JP2015532923A - 生体組織の治療のための方法及びシステム - Google Patents
生体組織の治療のための方法及びシステム Download PDFInfo
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Abstract
Description
用語「心臓組織の損傷」、「心臓組織の傷害」、及び「心血管組織の損傷」は、本明細書において互換的に使用され、心外膜、心内膜、及び/又は心筋の損傷を含む疾病、疾患、傷害又は損傷によって引き起こされた心血管系又は心臓内の任意の異常な組織の領域を意味し、含む。心血管組織損傷の原因の例としては、急性又は慢性ストレス(全身性高血圧、肺高血圧症、弁機能障害等)、冠動脈不全、虚血又は梗塞、炎症性疾患及び心筋症が含まれるがこれらに限定されない。
以下の実施例は、当業者が本発明をより明確に理解し及び本発明を実施できるようにするために提供される。それらは本発明の範囲を限定するものと見なされるべきではなく、単に本発明の代表として説明される。
五つ(5)のブタの心臓が仔ブタから得られた。除去後、心臓は生理食塩水浴に保存された。
連続してマイクロスフィアを冠動脈に注入することによりCHFが誘導された仔ブタが提供された。
・損傷した生体組織、特に、新血管組織に送達されたときに、新血管形成を誘導し、損傷した心血管組織の生存及び再生を促進する薬理組成物の提供。
・損傷した生体組織、特に、新血管組織に送達されたときに、宿主組織の増殖、バイオリモデリング、及び部位特異的な構造的及び機能的特性を有する心血管組織構造の再生を誘導する細胞外マトリックス(ECM)組成物の提供。
・薬理組成物、特に、ECM組成物を損傷した又は罹患した生体組織に直接に投与するための改良された方法及びシステムの提供。
Claims (2)
- 損傷した心血管組織を治療するための注射可能な用組成物であって、
細胞外マトリックス(ECM)足場成分と生物活性剤成分とを有してなり、前記ECM足場成分は哺乳動物の組織を含み、該哺乳動物の組織は脱細胞化された心臓組織を含み、前記生物活性剤成分は抗生物質を含む、組成物。 - 前記抗生物質が、アミノグリコシド、セファロスポリン、クロラムフェニコール、クリンダマイシン、エリスロマイシン、フルオロキノロン、マクロライド、アゾリド、メトロニダゾール、ペニシリン、テトラサイクリン、トリメトプリム−スルファメトキサゾールおよびバンコマイシンからなる群から選択される、請求項1に記載の組成物。
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US13/573,569 | 2012-09-24 | ||
US13/573,569 US9072816B2 (en) | 2006-01-18 | 2012-09-24 | Composition for modulating inflammation of cardiovascular tissue |
PCT/US2013/046039 WO2014046752A1 (en) | 2012-09-24 | 2013-06-15 | Method and system for treatment of biological tissue |
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JP2015533045A Pending JP2015532922A (ja) | 2012-09-24 | 2013-05-29 | 生体組織の治療のための方法及びシステム |
JP2015533049A Pending JP2015531664A (ja) | 2012-09-24 | 2013-06-14 | 生体組織の治療のための方法及びシステム |
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JP2015533049A Pending JP2015531664A (ja) | 2012-09-24 | 2013-06-14 | 生体組織の治療のための方法及びシステム |
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KR101710615B1 (ko) * | 2016-09-07 | 2017-02-27 | 주식회사 파마리서치프로덕트 | 생착률을 증가시킨 이식용 진피층 및 이의 제조 방법 |
KR102235141B1 (ko) * | 2018-06-19 | 2021-04-05 | 푸와이 하스피틀, 차이니즈 아카데미 오브 메디컬 사이언시즈 앤드 페킹 유니언 메디컬 칼리지 | 약물 전처리에 기초한 간엽 줄기세포 유래 엑소좀 제조방법 |
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CA2883885A1 (en) | 2014-03-27 |
IL236021A0 (en) | 2015-01-29 |
WO2014046753A3 (en) | 2015-06-25 |
IN2015DN01780A (ja) | 2015-05-29 |
CA2875302A1 (en) | 2014-03-27 |
EP2897623A2 (en) | 2015-07-29 |
CA2884959A1 (en) | 2014-03-27 |
BR112014031796A2 (pt) | 2017-06-27 |
AU2013318552A1 (en) | 2015-03-19 |
EP2887948A1 (en) | 2015-07-01 |
WO2014046753A2 (en) | 2014-03-27 |
US9072816B2 (en) | 2015-07-07 |
SG11201501649TA (en) | 2015-04-29 |
CA2884959C (en) | 2021-08-17 |
EP2897624A4 (en) | 2016-05-18 |
EP2897623A4 (en) | 2016-07-06 |
AU2013318551B2 (en) | 2018-06-14 |
US20130058904A1 (en) | 2013-03-07 |
EP2897624A1 (en) | 2015-07-29 |
SG11201408808WA (en) | 2015-01-29 |
US20140087000A1 (en) | 2014-03-27 |
IL237568A0 (en) | 2015-04-30 |
EP2887948A4 (en) | 2016-04-13 |
US20150099007A1 (en) | 2015-04-09 |
JP2015531664A (ja) | 2015-11-05 |
AU2013318551A1 (en) | 2015-04-02 |
WO2014046752A1 (en) | 2014-03-27 |
CN104703614A (zh) | 2015-06-10 |
WO2014046744A1 (en) | 2014-03-27 |
JP2015532922A (ja) | 2015-11-16 |
BR112015006512A2 (pt) | 2017-08-08 |
AU2013318632A1 (en) | 2015-01-15 |
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