JP2015532923A5 - - Google Patents

Info

Publication number

JP2015532923A5

JP2015532923A5 JP2015533048A JP2015533048A JP2015532923A5 JP 2015532923 A5 JP2015532923 A5 JP 2015532923A5 JP 2015533048 A JP2015533048 A JP 2015533048A JP 2015533048 A JP2015533048 A JP 2015533048A JP 2015532923 A5 JP2015532923 A5 JP 2015532923A5

Authority

JP

Japan

Prior art keywords

composition

tissue

antibiotic

ecm

component

Prior art date

2013-06-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 3
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 3
• 210000002744 extracellular matrix Anatomy 0.000 claims 3
• 210000001519 tissue Anatomy 0.000 claims 3
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 2
• 230000003115 biocidal effect Effects 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• CFGDUGSIBUXRMR-UHFFFAOYSA-N 1,2-dihydropyrrol-2-ide Chemical compound C=1C=[C-]NC=1 CFGDUGSIBUXRMR-UHFFFAOYSA-N 0.000 claims 1
• WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 claims 1
• 229930186147 Cephalosporin Natural products 0.000 claims 1
• 229930182555 Penicillin Natural products 0.000 claims 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
• 239000004098 Tetracycline Substances 0.000 claims 1
• 108010059993 Vancomycin Proteins 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
• 229940126575 aminoglycoside Drugs 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 239000012867 bioactive agent Substances 0.000 claims 1
• 229940124587 cephalosporin Drugs 0.000 claims 1
• 150000001780 cephalosporins Chemical class 0.000 claims 1
• 229960005091 chloramphenicol Drugs 0.000 claims 1
• WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims 1
• 229960002227 clindamycin Drugs 0.000 claims 1
• KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims 1
• 229940047766 co-trimoxazole Drugs 0.000 claims 1
• 230000002526 effect on cardiovascular system Effects 0.000 claims 1
• 229960003276 erythromycin Drugs 0.000 claims 1
• 229940124307 fluoroquinolone Drugs 0.000 claims 1
• 210000005003 heart tissue Anatomy 0.000 claims 1
• 239000007972 injectable composition Substances 0.000 claims 1
• 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
• VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 1
• 229960000282 metronidazole Drugs 0.000 claims 1
• 229940049954 penicillin Drugs 0.000 claims 1
• 229960002180 tetracycline Drugs 0.000 claims 1
• 229930101283 tetracycline Natural products 0.000 claims 1
• 235000019364 tetracycline Nutrition 0.000 claims 1
• 150000003522 tetracyclines Chemical class 0.000 claims 1
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims 1
• 229960003165 vancomycin Drugs 0.000 claims 1
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 1