JP2016190847A5 - - Google Patents
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- Publication number
- JP2016190847A5 JP2016190847A5 JP2016087432A JP2016087432A JP2016190847A5 JP 2016190847 A5 JP2016190847 A5 JP 2016190847A5 JP 2016087432 A JP2016087432 A JP 2016087432A JP 2016087432 A JP2016087432 A JP 2016087432A JP 2016190847 A5 JP2016190847 A5 JP 2016190847A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- fusion polypeptide
- amino acid
- acid sequence
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 44
- 108090000765 processed proteins & peptides Proteins 0.000 claims 44
- 102000004196 processed proteins & peptides Human genes 0.000 claims 44
- 230000004927 fusion Effects 0.000 claims 30
- 125000003275 alpha amino acid group Chemical group 0.000 claims 13
- 102000004042 Fibroblast Growth Factor-23 Human genes 0.000 claims 6
- 108090000569 Fibroblast Growth Factor-23 Proteins 0.000 claims 6
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 5
- 102000015834 Klotho Human genes 0.000 claims 4
- 108050004036 Klotho Proteins 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 101001139093 Homo sapiens Klotho Proteins 0.000 claims 2
- 102100020686 Klotho Human genes 0.000 claims 2
- 206010049565 Muscle fatigue Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 208000020832 chronic kidney disease Diseases 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 102100020683 Beta-klotho Human genes 0.000 claims 1
- 101710104526 Beta-klotho Proteins 0.000 claims 1
- 208000024806 Brain atrophy Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000004434 Calcinosis Diseases 0.000 claims 1
- 206010011878 Deafness Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 108091008794 FGF receptors Proteins 0.000 claims 1
- 102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 206010028289 Muscle atrophy Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010040799 Skin atrophy Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000002308 calcification Effects 0.000 claims 1
- 201000009856 cataract 30 Diseases 0.000 claims 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims 1
- 230000003292 diminished effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000010370 hearing loss Effects 0.000 claims 1
- 231100000888 hearing loss Toxicity 0.000 claims 1
- 208000016354 hearing loss disease Diseases 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 201000005991 hyperphosphatemia Diseases 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000003468 luciferase reporter gene assay Methods 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 230000020763 muscle atrophy Effects 0.000 claims 1
- 201000000585 muscular atrophy Diseases 0.000 claims 1
- 210000003098 myoblast Anatomy 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000008085 renal dysfunction Effects 0.000 claims 1
- 208000001076 sarcopenia Diseases 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/696,693 US8420088B2 (en) | 2008-01-28 | 2010-01-29 | Methods and compositions using FGF23 fusion polypeptides |
| US12/696,693 | 2010-01-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550437A Division JP5964243B2 (ja) | 2010-01-29 | 2011-01-27 | Ｆｇｆ２３融合ポリペプチドを使用する方法および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016190847A JP2016190847A (ja) | 2016-11-10 |
| JP2016190847A5 true JP2016190847A5 (show.php) | 2017-01-19 |
Family
ID=43828141
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550437A Expired - Fee Related JP5964243B2 (ja) | 2010-01-29 | 2011-01-27 | Ｆｇｆ２３融合ポリペプチドを使用する方法および組成物 |
| JP2016087432A Pending JP2016190847A (ja) | 2010-01-29 | 2016-04-25 | Ｆｇｆ２３融合ポリペプチドを使用する方法および組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550437A Expired - Fee Related JP5964243B2 (ja) | 2010-01-29 | 2011-01-27 | Ｆｇｆ２３融合ポリペプチドを使用する方法および組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8420088B2 (show.php) |
| EP (2) | EP2529016B1 (show.php) |
| JP (2) | JP5964243B2 (show.php) |
| KR (1) | KR20130032296A (show.php) |
| CN (3) | CN105968208A (show.php) |
| AR (1) | AR080043A1 (show.php) |
| AU (1) | AU2011209380B2 (show.php) |
| CA (1) | CA2787285A1 (show.php) |
| EA (1) | EA201201047A1 (show.php) |
| ES (1) | ES2605302T3 (show.php) |
| MX (1) | MX336391B (show.php) |
| PL (1) | PL2529016T3 (show.php) |
| PT (1) | PT2529016T (show.php) |
| TW (2) | TWI569805B (show.php) |
| UY (1) | UY33204A (show.php) |
| WO (1) | WO2011092234A1 (show.php) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200936156A (en) | 2008-01-28 | 2009-09-01 | Novartis Ag | Methods and compositions using Klotho-FGF fusion polypeptides |
| US8420088B2 (en) | 2008-01-28 | 2013-04-16 | Novartis Ag | Methods and compositions using FGF23 fusion polypeptides |
| HRP20191713T1 (hr) | 2011-07-01 | 2019-12-27 | Ngm Biopharmaceuticals, Inc. | Pripravci, uporabe i metode za liječenje metaboličkih poremećaja i bolesti |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| HK1214832A1 (zh) | 2012-11-28 | 2016-08-05 | 恩格姆生物制药公司 | 用於代謝病症和疾病治療的組合物和方法 |
| CN102961739A (zh) * | 2012-12-12 | 2013-03-13 | 黄曙 | Klotho蛋白的用途 |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| ES2915851T3 (es) | 2012-12-27 | 2022-06-27 | Ngm Biopharmaceuticals Inc | Péptidos quiméricos de FGF19 para usar en el tratamiento de trastornos de ácidos biliares |
| WO2014152993A1 (en) * | 2013-03-14 | 2014-09-25 | The Board Of Regents Of The University Of Oklahoma | Use of klotho nucleic acids or proteins for treatment of diabetes and diabetes-related conditions |
| KR101492710B1 (ko) * | 2013-04-03 | 2015-02-13 | 중앙대학교 산학협력단 | Fgf23 유전자를 이용한 전립선암 진단용 마커 및 이를 이용한 전립선암 예측 및 진단 방법 |
| EP3061810B1 (en) * | 2013-10-24 | 2018-12-05 | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology | Muscle stem cell or myoblast, method for screening substances that participate in metabolic conversion using same, and pharmaceutical composition comprising substance obtained from said screening method |
| US10369199B2 (en) | 2013-10-28 | 2019-08-06 | Ngm Biopharmaceuticals, Inc. | Methods of using variants of FGF19 polypeptides for the treatment of cancer |
| TWI679976B (zh) | 2013-11-13 | 2019-12-21 | 瑞士商諾華公司 | 低及免疫增強劑量之ｍｔｏｒ抑制劑及其用途 |
| MX375032B (es) | 2014-01-24 | 2025-03-06 | Ngm Biopharmaceuticals Inc | Proteínas de unión y métodos para utilizarlas. |
| JP6370577B2 (ja) * | 2014-03-26 | 2018-08-08 | 国立大学法人京都工芸繊維大学 | 抗老化物質のスクリーニング方法 |
| WO2015183890A2 (en) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders and diseases |
| WO2015195509A2 (en) | 2014-06-16 | 2015-12-23 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| JP6949711B2 (ja) | 2014-10-23 | 2021-10-20 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | ペプチドバリアントを含む医薬組成物及びその使用方法 |
| WO2016073855A1 (en) | 2014-11-07 | 2016-05-12 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| CA2969307A1 (en) * | 2014-12-04 | 2016-06-09 | Novartis Ag | Methods and compositions using klotho variant polypeptides |
| EP3253403B1 (en) | 2015-02-06 | 2021-09-01 | The Regents of The University of California | Methods and compositions for improved cognition |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| US10744185B2 (en) | 2015-11-09 | 2020-08-18 | Ngm Biopharmaceuticals, Inc. | Methods of using variants of FGF19 polypeptides for the treatment of pruritus |
| MX2018014753A (es) * | 2016-06-02 | 2019-06-17 | Klotho Therapeutics Inc | Proteinas klotho recombinantes terapeuticas y composiciones y metodos que involucran a las mismas. |
| EA037848B1 (ru) * | 2016-07-14 | 2021-05-27 | Общество С Ограниченной Ответственностью "Биохимический Агент" | Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты) |
| CN106317226B (zh) | 2016-08-19 | 2017-09-05 | 安源医药科技（上海）有限公司 | 用于构建融合蛋白的连接肽 |
| WO2018032638A1 (zh) | 2016-08-19 | 2018-02-22 | 安源医药科技（上海）有限公司 | 用于构建融合蛋白的连接肽 |
| CN106279437B (zh) | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| CA3034399A1 (en) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
| JP7654562B2 (ja) * | 2019-04-19 | 2025-04-01 | ジェネトン | 線維芽細胞増殖因子２３関連低リン血症性疾患の遺伝子療法 |
| WO2021128065A1 (zh) * | 2019-12-25 | 2021-07-01 | 广州菲康生物技术有限公司 | 人fgf-23的荧光免疫层析试纸和人fgf-23的荧光免疫层析检测试剂盒 |
| US11028132B1 (en) | 2020-04-07 | 2021-06-08 | Yitzhak Rosen | Half-life optimized linker composition |
| US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
| WO2025101851A1 (en) * | 2023-11-10 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Engineered alpha klotho polypeptides and uses thereof |
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-
2010
- 2010-01-29 US US12/696,693 patent/US8420088B2/en not_active Expired - Fee Related
-
2011
- 2011-01-27 CN CN201610245160.1A patent/CN105968208A/zh not_active Withdrawn
- 2011-01-27 PT PT117058305T patent/PT2529016T/pt unknown
- 2011-01-27 AR ARP110100273A patent/AR080043A1/es unknown
- 2011-01-27 EA EA201201047A patent/EA201201047A1/ru unknown
- 2011-01-27 JP JP2012550437A patent/JP5964243B2/ja not_active Expired - Fee Related
- 2011-01-27 EP EP11705830.5A patent/EP2529016B1/en active Active
- 2011-01-27 CN CN201310049110.2A patent/CN103204941B/zh not_active Expired - Fee Related
- 2011-01-27 AU AU2011209380A patent/AU2011209380B2/en not_active Ceased
- 2011-01-27 ES ES11705830.5T patent/ES2605302T3/es active Active
- 2011-01-27 PL PL11705830T patent/PL2529016T3/pl unknown
- 2011-01-27 WO PCT/EP2011/051112 patent/WO2011092234A1/en not_active Ceased
- 2011-01-27 CN CN201180007622.1A patent/CN102725413B/zh not_active Expired - Fee Related
- 2011-01-27 EP EP16184724.9A patent/EP3124612A1/en not_active Withdrawn
- 2011-01-27 KR KR1020127022498A patent/KR20130032296A/ko not_active Withdrawn
- 2011-01-27 UY UY0001033204A patent/UY33204A/es not_active Application Discontinuation
- 2011-01-27 CA CA2787285A patent/CA2787285A1/en not_active Withdrawn
- 2011-01-27 MX MX2012008780A patent/MX336391B/es unknown
- 2011-01-28 TW TW103100421A patent/TWI569805B/zh not_active IP Right Cessation
- 2011-01-28 TW TW100103508A patent/TWI430805B/zh not_active IP Right Cessation
-
2013
- 2013-03-12 US US13/796,711 patent/US8932589B2/en not_active Expired - Fee Related
-
2014
- 2014-11-03 US US14/531,620 patent/US9475857B2/en active Active
-
2016
- 2016-04-25 JP JP2016087432A patent/JP2016190847A/ja active Pending
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