|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
IL97459A0
(en)
*
|
1990-03-09 |
1992-06-21 |
Hybritech Inc |
Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
|
|
US5091542A
(en)
*
|
1990-03-09 |
1992-02-25 |
Hybritech Incorporated |
Tris-maleimido compounds as intermediates in trifunctional antibody synthesis
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
US20080152586A1
(en)
|
1992-09-25 |
2008-06-26 |
Avipep Pty Limited |
High avidity polyvalent and polyspecific reagents
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
JPH08175990A
(ja)
|
1994-12-19 |
1996-07-09 |
Mitsubishi Chem Corp |
Pi3キナーゼ阻害剤とその製造法
|
|
JPH08176070A
(ja)
|
1994-12-19 |
1996-07-09 |
Mitsubishi Chem Corp |
ジデプシド誘導体及びpi3キナーゼ阻害剤
|
|
US6355780B1
(en)
|
1995-02-22 |
2002-03-12 |
Yeda Research And Development Co. Ltd. |
Antibodies to the death domain motifs of regulatory proteins
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
DK0821671T3
(da)
|
1995-04-20 |
2001-04-23 |
Pfizer |
Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer
|
|
GB9521987D0
(en)
|
1995-10-26 |
1996-01-03 |
Ludwig Inst Cancer Res |
Phosphoinositide 3-kinase modulators
|
|
GB9624482D0
(en)
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
|
DE69624081T2
(de)
|
1995-12-20 |
2003-06-12 |
Agouron Pharmaceuticals, Inc. |
Matrix-metalloprotease Inhibitoren
|
|
BR9707495A
(pt)
|
1996-02-13 |
1999-07-27 |
Zeneca Ltd |
Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
|
|
US6291455B1
(en)
|
1996-03-05 |
2001-09-18 |
Zeneca Limited |
4-anilinoquinazoline derivatives
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
EP0923585B1
(en)
|
1996-07-18 |
2002-05-08 |
Pfizer Inc. |
Phosphinate based inhibitors of matrix metalloproteases
|
|
WO1998007697A1
(en)
|
1996-08-23 |
1998-02-26 |
Pfizer Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
GB9718972D0
(en)
|
1996-09-25 |
1997-11-12 |
Zeneca Ltd |
Chemical compounds
|
|
WO1998030566A1
(en)
|
1997-01-06 |
1998-07-16 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
EP0977733B1
(en)
|
1997-02-03 |
2003-09-03 |
Pfizer Products Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
JP2000507975A
(ja)
|
1997-02-07 |
2000-06-27 |
ファイザー・インク |
N−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
|
|
EA002546B1
(ru)
|
1997-02-11 |
2002-06-27 |
Пфайзер Инк. |
Производные арилсульфонилгидроксамовой кислоты
|
|
DE69837529T2
(de)
|
1997-02-12 |
2007-07-26 |
Electrophoretics Ltd., Cobham |
Proteinmarker für lungenkrebs und deren verwendung
|
|
CA2297070A1
(en)
|
1997-08-01 |
1999-02-11 |
Morphosys Ag |
Novel method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex
|
|
AU730248B2
(en)
|
1997-08-08 |
2001-03-01 |
Pfizer Products Inc. |
Aryloxyarylsulfonylamino hydroxamic acid derivatives
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
JP4462654B2
(ja)
|
1998-03-26 |
2010-05-12 |
ソニー株式会社 |
映像素材選択装置及び映像素材選択方法
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
DK1004578T3
(da)
|
1998-11-05 |
2004-06-28 |
Pfizer Prod Inc |
5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater
|
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US6897044B1
(en)
|
1999-01-28 |
2005-05-24 |
Biogen Idec, Inc. |
Production of tetravalent antibodies
|
|
SK288365B6
(sk)
|
1999-02-10 |
2016-07-01 |
Astrazeneca Ab |
Medziprodukty pre chinazolínové deriváty ako inhibítory angiogenézy
|
|
CZ301689B6
(cs)
|
1999-11-05 |
2010-05-26 |
Astrazeneca Ab |
Derivát chinazolinu a farmaceutický prostredek, který ho obsahuje
|
|
SI1255752T1
(sl)
|
2000-02-15 |
2007-12-31 |
Pharmacia & Upjohn Co Llc |
S pirolom substituirani zaviralci 2-indolinon protein kinaza
|
|
JP2001247477A
(ja)
|
2000-03-03 |
2001-09-11 |
Teikoku Hormone Mfg Co Ltd |
抗腫瘍剤
|
|
US6608053B2
(en)
|
2000-04-27 |
2003-08-19 |
Yamanouchi Pharmaceutical Co., Ltd. |
Fused heteroaryl derivatives
|
|
US6403588B1
(en)
|
2000-04-27 |
2002-06-11 |
Yamanouchi Pharmaceutical Co., Ltd. |
Imidazopyridine derivatives
|
|
DE60140474D1
(de)
|
2000-09-08 |
2009-12-24 |
Univ Zuerich |
Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten
|
|
DE60203260T2
(de)
|
2001-01-16 |
2006-02-02 |
Glaxo Group Ltd., Greenford |
Pharmazeutische kombination, die ein 4-chinazolinamin und paclitaxel, carboplatin oder vinorelbin enthält, zur behandlung von krebs
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
US20040242545A1
(en)
|
2001-07-26 |
2004-12-02 |
Santen Phamaceutical Co., Ltd. |
Remedy for glaucoma comprising as the active ingredient compound having p13 kinase inhibitory effect
|
|
WO2003011909A1
(en)
|
2001-07-31 |
2003-02-13 |
University Of Southampton |
Binding agents with differential activity
|
|
US6703414B2
(en)
|
2001-09-14 |
2004-03-09 |
Arizona Board Of Regents On Behalf Of The University Of Arizona |
Device and method for treating restenosis
|
|
AU2002349912A1
(en)
|
2001-10-24 |
2003-05-06 |
Iconix Pharmaceuticals, Inc. |
Modulators of phosphoinositide 3-kinase
|
|
US6894055B2
(en)
|
2001-10-24 |
2005-05-17 |
Iconix Pharmaceuticals Inc. |
Thieno-2′,3′ -5,6pyrimido[3,4-A]-1,2,4-triazole derivatives as modulators of phoshoinositide 3-kinase
|
|
AU2002356871A1
(en)
|
2001-10-30 |
2003-05-12 |
Pharmacia Corporation |
Heteroaromatic carboxamide derivatives for the treatment of inflammation
|
|
JP2006500327A
(ja)
|
2002-07-10 |
2006-01-05 |
アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ |
精子の運動性を増大させるための化合物の使用
|
|
US20040092561A1
(en)
|
2002-11-07 |
2004-05-13 |
Thomas Ruckle |
Azolidinone-vinyl fused -benzene derivatives
|
|
CN1681811B
(zh)
|
2002-07-10 |
2010-05-26 |
默克雪兰诺有限公司 |
唑烷酮-乙烯基稠合的-苯衍生物
|
|
SI1545613T1
(sl)
|
2002-07-31 |
2011-11-30 |
Seattle Genetics Inc |
Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni
|
|
WO2004017950A2
(en)
|
2002-08-22 |
2004-03-04 |
Piramed Limited |
Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents
|
|
BR0316101A
(pt)
|
2002-11-07 |
2005-09-27 |
Immunogen Inc |
Anticorpos anticd33 e processo para tratamento de leucemia melóide aguda usando os mesmos
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
EP3225633B1
(en)
|
2004-05-21 |
2020-03-25 |
The UAB Research Foundation |
Variable lymphocyte receptors, related polypeptides and nucleic acids, and uses thereof
|
|
KR20120064120A
(ko)
|
2004-06-01 |
2012-06-18 |
제넨테크, 인크. |
항체 약물 접합체 및 방법
|
|
KR101270829B1
(ko)
*
|
2004-09-23 |
2013-06-07 |
제넨테크, 인크. |
시스테인 유전자조작 항체 및 접합체
|
|
GB0423653D0
(en)
|
2004-10-25 |
2004-11-24 |
Piramed Ltd |
Pharmaceutical compounds
|
|
US8431558B2
(en)
|
2004-11-01 |
2013-04-30 |
The Regents Of The University Of California |
Compositions and methods for modification of biomolecules
|
|
EP1817341A2
(en)
|
2004-11-29 |
2007-08-15 |
Seattle Genetics, Inc. |
Engineered antibodies and immunoconjugates
|
|
CA2597407C
(en)
|
2005-02-11 |
2013-09-10 |
Immunogen, Inc. |
Process for preparing stable drug conjugates
|
|
BRPI0613593A2
(pt)
|
2005-07-08 |
2011-01-18 |
Univ Zuerich |
método de teste "phage display" filamentoso, vetor de fago ou de fagomìdeo e biblioteca de vetores de fago ou fagomìdeo
|
|
EP3539572A1
(en)
|
2005-08-24 |
2019-09-18 |
ImmunoGen, Inc. |
Process for preparing maytansinoid antibody conjugates
|
|
GB0520657D0
(en)
|
2005-10-11 |
2005-11-16 |
Ludwig Inst Cancer Res |
Pharmaceutical compounds
|
|
WO2007062466A1
(en)
|
2005-11-29 |
2007-06-07 |
The University Of Sydney |
Demibodies: dimerisation-activated therapeutic agents
|
|
US7897568B2
(en)
|
2006-03-03 |
2011-03-01 |
Vinay K. Singh |
Compositions for treatment of cancer
|
|
ES2567402T3
(es)
*
|
2006-05-30 |
2016-04-22 |
Genentech, Inc. |
Anticuerpos anti CD22, sus inmunoconjugados y usos de los mismos
|
|
CA2655379A1
(en)
|
2006-06-22 |
2007-12-27 |
Walter And Eliza Hall Institute Of Medical Research |
Structure of the insulin receptor ectodomain
|
|
EP2144628B1
(en)
|
2007-05-08 |
2012-10-17 |
Genentech, Inc. |
Cysteine engineered anti-muc16 antibodies and antibody drug conjugates
|
|
DK2474557T3
(da)
*
|
2007-07-16 |
2014-11-10 |
Genentech Inc |
Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse
|
|
CA2700391A1
(en)
|
2007-09-24 |
2009-04-02 |
University Of Zuerich |
Designed armadillo repeat proteins
|
|
GB0724360D0
(en)
|
2007-12-14 |
2008-01-23 |
Glaxosmithkline Biolog Sa |
Method for preparing protein conjugates
|
|
SG187517A1
(en)
*
|
2008-01-31 |
2013-02-28 |
Genentech Inc |
Anti-cd79b antibodies and immunoconjugates and methods of use
|
|
KR20200058590A
(ko)
|
2008-04-30 |
2020-05-27 |
이뮤노젠 아이엔씨 |
가교제 및 그 용도
|
|
EP2350112A4
(en)
|
2008-10-03 |
2013-01-16 |
Advanced Proteome Therapeutics Inc |
Site specific N-termin protein modifications and conjugate formation
|
|
BRPI0919881B1
(pt)
|
2008-10-31 |
2021-09-08 |
Centocor Ortho Biotech Inc |
Proteína de arcabouço e seu método de geração, biblioteca e seu método de construção, molécula de ácido nucleico, vetor de ácido nucleico, célula hospedeira, composição, dispositivo médico e artigo de fabricação
|
|
BRPI1008532B1
(pt)
|
2009-02-12 |
2021-12-14 |
Janssen Biotech, Inc |
Arcabouço de proteína isolada, método para construção de uma biblioteca de arcabouço de proteína isolada, molécula de ácido nucleico isolada, vetor de ácido nucleico isolado, célula hospedeira de bactéria ou fungo, composição, dispositivo médico e artigo de manufatura para uso farmacêutico ou de diagnóstico em seres humanos
|
|
BRPI1010620B8
(pt)
|
2009-06-03 |
2021-05-25 |
Immunogen Inc |
métodos de conjugação
|
|
SG181814A1
(en)
|
2009-12-23 |
2012-07-30 |
Avipep Pty Ltd |
Immuno-conjugates and methods for producing them 2
|
|
CN103037900B
(zh)
|
2010-02-24 |
2016-04-06 |
伊缪诺金公司 |
叶酸受体1抗体与免疫缀合物以及其用途
|
|
DK2563753T6
(en)
|
2010-04-27 |
2016-04-04 |
Synaffix Bv |
Fused cyclooctynforbindelser and their use in metal-free click-reactions
|
|
EP3569256B1
(en)
|
2010-04-30 |
2022-06-15 |
Janssen Biotech, Inc. |
Stabilized fibronectin domain compositions, methods and uses
|
|
BR112012030311A2
(pt)
*
|
2010-06-08 |
2017-01-24 |
Genentech Inc |
anticorpo
|
|
CN103269712B
(zh)
*
|
2010-11-03 |
2016-09-21 |
伊缪诺金公司 |
包含新型安丝菌素衍生物的细胞毒性剂
|
|
RS58367B1
(sr)
|
2011-03-29 |
2019-03-29 |
Immunogen Inc |
Priprema konjugata antitela i majtanzinoida jednostepenim postupkom
|
|
WO2012145112A2
(en)
*
|
2011-04-18 |
2012-10-26 |
Immunogen, Inc. |
Novel maytansinoid derivatives with sulfoxide linker
|