|
US9914730B2
(en)
*
|
2012-09-28 |
2018-03-13 |
Cancer Research Technology Limited |
Azaquinazoline inhibitors of Atypical protein Kinase C
|
|
KR20150130389A
(ko)
|
2013-03-13 |
2015-11-23 |
더 리젠츠 오브 더 유니버시티 오브 미시간 |
티에노피리미딘 및 티에노피리딘 화합물을 포함하는 조성물 및 이의 사용 방법
|
|
WO2016040330A1
(en)
|
2014-09-09 |
2016-03-17 |
The Regents Of The University Of Michigan |
Thienopyrimidine and thienopyridine compounds and methods of use thereof
|
|
WO2016081732A1
(en)
*
|
2014-11-19 |
2016-05-26 |
Memorial Sloan-Kettering Cancer Center |
Thienopyrimidines and uses thereof
|
|
AR104020A1
(es)
*
|
2015-06-04 |
2017-06-21 |
Kura Oncology Inc |
Métodos y composiciones para inhibir la interacción de menina con proteínas mill
|
|
WO2016197027A1
(en)
*
|
2015-06-04 |
2016-12-08 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with mll proteins
|
|
GB201519573D0
(en)
|
2015-11-05 |
2015-12-23 |
King S College London |
Combination
|
|
EP4643952A3
(en)
*
|
2016-01-26 |
2026-01-14 |
Memorial Sloan Kettering Cancer Center |
Targeting chromatin regulators for inhibiting leukemogenic gene expression in npm1
|
|
CN109152784B
(zh)
*
|
2016-03-16 |
2021-12-28 |
库拉肿瘤学公司 |
经取代的menin-mll抑制剂及使用方法
|
|
CN109640987B
(zh)
|
2016-03-16 |
2022-12-02 |
库拉肿瘤学公司 |
Menin-mll的桥联双环抑制剂及使用方法
|
|
WO2017192543A1
(en)
|
2016-05-02 |
2017-11-09 |
Regents Of The University Of Michigan |
Piperidines as menin inhibitors
|
|
WO2017207387A1
(en)
|
2016-05-31 |
2017-12-07 |
Bayer Pharma Aktiengesellschaft |
Spiro condensed azetidine derivatives as inhibitors of the menin-mml1 interaction
|
|
EP3805215A1
(en)
*
|
2016-06-10 |
2021-04-14 |
Vitae Pharmaceuticals, LLC |
Inhibitors of the menin-mll interaction
|
|
WO2018024602A1
(en)
|
2016-08-04 |
2018-02-08 |
Bayer Aktiengesellschaft |
2,7-diazaspiro[4.4]nonanes
|
|
CN109689663B
(zh)
|
2016-09-14 |
2023-04-14 |
詹森药业有限公司 |
Menin-mll相互作用的螺二环抑制剂
|
|
US12084462B2
(en)
|
2016-09-14 |
2024-09-10 |
Janssen Pharmaceutica Nv |
Spiro bicyclic inhibitors of menin-MLL interaction
|
|
CA3033239A1
(en)
|
2016-09-14 |
2018-03-22 |
Janssen Pharmaceutica Nv |
Spiro bicyclic inhibitors of menin-mll interaction
|
|
MA46228A
(fr)
|
2016-09-14 |
2019-07-24 |
Janssen Pharmaceutica Nv |
Inhibiteurs bicycliques fusionnés de l'interaction ménine-mll
|
|
EA039109B1
(ru)
*
|
2016-12-07 |
2021-12-06 |
Кура Онколоджи, Инк. |
Мостиковые бициклические ингибиторы взаимодействия менин-mll и способы применения
|
|
BR112019012106A2
(pt)
*
|
2016-12-15 |
2019-10-29 |
Janssen Pharmaceutica Nv |
inibidores de azepano de interação menin-mill
|
|
EA201991448A1
(ru)
|
2017-01-06 |
2019-12-30 |
Янссен Фармацевтика Нв |
Азепановые ингибиторы взаимодействия менин-mll
|
|
EA038388B1
(ru)
*
|
2017-01-16 |
2021-08-19 |
Кура Онколоджи, Инк. |
Замещенные ингибиторы менина-mll и способы применения
|
|
CN110691779B
(zh)
*
|
2017-03-24 |
2023-10-10 |
库拉肿瘤学公司 |
治疗血液系统恶性肿瘤和尤因肉瘤的方法
|
|
CA3058448A1
(en)
|
2017-03-31 |
2018-10-04 |
The Regents Of The University Of Michigan |
Piperidines as covalent menin inhibitors
|
|
US11542248B2
(en)
|
2017-06-08 |
2023-01-03 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with MLL proteins
|
|
US11649251B2
(en)
|
2017-09-20 |
2023-05-16 |
Kura Oncology, Inc. |
Substituted inhibitors of menin-MLL and methods of use
|
|
US11396517B1
(en)
|
2017-12-20 |
2022-07-26 |
Janssen Pharmaceutica Nv |
Exo-aza spiro inhibitors of menin-MLL interaction
|
|
KR20200101389A
(ko)
*
|
2017-12-20 |
2020-08-27 |
얀센 파마슈티카 엔.브이. |
메닌-mll 상호작용의 엑소-아자 스피로 억제제
|
|
CN110204552B
(zh)
*
|
2018-02-28 |
2021-08-17 |
中国科学院上海药物研究所 |
一类噻吩并[3,2-d]嘧啶衍生物、其制备方法、药物组合物与用途
|
|
BR112020018094A2
(pt)
|
2018-03-08 |
2020-12-22 |
Incyte Corporation |
Compostos de aminopirazina diol como inibidores de pi3k-¿
|
|
US11325921B2
(en)
|
2018-03-30 |
2022-05-10 |
Sumitomo Dainippon Pharma Co., Ltd. |
Optically active crosslinked cyclic secondary amine derivative
|
|
US11046658B2
(en)
|
2018-07-02 |
2021-06-29 |
Incyte Corporation |
Aminopyrazine derivatives as PI3K-γ inhibitors
|
|
CA3108449A1
(en)
*
|
2018-08-08 |
2020-02-13 |
Sumitomo Dainippon Pharma Co., Ltd. |
Optically active bridged piperidine derivative
|
|
BR112021006273A2
(pt)
|
2018-10-03 |
2021-07-06 |
Agios Pharmaceuticals Inc |
inibidores de menin de pequenas moléculas
|
|
WO2020085504A1
(ja)
|
2018-10-26 |
2020-04-30 |
大鵬薬品工業株式会社 |
光照射ザンドマイヤー反応を用いたクロロアゾールカルボキシレート誘導体の製造方法
|
|
AU2019395201A1
(en)
|
2018-12-06 |
2021-05-20 |
Daiichi Sankyo Company, Limited |
Cycloalkane-1,3-diamine derivative
|
|
ES2974634T3
(es)
|
2018-12-21 |
2024-06-28 |
Celgene Corp |
Inhibidores de tienopiridinas de RIPK2
|
|
CA3128377A1
(en)
*
|
2019-02-01 |
2020-08-06 |
University Of South Carolina |
Bicyclic pyridine compositions and methods of using the same for cancer therapy
|
|
WO2020243423A1
(en)
|
2019-05-31 |
2020-12-03 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
|
KR20220030222A
(ko)
|
2019-05-31 |
2022-03-10 |
이케나 온콜로지, 인코포레이티드 |
Tead 억제제 및 이의 용도
|
|
CN112116960B
(zh)
*
|
2019-06-20 |
2024-10-11 |
中国石油化工股份有限公司 |
柴油加氢反应的组分含量确定方法、装置
|
|
TW202126636A
(zh)
|
2019-09-30 |
2021-07-16 |
美商阿吉歐斯製藥公司 |
作為ｍｅｎｉｎ抑制劑之六氫吡啶化合物
|
|
CN114867726B
(zh)
|
2019-10-28 |
2023-11-28 |
默沙东有限责任公司 |
Kras g12c突变体的小分子抑制剂
|
|
WO2021106231A1
(en)
*
|
2019-11-29 |
2021-06-03 |
Taiho Pharmaceutical Co., Ltd. |
A compound having inhibitory activity against kras g12d mutation
|
|
US12479834B2
(en)
|
2019-11-29 |
2025-11-25 |
Taiho Pharmaceutical Co., Ltd. |
Phenol compound or salt thereof
|
|
JP7554829B2
(ja)
|
2019-12-19 |
2024-09-20 |
ヤンセン ファーマシューティカ エヌ．ベー． |
置換直鎖スピロ誘導体
|
|
CN111297863B
(zh)
*
|
2020-03-30 |
2021-06-25 |
四川大学华西医院 |
menin-MLL抑制剂在制备治疗子宫内膜癌的药物中的应用
|
|
MX2022012471A
(es)
|
2020-04-07 |
2022-11-30 |
Syndax Pharmaceuticals Inc |
Combinaciones de inhibidores de menina e inhibidores de cyp3a4 y métodos de uso de las mismas.
|
|
WO2021207310A1
(en)
|
2020-04-08 |
2021-10-14 |
Agios Pharmaceuticals, Inc. |
Menin inhibitors and methods of use for treating cancer
|
|
TW202204333A
(zh)
|
2020-04-08 |
2022-02-01 |
美商阿吉歐斯製藥公司 |
Menin抑制劑及治療癌症之使用方法
|
|
AR122159A1
(es)
*
|
2020-05-28 |
2022-08-17 |
Novartis Ag |
Inhibidores de mll1 y agentes antineoplásicos
|
|
WO2022086986A1
(en)
*
|
2020-10-21 |
2022-04-28 |
Kura Oncology, Inc. |
Treatment of hematological malignancies with inhibitors of menin
|
|
MX2023013174A
(es)
|
2021-05-08 |
2023-11-30 |
Janssen Pharmaceutica Nv |
Derivados espiro sustituidos.
|
|
EP4334320A1
(en)
|
2021-05-08 |
2024-03-13 |
JANSSEN Pharmaceutica NV |
Substituted spiro derivatives
|
|
TW202311262A
(zh)
|
2021-05-14 |
2023-03-16 |
美商錫達斯醫藥股份有限公司 |
Menin-mll交互作用之抑制劑
|
|
WO2022253167A1
(en)
|
2021-06-01 |
2022-12-08 |
Janssen Pharmaceutica Nv |
SUBSTITUTED PHENYL-1H-PYRROLO [2, 3-c] PYRIDINE DERIVATIVES
|
|
CN117425659A
(zh)
|
2021-06-03 |
2024-01-19 |
詹森药业有限公司 |
哒嗪或被螺环胺取代的1,2,4-三嗪
|
|
CA3220099A1
(en)
|
2021-06-17 |
2022-12-22 |
Wei Cai |
(r)-n-ethyl-5-fluoro-n-isopropyl-2-((5-(2-(6-((2-methoxyethyl)(methyl)amino)-2-methylhexan-3-yl)-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl)oxy)benzamide besylate salt for the treatment of diseases such as cance
|
|
CN115515958B
(zh)
*
|
2021-08-04 |
2023-09-29 |
成都苑东生物制药股份有限公司 |
一种新型磺酰胺类menin-MLL相互作用抑制剂、其制备方法及医药用途
|
|
WO2023011446A1
(zh)
*
|
2021-08-04 |
2023-02-09 |
成都苑东生物制药股份有限公司 |
一种新型磺酰胺类menin-MLL相互作用抑制剂、其制备方法及医药用途
|
|
WO2023056589A1
(en)
|
2021-10-08 |
2023-04-13 |
Servier Pharmaceuticals Llc |
Menin inhibitors and methods of use for treating cancer
|
|
KR20240131421A
(ko)
*
|
2021-12-31 |
2024-08-30 |
히트젠 주식회사 |
메닌 저해제 및 이의 용도
|
|
WO2023215354A1
(en)
*
|
2022-05-03 |
2023-11-09 |
Board Of Regents, The University Of Texas System |
Menin proteolysis targeting chimeras (protacs)
|
|
CN120529900A
(zh)
|
2022-11-24 |
2025-08-22 |
奥莱松基因组股份有限公司 |
用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合
|
|
CN116199633B
(zh)
*
|
2022-12-27 |
2024-05-31 |
甘肃省化工研究院有限责任公司 |
一种制备瑞维鲁胺的方法
|
|
WO2025085748A1
(en)
|
2023-10-20 |
2025-04-24 |
Merck Sharp & Dohme Llc |
Small molecule inhibitors of kras proteins
|