JP2016500660A5 - - Google Patents

Info

Publication number

JP2016500660A5

JP2016500660A5 JP2015534747A JP2015534747A JP2016500660A5 JP 2016500660 A5 JP2016500660 A5 JP 2016500660A5 JP 2015534747 A JP2015534747 A JP 2015534747A JP 2015534747 A JP2015534747 A JP 2015534747A JP 2016500660 A5 JP2016500660 A5 JP 2016500660A5

Authority

JP

Japan

Prior art keywords

capromorelin

composition

companion animal

oral

pharmaceutical composition

Prior art date

2013-09-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• KVLLHLWBPNCVNR-SKCUWOTOSA-N capromorelin Chemical compound C([C@@]12CN(CCC1=NN(C2=O)C)C(=O)[C@@H](COCC=1C=CC=CC=1)NC(=O)C(C)(C)N)C1=CC=CC=C1 KVLLHLWBPNCVNR-SKCUWOTOSA-N 0.000 claims 47
• 229950004826 capromorelin Drugs 0.000 claims 47
• 239000000203 mixture Substances 0.000 claims 27
• 241001465754 Metazoa Species 0.000 claims 26
• 238000000034 method Methods 0.000 claims 25
• 239000008203 oral pharmaceutical composition Substances 0.000 claims 17
• 230000037396 body weight Effects 0.000 claims 12
• 235000003599 food sweetener Nutrition 0.000 claims 9
• 239000003765 sweetening agent Substances 0.000 claims 9
• HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims 8
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
• 208000022531 anorexia Diseases 0.000 claims 6
• 206010061428 decreased appetite Diseases 0.000 claims 6
• 239000001329 FEMA 3811 Substances 0.000 claims 5
• 239000001512 FEMA 4601 Substances 0.000 claims 5
• VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims 5
• 239000005913 Maltodextrin Substances 0.000 claims 5
• 229920002774 Maltodextrin Polymers 0.000 claims 5
• ILRKKHJEINIICQ-OOFFSTKBSA-N Monoammonium glycyrrhizinate Chemical compound N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ILRKKHJEINIICQ-OOFFSTKBSA-N 0.000 claims 5
• HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 claims 5
• 239000004376 Sucralose Substances 0.000 claims 5
• HELXLJCILKEWJH-UHFFFAOYSA-N entered according to Sigma 01432 Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O HELXLJCILKEWJH-UHFFFAOYSA-N 0.000 claims 5
• LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims 5
• 239000001685 glycyrrhizic acid Substances 0.000 claims 5
• 229960004949 glycyrrhizic acid Drugs 0.000 claims 5
• UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims 5
• 235000019410 glycyrrhizin Nutrition 0.000 claims 5
• LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims 5
• 229940035034 maltodextrin Drugs 0.000 claims 5
• ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 claims 5
• 229940089953 neohesperidin dihydrochalcone Drugs 0.000 claims 5
• 235000010434 neohesperidine DC Nutrition 0.000 claims 5
• 235000019203 rebaudioside A Nutrition 0.000 claims 5
• 235000019408 sucralose Nutrition 0.000 claims 5
• BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 5
• 239000000892 thaumatin Substances 0.000 claims 5
• 235000010436 thaumatin Nutrition 0.000 claims 5
• 235000009499 Vanilla fragrans Nutrition 0.000 claims 4
• 244000263375 Vanilla tahitensis Species 0.000 claims 4
• 235000012036 Vanilla tahitensis Nutrition 0.000 claims 4
• 235000013305 food Nutrition 0.000 claims 4
• JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 4
• 230000001965 increasing effect Effects 0.000 claims 4
• 239000003550 marker Substances 0.000 claims 4
• CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 4
• 230000004580 weight loss Effects 0.000 claims 4
• 244000228451 Stevia rebaudiana Species 0.000 claims 3
• 239000007788 liquid Substances 0.000 claims 3
• 244000144972 livestock Species 0.000 claims 3
• 239000002207 metabolite Substances 0.000 claims 3
• SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims 2
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
• 239000005715 Fructose Substances 0.000 claims 2
• 229930091371 Fructose Natural products 0.000 claims 2
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
• 241000202807 Glycyrrhiza Species 0.000 claims 2
• 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims 2
• 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims 2
• 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims 2
• 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 2
• 102100037852 Insulin-like growth factor I Human genes 0.000 claims 2
• 239000004384 Neotame Substances 0.000 claims 2
• 239000004383 Steviol glycoside Substances 0.000 claims 2
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
• 229930006000 Sucrose Natural products 0.000 claims 2
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 2
• 230000017531 blood circulation Effects 0.000 claims 2
• 239000003995 emulsifying agent Substances 0.000 claims 2
• 230000037406 food intake Effects 0.000 claims 2
• 235000012631 food intake Nutrition 0.000 claims 2
• 239000008103 glucose Substances 0.000 claims 2
• 235000011187 glycerol Nutrition 0.000 claims 2
• 229960000890 hydrocortisone Drugs 0.000 claims 2
• 239000000905 isomalt Substances 0.000 claims 2
• 235000010439 isomalt Nutrition 0.000 claims 2
• HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims 2
• 229940010454 licorice Drugs 0.000 claims 2
• 239000000845 maltitol Substances 0.000 claims 2
• 235000010449 maltitol Nutrition 0.000 claims 2
• VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 2
• 229940035436 maltitol Drugs 0.000 claims 2
• 210000003205 muscle Anatomy 0.000 claims 2
• 235000019412 neotame Nutrition 0.000 claims 2
• HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 claims 2
• 108010070257 neotame Proteins 0.000 claims 2
• 239000006186 oral dosage form Substances 0.000 claims 2
• 239000000243 solution Substances 0.000 claims 2
• 239000000600 sorbitol Substances 0.000 claims 2
• 235000010356 sorbitol Nutrition 0.000 claims 2
• 235000019411 steviol glycoside Nutrition 0.000 claims 2
• 229930182488 steviol glycoside Natural products 0.000 claims 2
• 150000008144 steviol glycosides Chemical class 0.000 claims 2
• 235000019202 steviosides Nutrition 0.000 claims 2
• 239000005720 sucrose Substances 0.000 claims 2
• 239000002562 thickening agent Substances 0.000 claims 2
• FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims 1
• 241000282326 Felis catus Species 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 208000010706 fatty liver disease Diseases 0.000 claims 1
• 239000004615 ingredient Substances 0.000 claims 1
• 229940085605 saccharin sodium Drugs 0.000 claims 1
• 239000012266 salt solution Substances 0.000 claims 1
• 238000005507 spraying Methods 0.000 claims 1
• 239000000725 suspension Substances 0.000 claims 1
• 230000004584 weight gain Effects 0.000 claims 1
• 235000019786 weight gain Nutrition 0.000 claims 1