JP2016520621A5 - - Google Patents

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Publication number
JP2016520621A5
JP2016520621A5 JP2016517067A JP2016517067A JP2016520621A5 JP 2016520621 A5 JP2016520621 A5 JP 2016520621A5 JP 2016517067 A JP2016517067 A JP 2016517067A JP 2016517067 A JP2016517067 A JP 2016517067A JP 2016520621 A5 JP2016520621 A5 JP 2016520621A5
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JP
Japan
Prior art keywords
alkyl
item
group
formula
pharmaceutically acceptable
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016517067A
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English (en)
Japanese (ja)
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JP2016520621A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/040387 external-priority patent/WO2014194292A1/en
Publication of JP2016520621A publication Critical patent/JP2016520621A/ja
Publication of JP2016520621A5 publication Critical patent/JP2016520621A5/ja
Pending legal-status Critical Current

Links

JP2016517067A 2013-05-31 2014-05-30 酸化ストレス障害の処置のためのカルボン酸誘導体 Pending JP2016520621A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361829886P 2013-05-31 2013-05-31
US61/829,886 2013-05-31
PCT/US2014/040387 WO2014194292A1 (en) 2013-05-31 2014-05-30 Carboxylic acid derivatives for treatment of oxidative stress disorders

Publications (2)

Publication Number Publication Date
JP2016520621A JP2016520621A (ja) 2016-07-14
JP2016520621A5 true JP2016520621A5 (https=) 2017-07-06

Family

ID=50983236

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016517067A Pending JP2016520621A (ja) 2013-05-31 2014-05-30 酸化ストレス障害の処置のためのカルボン酸誘導体

Country Status (8)

Country Link
US (1) US20160115141A1 (https=)
EP (1) EP3004071A1 (https=)
JP (1) JP2016520621A (https=)
AU (1) AU2014273891A1 (https=)
CA (1) CA2912871A1 (https=)
HK (1) HK1223369A1 (https=)
MX (1) MX2015016014A (https=)
WO (1) WO2014194292A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2471530B1 (en) 2005-06-01 2017-01-11 Edison Pharmaceuticals, Inc. Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
US9278085B2 (en) 2006-02-22 2016-03-08 Edison Pharmaceuticals, Inc. Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
WO2009061744A2 (en) 2007-11-06 2009-05-14 Edison Pharmaceuticals, Inc. 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases
EA023618B1 (ru) 2008-01-08 2016-06-30 Эдисон Фармасьютикалз, Инк. Производные (гет)арил-п-хинона для лечения митохондриальных болезней
EP2344142B1 (en) 2008-09-10 2024-06-26 PTC Therapeutics, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
CA2741767C (en) 2008-10-28 2017-09-12 Ptc Therapeutics, Inc. Process for the production of alpha-tocotrienol and derivatives
PL2424495T3 (pl) 2009-04-28 2018-06-29 Bioelectron Technology Corporation Leczenie dziedzicznej neuropatii nerwów wzrokowych lebera i dominującego zaniku nerwu wzrokowego chinonami tokotrienolu
WO2012174286A1 (en) 2011-06-14 2012-12-20 Edison Pharmaceuticals, Inc. Catechol derivatives for treatment of oxidative stress diseases
JP2014520894A (ja) 2011-07-19 2014-08-25 エジソン ファーマシューティカルズ, インコーポレイテッド 非アルファトコトリエノールの存在下でのアルファトコトリエノールの選択的酸化のための方法
CA2883879A1 (en) 2012-09-07 2014-03-13 Edison Pharmaceuticals, Inc. Quinone derivatives for use in the modulation of redox status of individuals
US9868711B2 (en) 2013-03-15 2018-01-16 Bioelectron Technology Corporation Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
US9670170B2 (en) 2013-03-15 2017-06-06 Bioelectron Technology Corporation Resorufin derivatives for treatment of oxidative stress disorders
US10189830B2 (en) 2013-03-15 2019-01-29 Bioelectron Technology Corporation Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders
AU2015364640B2 (en) 2014-12-16 2020-08-13 Ptc Therapeutics, Inc. Polymorphic and amorphous forms of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide
JP7137745B2 (ja) * 2015-05-22 2022-09-15 ズィ・エイツー・ミルク・カンパニー・リミテッド ベータカゼインa2および抗酸化能
ES3033538T3 (en) * 2015-10-08 2025-08-05 Khondrion Ip B V Novel compounds for treating mitochondrial disease
EP3390377B1 (en) 2015-12-16 2026-03-25 PTC Therapeutics, Inc. Improved methods for enriching alpha-tocotrienol from mixed tocol compositions
WO2017106803A1 (en) 2015-12-17 2017-06-22 Bioelectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
JP2018083799A (ja) 2016-11-15 2018-05-31 バイオエレクトロン テクノロジー コーポレイション 2−置換アミノ−ナフト[1,2−d]イミダゾール−5−オン化合物またはその製薬学上許容される塩
WO2018093957A1 (en) * 2016-11-15 2018-05-24 Bioelectron Technology Corporation 2-substituted amino-naphth[1,2-d]imidazol-5-one compounds or pharmaceutically acceptable salts thereof cross reference to related applications
CN110582480B (zh) * 2017-04-21 2023-11-10 塔斯马尼亚大学 治疗化合物和方法
WO2019160150A1 (ja) * 2018-02-19 2019-08-22 國子 草間 バレロラクトン(Valerolactone)系新規化合物、及び、医薬
KR20210076956A (ko) 2018-10-17 2021-06-24 피티씨 테라퓨틱스, 인크. α-시누클레인병증, 타우병증 및 기타 장애를 억제 및 치료하기 위한 2,3,5-트리메틸-6-노닐사이클로헥사-2,5-디엔-1,4-디온
PE20240893A1 (es) 2021-07-08 2024-04-24 Ptc Therapeutics Inc Composiciones farmaceuticas que comprenden 2,3,5-trimetil-6-nonilciclohexa-2,5-dien-1,4-diona

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5621021B2 (https=) * 1973-12-19 1981-05-16
JPS5640651A (en) * 1979-09-12 1981-04-16 Takeda Chem Ind Ltd Quinone compound and its preparation
JPH07316049A (ja) * 1994-05-25 1995-12-05 Nippon Oil & Fats Co Ltd 細胞傷害防御剤
US6150402A (en) * 1994-08-15 2000-11-21 Loma Linda University Medical Center Natriuretic compounds
NZ513547A (en) 2001-08-13 2002-09-27 Antipodean Biotechnology Ltd Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone)
GB0204232D0 (en) 2002-02-22 2002-04-10 Isis Innovation Assay
DE60211875T2 (de) 2002-07-01 2006-10-26 Santhera Pharmaceuticals (Schweiz) Ag Screeningverfahren und Verbindungen zur Behandlung von Friedreich ataxia
EP2471530B1 (en) 2005-06-01 2017-01-11 Edison Pharmaceuticals, Inc. Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
CA2883879A1 (en) 2012-09-07 2014-03-13 Edison Pharmaceuticals, Inc. Quinone derivatives for use in the modulation of redox status of individuals

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