JP2016135783A5 - - Google Patents
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- JP2016135783A5 JP2016135783A5 JP2016011829A JP2016011829A JP2016135783A5 JP 2016135783 A5 JP2016135783 A5 JP 2016135783A5 JP 2016011829 A JP2016011829 A JP 2016011829A JP 2016011829 A JP2016011829 A JP 2016011829A JP 2016135783 A5 JP2016135783 A5 JP 2016135783A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- seq
- variable region
- chain variable
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012634 fragment Substances 0.000 claims 22
- 239000000427 antigen Substances 0.000 claims 19
- 102000036639 antigens Human genes 0.000 claims 19
- 108091007433 antigens Proteins 0.000 claims 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 108010040471 CC Chemokines Proteins 0.000 claims 3
- 102000001902 CC Chemokines Human genes 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 102100032367 C-C motif chemokine 5 Human genes 0.000 claims 1
- 108700012434 CCL3 Proteins 0.000 claims 1
- 102000000013 Chemokine CCL3 Human genes 0.000 claims 1
- 102000001326 Chemokine CCL4 Human genes 0.000 claims 1
- 108010055165 Chemokine CCL4 Proteins 0.000 claims 1
- 108010055166 Chemokine CCL5 Proteins 0.000 claims 1
- 102000001327 Chemokine CCL5 Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23801509P | 2009-08-28 | 2009-08-28 | |
| US61/238,015 | 2009-08-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527033A Division JP6109571B2 (ja) | 2009-08-28 | 2010-08-27 | 複数種のＣＣケモカインと結合するａｎｔｉｋｉｎｅ抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016135783A JP2016135783A (ja) | 2016-07-28 |
| JP2016135783A5 true JP2016135783A5 (https=) | 2016-10-20 |
Family
ID=43628404
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527033A Active JP6109571B2 (ja) | 2009-08-28 | 2010-08-27 | 複数種のＣＣケモカインと結合するａｎｔｉｋｉｎｅ抗体 |
| JP2016011829A Pending JP2016135783A (ja) | 2009-08-28 | 2016-01-25 | 複数種のＣＣケモカインと結合するａｎｔｉｋｉｎｅ抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527033A Active JP6109571B2 (ja) | 2009-08-28 | 2010-08-27 | 複数種のＣＣケモカインと結合するａｎｔｉｋｉｎｅ抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8313747B2 (https=) |
| EP (1) | EP2470671B1 (https=) |
| JP (2) | JP6109571B2 (https=) |
| KR (1) | KR101778813B1 (https=) |
| CN (1) | CN102782148B (https=) |
| AU (1) | AU2010286516B2 (https=) |
| BR (1) | BR112012004387A2 (https=) |
| CA (1) | CA2771781C (https=) |
| DK (1) | DK2470671T3 (https=) |
| ES (1) | ES2531561T3 (https=) |
| HR (1) | HRP20150162T1 (https=) |
| IN (1) | IN2012DN01769A (https=) |
| MX (1) | MX2012002427A (https=) |
| PL (1) | PL2470671T3 (https=) |
| PT (1) | PT2470671E (https=) |
| SI (1) | SI2470671T1 (https=) |
| SM (1) | SMT201500011B (https=) |
| WO (1) | WO2011025962A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2470671T3 (en) * | 2009-08-28 | 2015-02-09 | Regeneron Pharma | ANTIKIN- ANTIBODIES BINDING TO MULTIPLE CC chemokines |
| ES2800316T3 (es) * | 2011-06-13 | 2020-12-29 | Tla Targeted Immunotherapies Ab | Tratamiento del cáncer |
| WO2013033206A2 (en) * | 2011-08-29 | 2013-03-07 | University Of Rochester | Compositions and methods for inhibiting ccl3 |
| EP2763540A4 (en) * | 2011-09-09 | 2015-04-22 | Univ Yale | COMPOSITIONS AND METHODS FOR THE EVALUATION AND TREATMENT OF INFLAMMATORY DISEASES AND DISEASES |
| PL3489261T3 (pl) | 2012-08-24 | 2021-08-16 | The Regents Of The University Of California | Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu |
| JO3580B1 (ar) * | 2013-03-15 | 2020-07-05 | Lilly Co Eli | أجسام مضادة لكيموكين elr+ cxc شامل |
| CA2912443A1 (en) * | 2013-05-23 | 2014-11-27 | Shire Human Genetic Therapies, Inc. | Anti-ccl2 and anti-loxl2 combination therapy for treatment of scleroderma |
| JP6220222B2 (ja) * | 2013-10-28 | 2017-10-25 | シスメックス株式会社 | 関節リウマチの診断を補助するための方法、システム及びコンピュータプログラム製品 |
| KR102311761B1 (ko) * | 2013-12-09 | 2021-10-13 | 알라코스 인크. | 항-Siglec-8 항체 및 그의 사용 방법 |
| CA2939931C (en) | 2014-02-28 | 2025-04-22 | Allakos Inc. | METHODS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH SIGLEC8 |
| PT3114139T (pt) | 2014-03-04 | 2022-09-13 | Chemomab Ltd | Anticorpos anti-eotaxina-2 que reconhecem quimiocinas adicionais de ligação a ccr3 |
| CN104198727A (zh) * | 2014-08-22 | 2014-12-10 | 广西南宁隆吉维特生物科技有限公司 | 人血清ccl2酶联免疫检测试剂盒及其制备和使用方法 |
| TWI576112B (zh) * | 2014-10-24 | 2017-04-01 | 國立陽明大學 | 巨噬細胞發炎蛋白－１β（ＭＩＰ－１β）抑制劑用以保護胰臟及防止血糖升高的用途 |
| HUE052606T2 (hu) * | 2014-12-09 | 2021-05-28 | Regeneron Pharma | Humanizált differenciációs klaszter 274 génnel rendelkezõ nem humán állatok |
| US10774145B2 (en) | 2015-06-17 | 2020-09-15 | Allakos Inc. | Methods and compositions for treating fibrotic diseases |
| US10604577B2 (en) | 2015-10-22 | 2020-03-31 | Allakos Inc. | Methods and compositions for treating systemic mastocytosis |
| IL299099B2 (en) | 2016-06-27 | 2025-07-01 | Univ California | Cancer treatment combinations |
| US10610104B2 (en) | 2016-12-07 | 2020-04-07 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3045310A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| JP7122002B2 (ja) * | 2017-03-01 | 2022-08-19 | 国立大学法人北海道大学 | 疾患モデル非ヒト動物の製造方法、疾患モデル非ヒト動物、該動物を用いた薬剤のスクリーニング方法及び疾患リスク判定方法 |
| BR112019020909A2 (pt) * | 2017-04-05 | 2020-05-12 | Korea Research Institute Of Bioscience And Biotechnology | Proteína de fusão ativadora de célula nk, célula nk e composição farmacêutica incluindo a mesma |
| KR20200016232A (ko) | 2017-05-05 | 2020-02-14 | 알라코스 인크. | 알레르기성 안구 질환을 치료하기 위한 방법 및 조성물 |
| WO2019037067A1 (zh) * | 2017-08-25 | 2019-02-28 | 法玛科技顾问股份有限公司 | 巨噬细胞发炎蛋白-1β(MIP-1β)抑制剂用以治疗及控管动脉粥状硬化的用途 |
| WO2019075472A1 (en) * | 2017-10-13 | 2019-04-18 | A&G Pharmaceutical, Inc. | MONOCLONAL AND CONJUGATED ANTIBODIES AGAINST THE PROSTAGLANDIN F2 RECEPTOR INHIBITOR AND USES THEREOF |
| US11891439B2 (en) | 2017-12-28 | 2024-02-06 | Astute Medical, Inc. | Antibodies and assays for CCL14 |
| WO2019165397A1 (en) * | 2018-02-26 | 2019-08-29 | Cornell University | Quantitative biomarkers of ehv-1 susceptibility and protection |
| KR20210039985A (ko) * | 2018-05-11 | 2021-04-12 | 헬시언 테라퓨틱스 인코포레이티드 | Gasp-1 과립을 표적으로 하는 결합 단백질 및 키메라 항원 수용체 t 세포, 및 이의 용도 |
| US20220249814A1 (en) | 2018-11-19 | 2022-08-11 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
| CN110117329B (zh) * | 2019-04-03 | 2020-12-08 | 河北浓孚雨生物科技有限公司 | 包含趋化因子与结合伴侣的融合多肽及其用途 |
| KR102489282B1 (ko) * | 2019-07-02 | 2023-01-17 | 고려대학교 산학협력단 | Ccl4, ccl5, ccl20, 및 ccl21을 유효성분으로 포함하는 임신촉진용 조성물 |
| CA3145667A1 (en) * | 2019-07-02 | 2021-01-07 | Astute Medical, Inc | Antibodies and assays for ccl14 |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| CN113893331B (zh) * | 2020-07-06 | 2024-11-26 | 中国农业科学院特产研究所 | 一种诱导母鹿生茸的产品及其制备方法和诱导母鹿生茸的方法和应用 |
| EP4178614A4 (en) * | 2020-07-08 | 2024-10-30 | Georgia Tech Research Corporation | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF SARS-COV-2 VIRUS INFECTIONS |
| CN115052892B (zh) * | 2020-10-16 | 2023-07-07 | 礼新医药科技(上海)有限公司 | 抗ccr8单克隆抗体及其用途 |
| CN115598111B (zh) * | 2021-07-08 | 2025-03-25 | 南京大学 | 基于邻位诱导免疫分析的特异性杂交瘤细胞化学发光筛选方法 |
| CN114990073A (zh) * | 2022-05-27 | 2022-09-02 | 河南农业大学 | 一种抗猪ccl2蛋白的单克隆抗体及其制备方法和应用 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| NZ255101A (en) * | 1992-07-24 | 1997-08-22 | Cell Genesys Inc | A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor |
| US6498015B1 (en) * | 1995-06-07 | 2002-12-24 | Icos Corporation | Methods of identifying agents that modulate the binding between MDC and an MDC receptor |
| US7018627B1 (en) | 1995-06-07 | 2006-03-28 | Icos Corporation | Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof |
| US6316420B1 (en) * | 1998-07-28 | 2001-11-13 | Technion Research And Development Foundation Ltd. | DNA cytokine vaccines and use of same for protective immunity against multiple sclerosis |
| US6420346B1 (en) * | 2000-02-07 | 2002-07-16 | Rappaport Family Institute For Research In The Medical Sciences | Polynucleotides encoding MIP-1α, MCP-1, MIP-1β, Rantes and TNF-α, and methods for treating rheumatoid arthritis |
| CA2496419A1 (en) | 2002-08-19 | 2004-02-26 | Abgenix, Inc. | Antibodies directed to monocyte chemo-attractant protein-1 (mcp-1) and uses thereof |
| WO2004050836A2 (en) * | 2002-11-27 | 2004-06-17 | Biogen Idec Ma Inc. | Humanized antibodies against monocyte chemotactic proteins |
| CA2590446A1 (en) | 2004-12-21 | 2006-06-29 | Laboratoires Serono S.A. | Cc-chemokine antagonists |
| US8012474B2 (en) * | 2007-08-02 | 2011-09-06 | Nov Immune S.A. | Anti-RANTES antibodies |
| DK2470671T3 (en) * | 2009-08-28 | 2015-02-09 | Regeneron Pharma | ANTIKIN- ANTIBODIES BINDING TO MULTIPLE CC chemokines |
-
2010
- 2010-08-27 DK DK10812667T patent/DK2470671T3/en active
- 2010-08-27 KR KR1020127007885A patent/KR101778813B1/ko not_active Expired - Fee Related
- 2010-08-27 HR HRP20150162TT patent/HRP20150162T1/hr unknown
- 2010-08-27 BR BR112012004387A patent/BR112012004387A2/pt active Search and Examination
- 2010-08-27 CN CN201080048961.XA patent/CN102782148B/zh not_active Expired - Fee Related
- 2010-08-27 ES ES10812667.3T patent/ES2531561T3/es active Active
- 2010-08-27 CA CA2771781A patent/CA2771781C/en active Active
- 2010-08-27 WO PCT/US2010/047004 patent/WO2011025962A1/en not_active Ceased
- 2010-08-27 JP JP2012527033A patent/JP6109571B2/ja active Active
- 2010-08-27 MX MX2012002427A patent/MX2012002427A/es active IP Right Grant
- 2010-08-27 AU AU2010286516A patent/AU2010286516B2/en active Active
- 2010-08-27 PT PT10812667T patent/PT2470671E/pt unknown
- 2010-08-27 EP EP20100812667 patent/EP2470671B1/en active Active
- 2010-08-27 SI SI201030901T patent/SI2470671T1/sl unknown
- 2010-08-27 IN IN1769DEN2012 patent/IN2012DN01769A/en unknown
- 2010-08-27 US US12/870,573 patent/US8313747B2/en active Active
- 2010-08-27 PL PL10812667T patent/PL2470671T3/pl unknown
-
2012
- 2012-10-22 US US13/657,120 patent/US9005617B2/en active Active
-
2015
- 2015-01-16 SM SM201500011T patent/SMT201500011B/xx unknown
- 2015-02-24 US US14/630,112 patent/US20150166647A1/en not_active Abandoned
-
2016
- 2016-01-25 JP JP2016011829A patent/JP2016135783A/ja active Pending
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