JP2016505824A5 - - Google Patents
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- Publication number
- JP2016505824A5 JP2016505824A5 JP2015545102A JP2015545102A JP2016505824A5 JP 2016505824 A5 JP2016505824 A5 JP 2016505824A5 JP 2015545102 A JP2015545102 A JP 2015545102A JP 2015545102 A JP2015545102 A JP 2015545102A JP 2016505824 A5 JP2016505824 A5 JP 2016505824A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen
- luminophore
- ionophore
- coor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229910052739 hydrogen Inorganic materials 0.000 claims 28
- 239000001257 hydrogen Substances 0.000 claims 28
- 150000002431 hydrogen Chemical class 0.000 claims 25
- 239000002555 ionophore Substances 0.000 claims 21
- -1 C 1 -C 12 -alkyl Chemical class 0.000 claims 15
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims 15
- 229910001425 magnesium ion Inorganic materials 0.000 claims 15
- 150000001768 cations Chemical class 0.000 claims 9
- 229910001424 calcium ion Inorganic materials 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 7
- 229920000642 polymer Polymers 0.000 claims 7
- 239000007787 solid Substances 0.000 claims 7
- LXTVFZSAMNLFQU-UHFFFAOYSA-N (methoxyamino)oxyethane Chemical compound CCONOC LXTVFZSAMNLFQU-UHFFFAOYSA-N 0.000 claims 6
- 230000008878 coupling Effects 0.000 claims 6
- 238000010168 coupling process Methods 0.000 claims 6
- 238000005859 coupling reaction Methods 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 125000002091 cationic group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000000758 substrate Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- FTEDXVNDVHYDQW-UHFFFAOYSA-N BAPTA Chemical compound OC(=O)CN(CC(O)=O)C1=CC=CC=C1OCCOC1=CC=CC=C1N(CC(O)=O)CC(O)=O FTEDXVNDVHYDQW-UHFFFAOYSA-N 0.000 claims 2
- 210000001124 body fluid Anatomy 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- LFQRKUIOSYPVFY-UHFFFAOYSA-L dipotassium diacetate Chemical compound [K+].[K+].CC([O-])=O.CC([O-])=O LFQRKUIOSYPVFY-UHFFFAOYSA-L 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 230000000236 ionophoric effect Effects 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 229920006267 polyester film Polymers 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 claims 1
- 229940039790 sodium oxalate Drugs 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/689,350 | 2012-11-29 | ||
| US13/689,350 US9360474B2 (en) | 2012-11-29 | 2012-11-29 | Multi-layer device for selectively determining magnesium ion |
| PCT/US2013/071004 WO2014085160A1 (en) | 2012-11-29 | 2013-11-20 | Multi-layer device for selectively determining magnesium ion |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505824A JP2016505824A (ja) | 2016-02-25 |
| JP2016505824A5 true JP2016505824A5 (enExample) | 2017-02-16 |
| JP6177931B2 JP6177931B2 (ja) | 2017-08-09 |
Family
ID=50773621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545102A Active JP6177931B2 (ja) | 2012-11-29 | 2013-11-20 | 選択的にマグネシウムイオンを決定するための多層デバイス |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9360474B2 (enExample) |
| EP (1) | EP2926121B1 (enExample) |
| JP (1) | JP6177931B2 (enExample) |
| CA (1) | CA2892053C (enExample) |
| WO (1) | WO2014085160A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108069966B (zh) * | 2016-11-14 | 2020-03-31 | 中国科学院大连化学物理研究所 | 用于snap蛋白标记的小分子荧光探针及其合成方法与应用 |
| CN108069967B (zh) * | 2016-11-15 | 2020-03-27 | 中国科学院大连化学物理研究所 | 一种用于细胞内蛋白标记的荧光探针及其合成方法和应用 |
| CN108675989B (zh) * | 2018-04-25 | 2019-07-02 | 中国科学院生物物理研究所 | Fe3+分子荧光测试剂及其制备方法 |
| CN108864046B (zh) * | 2018-04-25 | 2019-11-05 | 苏州首通科技发展有限公司 | Fe2+分子荧光测试液、其制备方法及其应用 |
| CN109060733B (zh) * | 2018-04-25 | 2019-11-05 | 苏州首通科技发展有限公司 | 铁离子分子荧光传感器及其制备方法 |
| CN108801992B (zh) * | 2018-04-25 | 2019-08-02 | 中国科学院生物物理研究所 | Fe3+分子荧光传感器及其制备方法 |
| CN111650191A (zh) * | 2020-06-12 | 2020-09-11 | 吉林基蛋生物科技有限公司 | 一种抗镁离子干扰的尿液钙离子检测试纸制备方法 |
| CN115073311B (zh) * | 2022-03-23 | 2023-05-23 | 河南大学 | 一种高效制备n,n′-二（2羟乙基）苯胺的合成方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2842862A1 (de) | 1978-10-02 | 1980-04-10 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung von ionen, polaren und/oder lipophilen substanzen in fluessigkeiten |
| US4603209A (en) | 1984-09-07 | 1986-07-29 | The Regents Of The University Of California | Fluorescent indicator dyes for calcium ions |
| IL79087A0 (en) | 1985-07-02 | 1986-09-30 | Miles Lab | Multilayer ion test means |
| US5215925A (en) * | 1986-04-29 | 1993-06-01 | Eastman Kodak Company | Method and composition for magnesium ion detection using hydroxy-substituted cyanoformazans |
| US4774339A (en) | 1987-08-10 | 1988-09-27 | Molecular Probes, Inc. | Chemically reactive dipyrrometheneboron difluoride dyes |
| WO1993008684A1 (en) * | 1991-10-28 | 1993-05-13 | Steinman Gary D | Process and device for measuring magnesium in biological fluids and method of preparing the device |
| US5310888A (en) * | 1992-10-22 | 1994-05-10 | Miles Inc. | Arylazo chromoionophores |
| US5516911A (en) | 1993-12-30 | 1996-05-14 | The United States Of America As Represented By The Department Of Health And Human Services | Fluorescent intracellular calcium indicators |
| CN1107229C (zh) * | 1996-03-29 | 2003-04-30 | 株式会社京都第一科学 | 用于测定生物体液中镁的测试片 |
| JP3809484B2 (ja) * | 1996-03-29 | 2006-08-16 | アークレイ株式会社 | 体液中のマグネシウム測定用試験片 |
| AT405103B (de) | 1996-10-16 | 1999-05-25 | Avl Verbrennungskraft Messtech | Sensorschicht zur quantitativen bestimmung zumindest einer chemischen komponente einer gasförmigen oder flüssigen probe |
| KR100207515B1 (ko) | 1996-10-31 | 1999-07-15 | 윤종용 | Y/c 간섭 제거회로 |
| AT405462B (de) | 1997-05-30 | 1999-08-25 | Avl List Gmbh | Verfahren zur bestimmung eines alkaliions |
| US6171866B1 (en) | 1998-09-30 | 2001-01-09 | Avl Medical Instruments | Luminescence indicator for determining calcium ions |
| JP2000258414A (ja) * | 1999-03-08 | 2000-09-22 | Fuji Photo Film Co Ltd | 一体型多層化学分析要素および定量方法 |
| DE60045816D1 (de) | 1999-04-27 | 2011-05-19 | Bio Rad Laboratories | Probenhalter für ein gasphaseionenspektrometer |
| US6211359B1 (en) * | 1999-08-17 | 2001-04-03 | Avl Medical Instruments | Triaza-cryptand and method of determining an alkali ion |
| US6706528B2 (en) * | 2000-03-24 | 2004-03-16 | The United States Of America As Represented By The Department Of Health And Human Services | Fluorescent magnesium indicators |
| US7109043B2 (en) * | 2000-07-28 | 2006-09-19 | Japan Science And Technology Corporation | Fluorescent probe for magnesium ion determination |
| AU7918501A (en) | 2000-08-04 | 2002-02-18 | Molecular Probes Inc | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings |
| WO2005085811A1 (ja) * | 2004-03-04 | 2005-09-15 | Daiichi Pure Chemicals Co., Ltd. | 蛍光プローブ |
| US8097725B2 (en) | 2004-12-03 | 2012-01-17 | Roche Diagnostics Operations, Inc. | Luminescent indicator dye and optical sensor |
| WO2007131048A2 (en) | 2006-05-03 | 2007-11-15 | Opti Medical Systems, Inc. | Chromoionphore and method of determining calcium ions |
| KR100858560B1 (ko) * | 2007-05-25 | 2008-09-16 | 고려대학교 산학협력단 | 세포질 내 마그네슘의 실시간 모니터링용 이광자 염료, 그제조방법 및 이를 이용한 세포질 내 마그네슘의 실시간모니터링 방법 |
-
2012
- 2012-11-29 US US13/689,350 patent/US9360474B2/en active Active
-
2013
- 2013-11-20 JP JP2015545102A patent/JP6177931B2/ja active Active
- 2013-11-20 EP EP13858809.0A patent/EP2926121B1/en active Active
- 2013-11-20 CA CA2892053A patent/CA2892053C/en active Active
- 2013-11-20 WO PCT/US2013/071004 patent/WO2014085160A1/en not_active Ceased
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