JP2016505582A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016505582A5 JP2016505582A5 JP2015548459A JP2015548459A JP2016505582A5 JP 2016505582 A5 JP2016505582 A5 JP 2016505582A5 JP 2015548459 A JP2015548459 A JP 2015548459A JP 2015548459 A JP2015548459 A JP 2015548459A JP 2016505582 A5 JP2016505582 A5 JP 2016505582A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydroxy
- amino
- oxo
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 3-bromoisoxazol-5-yl Chemical group 0.000 claims 85
- 150000001875 compounds Chemical class 0.000 claims 33
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 33
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 24
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 19
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 125000001424 substituent group Chemical group 0.000 claims 18
- 125000005843 halogen group Chemical group 0.000 claims 17
- 229910052757 nitrogen Inorganic materials 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 14
- 229910052760 oxygen Inorganic materials 0.000 claims 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 14
- 229910052717 sulfur Inorganic materials 0.000 claims 14
- 125000005842 heteroatom Chemical group 0.000 claims 13
- 125000002950 monocyclic group Chemical group 0.000 claims 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000002619 bicyclic group Chemical group 0.000 claims 10
- 125000004122 cyclic group Chemical group 0.000 claims 10
- 229920006395 saturated elastomer Polymers 0.000 claims 10
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 9
- 125000006269 biphenyl-2-yl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(*)C([H])=C([H])C([H])=C1[H] 0.000 claims 8
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000004043 oxo group Chemical group O=* 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 5
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 3
- 125000004450 alkenylene group Chemical group 0.000 claims 3
- 125000004419 alkynylene group Chemical group 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims 3
- 230000001575 pathological effect Effects 0.000 claims 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 150000001408 amides Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 claims 1
- WESNIBJUEFXARC-AQGBOPFGSA-N C(N)(OC1=C(C=CC(=C1)CCC(=O)N[C@@H]1CC[C@H](CC1)CNC[C@@H](C1=C2C=CC(NC2=C(C=C1)O)=O)O)C1=CC=CC=C1)=O Chemical compound C(N)(OC1=C(C=CC(=C1)CCC(=O)N[C@@H]1CC[C@H](CC1)CNC[C@@H](C1=C2C=CC(NC2=C(C=C1)O)=O)O)C1=CC=CC=C1)=O WESNIBJUEFXARC-AQGBOPFGSA-N 0.000 claims 1
- DKPOBCUZPDDHGX-PMERELPUSA-N C(N)(OC1=C(C=CC(=C1)CCCC(=O)NC1=C(C=C(C(=C1)OC)CNC[C@@H](C1=C2C=CC(NC2=C(C=C1)O)=O)O)Cl)C1=CC=CC=C1)=O Chemical compound C(N)(OC1=C(C=CC(=C1)CCCC(=O)NC1=C(C=C(C(=C1)OC)CNC[C@@H](C1=C2C=CC(NC2=C(C=C1)O)=O)O)Cl)C1=CC=CC=C1)=O DKPOBCUZPDDHGX-PMERELPUSA-N 0.000 claims 1
- 208000020446 Cardiac disease Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 1
- 208000006399 Premature Obstetric Labor Diseases 0.000 claims 1
- RHQDFWAXVIIEBN-UHFFFAOYSA-N Trifluoroethanol Chemical compound OCC(F)(F)F RHQDFWAXVIIEBN-UHFFFAOYSA-N 0.000 claims 1
- GALAHBSBWJKUAV-LJAQVGFWSA-N [5-[3-[2-chloro-4-[[[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]methyl]-5-methoxyanilino]-3-oxopropyl]-2-phenylphenyl] carbamate Chemical compound C(N)(OC1=C(C=CC(=C1)CCC(=O)NC1=C(C=C(C(=C1)OC)CNC[C@@H](C1=C2C=CC(NC2=C(C=C1)O)=O)O)Cl)C1=CC=CC=C1)=O GALAHBSBWJKUAV-LJAQVGFWSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 230000001800 adrenalinergic effect Effects 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000013066 combination product Substances 0.000 claims 1
- 229940127555 combination product Drugs 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000003149 muscarinic antagonist Substances 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12382513.5 | 2012-12-18 | ||
| EP12382513 | 2012-12-18 | ||
| US201361750959P | 2013-01-10 | 2013-01-10 | |
| US61/750,959 | 2013-01-10 | ||
| PCT/EP2013/076973 WO2014095920A1 (en) | 2012-12-18 | 2013-12-17 | New cyclohexyl and quinuclidinyl carbamate derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505582A JP2016505582A (ja) | 2016-02-25 |
| JP2016505582A5 true JP2016505582A5 (OSRAM) | 2017-01-26 |
| JP6307091B2 JP6307091B2 (ja) | 2018-04-04 |
Family
ID=47458807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015548459A Expired - Fee Related JP6307091B2 (ja) | 2012-12-18 | 2013-12-17 | β２アドレナリンアゴニスト活性およびＭ３ムスカリンアンタゴニスト活性を有する新規のシクロヘキシルおよびキヌクリジニルカルバメート誘導体 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US9518050B2 (OSRAM) |
| EP (1) | EP2934594B1 (OSRAM) |
| JP (1) | JP6307091B2 (OSRAM) |
| KR (1) | KR20150096732A (OSRAM) |
| CN (1) | CN105142673B8 (OSRAM) |
| AP (1) | AP2015008573A0 (OSRAM) |
| AR (1) | AR094100A1 (OSRAM) |
| AU (1) | AU2013360866A1 (OSRAM) |
| BR (1) | BR112015013628A2 (OSRAM) |
| CA (1) | CA2892931A1 (OSRAM) |
| CL (1) | CL2015001753A1 (OSRAM) |
| DO (1) | DOP2015000145A (OSRAM) |
| EA (1) | EA201500651A1 (OSRAM) |
| ES (1) | ES2750523T3 (OSRAM) |
| HK (1) | HK1215166A1 (OSRAM) |
| IL (1) | IL239118A0 (OSRAM) |
| MA (1) | MA38260B1 (OSRAM) |
| MX (1) | MX2015007279A (OSRAM) |
| NI (1) | NI201500080A (OSRAM) |
| PE (1) | PE20151414A1 (OSRAM) |
| PH (1) | PH12015501398A1 (OSRAM) |
| SG (1) | SG11201504452WA (OSRAM) |
| TN (1) | TN2015000271A1 (OSRAM) |
| TW (1) | TW201446743A (OSRAM) |
| UY (1) | UY35199A (OSRAM) |
| WO (1) | WO2014095920A1 (OSRAM) |
| ZA (1) | ZA201503619B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20110083U1 (it) | 2010-05-13 | 2011-11-14 | De La Cruz Jose Antonio Freire | Piastra per la costruzione di carrelli per aeroplani |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| JP6307091B2 (ja) | 2012-12-18 | 2018-04-04 | アルミラル・ソシエダッド・アノニマＡｌｍｉｒａｌｌ， Ｓ．Ａ． | β２アドレナリンアゴニスト活性およびＭ３ムスカリンアンタゴニスト活性を有する新規のシクロヘキシルおよびキヌクリジニルカルバメート誘導体 |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽 |
| US11175268B2 (en) | 2014-06-09 | 2021-11-16 | Biometry Inc. | Mini point of care gas chromatographic test strip and method to measure analytes |
| JP6903574B2 (ja) | 2014-06-09 | 2021-07-14 | バイオメトリー・インコーポレイテッドＢｉｏｍｅｔｒｙ Ｉｎｃ． | 検体を測定するための低コストテストストリップ及び方法 |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
| EP4464772A3 (en) | 2016-07-19 | 2024-12-04 | Biometry Inc. | Methods of and systems for measuring analytes using batch calibratable test strips |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT7920688U1 (it) | 1979-02-05 | 1980-08-05 | Chiesi Paolo | Inalatore per sostanze medicamentose pulverulente, con combinata funzione di dosatore |
| ATE23272T1 (de) | 1981-07-08 | 1986-11-15 | Draco Ab | Pulverinhalator. |
| IT1212742B (it) | 1983-05-17 | 1989-11-30 | Dompe Farmaceutici Spa | Derivati dibenzo [1,4]diazepinonici pirido [1,4] benzodiazepinonici,pirido [1,5] benzodiazepinonici e loro attivita' farmacologica |
| US4570630A (en) | 1983-08-03 | 1986-02-18 | Miles Laboratories, Inc. | Medicament inhalation device |
| DE3370320D1 (en) | 1983-09-26 | 1987-04-23 | Magis Farmaceutici | Aminocyclohexanol derivatives having an expectorant activity, process for their preparation and pharmaceutical compositions containing them |
| FI69963C (fi) | 1984-10-04 | 1986-09-12 | Orion Yhtymae Oy | Doseringsanordning |
| DE3927170A1 (de) | 1989-08-17 | 1991-02-21 | Boehringer Ingelheim Kg | Inhalator |
| EP1078629A3 (en) | 1989-09-07 | 2001-05-23 | Glaxo Group Limited | Use of Salmeterol and salts for the treatment of inflammation and allergy |
| IT1237118B (it) | 1989-10-27 | 1993-05-18 | Miat Spa | Inalatore multidose per farmaci in polvere. |
| US5201308A (en) | 1990-02-14 | 1993-04-13 | Newhouse Michael T | Powder inhaler |
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| SG45171A1 (en) | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
| GB9015522D0 (en) | 1990-07-13 | 1990-08-29 | Braithwaite Philip W | Inhaler |
| WO1992003175A1 (en) | 1990-08-11 | 1992-03-05 | Fisons Plc | Inhalation device |
| DE4027391A1 (de) | 1990-08-30 | 1992-03-12 | Boehringer Ingelheim Kg | Treibgasfreies inhalationsgeraet |
| GB9020051D0 (en) | 1990-09-13 | 1990-10-24 | Pfizer Ltd | Muscarinic receptor antagonists |
| ES2113889T3 (es) | 1990-09-26 | 1998-05-16 | Pharmachemie Bv | Dispositivos inhaladores provistos de un deposito para varias dosis de producto de inhalacion, dispositivo de transporte y camaras de turbulencia. |
| GB9026025D0 (en) | 1990-11-29 | 1991-01-16 | Boehringer Ingelheim Kg | Inhalation device |
| AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
| DE4239402A1 (de) | 1992-11-24 | 1994-05-26 | Bayer Ag | Pulverinhalator |
| CA2152088C (en) | 1992-12-18 | 1999-12-07 | Thomas J. Ambrosio | Inhaler for powdered medications |
| AU718263B2 (en) | 1995-04-14 | 2000-04-13 | Smithkline Beecham Corporation | Metered dose inhaler for salmeterol |
| CN1325129C (zh) | 1995-06-21 | 2007-07-11 | Meda制药有限及两合公司 | 带整体计量装置的药筒和药粉吸入器 |
| DE19536902A1 (de) | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung |
| WO1998009632A1 (en) | 1996-09-06 | 1998-03-12 | Merck & Co., Inc. | Methods and compositions for treating preterm labor |
| SE9704644D0 (sv) | 1997-12-12 | 1997-12-12 | Astra Ab | New use |
| US6673908B1 (en) | 1999-02-22 | 2004-01-06 | Nuvelo, Inc. | Tumor necrosis factor receptor 2 |
| EP1204643B1 (en) | 1999-08-20 | 2008-06-04 | Dow AgroSciences LLC | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
| DE10129703A1 (de) | 2001-06-22 | 2003-01-02 | Sofotec Gmbh & Co Kg | Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren |
| US6653323B2 (en) | 2001-11-13 | 2003-11-25 | Theravance, Inc. | Aryl aniline β2 adrenergic receptor agonists |
| ES2195785B1 (es) | 2002-05-16 | 2005-03-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| ES2211344B1 (es) | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| US7317102B2 (en) | 2003-04-01 | 2008-01-08 | Theravance, Inc. | Diarylmethyl and related compounds |
| EP1626970B1 (en) | 2003-05-28 | 2009-07-08 | Theravance, Inc. | Azabicycloalkane compounds as muscarinic receptor antagonists |
| ES2232306B1 (es) | 2003-11-10 | 2006-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| US7320990B2 (en) | 2004-02-13 | 2008-01-22 | Theravance, Inc. | Crystalline form of a biphenyl compound |
| DE102004024453A1 (de) | 2004-05-14 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue langwirksame Bronchodilatoren zur Behandlung von Atemwegserkrankungen |
| ES2251866B1 (es) | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| ES2251867B1 (es) | 2004-06-21 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| AU2005263486B2 (en) | 2004-07-16 | 2011-05-12 | Astrazeneca Ab | Inhaler for the administration of powdered pharmaceuticals, and a powder cartridge system for use with this inhaler |
| WO2006023457A1 (en) | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| JP2008510015A (ja) | 2004-08-16 | 2008-04-03 | セラヴァンス， インコーポレーテッド | β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物 |
| TWI374883B (en) | 2004-08-16 | 2012-10-21 | Theravance Inc | Crystalline form of a biphenyl compound |
| EP1924553A1 (en) | 2005-08-08 | 2008-05-28 | Argenta Discovery Limited | Bicyclo[2.2.]hept-7-ylamine derivatives and their uses |
| CN101340946A (zh) * | 2005-12-20 | 2009-01-07 | 辉瑞产品公司 | 用于治疗luts的包含pde5抑制剂和蕈毒碱拮抗剂的药物组合 |
| GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
| WO2007107828A2 (en) | 2006-03-20 | 2007-09-27 | Pfizer Limited | Amine derivatives |
| GB0613154D0 (en) | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
| WO2008017827A2 (en) | 2006-08-08 | 2008-02-14 | Argenta Discovery Limited | Azole and thiazole derivatives and their uses |
| GB0702384D0 (en) | 2007-02-07 | 2007-03-21 | Argenta Discovery Ltd | Chemical compounds |
| EP1894568A1 (en) | 2006-08-31 | 2008-03-05 | Novartis AG | Pharmaceutical compositions for the treatment of inflammatory or obstructive airway diseases |
| AU2007303909A1 (en) | 2006-10-04 | 2008-04-10 | Pfizer Limited | Sulfonamide derivatives as adrenergic agonists and muscarinic antagonists |
| GB0700972D0 (en) | 2007-01-18 | 2007-02-28 | Imp Innovations Ltd | Treatment of inflammatory disease |
| GB0702413D0 (en) | 2007-02-07 | 2007-03-21 | Argenta Discovery Ltd | New chemical compounds |
| WO2008096129A1 (en) | 2007-02-07 | 2008-08-14 | Argenta Discovery Ltd | Nitrogen containing hetrocyclic compounds useful as bifunctional modulators of m3 receptors and beta- 2 receptors |
| WO2008149110A1 (en) | 2007-06-08 | 2008-12-11 | Argenta Discovery Limited | Bicyclor [2.2.1] hept-7-ylamine derivatives and their use in the treatment of diseases and conditions in which m3 muscarinic receptor activity and beta-adrenergic activity are implicated |
| UY31235A1 (es) | 2007-07-21 | 2009-03-02 | Nuevos medicamentos pulverulentos que contienen tiotropio y salmeterol, asi como lactosa como excipiente | |
| WO2009017813A1 (en) | 2007-08-02 | 2009-02-05 | Teva Pharmaceutical Industries Ltd. | O-desmethyl venlafaxine saccharinate |
| ES2320961B1 (es) | 2007-11-28 | 2010-03-17 | Laboratorios Almirall, S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2. |
| CA2713322C (en) | 2008-02-06 | 2017-01-17 | Astrazeneca Ab | Diazaspiro [5.5] undecane derivatives and their use in the treatment of pulmonary disorders |
| EP2096105A1 (en) | 2008-02-28 | 2009-09-02 | Laboratorios Almirall, S.A. | Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor |
| CN101544572B (zh) | 2008-03-26 | 2013-03-20 | 连云港恒邦医药科技有限公司 | 一种氨溴索衍生物及其制备方法 |
| GB0808708D0 (en) | 2008-05-13 | 2008-06-18 | Astrazeneca Ab | New compounds 274 |
| US8263623B2 (en) | 2008-07-11 | 2012-09-11 | Pfizer Inc. | Triazol derivatives useful for the treatment of diseases |
| WO2010015792A1 (en) | 2008-08-06 | 2010-02-11 | Argenta Discovery Limited | Nitrogen containing heterocyclic compounds useful as bifunctional modulators of m3 receptors and beta-2 receptors |
| EP2196465A1 (en) | 2008-12-15 | 2010-06-16 | Almirall, S.A. | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors |
| CN102405218B (zh) | 2009-04-23 | 2014-06-04 | 施万制药 | 具蕈毒碱受体拮抗剂和β2 肾上腺素受体激动剂活性的二酰胺化合物 |
| JP5379224B2 (ja) * | 2009-04-30 | 2013-12-25 | 帝人ファーマ株式会社 | 四級アンモニウム塩化合物 |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| ITRM20110083U1 (it) | 2010-05-13 | 2011-11-14 | De La Cruz Jose Antonio Freire | Piastra per la costruzione di carrelli per aeroplani |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| AR083115A1 (es) | 2010-09-30 | 2013-01-30 | Theravance Inc | Sales oxalato cristalinas de un compuesto diamida |
| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| RU2606121C2 (ru) | 2011-06-10 | 2017-01-10 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Соединения, обладающие антагонистической активностью в отношении мускариновых рецепторов и агонистической активностью в отношении бета2-адренорецепторов |
| RS54365B1 (sr) | 2011-06-10 | 2016-04-28 | Chiesi Farmaceutici S.P.A. | Jedinjenja koja imaju aktivnost antagonista muskarinskih receptora i agonist beta2 adrenergičnog receptora |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| UA111867C2 (uk) | 2011-11-11 | 2016-06-24 | Аллерган, Інк. | ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ І СПОСІБ ЗАСТОСУВАННЯ ПОХІДНИХ 4-ПРЕГНЕН-11β-17-21-ТРІОЛ-3,20-ДІОНУ |
| EP2592077A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| BR112014011351B1 (pt) | 2011-11-11 | 2021-02-17 | Gilead Apollo, Llc. | inibidores de acc e usos dos mesmos |
| GEP201706656B (en) | 2011-11-11 | 2017-04-25 | Pfizer | 2-thiopyrimidinones |
| HRP20180915T1 (hr) | 2012-12-06 | 2018-07-27 | Chiesi Farmaceutici S.P.A. | Spojevi koji imaju aktivnost kao antagonist muskarinskog receptora i kao agonist beta2 adrenergijskog receptora |
| CN104854105B (zh) | 2012-12-06 | 2017-05-17 | 奇斯药制品公司 | 具有毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂活性的化合物 |
| JP6307091B2 (ja) | 2012-12-18 | 2018-04-04 | アルミラル・ソシエダッド・アノニマＡｌｍｉｒａｌｌ， Ｓ．Ａ． | β２アドレナリンアゴニスト活性およびＭ３ムスカリンアンタゴニスト活性を有する新規のシクロヘキシルおよびキヌクリジニルカルバメート誘導体 |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| TW201440768A (zh) | 2013-02-27 | 2014-11-01 | Almirall Sa | 雙毒蕈鹼拮抗劑-β2腎上腺素促效劑複合物及皮質類固醇之組合物 |
| US20140250290A1 (en) | 2013-03-01 | 2014-09-04 | St-Ericsson Sa | Method for Software Anti-Rollback Recovery |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽 |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
-
2013
- 2013-12-17 JP JP2015548459A patent/JP6307091B2/ja not_active Expired - Fee Related
- 2013-12-17 HK HK16103131.6A patent/HK1215166A1/zh unknown
- 2013-12-17 ES ES13810937T patent/ES2750523T3/es active Active
- 2013-12-17 MX MX2015007279A patent/MX2015007279A/es unknown
- 2013-12-17 CA CA2892931A patent/CA2892931A1/en not_active Abandoned
- 2013-12-17 KR KR1020157019053A patent/KR20150096732A/ko not_active Withdrawn
- 2013-12-17 US US14/653,048 patent/US9518050B2/en not_active Expired - Fee Related
- 2013-12-17 PE PE2015000910A patent/PE20151414A1/es not_active Application Discontinuation
- 2013-12-17 AP AP2015008573A patent/AP2015008573A0/xx unknown
- 2013-12-17 SG SG11201504452WA patent/SG11201504452WA/en unknown
- 2013-12-17 EP EP13810937.6A patent/EP2934594B1/en active Active
- 2013-12-17 CN CN201380073299.7A patent/CN105142673B8/zh not_active Expired - Fee Related
- 2013-12-17 EA EA201500651A patent/EA201500651A1/ru unknown
- 2013-12-17 MA MA38260A patent/MA38260B1/fr unknown
- 2013-12-17 WO PCT/EP2013/076973 patent/WO2014095920A1/en not_active Ceased
- 2013-12-17 BR BR112015013628A patent/BR112015013628A2/pt active Search and Examination
- 2013-12-17 AU AU2013360866A patent/AU2013360866A1/en not_active Abandoned
- 2013-12-18 UY UY0001035199A patent/UY35199A/es not_active Application Discontinuation
- 2013-12-18 TW TW102146875A patent/TW201446743A/zh unknown
- 2013-12-18 AR ARP130104838A patent/AR094100A1/es unknown
-
2015
- 2015-05-21 ZA ZA2015/03619A patent/ZA201503619B/en unknown
- 2015-06-01 IL IL239118A patent/IL239118A0/en unknown
- 2015-06-11 TN TNP2015000271A patent/TN2015000271A1/fr unknown
- 2015-06-11 NI NI201500080A patent/NI201500080A/es unknown
- 2015-06-12 DO DO2015000145A patent/DOP2015000145A/es unknown
- 2015-06-18 PH PH12015501398A patent/PH12015501398A1/en unknown
- 2015-06-18 CL CL2015001753A patent/CL2015001753A1/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016505582A5 (OSRAM) | ||
| JP2020143086A (ja) | アミロイド標的剤及びその使用方法 | |
| ME02489B (me) | NOVI CIKLOHEKSILAMINSKI DERIVATI KOJI IMAJU AKTIVNOSTI BETA2 ADRENERGIJSKOG AGONISTA l M3 MUSKARINSKOG ANTAGONISTA | |
| JP6795517B2 (ja) | ５−芳香族アルキニル基置換ベンズアミド系化合物並びにその製造方法、薬物組成物及び使用 | |
| CA2395717C (en) | Fused imidazolium derivatives | |
| JP2005533868A5 (OSRAM) | ||
| JP2009536620A5 (OSRAM) | ||
| RU2007124187A (ru) | Производные фенэтаноламина для лечения респираторных заболеваний | |
| RU2011108281A (ru) | Трипиридилкарбоксамидные антагонисты орексиновых рецепторов | |
| JP2008509187A5 (OSRAM) | ||
| JP2014530900A5 (OSRAM) | ||
| JP2007532651A5 (OSRAM) | ||
| RU2012116877A (ru) | Соединения 2-пиридона, применяемые в качестве ингибиторов нейтрофильной эластазы | |
| JP2017533968A5 (OSRAM) | ||
| JP2018536648A5 (OSRAM) | ||
| JP2004504301A5 (OSRAM) | ||
| JP2017528487A5 (OSRAM) | ||
| JP2018158931A (ja) | 非選択的キナーゼ阻害剤 | |
| JP2015504067A5 (OSRAM) | ||
| JP2016534153A (ja) | 噴霧乾燥製剤 | |
| RU2014148316A (ru) | Производные 1-фенил-2-пиридинил-алкиловых спиртов в качестве ингибиторов фосфодиэстеразы | |
| AR086676A1 (es) | Derivados de alcoholes 1-fenil-2-piridinil alquilicos como inhibidores de fosfodiesterasa | |
| JP2010241788A (ja) | 退行性脳疾患の診断用または治療用の医薬組成物 | |
| JP2013520473A5 (OSRAM) | ||
| RU2014115290A (ru) | Производные 1-фенил 2-пиридинилалкиловых спиртов в качестве ингибиторов |