JP2015533794A5 - - Google Patents
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- JP2015533794A5 JP2015533794A5 JP2015531266A JP2015531266A JP2015533794A5 JP 2015533794 A5 JP2015533794 A5 JP 2015533794A5 JP 2015531266 A JP2015531266 A JP 2015531266A JP 2015531266 A JP2015531266 A JP 2015531266A JP 2015533794 A5 JP2015533794 A5 JP 2015533794A5
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- Prior art keywords
- alkyl
- dione
- compound
- dien
- deficiency
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 69
- 238000000034 method Methods 0.000 claims description 66
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 35
- 239000000203 mixture Substances 0.000 claims description 35
- 208000013200 Stress disease Diseases 0.000 claims description 28
- 230000036542 oxidative stress Effects 0.000 claims description 28
- -1 2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl Chemical group 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 239000012453 solvate Substances 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 11
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- WMKDFHJGEGZOQZ-UHFFFAOYSA-N 13-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)trideca-5,8-dienenitrile Chemical compound CC1=C(C)C(=O)C(CCCCC=CCC=CCCCC#N)=C(C)C1=O WMKDFHJGEGZOQZ-UHFFFAOYSA-N 0.000 claims description 4
- SRZOVFGPTNSKBA-UHFFFAOYSA-N 13-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)trideca-5,8-dienoic acid Chemical compound CC1=C(C)C(=O)C(CCCCC=CCC=CCCCC(O)=O)=C(C)C1=O SRZOVFGPTNSKBA-UHFFFAOYSA-N 0.000 claims description 4
- WZDMDZDQIITTBR-UHFFFAOYSA-N 2-(10-hydroxydeca-5,8-dienyl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione Chemical compound CC1=C(C)C(=O)C(CCCCC=CCC=CCO)=C(C)C1=O WZDMDZDQIITTBR-UHFFFAOYSA-N 0.000 claims description 4
- WAXIFTIATZBGGS-UHFFFAOYSA-N 2-(10-hydroxydeca-5,8-dienyl)-3-methylnaphthalene-1,4-dione Chemical compound CC1=C(CCCCC=CCC=CCO)C(=O)c2ccccc2C1=O WAXIFTIATZBGGS-UHFFFAOYSA-N 0.000 claims description 4
- DUSWGTOWKNQCKJ-UHFFFAOYSA-N 2-(12-hydroxydodeca-5,8-dienyl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione Chemical compound CC1=C(C)C(=O)C(CCCCC=CCC=CCCCO)=C(C)C1=O DUSWGTOWKNQCKJ-UHFFFAOYSA-N 0.000 claims description 4
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- WDEABJKSGGRCQA-UHFFFAOYSA-N docebenone Chemical group CC1=C(C)C(=O)C(CCCCC#CCCCC#CCO)=C(C)C1=O WDEABJKSGGRCQA-UHFFFAOYSA-N 0.000 claims description 4
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- 108010027062 Long-Chain Acyl-CoA Dehydrogenase Proteins 0.000 claims description 2
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 201000004010 carnitine palmitoyltransferase I deficiency Diseases 0.000 claims description 2
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- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 1
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims 1
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- ASARMUCNOOHMLO-WLORSUFZSA-L cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2s)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O ASARMUCNOOHMLO-WLORSUFZSA-L 0.000 claims 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261698431P | 2012-09-07 | 2012-09-07 | |
| US61/698,431 | 2012-09-07 | ||
| US201361792797P | 2013-03-15 | 2013-03-15 | |
| US61/792,797 | 2013-03-15 | ||
| PCT/US2013/058637 WO2014039917A1 (en) | 2012-09-07 | 2013-09-06 | Benzoquinone derivatives for treating oxidative stress disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015533794A JP2015533794A (ja) | 2015-11-26 |
| JP2015533794A5 true JP2015533794A5 (https=) | 2016-10-27 |
Family
ID=49170942
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531266A Ceased JP2015533794A (ja) | 2012-09-07 | 2013-09-06 | 酸化ストレス障害を処置するためのベンゾキノン誘導体 |
| JP2015531249A Expired - Fee Related JP6393684B2 (ja) | 2012-09-07 | 2013-09-06 | 個体のレドックス状態の調節において使用するためのキノン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531249A Expired - Fee Related JP6393684B2 (ja) | 2012-09-07 | 2013-09-06 | 個体のレドックス状態の調節において使用するためのキノン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20150216820A1 (https=) |
| EP (2) | EP2892516A1 (https=) |
| JP (2) | JP2015533794A (https=) |
| CA (2) | CA2883879A1 (https=) |
| HK (1) | HK1211872A1 (https=) |
| WO (2) | WO2014039917A1 (https=) |
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-
2013
- 2013-09-06 CA CA2883879A patent/CA2883879A1/en not_active Abandoned
- 2013-09-06 CA CA2883882A patent/CA2883882A1/en not_active Abandoned
- 2013-09-06 US US14/426,130 patent/US20150216820A1/en not_active Abandoned
- 2013-09-06 US US14/426,135 patent/US9629815B2/en not_active Expired - Fee Related
- 2013-09-06 EP EP13765880.3A patent/EP2892516A1/en not_active Withdrawn
- 2013-09-06 WO PCT/US2013/058637 patent/WO2014039917A1/en not_active Ceased
- 2013-09-06 JP JP2015531266A patent/JP2015533794A/ja not_active Ceased
- 2013-09-06 EP EP13762705.5A patent/EP2892515A1/en not_active Withdrawn
- 2013-09-06 JP JP2015531249A patent/JP6393684B2/ja not_active Expired - Fee Related
- 2013-09-06 HK HK16100029.7A patent/HK1211872A1/xx unknown
- 2013-09-06 WO PCT/US2013/058568 patent/WO2014039862A1/en not_active Ceased
-
2017
- 2017-04-10 US US15/483,933 patent/US20170209393A1/en not_active Abandoned
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