JP2016504390A5 - - Google Patents
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- Publication number
- JP2016504390A5 JP2016504390A5 JP2015551869A JP2015551869A JP2016504390A5 JP 2016504390 A5 JP2016504390 A5 JP 2016504390A5 JP 2015551869 A JP2015551869 A JP 2015551869A JP 2015551869 A JP2015551869 A JP 2015551869A JP 2016504390 A5 JP2016504390 A5 JP 2016504390A5
- Authority
- JP
- Japan
- Prior art keywords
- lorazepam
- pharmaceutical composition
- hours
- release
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 claims description 58
- 229960004391 lorazepam Drugs 0.000 claims description 58
- 239000008194 pharmaceutical composition Substances 0.000 claims description 38
- 239000011324 bead Substances 0.000 claims description 27
- 238000013268 sustained release Methods 0.000 claims description 20
- 239000012730 sustained-release form Substances 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 19
- 230000003111 delayed effect Effects 0.000 claims description 13
- 238000007922 dissolution test Methods 0.000 claims description 11
- 238000000338 in vitro Methods 0.000 claims description 11
- 238000004090 dissolution Methods 0.000 claims description 9
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 6
- 239000011159 matrix material Substances 0.000 claims description 6
- 239000008363 phosphate buffer Substances 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 6
- 239000002702 enteric coating Substances 0.000 claims description 4
- 238000009505 enteric coating Methods 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims description 2
- 239000006186 oral dosage form Substances 0.000 claims description 2
- 238000013270 controlled release Methods 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000013265 extended release Methods 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 1
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361750797P | 2013-01-09 | 2013-01-09 | |
| US61/750,797 | 2013-01-09 | ||
| US201361762833P | 2013-02-08 | 2013-02-08 | |
| US61/762,833 | 2013-02-08 | ||
| PCT/US2014/010854 WO2014110245A1 (en) | 2013-01-09 | 2014-01-09 | Sustained release formulations of lorazepam |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016216160A Division JP2017019880A (ja) | 2013-01-09 | 2016-11-04 | ロラゼパムの徐放性製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016504390A JP2016504390A (ja) | 2016-02-12 |
| JP2016504390A5 true JP2016504390A5 (enExample) | 2016-06-16 |
| JP6039823B2 JP6039823B2 (ja) | 2016-12-07 |
Family
ID=50064764
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551869A Active JP6039823B2 (ja) | 2013-01-09 | 2014-01-09 | ロラゼパムの徐放性製剤 |
| JP2016216160A Abandoned JP2017019880A (ja) | 2013-01-09 | 2016-11-04 | ロラゼパムの徐放性製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016216160A Abandoned JP2017019880A (ja) | 2013-01-09 | 2016-11-04 | ロラゼパムの徐放性製剤 |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US8999393B1 (enExample) |
| EP (1) | EP2943185B1 (enExample) |
| JP (2) | JP6039823B2 (enExample) |
| KR (1) | KR102318274B1 (enExample) |
| CN (1) | CN105209018B (enExample) |
| AU (1) | AU2014205440B2 (enExample) |
| BR (1) | BR112015016304A8 (enExample) |
| CA (1) | CA2897302C (enExample) |
| CL (1) | CL2015001920A1 (enExample) |
| CY (1) | CY1123933T1 (enExample) |
| DK (1) | DK2943185T3 (enExample) |
| ES (1) | ES2856181T3 (enExample) |
| HR (1) | HRP20210236T1 (enExample) |
| HU (1) | HUE054005T2 (enExample) |
| IL (1) | IL239777B (enExample) |
| LT (1) | LT2943185T (enExample) |
| MX (1) | MX367364B (enExample) |
| NZ (1) | NZ710860A (enExample) |
| PE (1) | PE20151432A1 (enExample) |
| PH (1) | PH12015501534B1 (enExample) |
| PL (1) | PL2943185T3 (enExample) |
| PT (1) | PT2943185T (enExample) |
| RS (1) | RS61857B1 (enExample) |
| RU (1) | RU2678324C2 (enExample) |
| SG (1) | SG11201505349RA (enExample) |
| SI (1) | SI2943185T1 (enExample) |
| SM (1) | SMT202100091T1 (enExample) |
| UA (1) | UA117233C2 (enExample) |
| WO (1) | WO2014110245A1 (enExample) |
| ZA (1) | ZA201505082B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019039836A2 (ko) * | 2017-08-22 | 2019-02-28 | 아주대학교산학협력단 | 퇴행성 신경질환 치료용 복합 제형 조성물 |
| RU2020117757A (ru) * | 2017-11-01 | 2021-11-29 | Эджмонт Фармасьютикалс, Ллк Траст | Оральные фармацевтические композиции лоразепама, устойчивые к спирту |
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| DD146547A5 (de) | 1978-07-15 | 1981-02-18 | Boehringer Sohn Ingelheim | Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen |
| US4361545A (en) | 1979-05-21 | 1982-11-30 | Rowell Laboratories, Inc. | Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion |
| FR2473884B1 (fr) * | 1980-01-21 | 1985-06-07 | Wellcome Found | Associations d'une halogeno-propiophenone et d'une diazepine, medicaments tranquillisants contenant de telles associations, et leur preparation |
| WO1985004100A1 (en) * | 1984-03-21 | 1985-09-26 | American Home Products Corporation | Sustained release pharmaceutical capsules |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US4624847A (en) | 1985-04-22 | 1986-11-25 | Alza Corporation | Drug delivery device for programmed delivery of beneficial drug |
| IT1188212B (it) | 1985-12-20 | 1988-01-07 | Paolo Colombo | Sistema per il rilascio a velocita' controllata di sostanze attive |
| US4794001A (en) | 1986-03-04 | 1988-12-27 | American Home Products Corporation | Formulations providing three distinct releases |
| US5009895A (en) | 1990-02-02 | 1991-04-23 | Merck & Co., Inc. | Sustained release with high and low viscosity HPMC |
| IT1241417B (it) | 1990-03-06 | 1994-01-14 | Vectorpharma Int | Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione |
| US5273758A (en) | 1991-03-18 | 1993-12-28 | Sandoz Ltd. | Directly compressible polyethylene oxide vehicle for preparing therapeutic dosage forms |
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| CA2144077C (en) | 1992-09-18 | 2005-05-24 | Kazuhiro Sako | Hydrogel-type sustained-release preparation |
| US5871776A (en) | 1995-01-31 | 1999-02-16 | Mehta; Atul M. | Controlled-release nifedipine |
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| US6348469B1 (en) | 1995-04-14 | 2002-02-19 | Pharma Pass Llc | Solid compositions containing glipizide and polyethylene oxide |
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| WO2000059481A1 (en) * | 1999-04-06 | 2000-10-12 | Pharmaquest Ltd. | PHARMACEUTICAL DOSAGE FORM FOR PULSATILE DELIVERY OF d-threo-METHYLPHENIDATE AND A SECOND CNS STIMULANT |
| US6500459B1 (en) * | 1999-07-21 | 2002-12-31 | Harinderpal Chhabra | Controlled onset and sustained release dosage forms and the preparation thereof |
| US6610271B2 (en) * | 2000-05-10 | 2003-08-26 | University Of Kentucky Research Foundation | System and method for intranasal administration of lorazepam |
| AU2141202A (en) | 2000-12-05 | 2002-06-18 | Alexander Macgregor | Hydrostatic delivery system for controlled delivery of agent |
| EP1250937B1 (en) | 2001-04-09 | 2009-05-13 | Rohm And Haas Company | Controlled dissolution of active ingredients |
| JP4426286B2 (ja) | 2001-07-10 | 2010-03-03 | テバ ファーマシューティカル インダストリーズ リミティド | ０次、０次−二相性、上昇型又は下降型薬物放出のための薬物送達システム |
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| WO2009137067A1 (en) * | 2008-05-08 | 2009-11-12 | Supernus Pharmaceuticals Inc. | Controlled release formulations of alprazolam |
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| US20120135050A1 (en) | 2010-07-08 | 2012-05-31 | Wellesley Pharmaceuticals, Llc | Extended-release formulation for reducing the frequency of urination and method of use thereof |
-
2014
- 2014-01-08 US US14/150,375 patent/US8999393B1/en active Active
- 2014-01-09 ES ES14702977T patent/ES2856181T3/es active Active
- 2014-01-09 BR BR112015016304A patent/BR112015016304A8/pt not_active Application Discontinuation
- 2014-01-09 EP EP14702977.1A patent/EP2943185B1/en active Active
- 2014-01-09 RS RS20210047A patent/RS61857B1/sr unknown
- 2014-01-09 SM SM20210091T patent/SMT202100091T1/it unknown
- 2014-01-09 CN CN201480012336.8A patent/CN105209018B/zh active Active
- 2014-01-09 KR KR1020157020977A patent/KR102318274B1/ko active Active
- 2014-01-09 HU HUE14702977A patent/HUE054005T2/hu unknown
- 2014-01-09 HR HRP20210236TT patent/HRP20210236T1/hr unknown
- 2014-01-09 AU AU2014205440A patent/AU2014205440B2/en active Active
- 2014-01-09 DK DK14702977.1T patent/DK2943185T3/da active
- 2014-01-09 RU RU2015128915A patent/RU2678324C2/ru active
- 2014-01-09 PE PE2015001248A patent/PE20151432A1/es active IP Right Grant
- 2014-01-09 SI SI201431768T patent/SI2943185T1/sl unknown
- 2014-01-09 JP JP2015551869A patent/JP6039823B2/ja active Active
- 2014-01-09 MX MX2015008756A patent/MX367364B/es active IP Right Grant
- 2014-01-09 WO PCT/US2014/010854 patent/WO2014110245A1/en not_active Ceased
- 2014-01-09 SG SG11201505349RA patent/SG11201505349RA/en unknown
- 2014-01-09 UA UAA201507784A patent/UA117233C2/uk unknown
- 2014-01-09 CA CA2897302A patent/CA2897302C/en active Active
- 2014-01-09 NZ NZ710860A patent/NZ710860A/en unknown
- 2014-01-09 PT PT147029771T patent/PT2943185T/pt unknown
- 2014-01-09 PL PL14702977T patent/PL2943185T3/pl unknown
- 2014-01-09 LT LTEP14702977.1T patent/LT2943185T/lt unknown
-
2015
- 2015-03-04 US US14/639,027 patent/US20150174078A1/en not_active Abandoned
- 2015-07-05 IL IL239777A patent/IL239777B/en active IP Right Grant
- 2015-07-06 CL CL2015001920A patent/CL2015001920A1/es unknown
- 2015-07-07 PH PH12015501534A patent/PH12015501534B1/en unknown
- 2015-07-15 ZA ZA2015/05082A patent/ZA201505082B/en unknown
- 2015-12-23 US US14/757,465 patent/US20160228378A1/en not_active Abandoned
-
2016
- 2016-11-04 JP JP2016216160A patent/JP2017019880A/ja not_active Abandoned
-
2021
- 2021-01-21 CY CY20211100046T patent/CY1123933T1/el unknown
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