOCP-DLBZAZTESA-N NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCOCC1)F Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCOCC1)F QVWUBNLKHZJOCP-DLBZAZTESA-N 0.000 claims 1
• QGMMMULJXSHJOI-ZWKOTPCHSA-N NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=CC=C(C=C1)F)=O)F Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=CC=C(C=C1)F)=O)F QGMMMULJXSHJOI-ZWKOTPCHSA-N 0.000 claims 1
• RMALHWQGKNSUSV-MRRFBWAASA-N NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@](C(F)(F)F)(C)O)=O)F Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C([C@@](C(F)(F)F)(C)O)=O)F RMALHWQGKNSUSV-MRRFBWAASA-N 0.000 claims 1
• PCEXRPUZHRYBTQ-LSDHHAIUSA-N NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)C(F)(F)F)C=1)OC)C#N Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2(CC2)C(F)(F)F)C=1)OC)C#N PCEXRPUZHRYBTQ-LSDHHAIUSA-N 0.000 claims 1
• DHNIDMZLTCZQSV-XDOPGVLMSA-N NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(C(F)(F)F)O)C=1)OC)C#N Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)C2CCC(CC2)(C(F)(F)F)O)C=1)OC)C#N DHNIDMZLTCZQSV-XDOPGVLMSA-N 0.000 claims 1
• PSNBJACOQJKERT-LSDHHAIUSA-N NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)C)=O)C=1)OC)C#N Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C(F)(F)F)(C)C)=O)C=1)OC)C#N PSNBJACOQJKERT-LSDHHAIUSA-N 0.000 claims 1
• RGUAFQFWUOVQCN-LSDHHAIUSA-N NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OC)C#N Chemical compound NC1=NC=NN2C1=CC(=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(C(C)(C)F)=O)C=1)OC)C#N RGUAFQFWUOVQCN-LSDHHAIUSA-N 0.000 claims 1
• KJCVBYXJGCDZIV-KFTPUPIBSA-N NC1=NC=NN2C1=CC=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1C(C1)(F)F Chemical compound NC1=NC=NN2C1=CC=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1C(C1)(F)F KJCVBYXJGCDZIV-KFTPUPIBSA-N 0.000 claims 1
• XQYUJSDQPJAWSW-XNZZJLCSSA-N NC1=NC=NN2C1=CC=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(C1)F Chemical compound NC1=NC=NN2C1=CC=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CC(C1)F XQYUJSDQPJAWSW-XNZZJLCSSA-N 0.000 claims 1
• RDBOHGACHAKGIK-DLBZAZTESA-N NC1=NC=NN2C1=CC=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCC(CC1)(F)F Chemical compound NC1=NC=NN2C1=CC=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCC(CC1)(F)F RDBOHGACHAKGIK-DLBZAZTESA-N 0.000 claims 1
• LIUQXHYJVLRMGJ-DLBZAZTESA-N NC1=NC=NN2C1=CC=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCOCC1 Chemical compound NC1=NC=NN2C1=CC=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)C1CCOCC1 LIUQXHYJVLRMGJ-DLBZAZTESA-N 0.000 claims 1
• MPZQNSXXFSBSDR-ZWKOTPCHSA-N NC1=NC=NN2C1=CC=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=CC=C(C=C1)F)=O Chemical compound NC1=NC=NN2C1=CC=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(C1=CC=C(C=C1)F)=O MPZQNSXXFSBSDR-ZWKOTPCHSA-N 0.000 claims 1
• ULNKJMPHISFNBS-FHLIZLRMSA-N [(2R)-1-hydroxy-4-methylpentan-2-yl] (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=NC(=C(C(=O)N[C@@H]2CN(C[C@@H]2F)C(=O)O[C@@H](CO)CC(C)C)C=1)OC)C(F)(F)F ULNKJMPHISFNBS-FHLIZLRMSA-N 0.000 claims 1
• FTOWABDCAYIAHR-NZVBXONLSA-N [(2S)-2-hydroxypropyl] (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OC[C@H](C)O)C(F)(F)F FTOWABDCAYIAHR-NZVBXONLSA-N 0.000 claims 1
• XNSUOTVUMPRYMT-JKSUJKDBSA-N butyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OCCCC)C(F)(F)F XNSUOTVUMPRYMT-JKSUJKDBSA-N 0.000 claims 1
• IFHDRCFDCNEBJW-JKSUJKDBSA-N cyclobutyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OC1CCC1)C(F)(F)F IFHDRCFDCNEBJW-JKSUJKDBSA-N 0.000 claims 1
• LRSUCNBXRLQXTK-DLBZAZTESA-N cyclobutylmethyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OCC1CCC1)C(F)(F)F LRSUCNBXRLQXTK-DLBZAZTESA-N 0.000 claims 1
• NXBDYGFIERFIOP-ZWKOTPCHSA-N cyclohexyl (3R,4S)-3-[[5-[4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-methoxypyridine-3-carbonyl]amino]-4-fluoropyrrolidine-1-carboxylate Chemical compound NC1=NC=NN2C1=C(C=C2C=1C=C(C(=NC=1)OC)C(=O)N[C@@H]1CN(C[C@@H]1F)C(=O)OC1CCCCC1)C(F)(F)F NXBDYGFIERFIOP-ZWKOTPCHSA-N 0.000 claims 1
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