JP2018008912A - 臓器線維化抑制組成物 - Google Patents
臓器線維化抑制組成物 Download PDFInfo
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- JP2018008912A JP2018008912A JP2016140650A JP2016140650A JP2018008912A JP 2018008912 A JP2018008912 A JP 2018008912A JP 2016140650 A JP2016140650 A JP 2016140650A JP 2016140650 A JP2016140650 A JP 2016140650A JP 2018008912 A JP2018008912 A JP 2018008912A
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- fibrosis
- turmeric extract
- organ fibrosis
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Abstract
Description
(1)ウコン抽出物を含有することを特徴とする、臓器線維化抑制組成物。
(2)前記ウコン抽出物が、水溶性ウコン抽出物を含有する、(1)に記載の臓器線維化抑制組成物。
(3)前記ウコン抽出物がビサクロンを含有する、(1)又は(2)に記載の臓器線維化抑制組成物。
(4)臓器線維化が肝線維化である(1)〜(3)のいずれかに記載の臓器線維化抑制組成物。
(5)肝線維化が非アルコール性の肝線維化である(4)に記載の臓器線維化抑制組成物。
本発明の組成物は、食品の成分であるウコン抽出物を有効成分としているため、ヒト又は他の動物による継続的な摂取又は投与での安全性が高いと考えられる。
本発明の組成物は、少なくともウコン抽出物を含有することを特徴とする。
本発明の組成物は、ウコン抽出物以外の成分を含んでも良い。
本発明の組成物は、一実施形態では、ウコン抽出物からなる。
本発明の組成物は、少なくとも1種の他の成分とともに製剤化されることができる。
本発明においてウコン抽出物とは、ショウガ科ウコン属の植物に由来する植物原料の抽出溶媒による抽出物(ウコンエキス)をいう。ウコン抽出物は、抽出溶媒による抽出により得られた溶媒抽出物に限らず、溶媒抽出物を更に、カラムクロマトグラフィー等で分画精製したものをも包含する。本発明で用いるウコン抽出物は、抽出操作(分画精製を行う場合は分画精製操作も含む)の完了した抽出液、抽出液から溶媒を部分的に除去した濃縮物、或いは、抽出液から溶媒を除去した乾燥物の形態であることができる。抽出物からの溶媒の除去は、加熱及び/又は減圧等により溶媒を揮発することにより行うことができる。これらの加熱、減圧の方法は特に限定されず、例えば従来公知の方法を使用することができる。
「臓器線維化」とは、臓器を構成する組織の各所にコラーゲンなどの線維成分が過剰に蓄積した状態を指し、臓器の線維化は臓器不全に共通の病態である。たとえば、肝臓の線維化は、ウイルス感染、薬剤の過剰投与、糖質や脂質の過剰摂取によって生じる。「非アルコール性の肝線維化」とは、アルコール以外、特に脂肪が要因となる肝線維化を指す。臓器線維化の抑制が望まれる臓器としては、肝臓、心臓、肺、腎臓、膵臓、胃、腸管(小腸、大腸、結腸等)、血管、骨髄、筋肉、皮膚、眼等が挙げられる。本発明の臓器線維化抑制組成物は、好ましくは、肝臓、心臓、肺、腎臓、膵臓、胃、腸管(小腸、大腸、結腸等)、血管、骨髄、筋肉、皮膚及び眼から選択される1以上の臓器での線維化を抑制するための組成物である。
上記の通り、本発明の臓器線維化抑制組成物は、ウコン抽出物と、他の成分1種又は2種以上とを含むことができる。当該他の成分としては、特に限定されないが、好ましくは、医薬品(ヒト又は非ヒト動物用)、飲食品、飼料、食品添加剤、健康食品、サプリメント、飼料添加剤等の、経口又は経鼻による摂取又は投与において許容される成分である。他の成分としては、例えば、果糖ブドウ糖液糖、デキストリン、酸味料、ビタミン類、増粘剤、ウコン色素、イノシトール、香料、環状オリゴ糖、甘味料、ミネラル、酸化防止剤、乳化剤等や、後述する各種組成物の具体例に関して言及する他の成分が挙げられる。
酸化防止剤としては、ビタミンC、酵素処理ルチン等が挙げられる。
甘味料としては、果糖、ブドウ糖、液糖等の糖類、はちみつ、スクラロース、アセスルファムカリウム、ソーマチン、アスパルテーム等の高甘味度甘味料が挙げられる。
・肝線維化の動物モデルとして、マウスに、メチオニンを少量添加したメチオニン・コリン欠乏高脂肪食を与えるものがある(Int J Exp Pathol. 2013 ;94(2):93−103)。
当該モデルを用いて、ウコン抽出物が肝線維化を抑制することができるかどうかを検討した。
1)ウコン抽出物の調製
ウコン抽出物は、ウコン(Curcuma longa)の根茎部分を水にて抽出し、得られた抽出液を減圧加熱乾燥して水分を除去することにより調製した。
カラム:Thermo ODS HYPERSIL(登録商標) 250mm×φ4.6mm(サーモサイエンティフィック社製)
移動相:65%アセトニトリル(20min)⇒80%アセトニトリル(5min)⇒65%アセトニトリル(10min)
流速:0.7ml/min
温度:40℃
検出波長:242nm
その結果、ウコン抽出物中のビサクロンの量は約0.15質量%以上、クルクミンの量は0.5重量%以下であることを確認した。
マウスに肝臓の線維化を誘導する飼料としてメチオニン0.05%、コリン不含の高脂肪食を用いた。この飼料をC57BL/6Jマウス(雄性、6週齢)に2週間与えた後、ウコン抽出物を0%(対照群、n=6)、0.02%(ビサクロンとして80 μg/kg/day、n=6)、0.08%(ビサクロンとして320 μg/kg/day、n=6)となるように配合した上述の肝臓の線維化を誘導する飼料をさらに8週間与えた後、肝臓を摘出して病理標本を作製し、肝組織の線維化部位を染色するためシリウスレッド染色を行った。
肝臓の線維化部分を染色し、染色面積(線維化が起こっている部分)を定量化して、線維化の程度を評価した。
Claims (5)
- ウコン抽出物を含有することを特徴とする、臓器線維化抑制組成物。
- 前記ウコン抽出物が、水溶性ウコン抽出物を含有する、請求項1に記載の臓器線維化抑制組成物。
- 前記ウコン抽出物がビサクロンを含有する、請求項1又は2に記載の臓器線維化抑制組成物。
- 臓器線維化が肝線維化である請求項1〜3のいずれか1項に記載の臓器線維化抑制組成物。
- 肝線維化が非アルコール性の肝線維化である請求項4に記載の臓器線維化抑制組成物。
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