JP2015536308A5 - - Google Patents
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- JP2015536308A5 JP2015536308A5 JP2015537017A JP2015537017A JP2015536308A5 JP 2015536308 A5 JP2015536308 A5 JP 2015536308A5 JP 2015537017 A JP2015537017 A JP 2015537017A JP 2015537017 A JP2015537017 A JP 2015537017A JP 2015536308 A5 JP2015536308 A5 JP 2015536308A5
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- Japan
- Prior art keywords
- cancer
- composition
- gene
- amino acid
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261714145P | 2012-10-15 | 2012-10-15 | |
| US201261714045P | 2012-10-15 | 2012-10-15 | |
| US201261714140P | 2012-10-15 | 2012-10-15 | |
| US61/714,045 | 2012-10-15 | ||
| US61/714,140 | 2012-10-15 | ||
| US61/714,145 | 2012-10-15 | ||
| US201361758972P | 2013-01-31 | 2013-01-31 | |
| US61/758,972 | 2013-01-31 | ||
| US201361780703P | 2013-03-13 | 2013-03-13 | |
| US61/780,703 | 2013-03-13 | ||
| US201361786277P | 2013-03-14 | 2013-03-14 | |
| US61/786,277 | 2013-03-14 | ||
| PCT/US2013/065112 WO2014062720A2 (en) | 2012-10-15 | 2013-10-15 | Methods of treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018012593A Division JP2018062535A (ja) | 2012-10-15 | 2018-01-29 | ガンの治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015536308A JP2015536308A (ja) | 2015-12-21 |
| JP2015536308A5 true JP2015536308A5 (https=) | 2017-01-12 |
| JP6351182B2 JP6351182B2 (ja) | 2018-07-04 |
Family
ID=49519104
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015537017A Active JP6351182B2 (ja) | 2012-10-15 | 2013-10-15 | ガンの治療方法 |
| JP2018012593A Withdrawn JP2018062535A (ja) | 2012-10-15 | 2018-01-29 | ガンの治療方法 |
| JP2019162839A Withdrawn JP2020011971A (ja) | 2012-10-15 | 2019-09-06 | ガンの治療方法 |
| JP2021089951A Withdrawn JP2021120420A (ja) | 2012-10-15 | 2021-05-28 | ガンの治療方法 |
| JP2023215651A Pending JP2024029066A (ja) | 2012-10-15 | 2023-12-21 | ガンの治療方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018012593A Withdrawn JP2018062535A (ja) | 2012-10-15 | 2018-01-29 | ガンの治療方法 |
| JP2019162839A Withdrawn JP2020011971A (ja) | 2012-10-15 | 2019-09-06 | ガンの治療方法 |
| JP2021089951A Withdrawn JP2021120420A (ja) | 2012-10-15 | 2021-05-28 | ガンの治療方法 |
| JP2023215651A Pending JP2024029066A (ja) | 2012-10-15 | 2023-12-21 | ガンの治療方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (7) | US9688665B2 (https=) |
| EP (2) | EP2908823B1 (https=) |
| JP (5) | JP6351182B2 (https=) |
| KR (3) | KR20230156450A (https=) |
| CN (2) | CN110898067A (https=) |
| AU (4) | AU2013331368A1 (https=) |
| BR (1) | BR112015008447A2 (https=) |
| CA (2) | CA3177498A1 (https=) |
| CY (1) | CY1122186T1 (https=) |
| ES (1) | ES2750199T3 (https=) |
| HR (1) | HRP20191814T1 (https=) |
| HU (1) | HUE046790T2 (https=) |
| IL (4) | IL308613A (https=) |
| LT (1) | LT2908823T (https=) |
| MX (2) | MX376008B (https=) |
| NZ (2) | NZ706836A (https=) |
| PL (1) | PL2908823T3 (https=) |
| PT (1) | PT2908823T (https=) |
| RS (1) | RS59541B1 (https=) |
| RU (2) | RU2677276C2 (https=) |
| SI (1) | SI2908823T1 (https=) |
| SM (1) | SMT201900593T1 (https=) |
| WO (1) | WO2014062720A2 (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130102477A1 (en) | 2010-06-23 | 2013-04-25 | Ryan D. Morin | Biomarkers for non-hodgkin lymphomas and uses thereof |
| JO3363B1 (ar) | 2011-04-13 | 2019-03-13 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| EP2780013A4 (en) | 2011-11-18 | 2015-07-01 | Constellation Pharmaceuticals Inc | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF |
| NZ628762A (en) | 2012-02-10 | 2016-07-29 | Constellation Pharmaceuticals Inc | Modulators of methyl modifying enzymes, compositions and uses thereof |
| PT3184523T (pt) | 2012-04-13 | 2019-09-26 | Eisai R&D Man Co Ltd | Bromidrato de n-((4,6-dimetil-2-oxo-l,2-di-hidropiridin- 3-il)metil)-5-(etil(tetra-hidro-2h-piran-4-il)amino)-4- metil-4¿-(morfolinometil)-[l,1¿-bofenil]-3-carboxamida para utilização no tratamento de uma doença proliferativa celular do sistema hematológico |
| MX2015004721A (es) | 2012-10-15 | 2016-01-25 | Epizyme Inc | Compuestos de benceno sustituidos. |
| KR20230156450A (ko) | 2012-10-15 | 2023-11-14 | 에피자임, 인코포레이티드 | 암을 치료하는 방법 |
| UA118548C2 (uk) | 2012-12-21 | 2019-02-11 | Епізайм, Інк. | Тетрагідро- та дигідроізохіноліни як інгібітори prmt5 та їх застосування |
| WO2014151142A1 (en) | 2013-03-15 | 2014-09-25 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| EP3033334A1 (en) | 2013-08-15 | 2016-06-22 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
| MA38949A1 (fr) | 2013-10-16 | 2017-07-31 | Eisai R&D Man Co Ltd | Forme saline d'hydrochlorure pour inhibition d'ezh2 |
| WO2015058125A1 (en) * | 2013-10-18 | 2015-04-23 | Epizyme, Inc. | Method of treating cancer |
| CN116019921A (zh) | 2013-12-06 | 2023-04-28 | Epizyme股份有限公司 | 用于治疗癌症的组合疗法 |
| BR112016029492A2 (pt) * | 2014-06-17 | 2017-10-17 | Eisai R&D Man Co Ltd | método para tratamento de linfoma não hodgkin |
| SG11201610610YA (en) | 2014-06-19 | 2017-01-27 | Sloan Kettering Inst Cancer | Biomarkers for response to ezh2 inhibitors |
| EA201790845A1 (ru) * | 2014-10-16 | 2017-08-31 | Эпизайм, Инк. | Способ лечения рака |
| HUE062159T2 (hu) | 2014-11-17 | 2023-10-28 | Epizyme Inc | Módszer a rák kezelésére N-((4,6-dimetil-2-oxo-l,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2H -pirán-4-il)amino)-4-metil-4'-(morfolinmetil)-[1,1'-bifenil]-3-karboxamiddal |
| AR102767A1 (es) | 2014-12-05 | 2017-03-22 | Lilly Co Eli | Inhibidores de ezh2 |
| WO2016101956A2 (en) | 2014-12-23 | 2016-06-30 | University Of Copenhagen | Treatment of cancer by inhibiting ezh2 activity |
| WO2016172199A1 (en) * | 2015-04-20 | 2016-10-27 | Epizyme, Inc. | Combination therapy for treating cancer |
| AU2016275051A1 (en) | 2015-06-10 | 2017-12-07 | Epizyme, Inc. | EZH2 inhibitors for treating lymphoma |
| WO2017035234A1 (en) | 2015-08-24 | 2017-03-02 | Epizyme, Inc. | Method for treating cancer |
| TW201718598A (zh) | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ｅｚｈ２抑制劑 |
| US10577350B2 (en) | 2015-08-28 | 2020-03-03 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide |
| CA2999898A1 (en) * | 2015-09-25 | 2017-03-30 | Epizyme, Inc. | Method of treating malignant rhabdoid tumor of the ovary (mrto)/small cell cancer of the ovary of the hypercalcemic type (sccoht) with an ezh2 inhibitor |
| AU2016333982A1 (en) * | 2015-10-06 | 2018-04-26 | Epizyme, Inc. | Method of treating medulloblastoma with an EZH2 inhibitor |
| EP3370725A4 (en) * | 2015-11-06 | 2019-07-03 | Epizyme, Inc. | PEDIATRIC DOSAGE FOR THE TREATMENT OF CANCER WITH AN EZH2 INHIBITOR |
| CN105440023A (zh) * | 2015-12-10 | 2016-03-30 | 江苏理工学院 | Epz-6438的合成方法 |
| EP3407978A4 (en) | 2016-01-29 | 2020-01-15 | Epizyme Inc | POLYTHERAPY FOR THE TREATMENT OF CANCER |
| JP2019508406A (ja) * | 2016-02-08 | 2019-03-28 | エピザイム，インコーポレイティド | 癌を処置する方法 |
| EP3463355B1 (en) * | 2016-05-26 | 2024-08-28 | Sonic Master Limited | Modulators of dux4 for regulation of muscle function |
| CA3025933A1 (en) | 2016-06-01 | 2017-12-07 | Epizyme, Inc. | Use of ezh2 inhibitors for treating cancer |
| US20200129519A1 (en) * | 2016-06-08 | 2020-04-30 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
| WO2017218953A1 (en) | 2016-06-17 | 2017-12-21 | Epizyme, Inc. | Ezh2 inhibitors for treating cancer |
| US20190192521A1 (en) * | 2016-08-15 | 2019-06-27 | The Wistar Institute Of Anatomy And Biology | Methods of Treating Arid1A-Mutated Cancers With HDAC6 Inhibitors and EZH2 Inhibitors |
| WO2018049000A1 (en) * | 2016-09-08 | 2018-03-15 | The General Hospital Corporation | Treatment of cancers having alterations within the swi/snf chromatin remodeling complex |
| US10457640B2 (en) | 2016-10-19 | 2019-10-29 | Constellation Pharmaceuticals, Inc. | Synthesis of inhibitors of EZH2 |
| CN110730819A (zh) | 2016-10-26 | 2020-01-24 | 索尼克马斯特有限公司 | 肌肉谱系细胞的改善产生及其治疗用途 |
| CN108314677B (zh) | 2017-01-17 | 2020-06-30 | 安徽中科拓苒药物科学研究有限公司 | 一种ezh2抑制剂及其用途 |
| US20190350929A1 (en) * | 2017-02-02 | 2019-11-21 | Epizyme, Inc. | Cancer treatment modalities |
| US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
| WO2018183885A1 (en) | 2017-03-31 | 2018-10-04 | Epizyme, Inc. | Combination therapy for treating cancer |
| AU2018275123A1 (en) | 2017-06-02 | 2020-01-30 | Epizyme, Inc. | Use of EZH2 inhibitors for treating cancer |
| EP3654956A4 (en) | 2017-07-19 | 2021-04-28 | Children's Medical Center Corporation | COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH IMPRESSION DEFECTS |
| RU2020111019A (ru) | 2017-08-18 | 2021-09-20 | Трагара Фармасьютикалз, Инк. | Полиморфная форма tg02 |
| CN111093660A (zh) | 2017-09-05 | 2020-05-01 | Epizyme股份有限公司 | 用于治疗癌症的组合疗法 |
| KR20200088386A (ko) | 2017-11-14 | 2020-07-22 | 화이자 인코포레이티드 | Ezh2 억제제 병용 요법 |
| DK3746446T3 (da) | 2018-01-31 | 2022-06-27 | Mirati Therapeutics Inc | PRC2-inhibitorer |
| CA3104209A1 (en) * | 2018-07-09 | 2020-01-16 | Fondation Asile Des Aveugles | Inhibition of prc2 subunits to treat eye disorders |
| TWI798532B (zh) * | 2019-03-25 | 2023-04-11 | 大陸商深圳微芯生物科技股份有限公司 | Ｋｄｍ５ａ基因和ａｔｒｘ基因的應用 |
| WO2020198717A1 (en) * | 2019-03-27 | 2020-10-01 | The Johns Hopkins University | Methods and materials for assessing and treating cancer |
| US12421228B2 (en) | 2019-04-22 | 2025-09-23 | Mirati Therapeutics, Inc. | Naphthyridine derivatives as PRC2 inhibitors |
| JP7684910B2 (ja) | 2019-04-22 | 2025-05-28 | ユニバーシティ オブ ピッツバーグ －オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 小児対象において神経膠腫を治療するためのｔｇ０２の使用 |
| WO2020247130A1 (en) * | 2019-06-03 | 2020-12-10 | Icahn School Of Medicine At Mount Sinai | Compounds and methods for inhibiting cancers via rest inhibition |
| US12252493B2 (en) | 2019-06-05 | 2025-03-18 | Mirati Therapeutics, Inc. | Imidazo[1,2-c]pyrimidine derivatives as PRC2 inhibitors for treating cancer |
| AU2020303943B2 (en) | 2019-06-28 | 2026-01-29 | Als Therapy Development Institute | Inhibition of dipeptide repeat proteins |
| WO2021173960A1 (en) * | 2020-02-28 | 2021-09-02 | The Wistar Institute Of Anatomy And Biology | Treatment of carm1-overexpressing and/or arid1a mutant cancers with ire-1/xbp-1 inhibitors |
| AU2021293943A1 (en) * | 2020-06-18 | 2023-02-23 | Epizyme, Inc. | SMARCA4 inhibition for the treatment of cancer |
| CN111773387A (zh) * | 2020-07-08 | 2020-10-16 | 北京大学 | 一种通过改变bin1剪切体比例改善心脏横管结构的方法 |
| WO2023025856A1 (en) | 2021-08-25 | 2023-03-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of ezh2 inhibitors for the treatment of aortic valve stenosis |
| CN116019916A (zh) * | 2021-10-27 | 2023-04-28 | 蚌埠医学院第一附属医院 | 非小细胞肺癌靶点arid1a及其抑制剂在制备肺癌治疗药物中的用途 |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5455044A (en) | 1993-05-14 | 1995-10-03 | Depotech Corporation | Method for treating neurological disorders |
| US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| US7229774B2 (en) | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
| DK2238982T3 (da) | 2003-06-27 | 2013-01-28 | Astellas Pharma Inc | Terapeutisk middel til blødt væv-sarcom |
| US20090012031A1 (en) * | 2007-07-03 | 2009-01-08 | The Regents Of The University Of Michigan | EZH2 Cancer Markers |
| US20120114670A1 (en) * | 2007-10-02 | 2012-05-10 | University Of Rochester | Methods and compositions related to synergistic responses to oncogenic mutations |
| US20110064664A1 (en) * | 2007-10-08 | 2011-03-17 | The Board Of Regents Of The University Of Texas System | Methods and compositions involving chitosan nanoparticles |
| WO2011103016A2 (en) * | 2010-02-19 | 2011-08-25 | The Regents Of The University Of Michigan | Compositions and methods for inhibiting ezh2 |
| UA110112C2 (uk) | 2010-05-07 | 2015-11-25 | Глаксосмітклайн Ллс | Індоли |
| JP5889875B2 (ja) | 2010-05-07 | 2016-03-22 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | アザインダゾール |
| US8846935B2 (en) | 2010-05-07 | 2014-09-30 | Glaxosmithkline Llc | Indazoles |
| WO2012071096A2 (en) * | 2010-09-03 | 2012-05-31 | The Johns Hopkins University | Arid1a and ppp2r1a mutations in cancer |
| BR112013005806B1 (pt) | 2010-09-10 | 2022-05-10 | Epizyme, Inc | Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2 |
| US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
| US20130310379A1 (en) | 2010-11-19 | 2013-11-21 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
| ES2607064T3 (es) * | 2010-12-01 | 2017-03-29 | Glaxosmithkline Llc | Indoles |
| ES2951688T3 (es) | 2011-02-28 | 2023-10-24 | Epizyme Inc | Compuestos de heteroarilo biciclico fusionados en 6,5 sustituidos |
| US20140296248A1 (en) | 2011-04-04 | 2014-10-02 | Stichting het Nederlands Kanker Instiuut-Antoni van Leeuwenhoek ziekenhuis | Methods and compositions for predicting resistance to anticancer treatment |
| TWI598336B (zh) * | 2011-04-13 | 2017-09-11 | 雅酶股份有限公司 | 經取代之苯化合物 |
| JO3363B1 (ar) | 2011-04-13 | 2019-03-13 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| EP2709629B1 (en) | 2011-05-16 | 2017-10-11 | Ulrike Nuber | Novel cancer therapies and methods |
| EP2755962B1 (en) * | 2011-09-13 | 2017-03-01 | Glaxosmithkline LLC | Azaindazoles |
| CA2850570A1 (en) * | 2011-09-30 | 2013-04-04 | Glaxosmithkline Llc | Methods of treating cancer |
| WO2013059944A1 (en) | 2011-10-28 | 2013-05-02 | British Columbia Cancer Agency Branch | Epigenetic regulators and uses thereof |
| NZ628762A (en) | 2012-02-10 | 2016-07-29 | Constellation Pharmaceuticals Inc | Modulators of methyl modifying enzymes, compositions and uses thereof |
| EP3536314A1 (en) | 2012-03-12 | 2019-09-11 | Epizyme, Inc. | Inhibitors of human ezh2, and methods of use thereof |
| EP2828250B1 (en) | 2012-03-19 | 2021-03-10 | Imperial College Innovations Limited | Quinazoline compounds and their use in therapy |
| SG10201912111TA (en) | 2012-04-13 | 2020-02-27 | Epizyme Inc | Combination therapy for treating cancer |
| PT3184523T (pt) | 2012-04-13 | 2019-09-26 | Eisai R&D Man Co Ltd | Bromidrato de n-((4,6-dimetil-2-oxo-l,2-di-hidropiridin- 3-il)metil)-5-(etil(tetra-hidro-2h-piran-4-il)amino)-4- metil-4¿-(morfolinometil)-[l,1¿-bofenil]-3-carboxamida para utilização no tratamento de uma doença proliferativa celular do sistema hematológico |
| WO2013173441A2 (en) | 2012-05-16 | 2013-11-21 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
| KR20230156450A (ko) | 2012-10-15 | 2023-11-14 | 에피자임, 인코포레이티드 | 암을 치료하는 방법 |
| MX2015004721A (es) | 2012-10-15 | 2016-01-25 | Epizyme Inc | Compuestos de benceno sustituidos. |
| US20140120083A1 (en) | 2012-11-01 | 2014-05-01 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| US9895390B2 (en) | 2012-12-10 | 2018-02-20 | Children's Medical Center Corporation | Methods and assays for combination treatment of cancer |
| AU2013361060B2 (en) | 2012-12-21 | 2018-04-19 | Epizyme, Inc. | 1,4-pyridone compounds |
| CA2894222A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | 1,4-pyridone bicyclic heteroaryl compounds |
| SI2953941T1 (sl) | 2013-02-11 | 2017-08-31 | Constellation Pharmaceuticals, Inc. | Modulatorji metil-modificirajočih encimov, sestavki in uporabe le-teh |
| US9776996B2 (en) | 2013-03-15 | 2017-10-03 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| US9045477B2 (en) | 2013-03-15 | 2015-06-02 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| CA2903572A1 (en) | 2013-03-15 | 2014-10-23 | Epizyme, Inc. | Substituted benzene compounds |
| US9243001B2 (en) | 2013-03-15 | 2016-01-26 | Epizyme, Inc. | Substituted benzene compounds |
| US20160091485A1 (en) | 2013-04-25 | 2016-03-31 | The Broad Institute, Inc. | Markers for ezh2 inhibitors |
| EP2991980B1 (en) | 2013-04-30 | 2019-01-02 | Glaxosmithkline Intellectual Property (No. 2) Limited | Enhancer of zeste homolog 2 inhibitors |
| BR112015030515A2 (pt) | 2013-06-06 | 2017-07-25 | Glaxosmithkline Ip No 2 Ltd | intensificadores de inibidores de homólogo 2 de zeste |
| KR20160030221A (ko) | 2013-07-10 | 2016-03-16 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 제스트 인핸서 상동체 2 억제제 |
| US10150764B2 (en) | 2013-07-19 | 2018-12-11 | Epizyme, Inc. | Substituted benzene compounds |
| WO2015010078A2 (en) | 2013-07-19 | 2015-01-22 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| MA38949A1 (fr) | 2013-10-16 | 2017-07-31 | Eisai R&D Man Co Ltd | Forme saline d'hydrochlorure pour inhibition d'ezh2 |
| WO2015058125A1 (en) | 2013-10-18 | 2015-04-23 | Epizyme, Inc. | Method of treating cancer |
| CN116019921A (zh) | 2013-12-06 | 2023-04-28 | Epizyme股份有限公司 | 用于治疗癌症的组合疗法 |
| US20160326596A1 (en) | 2013-12-31 | 2016-11-10 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for the diagnosis and treatment of ovarian cancers that are associated with reduced smarca4 gene expression or protein function |
| WO2015128837A1 (en) | 2014-02-26 | 2015-09-03 | Glaxosmithkline Intellectual Property (No.2) Limited | Methods of treating cancer patients responding to ezh2 inhibitor gsk126 |
| CN106255693A (zh) | 2014-03-07 | 2016-12-21 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | Zeste增强子同源物2的抑制剂 |
| NZ724368A (en) | 2014-03-19 | 2023-07-28 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| BR112016029492A2 (pt) | 2014-06-17 | 2017-10-17 | Eisai R&D Man Co Ltd | método para tratamento de linfoma não hodgkin |
| WO2015193768A1 (en) | 2014-06-17 | 2015-12-23 | Pfizer Inc. | Aryl fused lactams as ezh2 modulators |
| SG11201610610YA (en) | 2014-06-19 | 2017-01-27 | Sloan Kettering Inst Cancer | Biomarkers for response to ezh2 inhibitors |
| WO2015200650A1 (en) | 2014-06-25 | 2015-12-30 | Epizyme, Inc. | Substituted benzene and 6,5-fused bicyclic heteroaryl compounds |
| EP3189036B1 (en) | 2014-09-05 | 2023-07-19 | ArQule, Inc. | Compositions and methods for treating proliferation disorders |
| EA201790845A1 (ru) | 2014-10-16 | 2017-08-31 | Эпизайм, Инк. | Способ лечения рака |
| HUE062159T2 (hu) | 2014-11-17 | 2023-10-28 | Epizyme Inc | Módszer a rák kezelésére N-((4,6-dimetil-2-oxo-l,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2H -pirán-4-il)amino)-4-metil-4'-(morfolinmetil)-[1,1'-bifenil]-3-karboxamiddal |
| WO2016172199A1 (en) | 2015-04-20 | 2016-10-27 | Epizyme, Inc. | Combination therapy for treating cancer |
| AU2016275051A1 (en) | 2015-06-10 | 2017-12-07 | Epizyme, Inc. | EZH2 inhibitors for treating lymphoma |
| WO2017035234A1 (en) | 2015-08-24 | 2017-03-02 | Epizyme, Inc. | Method for treating cancer |
| CA2999898A1 (en) | 2015-09-25 | 2017-03-30 | Epizyme, Inc. | Method of treating malignant rhabdoid tumor of the ovary (mrto)/small cell cancer of the ovary of the hypercalcemic type (sccoht) with an ezh2 inhibitor |
| AU2016333982A1 (en) | 2015-10-06 | 2018-04-26 | Epizyme, Inc. | Method of treating medulloblastoma with an EZH2 inhibitor |
| EP3370725A4 (en) | 2015-11-06 | 2019-07-03 | Epizyme, Inc. | PEDIATRIC DOSAGE FOR THE TREATMENT OF CANCER WITH AN EZH2 INHIBITOR |
| CN108697716A (zh) | 2015-12-07 | 2018-10-23 | Epizyme股份有限公司 | Ezh2抑制剂及其使用方法 |
| EP3407978A4 (en) | 2016-01-29 | 2020-01-15 | Epizyme Inc | POLYTHERAPY FOR THE TREATMENT OF CANCER |
| JP2019508406A (ja) | 2016-02-08 | 2019-03-28 | エピザイム，インコーポレイティド | 癌を処置する方法 |
| CA3025933A1 (en) | 2016-06-01 | 2017-12-07 | Epizyme, Inc. | Use of ezh2 inhibitors for treating cancer |
| US20200129519A1 (en) | 2016-06-08 | 2020-04-30 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
| WO2017218953A1 (en) | 2016-06-17 | 2017-12-21 | Epizyme, Inc. | Ezh2 inhibitors for treating cancer |
| US20190350929A1 (en) | 2017-02-02 | 2019-11-21 | Epizyme, Inc. | Cancer treatment modalities |
| WO2018183885A1 (en) | 2017-03-31 | 2018-10-04 | Epizyme, Inc. | Combination therapy for treating cancer |
| AU2018275123A1 (en) | 2017-06-02 | 2020-01-30 | Epizyme, Inc. | Use of EZH2 inhibitors for treating cancer |
| WO2018231973A1 (en) | 2017-06-13 | 2018-12-20 | Epizyme, Inc. | Inhibitors of ezh2 and methods of use thereof |
| CN111093660A (zh) | 2017-09-05 | 2020-05-01 | Epizyme股份有限公司 | 用于治疗癌症的组合疗法 |
| IL294108A (en) | 2019-12-20 | 2022-08-01 | Epizyme Inc | Crystalline hydrobromide salt of a ezh2 inhibitor, its preparation and pharmaceutical composition useful for the treatment of cancer |
| US20230201213A1 (en) | 2020-05-28 | 2023-06-29 | Epizyme, Inc. | Use of ezh2 inhibitors for treating cancer |
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