JP2016512434A5 - - Google Patents
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- Publication number
- JP2016512434A5 JP2016512434A5 JP2016501891A JP2016501891A JP2016512434A5 JP 2016512434 A5 JP2016512434 A5 JP 2016512434A5 JP 2016501891 A JP2016501891 A JP 2016501891A JP 2016501891 A JP2016501891 A JP 2016501891A JP 2016512434 A5 JP2016512434 A5 JP 2016512434A5
- Authority
- JP
- Japan
- Prior art keywords
- skin equivalent
- skin
- cryopreserved
- equivalent
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000003491 skin Anatomy 0.000 claims 36
- 238000000034 method Methods 0.000 claims 11
- 239000002577 cryoprotective agent Substances 0.000 claims 9
- 230000008014 freezing Effects 0.000 claims 6
- 238000007710 freezing Methods 0.000 claims 6
- 238000009792 diffusion process Methods 0.000 claims 5
- 206010052428 Wound Diseases 0.000 claims 3
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- 238000004113 cell culture Methods 0.000 claims 3
- 230000002500 effect on skin Effects 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 210000002510 keratinocyte Anatomy 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 230000002745 absorbent Effects 0.000 claims 2
- 239000002250 absorbent Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 238000004806 packaging method and process Methods 0.000 claims 2
- 238000010257 thawing Methods 0.000 claims 2
- 238000000134 MTT assay Methods 0.000 claims 1
- 231100000002 MTT assay Toxicity 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 210000005127 stratified epithelium Anatomy 0.000 claims 1
- 230000035899 viability Effects 0.000 claims 1
- 238000010792 warming Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361779661P | 2013-03-13 | 2013-03-13 | |
| US61/779,661 | 2013-03-13 | ||
| PCT/US2014/025599 WO2014160000A1 (en) | 2013-03-13 | 2014-03-13 | Cryopreservation of viable human skin substitutes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019154515A Division JP7220640B2 (ja) | 2013-03-13 | 2019-08-27 | 生育可能なヒト皮膚代用物の凍結保存 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512434A JP2016512434A (ja) | 2016-04-28 |
| JP2016512434A5 true JP2016512434A5 (enExample) | 2017-04-13 |
| JP6580028B2 JP6580028B2 (ja) | 2019-09-25 |
Family
ID=51527939
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501891A Active JP6580028B2 (ja) | 2013-03-13 | 2014-03-13 | 生育可能なヒト皮膚代用物の凍結保存 |
| JP2019154515A Active JP7220640B2 (ja) | 2013-03-13 | 2019-08-27 | 生育可能なヒト皮膚代用物の凍結保存 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019154515A Active JP7220640B2 (ja) | 2013-03-13 | 2019-08-27 | 生育可能なヒト皮膚代用物の凍結保存 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10091983B2 (enExample) |
| EP (3) | EP3900534A1 (enExample) |
| JP (2) | JP6580028B2 (enExample) |
| AU (4) | AU2014244264B2 (enExample) |
| CA (2) | CA3071928A1 (enExample) |
| DK (2) | DK3470018T3 (enExample) |
| ES (2) | ES2705043T3 (enExample) |
| IL (1) | IL241448B (enExample) |
| PT (2) | PT3470018T (enExample) |
| WO (1) | WO2014160000A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3900534A1 (en) * | 2013-03-13 | 2021-10-27 | Stratatech Corporation | Method for warming cryoconserved human skin substitutes |
| JP6826975B2 (ja) * | 2014-07-09 | 2021-02-10 | ジェネンテック， インコーポレイテッド | 細胞バンクの解凍復元を改善するためのｐＨ調整 |
| WO2016149254A1 (en) | 2015-03-17 | 2016-09-22 | Chimera Bioengineering, Inc. | Smart car devices, de car polypeptides, side cars and uses thereof |
| US11052111B2 (en) | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
| US10222369B2 (en) | 2016-05-17 | 2019-03-05 | Chimera Bioengineering, Inc. | Methods for making novel antigen binding domains |
| JP7045378B2 (ja) | 2016-09-01 | 2022-03-31 | キメラ・バイオエンジニアリング，インコーポレーテッド | Ｇｏｌｄ最適化ＣＡＲ Ｔ細胞 |
| WO2019160815A1 (en) | 2018-02-13 | 2019-08-22 | Chimera Bioengineering, Inc. | Coordinating gene expression using rna destabilizing elements |
| CA3109300C (en) | 2018-08-31 | 2024-05-14 | Wisconsin Alumni Research Foundation | Generating arterial endothelial cell-seeded vascular grafts |
| CN113424002B (zh) * | 2018-11-22 | 2023-12-01 | 维特拉菲生命科学有限公司 | 冷冻生物产品的方法和装置 |
| EP4013431A4 (en) | 2019-08-18 | 2024-05-01 | Chimera Bioengineering, Inc. | Combination therapy with gold controlled transgenes |
| US20220347353A1 (en) * | 2019-09-27 | 2022-11-03 | Stratatech Corporation | Methods for treating acute wounds and improving outcomes |
| CN114836291B (zh) * | 2021-02-01 | 2025-11-21 | 深圳拜尔洛克生物技术有限公司 | 生物材料解冻复苏的系统及其方法 |
| AU2022282461A1 (en) * | 2021-05-28 | 2023-11-16 | Stratatech Corporation | Tissue container systems |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4485096A (en) | 1982-02-26 | 1984-11-27 | Massachusetts Institute Of Technology | Tissue-equivalent and method for preparation thereof |
| IL95429A (en) | 1989-09-15 | 1997-09-30 | Organogenesis | Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production |
| USRE35399E (en) | 1990-04-24 | 1996-12-10 | Eisenberg; Mark | Composite living skin equivalents |
| IT1248934B (it) | 1990-06-01 | 1995-02-11 | Fidia Spa | Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle |
| US5145770A (en) * | 1990-06-04 | 1992-09-08 | Biosurface Technology, Inc. | Cryopreservation of cultured epithelial sheets |
| US5891617A (en) * | 1993-09-15 | 1999-04-06 | Organogenesis Inc. | Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing |
| US5518878A (en) * | 1993-09-15 | 1996-05-21 | Organogenesis Inc. | Cryopreservation of cultured skin or cornea equivalents with agitation |
| AU4106796A (en) | 1994-11-09 | 1996-06-06 | Federico Castro Munozledo | Wound repair dressings and methods for their preservation |
| IT1281870B1 (it) * | 1995-04-27 | 1998-03-03 | Fidia Advanced Biopolymers Srl | Pelle artificiale umana costituita da materiali biocompatibili a base di derivati dell'acido ialuronico |
| US5693332C1 (en) | 1995-08-11 | 2001-01-09 | Univ California | Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure |
| US5689961A (en) | 1996-01-30 | 1997-11-25 | Organogenesis Inc. | Ice seeding apparatus for cryopreservation systems |
| US5968546A (en) | 1997-05-16 | 1999-10-19 | Baur; Marcus | Keratinocyte culture from precursor cells |
| US5989837A (en) | 1998-07-13 | 1999-11-23 | Wisconsin Alumni Research Foundation | Immortalized human keratinocyte cell line |
| WO2002058588A2 (en) * | 2000-12-27 | 2002-08-01 | Ortec International, Inc. | Processes for making cryopreserved composite living constructs and products resulting therefrom |
| NZ549528A (en) | 2001-03-02 | 2008-04-30 | Stratatech Corp | Method of making skin equivalents having improved barrier function |
| US6974697B2 (en) | 2001-03-02 | 2005-12-13 | Stratech Corporation | Skin substitutes with improved barrier function |
| DE60332256D1 (de) | 2002-04-30 | 2010-06-02 | Stratatech Corp | Exogene angiogene wachstumsfaktoren exprimierende keratinozyten |
| WO2004013606A2 (en) | 2002-08-02 | 2004-02-12 | Stratatech Corporation | Species specific dna detection |
| EP1633858A4 (en) * | 2003-05-30 | 2006-11-02 | Stratatech Corp | STORAGE OF ORGANS AT ROOM TEMPERATURE |
| EP2481287B1 (en) | 2003-08-01 | 2016-07-20 | Stratatech Corporation | Human skin equivalents expressing exogenous polypeptides |
| WO2005041880A2 (en) * | 2003-10-29 | 2005-05-12 | Science & Technology Corporation @ Unm | RhPV AS A MODEL FOR HPV-INDUCED CANCERS |
| CA2600177C (en) | 2005-03-01 | 2011-06-14 | Stratatech Corporation | Human skin equivalents expressing exogenous polypeptides |
| US9295543B2 (en) | 2005-03-17 | 2016-03-29 | Stratatech Corporation | Skin substitutes with improved purity |
| KR100803384B1 (ko) | 2007-01-15 | 2008-02-13 | 한스바이오메드 주식회사 | 피부조직의 장기 보관 방법 |
| DK2215212T3 (da) | 2007-11-14 | 2017-11-27 | Stratatech Corp | Kold opbevaring af organotypisk dyrkede hudækvivalenter til kliniske anvendelser |
| ES2621324T3 (es) | 2008-11-04 | 2017-07-03 | Stratatech Corporation | Equivalentes de piel secos e irradiados listos para su uso |
| WO2010135655A2 (en) | 2009-05-21 | 2010-11-25 | Stratatech Corporation | Human skin substitutes expressing il-12 |
| US20130108670A1 (en) * | 2011-10-25 | 2013-05-02 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating full thickness burn injuries |
| US20130108683A1 (en) | 2011-10-25 | 2013-05-02 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating partial and full thickness wounds and injuries |
| EP3900534A1 (en) * | 2013-03-13 | 2021-10-27 | Stratatech Corporation | Method for warming cryoconserved human skin substitutes |
-
2014
- 2014-03-13 EP EP21177142.3A patent/EP3900534A1/en not_active Withdrawn
- 2014-03-13 DK DK18197432.0T patent/DK3470018T3/da active
- 2014-03-13 JP JP2016501891A patent/JP6580028B2/ja active Active
- 2014-03-13 EP EP18197432.0A patent/EP3470018B1/en active Active
- 2014-03-13 PT PT18197432T patent/PT3470018T/pt unknown
- 2014-03-13 EP EP14775892.4A patent/EP2967836B1/en active Active
- 2014-03-13 AU AU2014244264A patent/AU2014244264B2/en not_active Ceased
- 2014-03-13 CA CA3071928A patent/CA3071928A1/en active Pending
- 2014-03-13 ES ES14775892T patent/ES2705043T3/es active Active
- 2014-03-13 CA CA2905656A patent/CA2905656C/en active Active
- 2014-03-13 US US14/208,439 patent/US10091983B2/en active Active
- 2014-03-13 PT PT14775892T patent/PT2967836T/pt unknown
- 2014-03-13 ES ES18197432T patent/ES2893844T3/es active Active
- 2014-03-13 DK DK14775892.4T patent/DK2967836T3/en active
- 2014-03-13 WO PCT/US2014/025599 patent/WO2014160000A1/en not_active Ceased
-
2015
- 2015-09-10 IL IL241448A patent/IL241448B/en active IP Right Grant
-
2017
- 2017-07-17 AU AU2017206148A patent/AU2017206148B2/en not_active Ceased
-
2018
- 2018-09-05 US US16/122,598 patent/US11297829B2/en active Active
-
2019
- 2019-08-27 JP JP2019154515A patent/JP7220640B2/ja active Active
- 2019-09-17 AU AU2019232795A patent/AU2019232795B2/en not_active Ceased
-
2021
- 2021-11-05 AU AU2021261937A patent/AU2021261937B2/en not_active Ceased
-
2022
- 2022-03-14 US US17/694,245 patent/US20220192181A1/en not_active Abandoned
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