IL276269A - Aminopyrrolotriazines as kinase inhibitors - Google Patents

Aminopyrrolotriazines as kinase inhibitors

Info

Publication number
IL276269A
IL276269A IL276269A IL27626920A IL276269A IL 276269 A IL276269 A IL 276269A IL 276269 A IL276269 A IL 276269A IL 27626920 A IL27626920 A IL 27626920A IL 276269 A IL276269 A IL 276269A
Authority
IL
Israel
Prior art keywords
aminopyrrolotriazines
kinase inhibitors
kinase
inhibitors
Prior art date
Application number
IL276269A
Other languages
English (en)
Hebrew (he)
Inventor
Carolyn A Weigelt
William J Pitts
John E Macor
Junqing Guo
Murugaiah Subbaiah Murugaiah Andappan
Jie Chen
Guanglin Luo
Jianliang Shi
Sing-Yuen Sit
Scott Hunter Watterson
Hua Gong
Carolyn Diane Dzierba
Jason M Guernon
Amy C Hart
Brian Lee Venables
Yong-Jin Wu
Zhizhen Barbara Zheng
Original Assignee
Bristol Myers Squibb Co
Carolyn A Weigelt
William J Pitts
John E Macor
Junqing Guo
Murugaiah Subbaiah Murugaiah Andappan
Jie Chen
Guanglin Luo
Jianliang Shi
Sit Sing Yuen
Scott Hunter Watterson
Hua Gong
Carolyn Diane Dzierba
Jason M Guernon
Amy C Hart
Brian Lee Venables
Wu Yong Jin
Zhizhen Barbara Zheng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Carolyn A Weigelt, William J Pitts, John E Macor, Junqing Guo, Murugaiah Subbaiah Murugaiah Andappan, Jie Chen, Guanglin Luo, Jianliang Shi, Sit Sing Yuen, Scott Hunter Watterson, Hua Gong, Carolyn Diane Dzierba, Jason M Guernon, Amy C Hart, Brian Lee Venables, Wu Yong Jin, Zhizhen Barbara Zheng filed Critical Bristol Myers Squibb Co
Publication of IL276269A publication Critical patent/IL276269A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL276269A 2018-01-26 2020-07-24 Aminopyrrolotriazines as kinase inhibitors IL276269A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862622415P 2018-01-26 2018-01-26
PCT/US2019/014918 WO2019147782A1 (en) 2018-01-26 2019-01-24 Aminopyrrolotriazines as kinase inhibitors

Publications (1)

Publication Number Publication Date
IL276269A true IL276269A (en) 2020-09-30

Family

ID=65363405

Family Applications (1)

Application Number Title Priority Date Filing Date
IL276269A IL276269A (en) 2018-01-26 2020-07-24 Aminopyrrolotriazines as kinase inhibitors

Country Status (16)

Country Link
US (1) US11618753B2 (https=)
EP (1) EP3743430B1 (https=)
JP (1) JP7307734B2 (https=)
KR (1) KR102759231B1 (https=)
CN (1) CN112262139B (https=)
AR (1) AR114186A1 (https=)
AU (1) AU2019211382B2 (https=)
BR (1) BR112020014516A2 (https=)
CA (1) CA3088548A1 (https=)
EA (1) EA202091777A1 (https=)
ES (1) ES2959399T3 (https=)
IL (1) IL276269A (https=)
MX (1) MX2020007531A (https=)
SG (1) SG11202007035YA (https=)
TW (1) TW201940485A (https=)
WO (1) WO2019147782A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA47460A (fr) 2017-02-13 2019-12-18 Bristol Myers Squibb Co Aminotriazolopyridines utilisées en tant qu'inhibiteurs de kinase
HUE058292T2 (hu) 2017-10-30 2022-07-28 Bristol Myers Squibb Co Aminoimidazopiridazinok mint kináz inhibitorok
AU2019339355A1 (en) 2018-09-13 2021-05-13 Bristol-Myers Squibb Company Indazole carboxamides as kinase inhibitors
KR102906523B1 (ko) 2018-09-13 2025-12-30 브리스톨-마이어스 스큅 컴퍼니 수용체-상호작용 단백질 키나제 1 (ripk1) 억제제로서의 1h-인다졸 카르복스아미드
ES2969756T3 (es) 2019-10-03 2024-05-22 Bristol Myers Squibb Co Indazol carboxamidas como inhibidores de cinasas
JPWO2021157596A1 (https=) * 2020-02-07 2021-08-12
WO2022007921A1 (zh) * 2020-07-10 2022-01-13 北京范恩柯尔生物科技有限公司 三嗪类化合物及其组合物和用途
CN111925345B (zh) * 2020-08-21 2023-09-29 上海科利生物医药有限公司 一种手性2-氨甲基四氢呋喃的制备方法
AR123793A1 (es) 2020-10-19 2023-01-11 Bristol Myers Squibb Co Compuestos de triazolopiridinilo como inhibidores de quinasas
JPWO2022172889A1 (https=) * 2021-02-10 2022-08-18
CN113563214B (zh) * 2021-07-06 2024-02-02 山东鲁泰控股集团有限公司石墨烯高分子复合材料研发中心 一种氨基乙酸的合成方法
CN113527220A (zh) * 2021-07-26 2021-10-22 京博农化科技有限公司 一种脱硫丙硫菌唑异构体的合成方法
CN116574053B (zh) * 2022-06-21 2026-04-14 中国药科大学 Ripk1激酶靶点抑制剂及其医药用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2627839C (en) 2005-11-02 2014-08-19 Bayer Healthcare Ag Pyrrolo[2,1-f] [1,2,4] triazin-4-ylamines igf-1r kinase inhibitors for the treatment of cancer and other hyperproliferative diseases
EP2385053B1 (en) * 2005-11-17 2013-10-02 OSI Pharmaceuticals, Inc. Intermediates for the preparation of fused bicyclic mTOR inhibitors
KR101461680B1 (ko) 2005-12-02 2014-11-19 바이엘 헬스케어 엘엘씨 과다-증식성 장애 및 맥관형성과 관련된 질환의 치료에유용한 치환된 4-아미노-피롤로트리아진 유도체
PE20070855A1 (es) 2005-12-02 2007-10-14 Bayer Pharmaceuticals Corp Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
GB2467670B (en) * 2007-10-04 2012-08-01 Intellikine Inc Chemical entities and therapeutic uses thereof
EP2424368B1 (en) 2009-04-29 2014-12-31 Locus Pharmaceuticals, Inc. Pyrrolotriazine compounds
TW201107329A (en) 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
HRP20160967T1 (hr) 2009-10-06 2016-10-07 Millennium Pharmaceuticals, Inc. Heterociklički spojevi korisni kao pdk1 inhibitori
CN102918045A (zh) 2010-03-31 2013-02-06 百时美施贵宝公司 作为蛋白激酶抑制剂的取代的吡咯并三嗪
WO2014047024A1 (en) 2012-09-18 2014-03-27 Bristol-Myers Squibb Company Iap antagonists
WO2015054358A1 (en) 2013-10-11 2015-04-16 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US10023576B2 (en) * 2014-10-22 2018-07-17 Bristol-Myers Squibb Company Heteroaryl substituted pyrrolotriazine amine compounds as PI3K inhibitors
US10214537B2 (en) * 2014-10-22 2019-02-26 Bristol-Myers Squibb Company Bicyclic heteroaryl amine compounds
MD3436461T2 (ro) 2016-03-28 2024-05-31 Incyte Corp Compuși pirolotriazină ca inhibitori TAM
WO2018017435A1 (en) 2016-07-22 2018-01-25 Accro Bioscience Inc. Heteroaryl compounds as inhibitors of necrosis, composition and application thereof
MA47460A (fr) 2017-02-13 2019-12-18 Bristol Myers Squibb Co Aminotriazolopyridines utilisées en tant qu'inhibiteurs de kinase
HUE058292T2 (hu) 2017-10-30 2022-07-28 Bristol Myers Squibb Co Aminoimidazopiridazinok mint kináz inhibitorok
AU2019339355A1 (en) 2018-09-13 2021-05-13 Bristol-Myers Squibb Company Indazole carboxamides as kinase inhibitors
KR102906523B1 (ko) 2018-09-13 2025-12-30 브리스톨-마이어스 스큅 컴퍼니 수용체-상호작용 단백질 키나제 1 (ripk1) 억제제로서의 1h-인다졸 카르복스아미드

Also Published As

Publication number Publication date
CN112262139A (zh) 2021-01-22
EA202091777A1 (ru) 2020-10-14
BR112020014516A2 (pt) 2020-12-08
AU2019211382B2 (en) 2022-06-16
KR20200115550A (ko) 2020-10-07
EP3743430A1 (en) 2020-12-02
AR114186A1 (es) 2020-07-29
CA3088548A1 (en) 2019-08-01
MX2020007531A (es) 2020-09-09
CN112262139B (zh) 2023-07-25
EP3743430B1 (en) 2023-08-02
TW201940485A (zh) 2019-10-16
WO2019147782A1 (en) 2019-08-01
SG11202007035YA (en) 2020-08-28
JP7307734B2 (ja) 2023-07-12
JP2021511363A (ja) 2021-05-06
US20200347071A1 (en) 2020-11-05
KR102759231B1 (ko) 2025-01-22
AU2019211382A1 (en) 2020-09-17
US11618753B2 (en) 2023-04-04
ES2959399T3 (es) 2024-02-26

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