JP2016117676A - 内服用組成物 - Google Patents
内服用組成物 Download PDFInfo
- Publication number
- JP2016117676A JP2016117676A JP2014257747A JP2014257747A JP2016117676A JP 2016117676 A JP2016117676 A JP 2016117676A JP 2014257747 A JP2014257747 A JP 2014257747A JP 2014257747 A JP2014257747 A JP 2014257747A JP 2016117676 A JP2016117676 A JP 2016117676A
- Authority
- JP
- Japan
- Prior art keywords
- component
- fucoxanthin
- lactoferrin
- composition
- fat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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Abstract
Description
[1]成分(a):ラクトフェリンと成分(b):フコキサンチン及び/又はその代謝物とを含む内服用組成物。
[2]成分(a)の含有量に対する成分(b)の含有量の比率が、0.0001以上0.3未満である請求項1に記載の内服用組成物。
[3]成分(a):ラクトフェリンと成分(b):フコキサンチン及び/又はその代謝物とを有効成分とする体脂肪低減剤。
[4]成分(a):ラクトフェリンと成分(b):フコキサンチン及び/又はその代謝物とを有効成分とする体重減少促進剤。
[5]成分(a):ラクトフェリンと成分(b):フコキサンチン及び/又はその代謝物とを有効成分とする血中中性脂肪低減剤。
[6]成分(a):ラクトフェリンと成分(b):フコキサンチンとを有効成分とする血中遊離脂肪酸低減剤。
実施例で用いるコンブ由来フコキサンチン(FX)を以下の手順で製造した。
分液漏斗に、フコキサンチン1%オイル(株式会社サウスプロダクト製、コンブ由来)500g、ヘキサン500g、メタノール500gおよび飽和食塩水50gを入れ、1分間混合後、10分間静置し、下層(濃赤色)を回収した。残った上層(濃緑色)に対し、メタノール250gおよび飽和食塩水25gを入れて同様の操作を行い、下層を回収した。これら回収した下層とヘキサン250gとを分液漏斗にて混合し10分間静置後、下層を回収してエバポレーターで濃縮乾固させ、固形分を得た。得られた固形分をジエチルエーテル250gに溶解して分液漏斗に入れ、水100gを混合し10分間静置した。上層(濃赤色)を集め、硫酸ナトリウムで乾燥させて濾紙で濾過後、得られる濾液をエバポレーターで濃縮乾固し、粗製フコキサンチンを得た(17g、フコキサンチン純度:28%、フコキサンチン回収率:95%)。粗製フコキサンチンを下記2の工程に供した。
粗製フコキサンチン(9g)をヘキサン/アセトン=50/50(v/v) 50mLに溶解し、シリカゲルクロマトグラフィー(φ50mm×H500mm)にて精製した。展開はヘキサン/アセトン比率=70/30で開始し、最終比率を50/50とした。濃赤色の画分を集め、エバポレーターにて濃縮乾固し、精製フコキサンチンを得た(3.5g、フコキサンチン純度:65%、フコキサンチン回収率:92%)。精製フコキサンチンを下記3の工程に供した。
精製フコキサンチン(3.5g)を最小量のアセトンに溶解させ、水を適量添加し、エバポレーターを用いて結晶が析出しない程度にアセトンを留去した。その後、溶液を氷冷して結晶が生成するまで静置した。ヘキサンを洗浄液として吸引濾過を行い、結晶を集乾燥させ、高純度フコキサンチン(2g、フコキサンチン純度:99%、フコキサンチン回収率:83%)を得た。
・試料:20mgを精秤し、エタノールで50mLまで希釈して得られた溶液を10μL導入した。
・カラム:Inertsil ODS−3 (5μm,4.6mm(I.D.)×150mm)
・移動相:メタノール/水=85/15(0分〜)、100/0(8分〜)、100/0(35分〜)
・流速:1.0mL/min
・オーブン:60℃
・検出器:UV−VIS(440nm)
回収率=各工程の結果物におけるフコキサンチン重量/各工程の処理前の試料におけるフコキサンチン重量
フコキサンチン重量は、試料の重量に、上記のとおり測定されたフコキサンチンの純度を乗じて算出した。なお、各精製工程における処理前の試料とは、それぞれフコキサンチン1%オイル、粗製フコキサンチン、精製フコキサンチンである。
肥満モデル動物であるKK−Ayマウス(オス、5週齢)を用いて、体重、体脂肪低減、および中性脂肪および遊離脂肪酸の低減の評価を行った。
実施例で用いた餌の代わりに、通常食に質量比1質量%のラクトフェリンを添加した餌を用いたほかは、実施例1と同様に評価を行った(LF1%群、N=7)。
実施例で用いた餌の代わりに、通常食に質量比5質量%のラクトフェリンを添加した餌を用いたほかは、実施例1と同様に評価を行った(LF5%群、N=7)。
実施例で用いた餌の代わりに、通常食に質量比0.1質量%のフコキサンチンを添加した餌を用いたほかは、実施例1と同様に評価を行った(FX0.1%群、N=7)。
実施例で用いた餌の代わりに、通常食に質量比0.001質量%のフコキサンチンを添加した餌を用いたほかは、実施例1と同様に評価を行った(FX0.1%群、N=7)。
実施例で用いた餌の代わりに、通常食に質量比0.1質量%のショウガエキス(日本粉末薬品株式会社)を添加した餌を用いたほかは、実施例1と同様に評価を行った(GIN0.1%群、N=7)。
実施例で用いた餌の代わりに、通常食に質量比1質量%のラクトフェリンおよび質量比0.1質量%のショウガエキス(日本粉末薬品株式会社)を添加した餌を用いたほかは、実施例1と同様に評価を行った(LF1%+GIN0.1%群、N=7)。
ラクトフェリン100mg、フコキサンチン0.3mg、乳糖110mg、結晶セルロース80mg、カルボキシメチルセルロース−Ca5mg、及びショ糖脂肪酸エステル5mgを定法どおり打錠し、タブレットを作成した。
ラクトフェリン300mg、フコキサンチン1mg、デキストリン699mgを定法どおり造粒し、顆粒を作成した。
Claims (6)
- 成分(a):ラクトフェリンと成分(b):フコキサンチン及び/又はその代謝物とを含む内服用組成物。
- 成分(a)の含有量に対する成分(b)の含有量の比率が、0.0001以上0.3未満である請求項1に記載の内服用組成物。
- 成分(a):ラクトフェリンと成分(b):フコキサンチン及び/又はその代謝物とを有効成分とする体脂肪低減剤。
- 成分(a):ラクトフェリンと成分(b):フコキサンチン及び/又はその代謝物とを有効成分とする体重減少促進剤。
- 成分(a):ラクトフェリンと成分(b):フコキサンチン及び/又はその代謝物とを有効成分とする血中中性脂肪低減剤。
- 成分(a):ラクトフェリンと成分(b):フコキサンチン及び/又はその代謝物とを有効成分とする血中遊離脂肪酸低減剤。
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JP2014257747A JP6399920B2 (ja) | 2014-12-19 | 2014-12-19 | 体脂肪低減剤、体重減少促進剤、血中中性脂肪低減剤及び血中遊離脂肪酸低減剤 |
CN201580069149.8A CN107106633A (zh) | 2014-12-19 | 2015-12-18 | 内服用组合物 |
KR1020177015167A KR20170095843A (ko) | 2014-12-19 | 2015-12-18 | 내복용 조성물 |
TW104142587A TWI691334B (zh) | 2014-12-19 | 2015-12-18 | 內服用組成物、製劑、與用途 |
PCT/JP2015/085450 WO2016098874A1 (ja) | 2014-12-19 | 2015-12-18 | 内服用組成物 |
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