JP2016513956A5 - - Google Patents

Info

Publication number

JP2016513956A5

JP2016513956A5 JP2015558140A JP2015558140A JP2016513956A5 JP 2016513956 A5 JP2016513956 A5 JP 2016513956A5 JP 2015558140 A JP2015558140 A JP 2015558140A JP 2015558140 A JP2015558140 A JP 2015558140A JP 2016513956 A5 JP2016513956 A5 JP 2016513956A5

Authority

JP

Japan

Prior art keywords

seq

vaccine vector

polypeptide

subject

immunogenic fragment

Prior art date

2014-02-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229960005486 vaccine Drugs 0.000 claims description 53
• 229920001184 polypeptide Polymers 0.000 claims description 34
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 34
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
• 238000000034 method Methods 0.000 claims description 26
• 239000012634 fragment Substances 0.000 claims description 21
• 239000002157 polynucleotide Substances 0.000 claims description 20
• 102000040430 polynucleotide Human genes 0.000 claims description 20
• 108091033319 polynucleotide Proteins 0.000 claims description 20
• 230000002163 immunogen Effects 0.000 claims description 19
• 244000045947 parasite Species 0.000 claims description 10
• 230000003308 immunostimulating effect Effects 0.000 claims description 8
• 230000028993 immune response Effects 0.000 claims description 6
• 239000008194 pharmaceutical composition Substances 0.000 claims description 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
• 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 claims description 4
• 108700010013 HMGB1 Proteins 0.000 claims description 4
• 101150021904 HMGB1 gene Proteins 0.000 claims description 4
• 102100037907 High mobility group protein B1 Human genes 0.000 claims description 4
• 150000001413 amino acids Chemical class 0.000 claims description 4
• 208000015181 infectious disease Diseases 0.000 claims description 4
• 244000144977 poultry Species 0.000 claims description 3
• 241000193830 Bacillus <bacterium> Species 0.000 claims description 2
• 241000894006 Bacteria Species 0.000 claims description 2
• 101150013553 CD40 gene Proteins 0.000 claims description 2
• 241000223935 Cryptosporidium Species 0.000 claims description 2
• 241000223924 Eimeria Species 0.000 claims description 2
• 241000287828 Gallus gallus Species 0.000 claims description 2
• 241001147660 Neospora Species 0.000 claims description 2
• 241000224016 Plasmodium Species 0.000 claims description 2
• 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
• 230000005867 T cell response Effects 0.000 claims description 2
• 241000223996 Toxoplasma Species 0.000 claims description 2
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 2
• 241000700605 Viruses Species 0.000 claims description 2
• 230000005875 antibody response Effects 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 230000002708 enhancing effect Effects 0.000 claims description 2
• 238000007918 intramuscular administration Methods 0.000 claims description 2
• 239000002502 liposome Substances 0.000 claims description 2
• 125000006850 spacer group Chemical group 0.000 claims description 2
• 238000007920 subcutaneous administration Methods 0.000 claims description 2
• 241000224482 Apicomplexa Species 0.000 claims 5
• 241000283690 Bos taurus Species 0.000 claims 1
• 241000286209 Phasianidae Species 0.000 claims 1
• 241000282887 Suidae Species 0.000 claims 1
• 235000013330 chicken meat Nutrition 0.000 claims 1
• 230000003362 replicative effect Effects 0.000 claims 1
• 241000124008 Mammalia Species 0.000 description 1
• 235000013365 dairy product Nutrition 0.000 description 1