JP2016511236A - キャノーラエキスの使用による皮膚のホワイトニング方法 - Google Patents
キャノーラエキスの使用による皮膚のホワイトニング方法 Download PDFInfo
- Publication number
- JP2016511236A JP2016511236A JP2015555814A JP2015555814A JP2016511236A JP 2016511236 A JP2016511236 A JP 2016511236A JP 2015555814 A JP2015555814 A JP 2015555814A JP 2015555814 A JP2015555814 A JP 2015555814A JP 2016511236 A JP2016511236 A JP 2016511236A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- canola extract
- skin
- canola
- extract contains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 235000006008 Brassica napus var napus Nutrition 0.000 title claims abstract description 66
- 240000000385 Brassica napus var. napus Species 0.000 title claims abstract description 66
- 235000006618 Brassica rapa subsp oleifera Nutrition 0.000 title claims abstract description 66
- 235000004977 Brassica sinapistrum Nutrition 0.000 title claims abstract description 66
- 239000000284 extract Substances 0.000 title claims abstract description 63
- 238000000034 method Methods 0.000 title claims abstract description 42
- 230000002087 whitening effect Effects 0.000 title claims abstract description 27
- 239000000203 mixture Substances 0.000 claims abstract description 74
- 208000000069 hyperpigmentation Diseases 0.000 claims abstract description 11
- 230000003810 hyperpigmentation Effects 0.000 claims abstract description 11
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- PCMORTLOPMLEFB-ONEGZZNKSA-N sinapic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-ONEGZZNKSA-N 0.000 claims description 27
- PCMORTLOPMLEFB-UHFFFAOYSA-N sinapinic acid Natural products COC1=CC(C=CC(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-UHFFFAOYSA-N 0.000 claims description 27
- YQUVCSBJEUQKSH-UHFFFAOYSA-N 3,4-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 claims description 19
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- UEVAMYPIMMOEFW-UHFFFAOYSA-N trolamine salicylate Chemical compound OCCN(CCO)CCO.OC(=O)C1=CC=CC=C1O UEVAMYPIMMOEFW-UHFFFAOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 235000019386 wax ester Nutrition 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
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- Cosmetics (AREA)
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Abstract
Description
好ましい態様では、キャノーラエキスは、プロトカテク酸、バニリン酸、コーヒー酸、シリング酸、P-クマル酸、シナピン酸のうちの1以上を含んでいる。
細胞の培養
PROMOCELLから入手できるNHEM(皮膚、正常メラノサイト)を供給者の指示にしたがって培養した。簡潔に言えば、細胞を、加湿室において37℃、5%のCO2で、10%のFBSが補充されたM2(メラノサイト完全増殖培地、PROMOCELL)に維持した。細胞を、1×105細胞/ウェル(1mlの1×105細胞/ml)で、12ウェル組織培養プレート(濃度当り3ウェル)に置き、終夜培養し、細胞をプレート表面に付着させた。メラニン濃度の初期測定値は分光光度計で475nm波長と測定された。
高いフェノール酸キャノーラエキス(発明者がDermytol(商標名)と呼ぶ)化合物を量り取り、Dermytol(商標名) 10mg/mLの濃度で蒸留水中に溶解することにより、使用直前に調製すると、以下が形成された:
以下の表1に示されているように、Dermytol(商標名)の濃度の増加は、NHEM細胞増殖の阻害を増加する結果が得られた。
細胞の培養
ATCCから入手できるA375(皮膚、悪性黒色腫)を供給者の指示にしたがって培養した。簡潔に言えば、細胞を、加湿室において37℃、5%のCO2で、10%のFBSが補充されたDMEMに維持した。細胞を、1×105細胞/フラスコ(1mlの1×106細胞/ml)で、27 T25組織培養フラスコ(濃度当り3フラスコ)に置き、終夜培養し、細胞をプレート表面に付着させた。メラニン濃度の初期測定値は分光光度計で475nm波長と測定された。
高いフェノール酸キャノーラエキス(発明者がDermytol(商標名)と呼ぶ)化合物を量り取り、10mg/mLの濃度のDermytol(商標名)で、蒸留水中に溶解することにより、使用直前に調製すると、以下が形成された:
以下の表4は、フラスコ当たりの、処理についての生細胞のカウントを表している。
Claims (20)
- 美白またはホワイトニングが所望される皮膚の場所を特定し、その皮膚に対して、局所的に、(a)キャノーラエキスを含む皮膚美白剤と、(b)美容的に許容可能なキャリアとを含んでいる組成物を、適用する工程を含んでいる皮膚を美白する方法。
- キャノーラエキスは、プロトカテク酸、バニリン酸、コーヒー酸、シリング酸、P-クマル酸、シナピン酸を含んでいる請求項1記載の方法。
- キャノーラエキスは、プロトカテク酸を含んでいる請求項1記載の方法。
- キャノーラエキスは、バニリン酸を含んでいる請求項1記載の方法。
- キャノーラエキスは、コーヒー酸を含んでいる請求項1記載の方法。
- キャノーラエキスは、シリング酸を含んでいる請求項1記載の方法。
- キャノーラエキスは、P-クマル酸を含んでいる請求項1記載の方法。
- キャノーラエキスは、シナピン酸を含んでいる請求項1記載の方法。
- キャノーラエキスは、全フェノール、フェノール酸、カロテノイド、トコフェロール/ステロール、グルコシノレート、およびその組み合わせからなる群から選択される請求項1記載の方法。
- キャノーラエキスは、プロゴイトリン、シニグリン、グルコラファニン、ナポレフェリン、グルコアリシシン、グルコナピン、4-ハイドロキシブラシシン、グルコブラシシカナピン、グルコブラシシン、グルコナスターチン、4-メトキシ-グルコブラシシン、ネオグルコブラシシン、およびその組み合わせからなる群から選択される、グルコシノレートを含んでいる請求項9記載の方法。
- 色素過剰エリアを含む皮膚を特定し、その皮膚に対して、局所的に、(a)キャノーラエキスと、(b)美容的に許容可能なキャリアとを含む組成物を、適用する工程を含んでいる色素過剰の治療方法。
- キャノーラエキスは、プロトカテク酸、バニリン酸、コーヒー酸、シリング酸、P-クマル酸、シナピン酸を含んでいる請求項11記載の方法。
- キャノーラエキスは、プロトカテク酸を含んでいる請求項11記載の方法。
- キャノーラエキスは、バニリン酸を含んでいる請求項11記載の方法。
- キャノーラエキスは、コーヒー酸を含んでいる請求項11記載の方法。
- キャノーラエキスは、シリング酸を含んでいる請求項11記載の方法。
- キャノーラエキスは、P-クマル酸を含んでいる請求項11記載の方法。
- キャノーラエキスは、シナピン酸を含んでいる請求項11記載の方法。
- キャノーラエキスは、全フェノール、フェノール酸、カロテノイド、トコフェロール/ステロール、グルコシノレート、およびその組み合わせからなる群から選択される請求項11記載の方法。
- キャノーラエキスは、プロゴイトリン、シニグリン、グルコラファニン、ナポレフェリン、グルコアリシシン、グルコナピン、4-ハイドロキシブラシシン、グルコブラシシカナピン、グルコブラシシン、グルコナスターチン、4-メトキシ-グルコブラシシン、ネオグルコブラシシン、およびその組み合わせからなる群から選択される、グルコシノレートを含んでいる請求項19記載の方法。
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US13/755,143 US10172772B2 (en) | 2013-01-31 | 2013-01-31 | Methods of skin whitening by use of canola extracts |
US13/755,143 | 2013-01-31 | ||
PCT/IB2014/000019 WO2014118610A1 (en) | 2013-01-31 | 2014-01-09 | Methods of skin whitenening by use of canola extracts |
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JP2019212362A Division JP2020059727A (ja) | 2013-01-31 | 2019-11-25 | キャノーラエキスの使用による皮膚のホワイトニング方法 |
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JP2019212362A Pending JP2020059727A (ja) | 2013-01-31 | 2019-11-25 | キャノーラエキスの使用による皮膚のホワイトニング方法 |
JP2023012604A Pending JP2023065363A (ja) | 2013-01-31 | 2023-01-31 | キャノーラエキスの使用による皮膚のホワイトニング方法 |
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JP2023012604A Pending JP2023065363A (ja) | 2013-01-31 | 2023-01-31 | キャノーラエキスの使用による皮膚のホワイトニング方法 |
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EP (2) | EP4223279A1 (ja) |
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KR (3) | KR102481374B1 (ja) |
AU (2) | AU2014210919B2 (ja) |
CA (2) | CA2899814C (ja) |
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JP2018002702A (ja) * | 2016-06-22 | 2018-01-11 | オリザ油化株式会社 | カルボニル化抑制剤 |
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US20070098824A1 (en) | 2005-10-27 | 2007-05-03 | Kgk Synergize Inc. | Canola extracts containing high levels of phenolic acids |
US10172772B2 (en) | 2013-01-31 | 2019-01-08 | KGK Science, Inc. | Methods of skin whitening by use of canola extracts |
KR102662255B1 (ko) * | 2016-09-06 | 2024-05-02 | 주식회사 엘지생활건강 | 시니그린을 포함하는 화장료 조성물 |
CN106619168A (zh) * | 2016-11-25 | 2017-05-10 | 徐州得铸生物科技有限公司 | 一种含有天然化合物的美白活性组分 |
JP6861134B2 (ja) * | 2017-09-15 | 2021-04-21 | ヤクルトヘルスフーズ株式会社 | ヒアルロン酸産生促進剤及びヒアルロン酸産生促進用食品 |
CN111217874B (zh) * | 2018-11-23 | 2023-08-22 | 复旦大学 | 一种从板蓝根中提取分离新葡萄糖芸苔素的方法 |
CN109806199B (zh) * | 2019-03-19 | 2021-09-03 | 成都大学 | 一种美白护肤组合物及其制备方法 |
KR102272490B1 (ko) * | 2019-11-04 | 2021-07-05 | 주식회사 한국인삼공사 | 시냅알데히드 또는 이의 유도체를 포함하는 피부 미백용 화장료 조성물 |
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EP2950779A4 (en) | 2016-08-03 |
US20190374453A1 (en) | 2019-12-12 |
KR20150114534A (ko) | 2015-10-12 |
KR102670526B1 (ko) | 2024-05-28 |
ES2959418T3 (es) | 2024-02-26 |
KR20230004950A (ko) | 2023-01-06 |
JP2023065363A (ja) | 2023-05-12 |
KR102481374B1 (ko) | 2022-12-23 |
US20240173229A1 (en) | 2024-05-30 |
AU2014210919B2 (en) | 2018-11-08 |
JP2020059727A (ja) | 2020-04-16 |
KR102306035B1 (ko) | 2021-09-27 |
EP2950779A1 (en) | 2015-12-09 |
CA3151148A1 (en) | 2014-08-07 |
US20140213652A1 (en) | 2014-07-31 |
AU2014210919A1 (en) | 2015-08-20 |
EP4223279A1 (en) | 2023-08-09 |
KR20210119566A (ko) | 2021-10-05 |
EP2950779C0 (en) | 2023-08-16 |
CA2899814A1 (en) | 2014-08-07 |
US10172772B2 (en) | 2019-01-08 |
AU2019200853A1 (en) | 2019-02-28 |
AU2019200853B2 (en) | 2020-02-06 |
US20200397678A1 (en) | 2020-12-24 |
EP2950779B1 (en) | 2023-08-16 |
JP6815730B2 (ja) | 2021-01-20 |
US11896696B2 (en) | 2024-02-13 |
CA2899814C (en) | 2022-05-17 |
WO2014118610A1 (en) | 2014-08-07 |
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