JP2016104045A5 - - Google Patents
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- Publication number
- JP2016104045A5 JP2016104045A5 JP2016043151A JP2016043151A JP2016104045A5 JP 2016104045 A5 JP2016104045 A5 JP 2016104045A5 JP 2016043151 A JP2016043151 A JP 2016043151A JP 2016043151 A JP2016043151 A JP 2016043151A JP 2016104045 A5 JP2016104045 A5 JP 2016104045A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- glycoprotein
- seq
- protein comprises
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18340009P | 2009-06-02 | 2009-06-02 | |
| US61/183,400 | 2009-06-02 | ||
| US34885810P | 2010-05-27 | 2010-05-27 | |
| US61/348,858 | 2010-05-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014251541A Division JP2015051021A (ja) | 2009-06-02 | 2014-12-12 | フコシル化欠損細胞 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016202634A Division JP2017006147A (ja) | 2009-06-02 | 2016-10-14 | フコシル化欠損細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016104045A JP2016104045A (ja) | 2016-06-09 |
| JP2016104045A5 true JP2016104045A5 (cg-RX-API-DMAC7.html) | 2016-12-01 |
| JP6211642B2 JP6211642B2 (ja) | 2017-10-11 |
Family
ID=42338231
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514045A Expired - Fee Related JP5744856B2 (ja) | 2009-06-02 | 2010-06-01 | フコシル化欠損細胞 |
| JP2014251541A Withdrawn JP2015051021A (ja) | 2009-06-02 | 2014-12-12 | フコシル化欠損細胞 |
| JP2016043151A Expired - Fee Related JP6211642B2 (ja) | 2009-06-02 | 2016-03-07 | フコシル化欠損細胞 |
| JP2016202634A Pending JP2017006147A (ja) | 2009-06-02 | 2016-10-14 | フコシル化欠損細胞 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514045A Expired - Fee Related JP5744856B2 (ja) | 2009-06-02 | 2010-06-01 | フコシル化欠損細胞 |
| JP2014251541A Withdrawn JP2015051021A (ja) | 2009-06-02 | 2014-12-12 | フコシル化欠損細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016202634A Pending JP2017006147A (ja) | 2009-06-02 | 2016-10-14 | フコシル化欠損細胞 |
Country Status (16)
| Country | Link |
|---|---|
| US (8) | US8409838B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2438171B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP5744856B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101641526B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102459603B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010256753B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI1010035A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2764370C (cg-RX-API-DMAC7.html) |
| DK (3) | DK2438171T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2527173T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE038596T2 (cg-RX-API-DMAC7.html) |
| IL (1) | IL216624A (cg-RX-API-DMAC7.html) |
| PL (3) | PL2438171T3 (cg-RX-API-DMAC7.html) |
| SG (1) | SG176251A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI513818B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010141478A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140161782A1 (en) | 2008-06-09 | 2014-06-12 | Targazyme, Inc. | Augmentation of cell therapy efficacy including treatment with alpha 1-3 fucoslytransferase |
| JP5744856B2 (ja) | 2009-06-02 | 2015-07-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | フコシル化欠損細胞 |
| JP2014509850A (ja) | 2011-03-06 | 2014-04-24 | メルク セロノ ソシエテ アノニム | 低フコース細胞株およびその使用 |
| WO2013013013A2 (en) * | 2011-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for producing modified glycoproteins |
| TW201823460A (zh) | 2012-05-29 | 2018-07-01 | 美商再生元醫藥公司 | 生產細胞株增強子 |
| EP2722673B1 (en) | 2012-10-17 | 2017-07-12 | Hexal AG | Improved method of mapping glycans of glycoproteins |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| WO2015033343A1 (en) | 2013-09-03 | 2015-03-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions and methods for expressing recombinant polypeptides |
| US20150093782A1 (en) * | 2013-10-01 | 2015-04-02 | The University Of Wyoming | Compositions and methods for reducing fucosylation of glycoproteins in insect cells and methods of use thereof for production of recombinant glycoproteins |
| MA39313B1 (fr) | 2014-03-11 | 2018-12-31 | Regeneron Pharma | Anticorps anti-egfrviii et leurs utilisations dans le traitement de divers cancers |
| EP4083066A3 (en) * | 2014-05-30 | 2023-02-08 | New England Biolabs, Inc. | Deglycosylation reagents and methods |
| US20170121673A1 (en) * | 2014-07-07 | 2017-05-04 | Targazyme, Inc. | Manufacture and Cryopreservation of Fucosylated Cells for Therapeutic Use |
| CN105671109B (zh) * | 2014-11-20 | 2019-08-23 | 中国人民解放军军事医学科学院生物工程研究所 | 用糖基工程酵母制备具有动物细胞糖基化修饰流感血凝素糖蛋白的方法 |
| TWI710573B (zh) | 2015-01-26 | 2020-11-21 | 美商再生元醫藥公司 | 抗伊波拉病毒醣蛋白之人類抗體 |
| TWI797060B (zh) | 2015-08-04 | 2023-04-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| WO2017079165A1 (en) | 2015-11-02 | 2017-05-11 | Genentech, Inc. | Methods of making fucosylated and afucosylated forms of a protein |
| MX2018008447A (es) | 2016-01-06 | 2019-05-30 | Oncobiologics Inc | Modulacion de especies afucosilados en una composicion de anticuerpo monoclonal. |
| MX2018009341A (es) | 2016-02-03 | 2019-05-15 | Oncobiologics Inc | Formulaciones tamponadas para una mayor estabilidad de anticuerpos. |
| AR109451A1 (es) | 2016-04-20 | 2018-12-12 | Regeneron Pharma | Composiciones y métodos para preparar anticuerpos basados en el uso de loci mejoradores de expresión |
| WO2017184831A1 (en) | 2016-04-20 | 2017-10-26 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for making antibodies based on use of an expression-enhancing locus |
| EP3339444A1 (en) * | 2016-12-20 | 2018-06-27 | Mabxience Research, S.L. | Method for obtaining a glycoprotein with an increased percentage of afucosylated glycans |
| CN111954719B (zh) | 2018-03-26 | 2025-07-18 | 美国安进公司 | 细胞培养物中产生的抗体的总去岩藻糖基化糖型 |
| US20210317499A1 (en) * | 2018-08-29 | 2021-10-14 | United Biopharma Inc. | Afucosylated antibodies and manufacture thereof |
| TWI861023B (zh) | 2018-10-29 | 2024-11-11 | 日商免疫生物研究所股份有限公司 | 抗hiv抗體及其製造方法 |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| IL298194A (en) | 2020-05-26 | 2023-01-01 | Regeneron Pharma | Antibodies against sars-cov2-spike glycoprotein and antigen-binding fragments |
| EP4161960A1 (en) | 2020-06-03 | 2023-04-12 | Regeneron Pharmaceuticals, Inc. | Methods for treating or preventing sars-cov-2 infections and covid-19 with anti-sars-cov-2 spike glycoprotein antibodies |
| CN112843234B (zh) * | 2021-01-20 | 2022-09-06 | 四川大学华西第二医院 | 一种调控生物机体内gdp-甘露糖的浓度的装置 |
| AU2022289365A1 (en) | 2021-06-07 | 2023-12-14 | Amgen Inc. | Using fucosidase to control afucosylation level of glycosylated proteins |
| JP2024527235A (ja) | 2021-06-22 | 2024-07-24 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗ＥＧＦＲｖＩＩＩ抗体薬物コンジュゲート及びその使用 |
| KR20240046322A9 (ko) | 2021-07-14 | 2025-10-01 | 리제너론 파아마슈티컬스, 인크. | 항-sars-cov-2-스파이크 당단백질 항체 및 항원-결합 단편 |
| WO2023081434A2 (en) | 2021-11-07 | 2023-05-11 | Regeneron Pharmaceuticals, Inc. | Methods for treating or preventing sars-cov-2 infections and covid-19 with anti-sars-cov-2 spike glycoprotein antibodies |
| CN119053625A (zh) | 2022-03-02 | 2024-11-29 | 瑞泽恩制药公司 | 用于抗体生产的细胞培养方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1006070A (en) | 1909-05-11 | 1911-10-17 | George Walter Durbrow | Method of and means for extracting micro-organisms and solids from water. |
| PT1176195E (pt) * | 1999-04-09 | 2013-07-18 | Kyowa Hakko Kirin Co Ltd | Processo para controlar a actividade de uma molécula funcional sob o ponto de vista imunológico |
| JP2001145488A (ja) | 1999-11-19 | 2001-05-29 | Natl Inst Of Advanced Industrial Science & Technology Meti | シロイヌナズナ由来のｇｄｐ−４−ケト−６−デオキシ−ｄ−マンノース−３，５−エピメラーゼ−４−レダクターゼ遺伝子 |
| FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| EP3263702A1 (en) * | 2000-10-06 | 2018-01-03 | Kyowa Hakko Kirin Co., Ltd. | Cells producing antibody compositions |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| US20020150968A1 (en) | 2001-01-10 | 2002-10-17 | Wang Peng G. | Glycoconjugate and sugar nucleotide synthesis using solid supports |
| EP1392859B1 (en) | 2001-01-16 | 2006-05-10 | Regeneron Pharmaceuticals, Inc. | Isolating cells expressing secreted proteins |
| PL213948B1 (pl) | 2001-10-25 | 2013-05-31 | Genentech Inc | Kompozycje zawierajace glikoproteine, czasteczka kwasu nukleinowego kodujaca te glikoproteine, komórka gospodarza, sposób wytwarzania glikoproteiny, kompozycja do zastosowania do leczenia, zastosowanie kompozycji i zestaw zawierajacy kompozycje |
| KR100585140B1 (ko) | 2004-04-26 | 2006-05-30 | 삼성전자주식회사 | 와이어 본딩 장치 및 이를 이용한 반도체 패키지의 와이어본딩 방법 |
| US20060223147A1 (en) * | 2004-08-05 | 2006-10-05 | Kyowa Hakko Kogyo Co., Ltd., | Process for producing glycoprotein composition |
| CA2608818A1 (en) | 2005-06-03 | 2006-12-14 | Genentech, Inc. | Method of producing antibodies with modified fucosylation level |
| AU2007285976B2 (en) | 2006-08-14 | 2011-08-18 | Xencor, Inc | Optimized antibodies that target CD19 |
| JP2010519930A (ja) | 2007-03-07 | 2010-06-10 | グライコフィ， インコーポレイテッド | 糖タンパク質の修飾フコシル化を用いる産生 |
| EP2150617B1 (en) | 2007-06-04 | 2014-10-22 | Regeneron Pharmaceuticals, Inc. | Enhanced expression and stability regions |
| JP5662149B2 (ja) | 2008-08-13 | 2015-01-28 | 協和発酵キリン株式会社 | 遺伝子組換えプロテインｓ組成物 |
| JP5744856B2 (ja) | 2009-06-02 | 2015-07-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | フコシル化欠損細胞 |
| JP2014509850A (ja) | 2011-03-06 | 2014-04-24 | メルク セロノ ソシエテ アノニム | 低フコース細胞株およびその使用 |
-
2010
- 2010-06-01 JP JP2012514045A patent/JP5744856B2/ja not_active Expired - Fee Related
- 2010-06-01 TW TW099117652A patent/TWI513818B/zh not_active IP Right Cessation
- 2010-06-01 AU AU2010256753A patent/AU2010256753B2/en not_active Ceased
- 2010-06-01 US US12/791,637 patent/US8409838B2/en active Active
- 2010-06-01 BR BRPI1010035-0A patent/BRPI1010035A2/pt not_active Application Discontinuation
- 2010-06-01 KR KR1020147007025A patent/KR101641526B1/ko not_active Expired - Fee Related
- 2010-06-01 CN CN2010800294912A patent/CN102459603B/zh not_active Expired - Fee Related
- 2010-06-01 ES ES10721096.5T patent/ES2527173T3/es active Active
- 2010-06-01 EP EP10721096.5A patent/EP2438171B1/en active Active
- 2010-06-01 PL PL10721096T patent/PL2438171T3/pl unknown
- 2010-06-01 PL PL17192430T patent/PL3279326T3/pl unknown
- 2010-06-01 DK DK10721096.5T patent/DK2438171T3/en active
- 2010-06-01 EP EP17192430.1A patent/EP3279326B1/en active Active
- 2010-06-01 ES ES14179885.0T patent/ES2661074T3/es active Active
- 2010-06-01 SG SG2011087517A patent/SG176251A1/en unknown
- 2010-06-01 WO PCT/US2010/036914 patent/WO2010141478A1/en not_active Ceased
- 2010-06-01 CA CA2764370A patent/CA2764370C/en active Active
- 2010-06-01 DK DK17192430.1T patent/DK3279326T3/da active
- 2010-06-01 DK DK14179885.0T patent/DK2808393T3/en active
- 2010-06-01 HU HUE14179885A patent/HUE038596T2/hu unknown
- 2010-06-01 PL PL14179885T patent/PL2808393T3/pl unknown
- 2010-06-01 EP EP14179885.0A patent/EP2808393B1/en active Active
- 2010-06-01 KR KR1020117031320A patent/KR101441437B1/ko not_active Expired - Fee Related
-
2011
- 2011-11-27 IL IL216624A patent/IL216624A/en active IP Right Grant
-
2013
- 2013-02-28 US US13/779,952 patent/US9206455B2/en active Active
-
2014
- 2014-12-12 JP JP2014251541A patent/JP2015051021A/ja not_active Withdrawn
-
2015
- 2015-12-08 US US14/963,178 patent/US9550823B2/en active Active
-
2016
- 2016-03-07 JP JP2016043151A patent/JP6211642B2/ja not_active Expired - Fee Related
- 2016-10-14 JP JP2016202634A patent/JP2017006147A/ja active Pending
- 2016-12-14 US US15/378,670 patent/US10006070B2/en active Active
-
2018
- 2018-05-23 US US15/987,286 patent/US20190024129A1/en not_active Abandoned
-
2019
- 2019-08-30 US US16/556,334 patent/US20200080124A1/en not_active Abandoned
-
2021
- 2021-05-04 US US17/307,255 patent/US11560550B2/en active Active
-
2022
- 2022-12-15 US US18/066,303 patent/US12054751B2/en active Active
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