CA2904612A1 - Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof - Google Patents

Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof Download PDF

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Publication number
CA2904612A1
CA2904612A1 CA2904612A CA2904612A CA2904612A1 CA 2904612 A1 CA2904612 A1 CA 2904612A1 CA 2904612 A CA2904612 A CA 2904612A CA 2904612 A CA2904612 A CA 2904612A CA 2904612 A1 CA2904612 A1 CA 2904612A1
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CA
Canada
Prior art keywords
alkyl
substituted
group
aromatic ring
ring
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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CA2904612A
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English (en)
French (fr)
Inventor
Jolanta Grembecka
Tomasz Cierpicki
Dmitry Borkin
Jay Hess
Duxin Sun
Xiaoqin LI
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University of Michigan System
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University of Michigan System
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Application filed by University of Michigan System filed Critical University of Michigan System
Publication of CA2904612A1 publication Critical patent/CA2904612A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2904612A 2013-03-13 2014-03-10 Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof Abandoned CA2904612A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361780099P 2013-03-13 2013-03-13
US61/780,099 2013-03-13
PCT/US2014/022750 WO2014164543A1 (en) 2013-03-13 2014-03-10 Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
CA2904612A1 true CA2904612A1 (en) 2014-10-09

Family

ID=51529943

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2904612A Abandoned CA2904612A1 (en) 2013-03-13 2014-03-10 Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof

Country Status (11)

Country Link
US (4) US9505781B2 (https=)
EP (1) EP2968342B1 (https=)
JP (2) JP2016512514A (https=)
KR (1) KR20150130389A (https=)
CN (1) CN105188705A (https=)
AU (1) AU2014249233A1 (https=)
BR (1) BR112015022602A2 (https=)
CA (1) CA2904612A1 (https=)
IL (1) IL241193A0 (https=)
MX (1) MX2015011576A (https=)
WO (1) WO2014164543A1 (https=)

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WO2017192543A1 (en) 2016-05-02 2017-11-09 Regents Of The University Of Michigan Piperidines as menin inhibitors
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CN111297863B (zh) * 2020-03-30 2021-06-25 四川大学华西医院 menin-MLL抑制剂在制备治疗子宫内膜癌的药物中的应用
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Also Published As

Publication number Publication date
KR20150130389A (ko) 2015-11-23
US9505782B2 (en) 2016-11-29
JP2016512514A (ja) 2016-04-28
BR112015022602A2 (pt) 2017-07-18
US10160769B2 (en) 2018-12-25
MX2015011576A (es) 2016-05-16
EP2968342A1 (en) 2016-01-20
US9216993B2 (en) 2015-12-22
WO2014164543A1 (en) 2014-10-09
EP2968342A4 (en) 2016-07-27
US20160046647A1 (en) 2016-02-18
JP2018115214A (ja) 2018-07-26
US20170253611A1 (en) 2017-09-07
US20160137665A1 (en) 2016-05-19
CN105188705A (zh) 2015-12-23
EP2968342B1 (en) 2018-10-03
AU2014249233A1 (en) 2015-09-24
JP6670885B2 (ja) 2020-03-25
US9505781B2 (en) 2016-11-29
US20140275070A1 (en) 2014-09-18
IL241193A0 (en) 2015-11-30

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Effective date: 20190312