|
US4487603A
(en)
|
1982-11-26 |
1984-12-11 |
Cordis Corporation |
Implantable microinfusion pump system
|
|
US4501729A
(en)
*
|
1982-12-13 |
1985-02-26 |
Research Corporation |
Aerosolized amiloride treatment of retained pulmonary secretions
|
|
US4486194A
(en)
*
|
1983-06-08 |
1984-12-04 |
James Ferrara |
Therapeutic device for administering medicaments through the skin
|
|
US4959217A
(en)
|
1986-05-22 |
1990-09-25 |
Syntex (U.S.A.) Inc. |
Delayed/sustained release of macromolecules
|
|
US4925678A
(en)
|
1987-04-01 |
1990-05-15 |
Ranney David F |
Endothelial envelopment drug carriers
|
|
US5080646A
(en)
*
|
1988-10-03 |
1992-01-14 |
Alza Corporation |
Membrane for electrotransport transdermal drug delivery
|
|
AU630076B2
(en)
|
1987-09-21 |
1992-10-22 |
Gen-Probe Incorporated |
Non-nucleotide linking reagents for nucleotide probes
|
|
US5167616A
(en)
*
|
1989-12-14 |
1992-12-01 |
Alza Corporation |
Iontophoretic delivery method
|
|
US6153737A
(en)
|
1990-01-11 |
2000-11-28 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US5214136A
(en)
*
|
1990-02-20 |
1993-05-25 |
Gilead Sciences, Inc. |
Anthraquinone-derivatives oligonucleotides
|
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
US5378825A
(en)
|
1990-07-27 |
1995-01-03 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs
|
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
|
US5225182A
(en)
|
1991-10-31 |
1993-07-06 |
Sharma Yash P |
Vectored drug delivery system using a cephaloplastin linking agent and a methed of using the system
|
|
DK1695979T3
(da)
|
1991-12-24 |
2011-10-10 |
Isis Pharmaceuticals Inc |
Gappede modificerede oligonukleotider
|
|
AU687736B2
(en)
|
1992-05-11 |
1998-03-05 |
Ribozyme Pharmaceuticals, Inc. |
Method and reagent for inhibiting viral replication
|
|
US6582728B1
(en)
|
1992-07-08 |
2003-06-24 |
Inhale Therapeutic Systems, Inc. |
Spray drying of macromolecules to produce inhaleable dry powders
|
|
EP0786522A2
(en)
|
1992-07-17 |
1997-07-30 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic RNA molecules for treatment of stenotic conditions
|
|
US6235886B1
(en)
|
1993-09-03 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Methods of synthesis and use
|
|
WO1995006731A2
(en)
|
1993-09-02 |
1995-03-09 |
Ribozyme Pharmaceuticals, Inc. |
Non-nucleotide containing enzymatic nucleic acid
|
|
DE69433036T2
(de)
*
|
1993-09-03 |
2004-05-27 |
Isis Pharmaceuticals, Inc., Carlsbad |
Aminoderivatisierte nukleoside und oligonukleoside
|
|
US5624803A
(en)
*
|
1993-10-14 |
1997-04-29 |
The Regents Of The University Of California |
In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom
|
|
EP0725788B1
(en)
|
1993-10-27 |
1998-12-16 |
Ribozyme Pharmaceuticals, Inc. |
2'-amido and 2'-peptido modified oligonucleotides
|
|
US6051256A
(en)
*
|
1994-03-07 |
2000-04-18 |
Inhale Therapeutic Systems |
Dispersible macromolecule compositions and methods for their preparation and use
|
|
EP0755454B1
(en)
*
|
1994-04-13 |
2008-02-13 |
The Rockefeller University |
Aav-mediated delivery of dna to cells of the nervous system
|
|
US6447796B1
(en)
*
|
1994-05-16 |
2002-09-10 |
The United States Of America As Represented By The Secretary Of The Army |
Sustained release hydrophobic bioactive PLGA microspheres
|
|
CA2207593A1
(en)
|
1994-12-13 |
1996-06-20 |
John Gustofson |
Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses
|
|
ATE373672T1
(de)
*
|
1996-01-16 |
2007-10-15 |
Sirna Therapeutics Inc |
Synthese von methoxynukleoside und enzymatische nukleisäure moleküle
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
US6251666B1
(en)
|
1997-03-31 |
2001-06-26 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid catalysts comprising L-nucleotide analogs
|
|
US6235310B1
(en)
|
1997-04-04 |
2001-05-22 |
Valentis, Inc. |
Methods of delivery using cationic lipids and helper lipids
|
|
US6395713B1
(en)
|
1997-07-23 |
2002-05-28 |
Ribozyme Pharmaceuticals, Inc. |
Compositions for the delivery of negatively charged molecules
|
|
TW589189B
(en)
|
1997-08-04 |
2004-06-01 |
Scras |
Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis
|
|
KR100414936B1
(ko)
|
1997-09-12 |
2004-01-13 |
엑시콘 에이/에스 |
이환 및 삼환 뉴클레오시드, 뉴클레오타이드 및올리고뉴클레오타이드 동족체
|
|
US6565885B1
(en)
|
1997-09-29 |
2003-05-20 |
Inhale Therapeutic Systems, Inc. |
Methods of spray drying pharmaceutical compositions
|
|
EP1038016A2
(en)
|
1997-12-16 |
2000-09-27 |
Valentis Inc. |
Needle-free injection of formulated nucleic acid molecules
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
EP2138191A1
(en)
*
|
1998-01-05 |
2009-12-30 |
University Of Washington |
Enhanced transport using membrane disruptive agents
|
|
AR020078A1
(es)
|
1998-05-26 |
2002-04-10 |
Syngenta Participations Ag |
Metodo para alterar la expresion de un gen objetivo en una celula de planta
|
|
GB9827152D0
(en)
|
1998-07-03 |
1999-02-03 |
Devgen Nv |
Characterisation of gene function using double stranded rna inhibition
|
|
EP1096921B1
(en)
|
1998-07-20 |
2003-04-16 |
Protiva Biotherapeutics Inc. |
Liposomal encapsulated nucleic acid-complexes
|
|
WO2000044914A1
(en)
|
1999-01-28 |
2000-08-03 |
Medical College Of Georgia Research Institute, Inc. |
Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
|
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
|
NZ513402A
(en)
*
|
1999-02-12 |
2003-06-30 |
Sankyo Co |
Novel nucleosides and oligonucleotide analogues
|
|
EP1159441B8
(en)
|
1999-03-10 |
2008-10-29 |
Marie Curie Cancer Care |
Delivery of nucleic acids and proteins to cells
|
|
JP2001031588A
(ja)
|
1999-07-21 |
2001-02-06 |
Terumo Corp |
腹膜肥厚抑制剤
|
|
HK1047109A1
(zh)
|
1999-10-15 |
2003-02-07 |
University Of Massachusetts |
作为指定基因干预工具的rna干预轨迹基因
|
|
GB9927444D0
(en)
|
1999-11-19 |
2000-01-19 |
Cancer Res Campaign Tech |
Inhibiting gene expression
|
|
US20070026394A1
(en)
*
|
2000-02-11 |
2007-02-01 |
Lawrence Blatt |
Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
|
|
EP1309726B2
(en)
|
2000-03-30 |
2018-10-03 |
Whitehead Institute For Biomedical Research |
Rna sequence-specific mediators of rna interference
|
|
AU2001281730A1
(en)
|
2000-07-26 |
2002-02-05 |
Chemometec A/S |
Spatially resolved enzyme-linked assay
|
|
RU2322500C2
(ru)
*
|
2000-12-01 |
2008-04-20 |
Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. |
Малые молекулы рнк, опосредующие интерференцию рнк
|
|
US20020130430A1
(en)
|
2000-12-29 |
2002-09-19 |
Castor Trevor Percival |
Methods for making polymer microspheres/nanospheres and encapsulating therapeutic proteins and other products
|
|
WO2002087541A1
(en)
*
|
2001-04-30 |
2002-11-07 |
Protiva Biotherapeutics Inc. |
Lipid-based formulations for gene transfer
|
|
US6586524B2
(en)
|
2001-07-19 |
2003-07-01 |
Expression Genetics, Inc. |
Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier
|
|
JP2003159087A
(ja)
|
2001-09-13 |
2003-06-03 |
Japan Science & Technology Corp |
組織線維化抑制オリゴヌクレオチド
|
|
AUPR894201A0
(en)
|
2001-11-19 |
2001-12-13 |
Women's And Children's Hospital |
Respiratory delivery for gene therapy and lentiviral delivery particle
|
|
US7060498B1
(en)
|
2001-11-28 |
2006-06-13 |
Genta Salus Llc |
Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers
|
|
US7141540B2
(en)
|
2001-11-30 |
2006-11-28 |
Genta Salus Llc |
Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
|
|
US7795422B2
(en)
*
|
2002-02-20 |
2010-09-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
|
|
ES2280826T5
(es)
|
2002-08-05 |
2017-08-03 |
Silence Therapeutics Gmbh |
Nuevas formas adicionales de moléculas de ARN de interferencia
|
|
US20050106731A1
(en)
|
2002-08-05 |
2005-05-19 |
Davidson Beverly L. |
siRNA-mediated gene silencing with viral vectors
|
|
WO2004014933A1
(en)
|
2002-08-07 |
2004-02-19 |
University Of Massachusetts |
Compositions for rna interference and methods of use thereof
|
|
DK2284266T3
(da)
|
2002-11-14 |
2014-01-13 |
Thermo Fisher Scient Biosciences Inc |
sIRNA-MOLEKYLE MOD TP53
|
|
ES2576677T3
(es)
|
2003-03-21 |
2016-07-08 |
Roche Innovation Center Copenhagen A/S |
Análogos de ARN interfirientes cortos
|
|
JP4605799B2
(ja)
*
|
2003-04-02 |
2011-01-05 |
ダーマコン, インコーポレイテッド |
Rna干渉において使用するための修飾ポリヌクレオチド
|
|
US20040224405A1
(en)
*
|
2003-05-06 |
2004-11-11 |
Dharmacon Inc. |
siRNA induced systemic gene silencing in mammalian systems
|
|
ATE485394T1
(de)
|
2003-06-02 |
2010-11-15 |
Univ Massachusetts |
Verfahren und zusammensetzungen zur verbesserung der wirksamkeit und spezifität von fnai
|
|
US7750144B2
(en)
*
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
|
WO2005010213A2
(en)
*
|
2003-07-17 |
2005-02-03 |
Pacific Edge Biotechnology, Ltd. |
Markers for detection of gastric cancer
|
|
US20050136437A1
(en)
*
|
2003-08-25 |
2005-06-23 |
Nastech Pharmaceutical Company Inc. |
Nanoparticles for delivery of nucleic acids and stable double-stranded RNA
|
|
CN1845993B
(zh)
*
|
2003-08-28 |
2010-06-23 |
诺瓦提斯公司 |
具有平端和3'修饰的干扰rna双链体
|
|
JP5243789B2
(ja)
*
|
2004-03-15 |
2013-07-24 |
シティ・オブ・ホープ |
二本鎖rnaによる遺伝子発現の特異的阻害のための方法及び組成物
|
|
US20070265220A1
(en)
|
2004-03-15 |
2007-11-15 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
|
|
KR101147147B1
(ko)
*
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
|
US7842800B2
(en)
*
|
2004-04-02 |
2010-11-30 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory bacterial and bacterial associated oligonucleotides and uses thereof
|
|
CA2568735A1
(en)
*
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
|
EP2990410A1
(en)
*
|
2004-08-10 |
2016-03-02 |
Alnylam Pharmaceuticals Inc. |
Chemically modified oligonucleotides
|
|
US7358223B2
(en)
|
2004-10-04 |
2008-04-15 |
Nitto Denko Corporation |
Biodegradable cationic polymers
|
|
AU2005300688B2
(en)
*
|
2004-11-03 |
2012-02-02 |
Almac Diagnostics Limited |
Transcriptome microarray technology and methods of using the same
|
|
WO2006047842A2
(en)
|
2004-11-08 |
2006-05-11 |
K.U. Leuven Research And Development |
Modified nucleosides for rna interference
|
|
PT2730277T
(pt)
*
|
2004-12-22 |
2020-04-21 |
Nitto Denko Corp |
Veículo de fármaco e kit de veículo de fármaco para a inibição da fibrose
|
|
JP2009221164A
(ja)
*
|
2008-03-17 |
2009-10-01 |
Nitto Denko Corp |
肺線維症処置剤
|
|
US20060216722A1
(en)
*
|
2005-03-25 |
2006-09-28 |
Christer Betsholtz |
Glomerular expression profiling
|
|
JP5342834B2
(ja)
*
|
2008-09-05 |
2013-11-13 |
日東電工株式会社 |
骨髄線維症処置剤
|
|
CN1840709B
(zh)
*
|
2006-01-23 |
2010-05-26 |
南开大学 |
筛选与鉴定治疗免疫耐受相关疾病功能基因serpinh1的方法
|
|
JP2008167739A
(ja)
*
|
2006-06-14 |
2008-07-24 |
National Institute Of Advanced Industrial & Technology |
Rna干渉効果が高い修飾型二本鎖rna
|
|
EP2046993A4
(en)
*
|
2006-07-07 |
2010-11-17 |
Univ Massachusetts |
RNA SILENCING COMPOSITIONS, AND METHODS OF TREATING HUNTINGTON CHOREA
|
|
US20080132723A1
(en)
*
|
2006-12-04 |
2008-06-05 |
Celanese International Corporation |
Process for the production of ethylene, acetic acid and carbon monoxide from ethane
|
|
JP5252622B2
(ja)
*
|
2007-01-17 |
2013-07-31 |
独立行政法人産業技術総合研究所 |
高いヌクレアーゼ耐性と優れたrna干渉効果を発現可能な二本鎖rna
|
|
US20100215588A1
(en)
|
2007-04-26 |
2010-08-26 |
Rami Skaliter |
Therapeutic delivery of inhibitory nucleic acid molecules to the respiratory system
|
|
CA2698812A1
(en)
*
|
2007-09-14 |
2009-03-19 |
Nitto Denko Corporation |
Drug carriers
|
|
CA2701845A1
(en)
*
|
2007-10-03 |
2009-04-09 |
Quark Pharmaceuticals, Inc. |
Novel sirna structures
|
|
CN102159247A
(zh)
*
|
2008-07-30 |
2011-08-17 |
日东电工株式会社 |
药物载体
|
|
AU2010324658A1
(en)
|
2009-11-26 |
2012-05-03 |
Quark Pharmaceuticals, Inc. |
siRNA compounds comprising terminal substitutions
|
|
WO2011084193A1
(en)
|
2010-01-07 |
2011-07-14 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide compounds comprising non-nucleotide overhangs
|
|
TWI658830B
(zh)
|
2011-06-08 |
2019-05-11 |
日東電工股份有限公司 |
Hsp47表現調控強化用類視色素脂質體
|