JP2016513133A5 - - Google Patents
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- Publication number
- JP2016513133A5 JP2016513133A5 JP2015559595A JP2015559595A JP2016513133A5 JP 2016513133 A5 JP2016513133 A5 JP 2016513133A5 JP 2015559595 A JP2015559595 A JP 2015559595A JP 2015559595 A JP2015559595 A JP 2015559595A JP 2016513133 A5 JP2016513133 A5 JP 2016513133A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- donepezil
- release
- administered
- sustained
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 58
- 239000000203 mixture Substances 0.000 claims 51
- 229960003530 donepezil Drugs 0.000 claims 29
- 238000013268 sustained release Methods 0.000 claims 15
- 239000012730 sustained-release form Substances 0.000 claims 15
- 239000003795 chemical substances by application Substances 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 239000011248 coating agent Substances 0.000 claims 7
- 238000000576 coating method Methods 0.000 claims 7
- 238000013270 controlled release Methods 0.000 claims 6
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 4
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 claims 2
- 238000010828 elution Methods 0.000 claims 2
- 238000004448 titration Methods 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010029412 Nightmare Diseases 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 229960004373 acetylcholine Drugs 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN991KO2012 | 2013-02-28 | ||
| IN991/KOL/2012 | 2013-02-28 | ||
| PCT/IB2014/059302 WO2014132218A1 (en) | 2013-02-28 | 2014-02-27 | Pharmaceutical compositions of donepezil having specific in vitro dissolution profile or pharmacokinetics parameters |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513133A JP2016513133A (ja) | 2016-05-12 |
| JP2016513133A5 true JP2016513133A5 (enExample) | 2017-03-30 |
| JP6429808B2 JP6429808B2 (ja) | 2018-11-28 |
Family
ID=50288205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015559595A Expired - Fee Related JP6429808B2 (ja) | 2013-02-28 | 2014-02-27 | 特異的なインビトロ溶出プロファイルまたは薬物動態パラメーターを有するドネペジル医薬組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20160015698A1 (enExample) |
| EP (1) | EP2961393B1 (enExample) |
| JP (1) | JP6429808B2 (enExample) |
| KR (1) | KR102241113B1 (enExample) |
| CN (1) | CN105163723A (enExample) |
| BR (1) | BR112015020771A2 (enExample) |
| ES (1) | ES2842208T3 (enExample) |
| MX (1) | MX378413B (enExample) |
| RU (1) | RU2015140567A (enExample) |
| WO (1) | WO2014132218A1 (enExample) |
| ZA (1) | ZA201506665B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102142026B1 (ko) * | 2017-05-31 | 2020-08-06 | 주식회사 대웅제약 | 방출제어가 용이한 서방성 약물 미립자의 제조방법 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000030446A1 (en) * | 1998-11-23 | 2000-06-02 | Bonnie Davis | Dosage formulations for acetylcholinesterase inhibitors |
| KR20040047747A (ko) * | 2001-03-13 | 2004-06-05 | 펜웨스트 파머슈티칼즈 컴파니 | 변시치료 제형 |
| MY136318A (en) * | 2002-07-25 | 2008-09-30 | Pharmacia Corp | Sustained-release tablet composition |
| WO2005065645A2 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Donepezil formulations |
| US8058291B2 (en) * | 2005-04-06 | 2011-11-15 | Adamas Pharmaceuticals, Inc. | Methods and compositions for the treatment of CNS-related conditions |
| US20090208579A1 (en) * | 2004-12-27 | 2009-08-20 | Eisai R & D Management Co., Ltd. | Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same |
| US20070129402A1 (en) | 2004-12-27 | 2007-06-07 | Eisai Research Institute | Sustained release formulations |
| US20060159753A1 (en) | 2004-12-27 | 2006-07-20 | Eisai Co. Ltd. | Matrix type sustained-release preparation containing basic drug or salt thereof |
| CN101090737B (zh) * | 2004-12-27 | 2010-09-08 | 卫材R&D管理有限公司 | 稳定抗痴呆药物的方法 |
| US20060280789A1 (en) | 2004-12-27 | 2006-12-14 | Eisai Research Institute | Sustained release formulations |
| CA2592605C (en) * | 2004-12-27 | 2010-12-07 | Eisai R&D Management Co., Ltd. | Method for stabilizing anti-dementia drug |
| AU2005325930B2 (en) * | 2005-01-27 | 2012-01-19 | Alembic Limited | Extended release formulation of Levetiracetam |
| US20130059003A1 (en) | 2009-12-04 | 2013-03-07 | Dr. Reddy's Laboratories, Inc. | Sustained release donepezil formulations |
| US20110218216A1 (en) | 2010-01-29 | 2011-09-08 | Kumaravel Vivek | Extended release pharmaceutical composition of donepezil |
| EP2366378A1 (en) * | 2010-03-01 | 2011-09-21 | Dexcel Pharma Technologies Ltd. | Sustained-release donepezil formulations |
| GB201003734D0 (en) * | 2010-03-05 | 2010-04-21 | Univ Strathclyde | Delayed prolonged drug delivery |
| CN102309465B (zh) * | 2010-06-30 | 2015-04-22 | 天津药物研究院 | 含盐酸多奈哌齐活性成分的缓释片及其制备方法和用途 |
| WO2012035409A1 (en) * | 2010-09-14 | 2012-03-22 | Rubicon Research Private Limited | Sustained release compositions of anti-alzheimer's agents |
-
2014
- 2014-02-27 CN CN201480024046.5A patent/CN105163723A/zh active Pending
- 2014-02-27 MX MX2015011099A patent/MX378413B/es unknown
- 2014-02-27 US US14/771,241 patent/US20160015698A1/en not_active Abandoned
- 2014-02-27 WO PCT/IB2014/059302 patent/WO2014132218A1/en not_active Ceased
- 2014-02-27 BR BR112015020771A patent/BR112015020771A2/pt not_active Application Discontinuation
- 2014-02-27 EP EP14710647.0A patent/EP2961393B1/en not_active Not-in-force
- 2014-02-27 RU RU2015140567A patent/RU2015140567A/ru not_active Application Discontinuation
- 2014-02-27 KR KR1020157026728A patent/KR102241113B1/ko not_active Expired - Fee Related
- 2014-02-27 ES ES14710647T patent/ES2842208T3/es active Active
- 2014-02-27 JP JP2015559595A patent/JP6429808B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-09 ZA ZA2015/06665A patent/ZA201506665B/en unknown
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